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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei121SubstrateUniRule annotation1
Binding sitei146SubstrateUniRule annotation1
Binding sitei176SubstrateUniRule annotation1
Binding sitei180SubstrateUniRule annotation1
Binding sitei181NADUniRule annotation1
Binding sitei233NADUniRule annotation1
Binding sitei268NADUniRule annotation1
Binding sitei335NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi147 – 149NADUniRule annotation3
Nucleotide bindingi210 – 215NADUniRule annotation6
Nucleotide bindingi289 – 291NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:MA_1275
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000002487 Componenti: Chromosome

Subcellular locationi

Q8TRA5:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001170031 – 411AdenosylhomocysteinaseAdd BLAST411

Interactioni

Protein-protein interaction databases

STRINGi188937.MA1275.

Structurei

3D structure databases

ProteinModelPortaliQ8TRA5.
SMRiQ8TRA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04137. Archaea.
COG0499. LUCA.
InParanoidiQ8TRA5.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG093Z03XF.
PhylomeDBiQ8TRA5.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 2 hits.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TRA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQELVESG NMKMEWARNH MPVIAIIREK FEKEKPLKGL KVGMALHVEA
60 70 80 90 100
KTAVLVETLA AGGAQVAISG CNPLSTQDDV ARALDTRKNI SCFARYGCCT
110 120 130 140 150
SEYYEAIDKV LDIEPDITID DGADLIFKLH KERTDLLPKI LGGCEETTTG
160 170 180 190 200
VHRLHAMEKE GALKMPVIAV NDAMTKYLFD NRYGTGQSAW DGINRTTNLL
210 220 230 240 250
VAGKNVVVGG YGWCGRGVAM RAAGLGANVI VTEVDPIRAL EARMDGYRVM
260 270 280 290 300
RMADAARLGE IFVTTTGNRD ILTAEHFKVM PDGAVLANSG HFNVEIDMEA
310 320 330 340 350
LTSLAKSVKT VRHNIKEYDI GDRRINVIAE GRLVNLAAGD GHPAEVMDMS
360 370 380 390 400
FANQALCVRY IAENTLLNGV HGVPRGIDTY VAKLKLESMG ISIDELTSKQ
410
ECYMTGWECG T
Length:411
Mass (Da):44,900
Last modified:June 1, 2002 - v1
Checksum:iC3221440430631F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA. Translation: AAM04694.1.
RefSeqiWP_011021296.1. NC_003552.1.

Genome annotation databases

EnsemblBacteriaiAAM04694; AAM04694; MA_1275.
GeneIDi1473163.
KEGGimac:MA_1275.

Similar proteinsi

Entry informationi

Entry nameiSAHH_METAC
AccessioniPrimary (citable) accession number: Q8TRA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: June 1, 2002
Last modified: October 25, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families