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Q8TQG1 (Q8TQG1_METAC) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897
Gene names
Name:gyrA HAMAP MF_01897 EMBL AAM04996.1
Ordered Locus Names:MA_1583
OrganismMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifier188937 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length929 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP MF_01897

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897

Subcellular location

Cytoplasm By similarity HAMAP MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Sequences

Sequence LengthMass (Da)Tools
Q8TQG1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: D70086FBC7138236

FASTA929104,142
        10         20         30         40         50         60 
MAKYEEEKKS EAEMKKSYQA TLIPEERDDK QEHGDGSIPL TREESGKKLE LALSDPASDE 

        70         80         90        100        110        120 
TEDEGPEPDN NGVTAILIDD EMKRSYINYA MSVIVGRALP DARDGLKPVH RRILFSMKES 

       130        140        150        160        170        180 
GITHDKPYKK SARVVGDVLG KYHPHGDAAV YDSIVRMVQD FSLRYPLIDG QGNFGSIDGD 

       190        200        210        220        230        240 
EAAAMRYTEV RMDRIAEEML TDIEKETVPF RPNYDGSLEE PEVLPAKLPN LLINGSTGIA 

       250        260        270        280        290        300 
VGMATNMAPH NISEVIDGTL MLIDNPETPV SELMTVVKGP DFPTGAHILG TAGIRSAYTT 

       310        320        330        340        350        360 
GRGPVKIRAV AEIQELKKDR EQIIVTELPY QVNKARMIEN IAQLVREKVI SGISDLRDES 

       370        380        390        400        410        420 
DREGIRVVIE LSKGTNARVV LNQLYKHTQM ETTFGVINLA LVDGKPQELN LKQLLEIYLE 

       430        440        450        460        470        480 
YRMEIVQKRT LYDLKKSEER AHILEGLRIA LDNIDAVVAL IKGSANADEA RQGLMDNFTL 

       490        500        510        520        530        540 
DEVQAKAILD MRLQRLTGLE TKKILEELEN LIKLIAELKK ILESDELKYE IIRTELLGLK 

       550        560        570        580        590        600 
EKYGDVRRTK IVHYTEEVTD EDLIPEADVV VTITNSGYIK RIPLDTYSMQ RRGGRGIIGM 

       610        620        630        640        650        660 
EMKEEDFVEN LFISSTHNYI LFFTNRGRLY WQKVYEIPEG SRQSRGKAIV NLLELREGEM 

       670        680        690        700        710        720 
VNAMIPVKEF AEDRYLLMAT RAGTTKKTPL SEFRNPRKAG IIAVSLDEGD ELVKVLLTDG 

       730        740        750        760        770        780 
KQEVLMVSKK GKAIRFSEDD VRPMGRTARG VRGMILDGPE DEVVSMDLVD ETTTLLSVTE 

       790        800        810        820        830        840 
NGFGKRTEYS QYPMHRRGGK GVITIVTNLR NGFVANVKSV AEDDELMITS SEGIIIRVPA 

       850        860        870        880        890        900 
KDISIQGRNT QGVRIMNMKS GDKVVGMARI KAEDEDQKQL KITNLKSGKA VSVKSEFEVG 

       910        920 
KDESEEPEEA KDVEEAGVEE VEEEVDEEE

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE010299 Genomic DNA. Translation: AAM04996.1.
RefSeqNP_616516.1. NC_003552.1.

3D structure databases

HSSPHSSP built from PDB template 1AB4 based on UniProtKB P09097.
ProteinModelPortalQ8TQG1.
SMRQ8TQG1. Positions 95-551.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1473471.
GenomeReviewsGene locus MA_1583 in contig AE010299_GR.
KEGGmac:MA1583.
NMPDRfig|188937.1.peg.1542.

Phylogenomic databases

HOGENOMHBG635183.
OMATGRGRIY.
ProtClustDBPRK05560.

Family and domain databases

HAMAPMF_01897. GyrA.
[Tree]
InterProIPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_cen.
[Graphical view]
Gene3DG3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KOK02469.
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. GyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ8TQG1_METAC
AccessionPrimary (citable) accession number: Q8TQG1
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info