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Q8TQD4 (THRC_METAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Threonine synthase

Short name=TS
EC=4.2.3.1
Gene names
Name:thrC
Ordered Locus Names:MA_1610
OrganismMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) [Reference proteome] [HAMAP]
Taxonomic identifier188937 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. Does not catalyze the conversion of O-acetyl-L-homoserine into threonine. Ref.2

Catalytic activity

O-phospho-L-homoserine + H2O = L-threonine + phosphate. Ref.2

Cofactor

Pyridoxal phosphate. Ref.2

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.

Subunit structure

Homotrimer. Ref.2

Domain

The N-terminal 41 amino acids are required for activity. Ref.2

Sequence similarities

Belongs to the threonine synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   LigandPyridoxal phosphate
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionpyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

threonine synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 405405Threonine synthase
PRO_0000392651

Regions

Region231 – 2355Pyridoxal phosphate binding By similarity

Sites

Binding site1301Pyridoxal phosphate By similarity
Binding site3691Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue1041N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8TQD4 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 3D2A303B42A4D942

FASTA40543,285
        10         20         30         40         50         60 
MYHLKCIECG AEYSRDEVIY TCSKCDGLLD VIYDYSSIKI DMEKLKTECP SVWKYAKLLP 

        70         80         90        100        110        120 
VEREPVTIQE GGTPLYKCDR LAEKIGIKKL YVKHEGMNPT GSFKDRGMTV GVTKALELGM 

       130        140        150        160        170        180 
NTVACASTGN TSAALAIYGA KAGIPVVVLL PAGKVALGKV AQALMHGAKV LSIRGNFDDA 

       190        200        210        220        230        240 
LALVRTLCSQ EKIYLLNSIN PYRLEGQKTI GFEIADQLDF KVPDRIVLPV GNAGNITAIY 

       250        260        270        280        290        300 
KGFREFKILG ITDSLPKMTG IQAEGSCPIV KAIKSGAPAI TPEENPETVA TAIRIGNPVN 

       310        320        330        340        350        360 
ATKALSAIRE SGGTAESVTD EEILAAQKDL ARLEGIGVEP ASAASVAGLR KLVDMGVIGR 

       370        380        390        400 
DETVVCITTG HLLKDPQTVI DVCEEPTVVD ANIDAIREAI FGKAK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE010299 Genomic DNA. Translation: AAM05023.1.
RefSeqNP_616543.1. NC_003552.1.

3D structure databases

ProteinModelPortalQ8TQD4.
SMRQ8TQD4. Positions 51-384.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING188937.MA1610.

Proteomic databases

PRIDEQ8TQD4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM05023; AAM05023; MA_1610.
GeneID1473498.
KEGGmac:MA1610.

Phylogenomic databases

eggNOGCOG0498.
KOK01733.
OMAGTPLYKC.
PhylomeDBQ8TQD4.
ProtClustDBPRK06260.

Enzyme and pathway databases

BioCycMACE188937:GI2O-1626-MONOMER.
UniPathwayUPA00050; UER00065.

Family and domain databases

InterProIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR026260. Thr_Synthase_Gram_pos_bac.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamPF00291. PALP. 1 hit.
[Graphical view]
PIRSFPIRSF038945. Thr_synthase. 1 hit.
SUPFAMSSF53686. SSF53686. 1 hit.
TIGRFAMsTIGR00260. thrC. 1 hit.
PROSITEPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHRC_METAC
AccessionPrimary (citable) accession number: Q8TQD4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways