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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei635ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMACE188937:G1FZT-1699-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:MA_1611
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000002487 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521301 – 961Leucine--tRNA ligaseAdd BLAST961

Interactioni

Protein-protein interaction databases

STRINGi188937.MA1611

Structurei

3D structure databases

ProteinModelPortaliQ8TQD3
SMRiQ8TQD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 51"HIGH" regionAdd BLAST11
Motifi632 – 636"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
InParanoidiQ8TQD3
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D
PhylomeDBiQ8TQD3

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TQD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQDYKPHEI EEKWQKKWNE SLIFQADPDK REKFFITIPY PYLNGNLHAG
60 70 80 90 100
HTRTFTIGDV VARHKRMLGY NVLYPMGFHV TGTPIVGLAE LIASRDPQTM
110 120 130 140 150
DVYEHLHGIP GDILPTLDTP EKIVDYFKRE AEKAMRMIGY SIDWRRKFTT
160 170 180 190 200
TDPTYKKFIE WQYIRLEEKG LIVKGSHPVK WCPNDNNPVE DHDILYGEEA
210 220 230 240 250
TIVEYTLIKF RYNDLVLPCA TLRPETTFGV TNLWVNPDVD YVKARVEKDG
260 270 280 290 300
NEEFWVVSKE AFRKLTFTDR TVEYVEDVPA KSIIGIKLTN PITGDEVISL
310 320 330 340 350
PASFVKPENG SGIVMSVPAH APFDYLALRD LYDADLSEYG ITEDLRDIKL
360 370 380 390 400
ISLIQVPEFG EFPAKEIVES MGIANQKAPK AEEATKIVYR REFHGGVLKE
410 420 430 440 450
ITGKYRGYPV SKIKDVLTRD LIASNAGETF YEFSEPVVCR CGTPCVVNMV
460 470 480 490 500
KGQWFLNYSN PEWKAKVYKC LSQMRIIPEE YRVEFENKVD WLKDKACARR
510 520 530 540 550
KGLGTRLPFD KEWLIESLGD STIYMSYYII ARFLERGDLA LEQLTLSFFD
560 570 580 590 600
YVLLGIGDSA AVSAETGLKQ ELVEEIRSHF NYWYPVDLRS SGKDLVPNHL
610 620 630 640 650
LFFLFHHVAL FEEEKWPRAL AVNGFVSLEG QKMSKSKGPI LTLESAVSAY
660 670 680 690 700
GADITRMYIL STAEQTQDAD WQKTGIDSAR RQVDRFYSFA KDVIESGKRA
710 720 730 740 750
TLSTELKLID RWMLSRMQKY IMETNIALDS IQTREAIQNS FFLLINDVRW
760 770 780 790 800
YQRRGGEALL YYVLDNWVRL MAPFTPHLCE EIWEAMGHED PISLAQYPLD
810 820 830 840 850
NEDLIDEGAE LAEEAVKSTL NDIEEIVRVT KMTPQKVYLY TAPAWKAEAI
860 870 880 890 900
RCACELQIEA PLEVGALIKT LMANPELKRF GKEIPKFVQK IIPEFKSGGA
910 920 930 940 950
ERYETFAYLG LDEQALLKES ASFLEKEIGC PVEIYSADSP EYDPQKKSRF
960
AEPLRPAIYI E
Length:961
Mass (Da):110,402
Last modified:June 1, 2002 - v1
Checksum:i8DC8CE4760800A86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM05024.1
RefSeqiWP_011021621.1, NC_003552.1

Genome annotation databases

EnsemblBacteriaiAAM05024; AAM05024; MA_1611
GeneIDi1473499
KEGGimac:MA_1611

Similar proteinsi

Entry informationi

Entry nameiSYL_METAC
AccessioniPrimary (citable) accession number: Q8TQD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health