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Q8TQD3

- SYL_METAC

UniProt

Q8TQD3 - SYL_METAC

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei635 – 6351ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMACE188937:GI2O-1627-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:MA_1611
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000002487: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 961961Leucine--tRNA ligasePRO_0000152130Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi188937.MA1611.

Structurei

3D structure databases

ProteinModelPortaliQ8TQD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5111"HIGH" regionAdd
BLAST
Motifi632 – 6365"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
InParanoidiQ8TQD3.
KOiK01869.
OMAiHAPFDYL.
PhylomeDBiQ8TQD3.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TQD3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQDYKPHEI EEKWQKKWNE SLIFQADPDK REKFFITIPY PYLNGNLHAG
60 70 80 90 100
HTRTFTIGDV VARHKRMLGY NVLYPMGFHV TGTPIVGLAE LIASRDPQTM
110 120 130 140 150
DVYEHLHGIP GDILPTLDTP EKIVDYFKRE AEKAMRMIGY SIDWRRKFTT
160 170 180 190 200
TDPTYKKFIE WQYIRLEEKG LIVKGSHPVK WCPNDNNPVE DHDILYGEEA
210 220 230 240 250
TIVEYTLIKF RYNDLVLPCA TLRPETTFGV TNLWVNPDVD YVKARVEKDG
260 270 280 290 300
NEEFWVVSKE AFRKLTFTDR TVEYVEDVPA KSIIGIKLTN PITGDEVISL
310 320 330 340 350
PASFVKPENG SGIVMSVPAH APFDYLALRD LYDADLSEYG ITEDLRDIKL
360 370 380 390 400
ISLIQVPEFG EFPAKEIVES MGIANQKAPK AEEATKIVYR REFHGGVLKE
410 420 430 440 450
ITGKYRGYPV SKIKDVLTRD LIASNAGETF YEFSEPVVCR CGTPCVVNMV
460 470 480 490 500
KGQWFLNYSN PEWKAKVYKC LSQMRIIPEE YRVEFENKVD WLKDKACARR
510 520 530 540 550
KGLGTRLPFD KEWLIESLGD STIYMSYYII ARFLERGDLA LEQLTLSFFD
560 570 580 590 600
YVLLGIGDSA AVSAETGLKQ ELVEEIRSHF NYWYPVDLRS SGKDLVPNHL
610 620 630 640 650
LFFLFHHVAL FEEEKWPRAL AVNGFVSLEG QKMSKSKGPI LTLESAVSAY
660 670 680 690 700
GADITRMYIL STAEQTQDAD WQKTGIDSAR RQVDRFYSFA KDVIESGKRA
710 720 730 740 750
TLSTELKLID RWMLSRMQKY IMETNIALDS IQTREAIQNS FFLLINDVRW
760 770 780 790 800
YQRRGGEALL YYVLDNWVRL MAPFTPHLCE EIWEAMGHED PISLAQYPLD
810 820 830 840 850
NEDLIDEGAE LAEEAVKSTL NDIEEIVRVT KMTPQKVYLY TAPAWKAEAI
860 870 880 890 900
RCACELQIEA PLEVGALIKT LMANPELKRF GKEIPKFVQK IIPEFKSGGA
910 920 930 940 950
ERYETFAYLG LDEQALLKES ASFLEKEIGC PVEIYSADSP EYDPQKKSRF
960
AEPLRPAIYI E
Length:961
Mass (Da):110,402
Last modified:June 1, 2002 - v1
Checksum:i8DC8CE4760800A86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA. Translation: AAM05024.1.
RefSeqiNP_616544.1. NC_003552.1.

Genome annotation databases

EnsemblBacteriaiAAM05024; AAM05024; MA_1611.
GeneIDi1473499.
KEGGimac:MA1611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA. Translation: AAM05024.1 .
RefSeqi NP_616544.1. NC_003552.1.

3D structure databases

ProteinModelPortali Q8TQD3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 188937.MA1611.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM05024 ; AAM05024 ; MA_1611 .
GeneIDi 1473499.
KEGGi mac:MA1611.

Phylogenomic databases

eggNOGi COG0495.
InParanoidi Q8TQD3.
KOi K01869.
OMAi HAPFDYL.
PhylomeDBi Q8TQD3.

Enzyme and pathway databases

BioCyci MACE188937:GI2O-1627-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity."
    Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.
    , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.
    Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

Entry informationi

Entry nameiSYL_METAC
AccessioniPrimary (citable) accession number: Q8TQD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2002
Last modified: November 26, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3