Reviewed, UniProtKB/Swiss-Prot Q8TPX3 (RNP2_METAC)

Names and origin

Protein names

Recommended name:
    Ribonuclease P protein component 2
      Short name=RNase P component 2
    EC=3.1.26.5

Gene names

Name:	rnp2
Synonyms:	rnpB
Ordered Locus Names:	MA_1781

Organism

Methanosarcina acetivorans [Complete proteome] [HAMAP]

Taxonomic identifier

2214 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	132 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP MF_00755
Subunit structure	Consists of a catalytic RNA component and at least 4 protein subunits Potential.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

Ontologies

Keywords
Biological process	tRNA processing
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tRNA 5'-leader removal Inferred from electronic annotation. Source: HAMAP
Molecular function	ribonuclease P activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 132	132	Ribonuclease P protein component 2 HAMAP MF_00755		PRO_0000140019

Sequences

	Sequence		Length	Mass (Da)
	Q8TPX3-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: E74EC35B89A41D96	FASTA	132	14,556
	10 20 30 40 50 60 MKRLLPSLRT KKRYLAFELI SEEPAGRGDI VKEVISSASS LLGDITTSDC DIRVLGFEAG 70 80 90 100 110 120 KGIIQCSHTR VKETRAALAT LTRVNGKRAT LHVLGASGTV KKATEKFLKD YTVFEPEIHE 130 KRDSRKTPGK VD

References

[1]

"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity." Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P. , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B. Genome Res. 12:532-542(2002) [PubMed: 11932238] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE010299 Genomic DNA. Translation: AAM05187.1.
RefSeq	NP_616707.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1473670.
GenomeReviews	Gene locus MA_1781 in contig AE010299_GR.
KEGG	mac:MA1781.
NMPDR	fig|188937.1.peg.1733.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8TPX3.
OMA	ISEEPAG.
Enzyme and pathway databases
BioCyc	MACE188937:MA1781-MON.
BRENDA	3.1.26.5. 275708.
Family and domain databases
HAMAP	MF_00755. [Tree]
InterPro	IPR016434. RNase_P_comp-2. IPR002759. RNase_P_related. [Graphical view]
Pfam	PF01900. RNase_P_Rpp14. 1 hit. [Graphical view]
PIRSF	PIRSF004952. RNase_P_2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RNP2_METAC

Accession

Primary (citable) accession number: Q8TPX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2002
Last modified:	November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)