Q8TPX2 (RNP3_METAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein component 3
Short name=RNase P component 3
EC=3.1.26.5

Gene names

Name:	rnp3
Ordered Locus Names:	MA_1782

Organism

Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) [Reference proteome] [HAMAP]

Taxonomic identifier

188937 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina › Methanosarcina acetivorans

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity. HAMAP-Rule MF_00756
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP-Rule MF_00756
Subunit structure	Consists of a catalytic RNA component and at least 4 protein subunits Potential.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

Ontologies

Keywords
Biological process	tRNA processing
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tRNA 5'-leader removal Inferred from electronic annotation. Source: HAMAP
Molecular_function	ribonuclease P activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 239	239	Ribonuclease P protein component 3 HAMAP-Rule MF_00756		PRO_0000140038

Sequences

	Sequence		Length	Mass (Da)
	Q8TPX2 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: A6C8470FCF0E638F	FASTA	239	26,214
	10 20 30 40 50 60 MGKPKFYDFC VHAVPDGDST AQEQVSLGRH FGFSGIALAN HSDRLPDRKP ILPFIEGFEV 70 80 90 100 110 120 FRGIELVEEN PSKLHSLIGK FRNSMDVLIV HGGSEAVNRA ALENPRVDIL NHPAFDRSSG 130 140 150 160 170 180 LNQVLAKAAA ENGVAIGIIL RPLLHSRGSR RIRLLSDLKS NLELARKYDV SLVLCSDAMS 190 200 210 220 230 CFDLRSPMEM LALAEVCGLE EDEALEAIST VPEKIIAKNR PGPGYIKKGI EVLEGEDLF

References

[1]

"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity." Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P. , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B. Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE010299 Genomic DNA. Translation: AAM05188.1.
RefSeq	NP_616708.1. NC_003552.1.
3D structure databases
ProteinModelPortal	Q8TPX2.
ModBase	Search...
Protein-protein interaction databases
STRING	188937.MA1782.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM05188; AAM05188; MA_1782.
GeneID	1473671.
KEGG	mac:MA1782.
Phylogenomic databases
eggNOG	COG1603.
KO	K03539.
OMA	YVVSATP.
ProtClustDB	PRK00912.
Enzyme and pathway databases
BioCyc	MACE188937:GI2O-1842-MONOMER.
Family and domain databases
HAMAP	MF_00756. RNase_P_3.
InterPro	IPR016195. Pol/histidinol_Pase-like. IPR023539. RNase_P_comp-3_arc. IPR002738. RNase_P_p30. [Graphical view]
PANTHER	PTHR13031. PTHR13031. 1 hit.
Pfam	PF01876. RNase_P_p30. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RNP3_METAC

Accession

Primary (citable) accession number: Q8TPX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program