ID   Q8TPG4_METAC            Unreviewed;       468 AA.
AC   Q8TPG4;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2002, sequence version 1.
DT   27-MAR-2024, entry version 112.
DE   RecName: Full=glutamate decarboxylase {ECO:0000256|ARBA:ARBA00012421};
DE            EC=4.1.1.15 {ECO:0000256|ARBA:ARBA00012421};
GN   OrderedLocusNames=MA_1949 {ECO:0000313|EMBL:AAM05352.1};
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937 {ECO:0000313|EMBL:AAM05352.1, ECO:0000313|Proteomes:UP000002487};
RN   [1] {ECO:0000313|EMBL:AAM05352.1, ECO:0000313|Proteomes:UP000002487}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A
RC   {ECO:0000313|Proteomes:UP000002487};
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A., Hedderich R., Ingram-Smith C.,
RA   Kuettner C.H., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B.,
RA   Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H.,
RA   de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L.,
RA   Paulsen I., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H.,
RA   Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR602129-50, ECO:0000256|RuleBase:RU000382};
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|RuleBase:RU000382}.
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DR   EMBL; AE010299; AAM05352.1; -; Genomic_DNA.
DR   RefSeq; WP_011021944.1; NC_003552.1.
DR   AlphaFoldDB; Q8TPG4; -.
DR   STRING; 188937.MA_1949; -.
DR   EnsemblBacteria; AAM05352; AAM05352; MA_1949.
DR   GeneID; 1473838; -.
DR   KEGG; mac:MA_1949; -.
DR   HOGENOM; CLU_019582_2_2_2; -.
DR   InParanoid; Q8TPG4; -.
DR   OrthoDB; 56891at2157; -.
DR   PhylomeDB; Q8TPG4; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004351; F:glutamate decarboxylase activity; IBA:GO_Central.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0006538; P:glutamate catabolic process; IBA:GO_Central.
DR   CDD; cd06450; DOPA_deC_like; 1.
DR   Gene3D; 3.90.1150.160; -; 1.
DR   Gene3D; 4.10.280.50; -; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR010107; Glutamate_decarboxylase.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   NCBIfam; TIGR01788; Glu-decarb-GAD; 1.
DR   PANTHER; PTHR43321; GLUTAMATE DECARBOXYLASE; 1.
DR   PANTHER; PTHR43321:SF3; GLUTAMATE DECARBOXYLASE; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000382};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW   ECO:0000256|RuleBase:RU000382};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002487}.
FT   MOD_RES         279
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ   SEQUENCE   468 AA;  53077 MW;  F021DA7448872C97 CRC64;
     MISRKMNLES LDESKKYRVG AYSARYVPKT KEKGIPKYEF PEEGMSPRAA YQLVHDEQSL
     DGNPFLNLAS FVNTWMEPEA DKLVMENISK NIIDIFEYPQ TSRVIHHNMV NMLGRLFNGH
     HTDFVGTSTA GSSEAIMLGL LAHKWSWKKS GRGTDKPNII FGNDAHVCWD KFARYFDVDT
     RKVPIDKDRR TITAEAVAER IDENTICVGC VLGTTFTGEI DPVKDINDLL LEYKEEKGWD
     IPIHIDAASG GFILPFTEPD FEWDFRLERV KSINVSGHKY GLTYPGLGWL IFRNKNALPE
     DLIFHVNYLG EMEDSYTLNF SGGSAMVAAQ YYNFLRFGRA GYTGIMKKIL AVSQDLAEKV
     DRLGRFEMLN KGERLPIIAF RQKEKTGYSL LQLSHKLREK GWIVPAYCLP ENAADIEIMR
     IVVRENLTPD MASIIVEDLE KACQFLENGT EAGAEKPCPS GKDMAHIC
//