Q8TNH5 (ADEC_METAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine deaminase
Short name=Adenase
Short name=Adenine aminase
EC=3.5.4.2

Gene names

Name:	ade
Synonyms:	adeC
Ordered Locus Names:	MA_2310

Organism

Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

Taxonomic identifier

188937 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	553 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01518
Cofactor	Manganese By similarity. HAMAP MF_01518
Sequence similarities	Belongs to the adenine deaminase family.

Ontologies

Keywords
Ligand	Manganese
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	adenine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 553	553	Adenine deaminase HAMAP MF_01518		PRO_0000142439

Sequences

	Sequence		Length	Mass (Da)
	Q8TNH5 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: C58B219A5AEF73DB	FASTA	553	60,731
	10 20 30 40 50 60 MKKYLGIIVD AVSRRQFKGE ITVENGKILR VEEKEHDHER YILPGLVDAH VHIESSMTVP 70 80 90 100 110 120 SVFARMAVAK GTVAVVSDPH EIANVMGEEG IDFMLGDSKR SPLKVFFGVP SCVPATPFES 130 140 150 160 170 180 AGSVLDAEAV DRLLAREDLY YLSEMMNFPG VVLGFPDVMA KLESAKKCGK VIDGHAPGLR 190 200 210 220 230 240 GADLETYIGV GISTDHESFT YEEAVEKIKL GMKILIREGS SARNFETLYS LIDEYPEAVM 250 260 270 280 290 300 LCTDDSHPDT LIYEGHIDKL IRRGQEKGLD IFNLIRAAVI NPVEHYGLNV GLLREGDPAD 310 320 330 340 350 360 FITVDDLKSF NVLSTFIDGE CVYENGKVLF PMKKVPAKNV FNRNKISIDA AKLAVPAEET 370 380 390 400 410 420 GDRKEGMRKI RVIVARDGEL VTGQELAFPK VENGNMVSDP EKDILKMVVL SRYADDPVQI 430 440 450 460 470 480 GFIKNIGLKE GAIASSIAHD SHNIIAVGAT DKDIVEAVNR LVENKGGIVV GTAENLLDLP 490 500 510 520 530 540 LEVAGLMSTL DGVEVASRYR LLNEEARKLG TSLESPFMTL AFMSLLVIPE LKLGDKGLFD 550 VTKFEFVELF AEE

References

[1]

"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity." Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P. , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B. Genome Res. 12:532-542(2002) [PubMed: 11932238] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE010299 Genomic DNA. Translation: AAM05703.1.
RefSeq	NP_617223.1. NC_003552.1.
3D structure databases
ProteinModelPortal	Q8TNH5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1474199.
GenomeReviews	Gene locus MA_2310 in contig AE010299_GR.
KEGG	mac:MA2310.
NMPDR	fig|188937.1.peg.2249.
Phylogenomic databases
HOGENOM	HBG725357.
OMA	VGLGEMM.
ProtClustDB	CLSK2754571.
Enzyme and pathway databases
BioCyc	MACE188937:MA2310-MONOMER.
Family and domain databases
HAMAP	MF_01518. Adenine_deamin. [Tree]
InterPro	IPR006679. Adenine_deam. IPR006680. Amidohydro_1. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
KO	K01486.
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
SUPFAM	SSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMs	TIGR01178. Ade. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADEC_METAC

Accession

Primary (citable) accession number: Q8TNH5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	June 1, 2002
Last modified:	November 16, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program