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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciMACE188937:G1FZT-2703-MONOMER
UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:MA_2533
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002058571 – 404Nicotinate phosphoribosyltransferaseAdd BLAST404

Proteomic databases

PRIDEiQ8TMW6

Interactioni

Protein-protein interaction databases

STRINGi188937.MA2533

Structurei

3D structure databases

ProteinModelPortaliQ8TMW6
SMRiQ8TMW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01481 Archaea
COG1488 LUCA
InParanoidiQ8TMW6
KOiK00763
OMAiKLTMQCA
OrthoDBiPOG093Z04JA
PhylomeDBiQ8TMW6

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 2 hits
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TMW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKSILDNDL YKFTMQMAVL ELFPKAEAEY RFTNRGSHHF SEEFVEKLRR
60 70 80 90 100
VIDEDISALM LTEDEYQWLG ENCSFLKPMY LEYLKNFRFK PGEVEVCLTE
110 120 130 140 150
EKELDIRIKG PWHSTILWEI VLMAAVSELY FTTIEKEWNG KEWDGNISAT
160 170 180 190 200
SESILTAYGE KILEIGKILE ENGCLFAEFG TRRRRSFELH DQVMKTLLQI
210 220 230 240 250
ETLTGTSNVF FAKKYGLKPI GTVGHEWIMG TSALIGLRYA NRFAFENWVE
260 270 280 290 300
VYKGDLGIAL TDTFGSEAFF KDMDLKLSKI YDGFRHDSGD PFTFVDRVID
310 320 330 340 350
HYRKMGIDPM KKVIVFSDAL NAEAAIRLKK YCQDKINCSF GIGTSLTNNS
360 370 380 390 400
EFFRESPPLN MVIKLHSVNG IPVVKLSDSP EKETGERDAL RVANYIVGRK

GLDE
Length:404
Mass (Da):46,457
Last modified:June 1, 2002 - v1
Checksum:iF03CF0523D1A9770
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM05916.1
RefSeqiWP_011022501.1, NC_003552.1

Genome annotation databases

EnsemblBacteriaiAAM05916; AAM05916; MA_2533
GeneIDi1474422
KEGGimac:MA_2533

Similar proteinsi

Entry informationi

Entry nameiPNCB_METAC
AccessioniPrimary (citable) accession number: Q8TMW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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