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Q8TMW6

- PNCB_METAC

UniProt

Q8TMW6 - PNCB_METAC

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciMACE188937:GI2O-2558-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:MA_2533
    OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
    Taxonomic identifieri188937 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
    ProteomesiUP000002487: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404Nicotinate phosphoribosyltransferasePRO_0000205857Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi188937.MA2533.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TMW6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    KOiK00763.
    OMAiQAVFHRY.
    PhylomeDBiQ8TMW6.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 2 hits.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8TMW6-1 [UniParc]FASTAAdd to Basket

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    MIKSILDNDL YKFTMQMAVL ELFPKAEAEY RFTNRGSHHF SEEFVEKLRR    50
    VIDEDISALM LTEDEYQWLG ENCSFLKPMY LEYLKNFRFK PGEVEVCLTE 100
    EKELDIRIKG PWHSTILWEI VLMAAVSELY FTTIEKEWNG KEWDGNISAT 150
    SESILTAYGE KILEIGKILE ENGCLFAEFG TRRRRSFELH DQVMKTLLQI 200
    ETLTGTSNVF FAKKYGLKPI GTVGHEWIMG TSALIGLRYA NRFAFENWVE 250
    VYKGDLGIAL TDTFGSEAFF KDMDLKLSKI YDGFRHDSGD PFTFVDRVID 300
    HYRKMGIDPM KKVIVFSDAL NAEAAIRLKK YCQDKINCSF GIGTSLTNNS 350
    EFFRESPPLN MVIKLHSVNG IPVVKLSDSP EKETGERDAL RVANYIVGRK 400
    GLDE 404
    Length:404
    Mass (Da):46,457
    Last modified:June 1, 2002 - v1
    Checksum:iF03CF0523D1A9770
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010299 Genomic DNA. Translation: AAM05916.1.
    RefSeqiNP_617436.1. NC_003552.1.
    WP_011022501.1. NC_003552.1.

    Genome annotation databases

    EnsemblBacteriaiAAM05916; AAM05916; MA_2533.
    GeneIDi1474422.
    KEGGimac:MA2533.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010299 Genomic DNA. Translation: AAM05916.1 .
    RefSeqi NP_617436.1. NC_003552.1.
    WP_011022501.1. NC_003552.1.

    3D structure databases

    ProteinModelPortali Q8TMW6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 188937.MA2533.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM05916 ; AAM05916 ; MA_2533 .
    GeneIDi 1474422.
    KEGGi mac:MA2533.

    Phylogenomic databases

    eggNOGi COG1488.
    KOi K00763.
    OMAi QAVFHRY.
    PhylomeDBi Q8TMW6.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci MACE188937:GI2O-2558-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 2 hits.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity."
      Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.
      , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.
      Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

    Entry informationi

    Entry nameiPNCB_METAC
    AccessioniPrimary (citable) accession number: Q8TMW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3