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Q8TMW6 (PNCB_METAC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
Name:pncB
Ordered Locus Names:MA_2533
OrganismMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) [Reference proteome] [HAMAP]
Taxonomic identifier188937 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity. HAMAP-Rule MF_00570

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. HAMAP-Rule MF_00570

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 404404Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570
PRO_0000205857

Sequences

Sequence LengthMass (Da)Tools
Q8TMW6 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: F03CF0523D1A9770

FASTA40446,457
        10         20         30         40         50         60 
MIKSILDNDL YKFTMQMAVL ELFPKAEAEY RFTNRGSHHF SEEFVEKLRR VIDEDISALM 

        70         80         90        100        110        120 
LTEDEYQWLG ENCSFLKPMY LEYLKNFRFK PGEVEVCLTE EKELDIRIKG PWHSTILWEI 

       130        140        150        160        170        180 
VLMAAVSELY FTTIEKEWNG KEWDGNISAT SESILTAYGE KILEIGKILE ENGCLFAEFG 

       190        200        210        220        230        240 
TRRRRSFELH DQVMKTLLQI ETLTGTSNVF FAKKYGLKPI GTVGHEWIMG TSALIGLRYA 

       250        260        270        280        290        300 
NRFAFENWVE VYKGDLGIAL TDTFGSEAFF KDMDLKLSKI YDGFRHDSGD PFTFVDRVID 

       310        320        330        340        350        360 
HYRKMGIDPM KKVIVFSDAL NAEAAIRLKK YCQDKINCSF GIGTSLTNNS EFFRESPPLN 

       370        380        390        400 
MVIKLHSVNG IPVVKLSDSP EKETGERDAL RVANYIVGRK GLDE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE010299 Genomic DNA. Translation: AAM05916.1.
RefSeqNP_617436.1. NC_003552.1.

3D structure databases

ProteinModelPortalQ8TMW6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING188937.MA2533.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM05916; AAM05916; MA_2533.
GeneID1474422.
KEGGmac:MA2533.

Phylogenomic databases

eggNOGCOG1488.
KOK00763.
OMAQAVFHRY.
PhylomeDBQ8TMW6.

Enzyme and pathway databases

BioCycMACE188937:GI2O-2558-MONOMER.
UniPathwayUPA00253; UER00457.

Family and domain databases

HAMAPMF_00570. NAPRTase.
InterProIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 2 hits.
TIGRFAMsTIGR01514. NAPRTase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNCB_METAC
AccessionPrimary (citable) accession number: Q8TMW6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways