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Q8TMW6

- PNCB_METAC

UniProt

Q8TMW6 - PNCB_METAC

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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciMACE188937:GI2O-2558-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:MA_2533
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000002487: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Nicotinate phosphoribosyltransferasePRO_0000205857Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi188937.MA2533.

Structurei

3D structure databases

ProteinModelPortaliQ8TMW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
InParanoidiQ8TMW6.
KOiK00763.
OMAiQAVFHRY.
PhylomeDBiQ8TMW6.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 2 hits.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TMW6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKSILDNDL YKFTMQMAVL ELFPKAEAEY RFTNRGSHHF SEEFVEKLRR
60 70 80 90 100
VIDEDISALM LTEDEYQWLG ENCSFLKPMY LEYLKNFRFK PGEVEVCLTE
110 120 130 140 150
EKELDIRIKG PWHSTILWEI VLMAAVSELY FTTIEKEWNG KEWDGNISAT
160 170 180 190 200
SESILTAYGE KILEIGKILE ENGCLFAEFG TRRRRSFELH DQVMKTLLQI
210 220 230 240 250
ETLTGTSNVF FAKKYGLKPI GTVGHEWIMG TSALIGLRYA NRFAFENWVE
260 270 280 290 300
VYKGDLGIAL TDTFGSEAFF KDMDLKLSKI YDGFRHDSGD PFTFVDRVID
310 320 330 340 350
HYRKMGIDPM KKVIVFSDAL NAEAAIRLKK YCQDKINCSF GIGTSLTNNS
360 370 380 390 400
EFFRESPPLN MVIKLHSVNG IPVVKLSDSP EKETGERDAL RVANYIVGRK

GLDE
Length:404
Mass (Da):46,457
Last modified:June 1, 2002 - v1
Checksum:iF03CF0523D1A9770
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA. Translation: AAM05916.1.
RefSeqiNP_617436.1. NC_003552.1.
WP_011022501.1. NC_003552.1.

Genome annotation databases

EnsemblBacteriaiAAM05916; AAM05916; MA_2533.
GeneIDi1474422.
KEGGimac:MA2533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA. Translation: AAM05916.1 .
RefSeqi NP_617436.1. NC_003552.1.
WP_011022501.1. NC_003552.1.

3D structure databases

ProteinModelPortali Q8TMW6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 188937.MA2533.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM05916 ; AAM05916 ; MA_2533 .
GeneIDi 1474422.
KEGGi mac:MA2533.

Phylogenomic databases

eggNOGi COG1488.
InParanoidi Q8TMW6.
KOi K00763.
OMAi QAVFHRY.
PhylomeDBi Q8TMW6.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci MACE188937:GI2O-2558-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 2 hits.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity."
    Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.
    , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.
    Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

Entry informationi

Entry nameiPNCB_METAC
AccessioniPrimary (citable) accession number: Q8TMW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3