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Q8TMI8

- PGK1_METAC

UniProt

Q8TMI8 - PGK1_METAC

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Protein

Phosphoglycerate kinase 1

Gene

pgk1

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei122 – 1221SubstrateUniRule annotation
Binding sitei162 – 1621SubstrateUniRule annotation
Binding sitei336 – 3361ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi361 – 3644ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMACE188937:GI2O-2694-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase 1UniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgk1UniRule annotation
Ordered Locus Names:MA_2669
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000002487: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Phosphoglycerate kinase 1PRO_0000146054Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi188937.MA2669.

Structurei

3D structure databases

ProteinModelPortaliQ8TMI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni28 – 303Substrate bindingUniRule annotation
Regioni65 – 684Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0126.
InParanoidiQ8TMI8.
KOiK00927.
OMAiIPAGWMA.
PhylomeDBiQ8TMI8.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TMI8-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSQKTAGKDY LTMDDVELDN KRILLRVDFN SPMDANGNIL DDRKIKSHLY
60 70 80 90 100
TLRSLENSRV VMMSHQGRPG DKDYTTLEAH AKLATELLGR KVTYEDDIFS
110 120 130 140 150
ACARNAIKSL EKGDILLLEN TRFYAEENMN RAPEEQARTQ MVRKLYPLFD
160 170 180 190 200
VFINDAFSVS HRSQCSVVGF TEVLPSVAGI LMDREITGLD KGLKCHEHPA
210 220 230 240 250
VFALGGTKAK DIVKVISDIL KRGGADRILT TGVVATVFMM AIGIEVGEVN
260 270 280 290 300
RKFIEDHKYL DQVSIASRLL KEYSGKIIVP KDIALNNDGK REEVKVDKIK
310 320 330 340 350
GDLPIADIGP ETISDYSKFL KEAKLSVFHG PAGIFELESF RLGTEELLKA
360 370 380 390 400
AAQSNYSIAG GGHTLAAIDQ LGLESKYSHL SMGGGASITY LSGEHMPGIE
410
ALKNYASRCC KD
Length:412
Mass (Da):45,497
Last modified:June 1, 2002 - v1
Checksum:i4D41FC977625CEF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010299 Genomic DNA. Translation: AAM06047.1.
RefSeqiNP_617567.1. NC_003552.1.

Genome annotation databases

EnsemblBacteriaiAAM06047; AAM06047; MA_2669.
GeneIDi1474558.
KEGGimac:MA2669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010299 Genomic DNA. Translation: AAM06047.1 .
RefSeqi NP_617567.1. NC_003552.1.

3D structure databases

ProteinModelPortali Q8TMI8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 188937.MA2669.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM06047 ; AAM06047 ; MA_2669 .
GeneIDi 1474558.
KEGGi mac:MA2669.

Phylogenomic databases

eggNOGi COG0126.
InParanoidi Q8TMI8.
KOi K00927.
OMAi IPAGWMA.
PhylomeDBi Q8TMI8.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci MACE188937:GI2O-2694-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity."
    Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.
    , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.
    Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

Entry informationi

Entry nameiPGK1_METAC
AccessioniPrimary (citable) accession number: Q8TMI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3