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Q8TMI8 (PGK1_METAC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase 1

EC=2.7.2.3
Gene names
Name:pgk1
Ordered Locus Names:MA_2669
OrganismMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) [Reference proteome] [HAMAP]
Taxonomic identifier188937 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 412412Phosphoglycerate kinase 1 HAMAP-Rule MF_00145
PRO_0000146054

Regions

Nucleotide binding361 – 3644ATP By similarity
Region28 – 303Substrate binding By similarity
Region65 – 684Substrate binding By similarity

Sites

Binding site1221Substrate By similarity
Binding site1621Substrate By similarity
Binding site3361ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8TMI8 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 4D41FC977625CEF6

FASTA41245,497
        10         20         30         40         50         60 
MSQKTAGKDY LTMDDVELDN KRILLRVDFN SPMDANGNIL DDRKIKSHLY TLRSLENSRV 

        70         80         90        100        110        120 
VMMSHQGRPG DKDYTTLEAH AKLATELLGR KVTYEDDIFS ACARNAIKSL EKGDILLLEN 

       130        140        150        160        170        180 
TRFYAEENMN RAPEEQARTQ MVRKLYPLFD VFINDAFSVS HRSQCSVVGF TEVLPSVAGI 

       190        200        210        220        230        240 
LMDREITGLD KGLKCHEHPA VFALGGTKAK DIVKVISDIL KRGGADRILT TGVVATVFMM 

       250        260        270        280        290        300 
AIGIEVGEVN RKFIEDHKYL DQVSIASRLL KEYSGKIIVP KDIALNNDGK REEVKVDKIK 

       310        320        330        340        350        360 
GDLPIADIGP ETISDYSKFL KEAKLSVFHG PAGIFELESF RLGTEELLKA AAQSNYSIAG 

       370        380        390        400        410 
GGHTLAAIDQ LGLESKYSHL SMGGGASITY LSGEHMPGIE ALKNYASRCC KD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE010299 Genomic DNA. Translation: AAM06047.1.
RefSeqNP_617567.1. NC_003552.1.

3D structure databases

ProteinModelPortalQ8TMI8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING188937.MA2669.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM06047; AAM06047; MA_2669.
GeneID1474558.
KEGGmac:MA2669.

Phylogenomic databases

eggNOGCOG0126.
KOK00927.
OMAIPAGWMA.
PhylomeDBQ8TMI8.

Enzyme and pathway databases

BioCycMACE188937:GI2O-2694-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGK1_METAC
AccessionPrimary (citable) accession number: Q8TMI8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways