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Q8TMG9

- CAPPA_METAC

UniProt

Q8TMG9 - CAPPA_METAC

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Protein
Phosphoenolpyruvate carboxylase
Gene
ppcA, MA_2690
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciMACE188937:GI2O-2718-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylase (EC:4.1.1.31)
Short name:
PEPC
Short name:
PEPCase
Gene namesi
Name:ppcA
Ordered Locus Names:MA_2690
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000002487: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Phosphoenolpyruvate carboxylaseUniRule annotation
PRO_0000309602Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi188937.MA2690.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.

Phylogenomic databases

eggNOGiCOG1892.
KOiK01595.
OMAiDEYMPDY.
PhylomeDBiQ8TMG9.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TMG9-1 [UniParc]FASTAAdd to Basket

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MSRKSTYPKV MCTQHPDSAS RYISTQEEPG EAIEAAVVFG CDEYMPDYEG    50
KATPYHQNVQ IVSRLIEETD LVPGKDVFIT PRAPSAVQEN RFRQLMVMMS 100
IAEANHGALE YSDVQAINEF VHPMTGTVRE ILDAQQHMVD VSELAKKEFG 150
FAMEVPRIIP LIEDAPALLH AKELTENTLL AWKERFGTVP EKFRVFLGKS 200
DSALSFGHVA STLSCKYAIN GLSELNFELE TETGIVFGAG TLPFRGHLDL 250
KNAENFFREY RGIGTITLQS ALRYSHEKGD AEALVDLAKE KLPEIPELFS 300
AEEKEELVNL IGIFGTRYSL IIRELASTIN RLSDLLPQQR DRLMHRGSGG 350
YSRSAPDISG IVSLCRTDIG KELLASMPAE DLHLPRAIKF TGALYSIGLP 400
PEFIGTGAAL NEAREKLGDE ACERLLTKYF PSLVSDLNFA TGYLDLNVAS 450
RFLSGACFKE VSKDIEILHE TLGLETHPEP SYRILLEMMQ PELLQAGTSG 500
NCMDEEVSQL VCSTLTKMGK IRKALG 526
Length:526
Mass (Da):58,335
Last modified:November 13, 2007 - v2
Checksum:i8FB2AC2F5BED5CFD
GO

Sequence cautioni

The sequence AAM06068.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010299 Genomic DNA. Translation: AAM06068.1. Different initiation.
RefSeqiNP_617588.2. NC_003552.1.

Genome annotation databases

EnsemblBacteriaiAAM06068; AAM06068; MA_2690.
GeneIDi1474582.
KEGGimac:MA2690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010299 Genomic DNA. Translation: AAM06068.1 . Different initiation.
RefSeqi NP_617588.2. NC_003552.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 188937.MA2690.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM06068 ; AAM06068 ; MA_2690 .
GeneIDi 1474582.
KEGGi mac:MA2690.

Phylogenomic databases

eggNOGi COG1892.
KOi K01595.
OMAi DEYMPDY.
PhylomeDBi Q8TMG9.

Enzyme and pathway databases

BioCyci MACE188937:GI2O-2718-MONOMER.

Family and domain databases

HAMAPi MF_01904. PEPcase_type2.
InterProi IPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF14010. PEPcase_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006677. UCP006677. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR02751. PEPCase_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity."
    Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.
    , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.
    Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

Entry informationi

Entry nameiCAPPA_METAC
AccessioniPrimary (citable) accession number: Q8TMG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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