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Q8TMD5 (THIM_METAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:MA_2723
OrganismMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) [Reference proteome] [HAMAP]
Taxonomic identifier188937 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000156968

Sites

Binding site401Substrate; via amide nitrogen By similarity
Binding site1161ATP By similarity
Binding site1621ATP By similarity
Binding site1891Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8TMD5 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 1C119D21B4CDB056

FASTA26127,767
        10         20         30         40         50         60 
MNEPLKTIRE TKPLIHHITN WVTIYECANM TRAFGALPVM AHAPEECADM TKISSALVLN 

        70         80         90        100        110        120 
IGTLTSEIID SMLLSAAAAN ERDIPVVLDA VGVGATKFRD EMAAKILASV HIDIIKGNYS 

       130        140        150        160        170        180 
EIAKLAGENA ETKGVEATSI DADPAKVAKA FAKAESCVVV MTGKEDIISD GDRTFIVKNG 

       190        200        210        220        230        240 
HELMGSIVGT GCMAASIVGL FAAVNRDYCD AAKDALCYFG ASGELAAAKS SGPGSFKVHL 

       250        260 
YDEVFNLSDE KVKSMKNFEE K 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE010299 Genomic DNA. Translation: AAM06102.1.
RefSeqNP_617622.1. NC_003552.1.

3D structure databases

ProteinModelPortalQ8TMD5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING188937.MA2723.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM06102; AAM06102; MA_2723.
GeneID1474616.
KEGGmac:MA2723.

Phylogenomic databases

eggNOGCOG2145.
KOK00878.
OMASPVMAHA.
PhylomeDBQ8TMD5.
ProtClustDBPRK09355.

Enzyme and pathway databases

BioCycMACE188937:GI2O-2753-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_METAC
AccessionPrimary (citable) accession number: Q8TMD5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways