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Q8TLY9 (Q8TLY9_METAC) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length195 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region14 – 152Phosphate 1 binding
Region60 – 612Cyanide binding PDB 3ZJH PDB 3ZJI PDB 3ZJJ PDB 3ZJM PDB 3ZJN PDB 3ZJL PDB 3ZOL
Region135 – 1362Phosphate 2 binding

Sites

Metal binding1201Iron (heme axial ligand); via tele nitrogen PDB 2VEE PDB 3QZZ PDB 3R0G PDB 3ZH0 PDB 3ZJH PDB 3ZJI PDB 3ZJJ PDB 3ZJM PDB 3ZJN PDB 3ZJQ PDB 3ZJR PDB 3ZJL PDB 3ZOL PDB 3ZOM
Binding site601Azide 1 PDB 3ZJS
Binding site611Azide 2 PDB 3ZJO
Binding site611Azide 3 PDB 3ZJO
Binding site721Phosphate 2
Binding site1041Sulfate 1 PDB 3ZOL
Binding site1111Phosphate 1
Binding site1221Phosphate 3 PDB 3ZJN
Binding site1221Sulfate 2 PDB 3ZOL

Sequences

Sequence LengthMass (Da)Tools
Q8TLY9 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: EA883DAAB7AB138F

FASTA19523,000
        10         20         30         40         50         60 
MSVEKIPGYT YGETENRAPF NLEDLKLLKE AVMFTAEDEE YIQKAGEVLE DQVEEILDTW 

        70         80         90        100        110        120 
YGFVGSHPHL LYYFTSPDGT PNEKYLAAVR KRFSRWILDT CNRSYDQAWL DYQYEIGLRH 

       130        140        150        160        170        180 
HRTKKNQTDN VESVPNIGYR YLVAFIYPIT ATMKPFLARK GHTPEEVEKM YQAWFKATTL 

       190 
QVALWSYPYV KYGDF 

« Hide

References

« Hide 'large scale' references
[1]"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity."
Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P. expand/collapse author list , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A., Hedderich R., Ingram-Smith C., Kuettner C.H., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.
Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.
[2]"Archaeal protoglobin structure indicates new ligand diffusion paths and modulation of haem-reactivity."
Nardini M., Pesce A., Thijs L., Saito J.A., Dewilde S., Alam M., Ascenzi P., Coletta M., Ciaccio C., Moens L., Bolognesi M.
EMBO Rep. 9:157-163(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) IN COMPLEX WITH HEME AND PHOSPHATE.
[3]"Structural heterogeneity and ligand gating in ferric Methanosarcina acetivorans protoglobin mutants."
Pesce A., Tilleman L., Dewilde S., Ascenzi P., Coletta M., Ciaccio C., Bruno S., Moens L., Bolognesi M., Nardini M.
IUBMB Life 63:287-294(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) IN COMPLEX WITH HEME AND PHOSPHATE.
[4]"Functional and structural roles of the N-terminal extension in Methanosarcina acetivorans protoglobin."
Ciaccio C., Pesce A., Tundo G.R., Tilleman L., Bertolacci L., Dewilde S., Moens L., Ascenzi P., Bolognesi M., Nardini M., Coletta M.
Biochim. Biophys. Acta 1834:1813-1823(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 21-195 IN COMPLEX WITH HEME.
[5]"Structure and haem-distal site plasticity in Methanosarcina acetivorans protoglobin."
Pesce A., Tilleman L., Donne J., Aste E., Ascenzi P., Ciaccio C., Coletta M., Moens L., Viappiani C., Dewilde S., Bolognesi M., Nardini M.
PLoS ONE 8:e66144-e66144(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.38 ANGSTROMS) IN COMPLEX WITH AZIDE; CYANIDE; HEME AND PHOSPHATE.
[6]"Structural Bases for the Regulation of Co Binding in the Archaeal Protoglobin from Methanosarcina Acetivorans."
Tilleman L., Abbruzzetti S., Ciaccio C., De Sanctis G., Nardini M., Pesce A., Desmet F., Moens L., Van Doorslaer S., Bruno S., Bolognesi M., Ascenzi P., Coletta M., Viappiani C., Dewilde S.
Submitted (FEB-2013) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH HEME.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE010299 Genomic DNA. Translation: AAM06260.1.
RefSeqNP_617780.1. NC_003552.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2VEBX-ray1.30A1-195[»]
2VEEX-ray2.60A/B/C/D/E/F/G/H1-195[»]
3QZXX-ray1.30A1-195[»]
3QZZX-ray2.40A1-195[»]
3R0GX-ray2.20A/B1-195[»]
3ZH0X-ray2.00A/B/C/D21-195[»]
3ZJHX-ray1.70A/B1-195[»]
3ZJIX-ray1.50A/B1-195[»]
3ZJJX-ray2.00A/B/C1-195[»]
3ZJLX-ray1.50A/B1-195[»]
3ZJMX-ray1.50A/B/C1-195[»]
3ZJNX-ray1.60A/B1-195[»]
3ZJOX-ray1.80A/B1-195[»]
3ZJPX-ray1.38A1-195[»]
3ZJQX-ray1.90A/B1-195[»]
3ZJRX-ray3.00A1-195[»]
3ZJSX-ray2.30A/B1-195[»]
3ZOLX-ray1.60A/B1-195[»]
3ZOMX-ray2.20A/B1-195[»]
ProteinModelPortalQ8TLY9.
SMRQ8TLY9. Positions 6-195.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING188937.MA2883.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM06260; AAM06260; MA_2883.
GeneID1474779.
KEGGmac:MA2883.

Phylogenomic databases

eggNOGNOG11581.
OMAEKMHQAW.

Enzyme and pathway databases

BioCycMACE188937:GI2O-2918-MONOMER.

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR009050. Globin-like.
IPR012292. Globin_dom.
IPR012102. Protoglobin.
[Graphical view]
PIRSFPIRSF014300. Protoglobin. 1 hit.
SUPFAMSSF46458. SSF46458. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ8TLY9.

Entry information

Entry nameQ8TLY9_METAC
AccessionPrimary (citable) accession number: Q8TLY9
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)