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Q8TLY9

- Q8TLY9_METAC

UniProt

Q8TLY9 - Q8TLY9_METAC

Protein
Submitted name:

Uncharacterized protein

Gene

MA_2883

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi120 – 1201Iron (heme axial ligand); via tele nitrogenImported

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro

    GO - Biological processi

    1. oxygen transport Source: InterPro

    Keywords - Ligandi

    HemeImported, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMACE188937:GI2O-2918-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Ordered Locus Names:MA_2883Imported
    OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)Imported
    Taxonomic identifieri188937 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
    ProteomesiUP000002487: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi188937.MA2883.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2VEBX-ray1.30A1-195[»]
    2VEEX-ray2.60A/B/C/D/E/F/G/H1-195[»]
    3QZXX-ray1.30A1-195[»]
    3QZZX-ray2.40A1-195[»]
    3R0GX-ray2.20A/B1-195[»]
    3ZH0X-ray2.00A/B/C/D21-195[»]
    3ZJHX-ray1.70A/B1-195[»]
    3ZJIX-ray1.50A/B1-195[»]
    3ZJJX-ray2.00A/B/C1-195[»]
    3ZJLX-ray1.50A/B1-195[»]
    3ZJMX-ray1.50A/B/C1-195[»]
    3ZJNX-ray1.60A/B1-195[»]
    3ZJOX-ray1.80A/B1-195[»]
    3ZJPX-ray1.38A1-195[»]
    3ZJQX-ray1.90A/B1-195[»]
    3ZJRX-ray3.00A1-195[»]
    3ZJSX-ray2.30A/B1-195[»]
    3ZOLX-ray1.60A/B1-195[»]
    3ZOMX-ray2.20A/B1-195[»]
    ProteinModelPortaliQ8TLY9.
    SMRiQ8TLY9. Positions 6-195.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8TLY9.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG11581.
    OMAiEKMHQAW.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR012102. Protoglobin.
    [Graphical view]
    PIRSFiPIRSF014300. Protoglobin. 1 hit.
    SUPFAMiSSF46458. SSF46458. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8TLY9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVEKIPGYT YGETENRAPF NLEDLKLLKE AVMFTAEDEE YIQKAGEVLE    50
    DQVEEILDTW YGFVGSHPHL LYYFTSPDGT PNEKYLAAVR KRFSRWILDT 100
    CNRSYDQAWL DYQYEIGLRH HRTKKNQTDN VESVPNIGYR YLVAFIYPIT 150
    ATMKPFLARK GHTPEEVEKM YQAWFKATTL QVALWSYPYV KYGDF 195
    Length:195
    Mass (Da):23,000
    Last modified:June 1, 2002 - v1
    Checksum:iEA883DAAB7AB138F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010299 Genomic DNA. Translation: AAM06260.1.
    RefSeqiNP_617780.1. NC_003552.1.
    WP_011022833.1. NC_003552.1.

    Genome annotation databases

    EnsemblBacteriaiAAM06260; AAM06260; MA_2883.
    GeneIDi1474779.
    KEGGimac:MA2883.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010299 Genomic DNA. Translation: AAM06260.1 .
    RefSeqi NP_617780.1. NC_003552.1.
    WP_011022833.1. NC_003552.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2VEB X-ray 1.30 A 1-195 [» ]
    2VEE X-ray 2.60 A/B/C/D/E/F/G/H 1-195 [» ]
    3QZX X-ray 1.30 A 1-195 [» ]
    3QZZ X-ray 2.40 A 1-195 [» ]
    3R0G X-ray 2.20 A/B 1-195 [» ]
    3ZH0 X-ray 2.00 A/B/C/D 21-195 [» ]
    3ZJH X-ray 1.70 A/B 1-195 [» ]
    3ZJI X-ray 1.50 A/B 1-195 [» ]
    3ZJJ X-ray 2.00 A/B/C 1-195 [» ]
    3ZJL X-ray 1.50 A/B 1-195 [» ]
    3ZJM X-ray 1.50 A/B/C 1-195 [» ]
    3ZJN X-ray 1.60 A/B 1-195 [» ]
    3ZJO X-ray 1.80 A/B 1-195 [» ]
    3ZJP X-ray 1.38 A 1-195 [» ]
    3ZJQ X-ray 1.90 A/B 1-195 [» ]
    3ZJR X-ray 3.00 A 1-195 [» ]
    3ZJS X-ray 2.30 A/B 1-195 [» ]
    3ZOL X-ray 1.60 A/B 1-195 [» ]
    3ZOM X-ray 2.20 A/B 1-195 [» ]
    ProteinModelPortali Q8TLY9.
    SMRi Q8TLY9. Positions 6-195.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 188937.MA2883.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM06260 ; AAM06260 ; MA_2883 .
    GeneIDi 1474779.
    KEGGi mac:MA2883.

    Phylogenomic databases

    eggNOGi NOG11581.
    OMAi EKMHQAW.

    Enzyme and pathway databases

    BioCyci MACE188937:GI2O-2918-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q8TLY9.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR012102. Protoglobin.
    [Graphical view ]
    PIRSFi PIRSF014300. Protoglobin. 1 hit.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity."
      Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.
      , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A., Hedderich R., Ingram-Smith C., Kuettner C.H., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.
      Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2AImported.
    2. "Archaeal protoglobin structure indicates new ligand diffusion paths and modulation of haem-reactivity."
      Nardini M., Pesce A., Thijs L., Saito J.A., Dewilde S., Alam M., Ascenzi P., Coletta M., Ciaccio C., Moens L., Bolognesi M.
      EMBO Rep. 9:157-163(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) IN COMPLEX WITH HEME.
    3. "Structural heterogeneity and ligand gating in ferric Methanosarcina acetivorans protoglobin mutants."
      Pesce A., Tilleman L., Dewilde S., Ascenzi P., Coletta M., Ciaccio C., Bruno S., Moens L., Bolognesi M., Nardini M.
      IUBMB Life 63:287-294(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) IN COMPLEX WITH HEME.
    4. "Functional and structural roles of the N-terminal extension in Methanosarcina acetivorans protoglobin."
      Ciaccio C., Pesce A., Tundo G.R., Tilleman L., Bertolacci L., Dewilde S., Moens L., Ascenzi P., Bolognesi M., Nardini M., Coletta M.
      Biochim. Biophys. Acta 1834:1813-1823(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 21-195 IN COMPLEX WITH HEME.
    5. "Structure and haem-distal site plasticity in Methanosarcina acetivorans protoglobin."
      Pesce A., Tilleman L., Donne J., Aste E., Ascenzi P., Ciaccio C., Coletta M., Moens L., Viappiani C., Dewilde S., Bolognesi M., Nardini M.
      PLoS ONE 8:e66144-e66144(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.38 ANGSTROMS) IN COMPLEX WITH HEME.
    6. "Structural Bases for the Regulation of Co Binding in the Archaeal Protoglobin from Methanosarcina Acetivorans."
      Tilleman L., Abbruzzetti S., Ciaccio C., De Sanctis G., Nardini M., Pesce A., Desmet F., Moens L., Van Doorslaer S., Bruno S., Bolognesi M., Ascenzi P., Coletta M., Viappiani C., Dewilde S.
      Submitted (FEB-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH HEME.

    Entry informationi

    Entry nameiQ8TLY9_METAC
    AccessioniPrimary (citable) accession number: Q8TLY9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3