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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain 1 (trpB1), Tryptophan synthase beta chain 2 (trpB2)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciMACE188937:G1FZT-3199-MONOMER
UniPathwayiUPA00035; UER00042

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Ordered Locus Names:MA_2988
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000002487 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001544021 – 238N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST238

Proteomic databases

PRIDEiQ8TLP6

Interactioni

Protein-protein interaction databases

STRINGi188937.MA2988

Structurei

3D structure databases

ProteinModelPortaliQ8TLP6
SMRiQ8TLP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01983 Archaea
COG0135 LUCA
InParanoidiQ8TLP6
KOiK01817
OMAiFYAKSPR
OrthoDBiPOG093Z0IDC
PhylomeDBiQ8TLP6

Family and domain databases

CDDicd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TLP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTRPKTRIK TRVKICGIRS PKDIEFAALY GADAVGFITE VPVESPRKLD
60 70 80 90 100
SDTAAALISK VPKCLDSVMV IMPETSTSAL ELIEKVKPNI VQIHSDLPLS
110 120 130 140 150
ELKAVREKAD IPIIKTLSVP AEQEAPKLHN IVTRLLEEVR ELEESGIVDS
160 170 180 190 200
VLLDSGIAGK TGGTGCVHDW DLSRRIAEET ELPLILAGGL KPENVQEAIR
210 220 230
SVSPYAVDTA SGVETQGKKD SVKVRKFIEE VRCTYAFL
Length:238
Mass (Da):25,983
Last modified:March 25, 2003 - v2
Checksum:i08F18D35D2EEF893
GO

Sequence cautioni

The sequence AAM06361 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM06361.1 Different initiation.
RefSeqiWP_048065580.1, NC_003552.1

Genome annotation databases

EnsemblBacteriaiAAM06361; AAM06361; MA_2988
GeneIDi1474882
KEGGimac:MA_2988

Similar proteinsi

Entry informationi

Entry nameiTRPF_METAC
AccessioniPrimary (citable) accession number: Q8TLP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 25, 2003
Last modified: May 23, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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