Reviewed, UniProtKB/Swiss-Prot Q8TLM4 (PDAD1_METAC)

Names and origin

Protein names

Recommended name:
    Pyruvoyl-dependent arginine decarboxylase 1
      Short name=PvlArgDC 1
    EC=4.1.1.19
Cleaved into the following 2 chains:
    1- Recommended name:
            Pyruvoyl-dependent arginine decarboxylase 1 subunit beta
    2- Recommended name:
            Pyruvoyl-dependent arginine decarboxylase 1 subunit alpha

Gene names

Name:	pdaD1
Ordered Locus Names:	MA_3012

Organism

Methanosarcina acetivorans [Complete proteome] [HAMAP]

Taxonomic identifier

2214 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01404
Cofactor	Pyruvoyl group By similarity.
Sequence similarities	Belongs to the pdaD family.

Ontologies

Keywords
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 44	44	Pyruvoyl-dependent arginine decarboxylase 1 subunit beta By similarity		PRO_0000023310
	Chain	45 – 165	121	Pyruvoyl-dependent arginine decarboxylase 1 subunit alpha By similarity		PRO_0000023311
Sites
	Site	44 – 45	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	45	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8TLM4-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: CE50420335EE4139	FASTA	165	18,075
	10 20 30 40 50 60 MITKLIPRKV FFTSGVGLHS EKLESFEVSL RDAGIEKFNL VTVSSILPPN CEIVTKEEGL 70 80 90 100 110 120 KELSPGEVVF CVMSRISSNE PGKTLSTSVG CALPRDISKH GYISEYHAYE ENAQDVGEHA 130 140 150 160 KKLAGSMYST WTNEAPLKTF SIPRSSSVQE SGDWMTVISA AVFII

References

[1]

"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity." Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P. , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B. Genome Res. 12:532-542(2002) [PubMed: 11932238] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE010299 Genomic DNA. Translation: AAM06385.1.
RefSeq	NP_617905.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1474906.
GenomeReviews	Gene locus MA_3012 in contig AE010299_GR.
KEGG	mac:MA3012.
NMPDR	fig|188937.1.peg.2931.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8TLM4.
OMA	ISEYHAY.
Enzyme and pathway databases
BioCyc	MACE188937:MA3012-MON.
BRENDA	4.1.1.19. 275708.
Family and domain databases
HAMAP	MF_01404. [Tree]
InterPro	IPR016105. Pyr-dep_his/arg-deCO2ase_sand. IPR002724. Pyruvoyl-dep_arg_deCO2ase. [Graphical view]
Gene3D	G3DSA:3.50.20.10. Pyr-dep_his/arg-deCO2ase_sand. 1 hit.
Pfam	PF01862. PvlArgDC. 1 hit. [Graphical view]
PIRSF	PIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDom	PD010449. DUF44. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00286. PvlArgDC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDAD1_METAC

Accession

Primary (citable) accession number: Q8TLM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	June 1, 2002
Last modified:	November 3, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)