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Q8TLM4

- PDAD1_METAC

UniProt

Q8TLM4 - PDAD1_METAC

Protein

Pyruvoyl-dependent arginine decarboxylase 1

Gene

pdaD1

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-arginine = agmatine + CO2.

    Cofactori

    Pyruvoyl group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei44 – 452Cleavage (non-hydrolytic)By similarity

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine catabolic process Source: InterPro

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Ligandi

    Pyruvate

    Enzyme and pathway databases

    BioCyciMACE188937:GI2O-3045-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvoyl-dependent arginine decarboxylase 1 (EC:4.1.1.19)
    Short name:
    PvlArgDC 1
    Cleaved into the following 2 chains:
    Gene namesi
    Name:pdaD1
    Ordered Locus Names:MA_3012
    OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
    Taxonomic identifieri188937 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
    ProteomesiUP000002487: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4444Pyruvoyl-dependent arginine decarboxylase 1 subunit betaBy similarityPRO_0000023310Add
    BLAST
    Chaini45 – 165121Pyruvoyl-dependent arginine decarboxylase 1 subunit alphaBy similarityPRO_0000023311Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei45 – 451Pyruvic acid (Ser)By similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi188937.MA3012.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TLM4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdaD family.Curated

    Phylogenomic databases

    eggNOGiCOG1945.
    KOiK02626.
    OMAiGYISEYH.
    PhylomeDBiQ8TLM4.

    Family and domain databases

    Gene3Di3.50.20.10. 1 hit.
    HAMAPiMF_01404. PvlArgDC.
    InterProiIPR016104. Pyr-dep_his/arg-deCO2ase.
    IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
    IPR002724. Pyruvoyl-dep_arg_deCO2ase.
    [Graphical view]
    PfamiPF01862. PvlArgDC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
    ProDomiPD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF56271. SSF56271. 1 hit.
    TIGRFAMsiTIGR00286. TIGR00286. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8TLM4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MITKLIPRKV FFTSGVGLHS EKLESFEVSL RDAGIEKFNL VTVSSILPPN    50
    CEIVTKEEGL KELSPGEVVF CVMSRISSNE PGKTLSTSVG CALPRDISKH 100
    GYISEYHAYE ENAQDVGEHA KKLAGSMYST WTNEAPLKTF SIPRSSSVQE 150
    SGDWMTVISA AVFII 165
    Length:165
    Mass (Da):18,075
    Last modified:June 1, 2002 - v1
    Checksum:iCE50420335EE4139
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010299 Genomic DNA. Translation: AAM06385.1.
    RefSeqiNP_617905.1. NC_003552.1.
    WP_011022951.1. NC_003552.1.

    Genome annotation databases

    EnsemblBacteriaiAAM06385; AAM06385; MA_3012.
    GeneIDi1474906.
    KEGGimac:MA3012.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010299 Genomic DNA. Translation: AAM06385.1 .
    RefSeqi NP_617905.1. NC_003552.1.
    WP_011022951.1. NC_003552.1.

    3D structure databases

    ProteinModelPortali Q8TLM4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 188937.MA3012.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM06385 ; AAM06385 ; MA_3012 .
    GeneIDi 1474906.
    KEGGi mac:MA3012.

    Phylogenomic databases

    eggNOGi COG1945.
    KOi K02626.
    OMAi GYISEYH.
    PhylomeDBi Q8TLM4.

    Enzyme and pathway databases

    BioCyci MACE188937:GI2O-3045-MONOMER.

    Family and domain databases

    Gene3Di 3.50.20.10. 1 hit.
    HAMAPi MF_01404. PvlArgDC.
    InterProi IPR016104. Pyr-dep_his/arg-deCO2ase.
    IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
    IPR002724. Pyruvoyl-dep_arg_deCO2ase.
    [Graphical view ]
    Pfami PF01862. PvlArgDC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
    ProDomi PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF56271. SSF56271. 1 hit.
    TIGRFAMsi TIGR00286. TIGR00286. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity."
      Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.
      , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.
      Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

    Entry informationi

    Entry nameiPDAD1_METAC
    AccessioniPrimary (citable) accession number: Q8TLM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3