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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei613For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

BioCyciMACE188937:G1FZT-3230-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:MA_3023
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000002487 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001354242 – 618Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST617

Proteomic databases

PRIDEiQ8TLL3

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi188937.MA3023

Structurei

3D structure databases

ProteinModelPortaliQ8TLL3
SMRiQ8TLL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 226Glutamine amidotransferase type-2UniRule annotationAdd BLAST225
Domaini295 – 434SIS 1UniRule annotationAdd BLAST140
Domaini467 – 608SIS 2UniRule annotationAdd BLAST142

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiarCOG00057 Archaea
COG0449 LUCA
InParanoidiQ8TLL3
KOiK00820
OMAiASEYRYA
OrthoDBiPOG093Z014P
PhylomeDBiQ8TLL3

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TLL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGYAGR NAAAPVIIES LKKLEYRGYD SAGITVLSKG IETYKAVGKI
60 70 80 90 100
VNLEVEIPKN LGGTVGIGHT RWATHGRPST KNAHPHNSGG NPGKISLVHN
110 120 130 140 150
GIIENYMALK EQLTGEGYVF NSETDTEVIA HLVHKHIYGK PDGKEAKCEL
160 170 180 190 200
LVGLREALKE IEGSYALAIL SADEPGKLVL ARKDSPLVIG LGKGENFAAS
210 220 230 240 250
DVTAFLNHTR DVVFVNDFET AVLSPTSVEI FDREGKPREK KIEKIEWDFE
260 270 280 290 300
AAEKAGYEHF MLKEIHEQVT AIHNTLAGKV SELEGDIYLK ELNLSEDEIR
310 320 330 340 350
KLARVQILAC GTSWHAGLLG KYLFEQLAGI HCDIDICSEY RYRNPVMNEG
360 370 380 390 400
TLAIAITQSG ETADTLAAVR EIMSYNCPTL AITNVVGSTI TREANSVLYT
410 420 430 440 450
RAGPEIGVAA TKTFTTQLTL LYLLAVKFAL VRDRLSPDYV KSFITDLRKV
460 470 480 490 500
PGQIQQILNQ KEAIKECAEG FARSKSYFFL GRHLNYPIAL EGALKLKEIS
510 520 530 540 550
YVHAEGFAAG ELKHGPIALL DEGTPVVAIA TRGQTYEKML SNIKEVKARD
560 570 580 590 600
AFVIAVADNK DTEITKYVDV VLRVPQSDEL LAPLLSIVVL QLLAYYTALA
610
RNCSIDKPRN LAKSVTVE
Length:618
Mass (Da):67,753
Last modified:January 23, 2007 - v3
Checksum:i34DCAD41B546B572
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM06396.1
RefSeqiWP_011022962.1, NC_003552.1

Genome annotation databases

EnsemblBacteriaiAAM06396; AAM06396; MA_3023
GeneIDi1474917
KEGGimac:MA_3023

Entry informationi

Entry nameiGLMS_METAC
AccessioniPrimary (citable) accession number: Q8TLL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 102 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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