ID   Q8TLG5_METAC            Unreviewed;       667 AA.
AC   Q8TLG5;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2002, sequence version 1.
DT   27-MAR-2024, entry version 122.
DE   SubName: Full=Methyl-accepting chemotaxis protein {ECO:0000313|EMBL:AAM06444.1};
GN   Name=mcp-1 {ECO:0000313|EMBL:AAM06444.1};
GN   OrderedLocusNames=MA_3071 {ECO:0000313|EMBL:AAM06444.1};
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937 {ECO:0000313|EMBL:AAM06444.1, ECO:0000313|Proteomes:UP000002487};
RN   [1] {ECO:0000313|EMBL:AAM06444.1, ECO:0000313|Proteomes:UP000002487}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A
RC   {ECO:0000313|Proteomes:UP000002487};
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A., Hedderich R., Ingram-Smith C.,
RA   Kuettner C.H., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B.,
RA   Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H.,
RA   de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L.,
RA   Paulsen I., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H.,
RA   Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
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DR   EMBL; AE010299; AAM06444.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8TLG5; -.
DR   STRING; 188937.MA_3071; -.
DR   EnsemblBacteria; AAM06444; AAM06444; MA_3071.
DR   KEGG; mac:MA_3071; -.
DR   HOGENOM; CLU_412592_0_0_2; -.
DR   InParanoid; Q8TLG5; -.
DR   PhylomeDB; Q8TLG5; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013655; PAS_fold_3.
DR   NCBIfam; TIGR00229; sensory_box; 1.
DR   PANTHER; PTHR32089:SF92; LYSOZYME-LIKE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00283; MA; 1.
DR   SMART; SM00086; PAC; 2.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50113; PAC; 2.
DR   PROSITE; PS50112; PAS; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002487};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW   ProRule:PRU00284}.
FT   DOMAIN          29..103
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          106..158
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          227..280
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          283..335
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          361..604
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000259|PROSITE:PS50111"
FT   REGION          643..667
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   667 AA;  72959 MW;  F93591A845A8A4A5 CRC64;
     MQMSSIATDL ETTGQRNLSK NLVNDRGPEA KEVSSLIDNL PITVFRTSVD SSWAVRYISK
     NVDVLTGHTK MDFISQKISW SDIVYPEDAP LIEEIVQKAM KNRTAYQVEY RIKKTDGSTV
     FIQELAHLVN DDAGNLAYID GVFLDVTPQI LRREESQRAI VSSIPQPSLA LYVDASGKIK
     YINDYFVKVC KFKKAEDAIG VSPTDLMESG DKKSLAEKVL ESGEAVYNLE RPLKLRALDK
     PLHTVTSSVP IKDDSGAIIG NLTIITDMTE MKEKEKEIAE LLHYTNSCLK DLGEGIRRIG
     EGDLEVHLEK IKDDDFGKTF EEFNQLVANL KSVIEIILAD MLTTLEEARQ SEEAVSQMNT
     GMQQISTAAE QIATGSENLS RHAGTAATDV KASQDIFRKL SESSTKSSSY ASQAGKTSEE
     AQELNNMALE GVEQFVAEIF KLGNIVHSLD DAVNNIGAVT GKIKSIADQT NLLALNAAIE
     AARAGEYGRG FAVVADEVRK LAADSRKSTD EINEIVTNVQ KETKKVTEAI NAADIQAKTG
     SKNIKQALNK SHEIAAAVAT INSMLLELDK LADDGLNKID NIEKSISEAA STAEENAASS
     EETSAAIEEQ TAAMQQVSTS VQNVSELAQK TVDALIENFK VSGEQTNNQP SFGKPQHFDR
     KKSTRMY
//