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Q8TL41 (HISX_METAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:MA_3201
OrganismMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) [Reference proteome] [HAMAP]
Taxonomic identifier188937 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135893

Sites

Active site3261Proton acceptor By similarity
Active site3271Proton acceptor By similarity
Metal binding2591Zinc By similarity
Metal binding2621Zinc By similarity
Metal binding3601Zinc By similarity
Metal binding4191Zinc By similarity
Binding site1291NAD By similarity
Binding site1911NAD By similarity
Binding site2141NAD By similarity
Binding site2371Substrate By similarity
Binding site2591Substrate By similarity
Binding site2621Substrate By similarity
Binding site3271Substrate By similarity
Binding site3601Substrate By similarity
Binding site4141Substrate By similarity
Binding site4191Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8TL41 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 813FA41F53F6DC65

FASTA43346,042
        10         20         30         40         50         60 
MVTMLFKKLS DASEAEMKKL ISRGSGLADV GETVSSVLSD VRVRGDAALR EYTKKFDKVE 

        70         80         90        100        110        120 
LAGFEVSEAE FEEALSGVGP ELLEHLKVAA ANIRVFHEAQ LPETTWFMEV QPGVVLGQKA 

       130        140        150        160        170        180 
TALESVGAYA PGGRASYPST VLMTVIPARV AGVKQVIVCT PPRADGSIHP LTLAAAKVAG 

       190        200        210        220        230        240 
ADKVFKLGGV QAVGAMAYGT ETVPKVDKIV GPGNVFVTSA KMQVRNVAEI DFPAGPSEVL 

       250        260        270        280        290        300 
IIADDSADAA MVASDIIAQA EHDPNAVSVL VTTSEILAEA VRQEVLLQAE NTARSEIVKT 

       310        320        330        340        350        360 
SLENAAVLIS DTLEQSIDFS NKFAPEHLEI MVEDSDFVLN RIKNAGSIFV GNYAPVPVGD 

       370        380        390        400        410        420 
YASGTNHVLP TAGYARIYSG LNINHFLKYS SIQKISKSGL ESLKETIIAL AEEEGLQAHA 

       430 
DAIRTRFGYK PSK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE010299 Genomic DNA. Translation: AAM06572.1.
RefSeqNP_618092.1. NC_003552.1.

3D structure databases

ProteinModelPortalQ8TL41.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING188937.MA3201.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM06572; AAM06572; MA_3201.
GeneID1475094.
KEGGmac:MA3201.

Phylogenomic databases

eggNOGCOG0141.
KOK00013.
OMAPSEILII.
PhylomeDBQ8TL41.
ProtClustDBPRK00877.

Enzyme and pathway databases

BioCycMACE188937:GI2O-3236-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_METAC
AccessionPrimary (citable) accession number: Q8TL41
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways