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Protein

AMP phosphorylase

Gene

MA_3242

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei167AMP; via amide nitrogenUniRule annotation1
Binding sitei202AMP; via amide nitrogenUniRule annotation1
Active sitei255Proton donorUniRule annotation1
Binding sitei263AMPUniRule annotation1
Binding sitei287AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi193 – 198AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMACE188937:G1FZT-3450-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:MA_3242
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000002487 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000590871 – 506AMP phosphorylaseAdd BLAST506

Interactioni

Protein-protein interaction databases

STRINGi188937.MA3242

Structurei

3D structure databases

ProteinModelPortaliQ8TL01
SMRiQ8TL01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013 Archaea
COG0213 LUCA
InParanoidiQ8TL01
KOiK18931
OMAiVHSIGGV
OrthoDBiPOG093Z01M3
PhylomeDBiQ8TL01

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
HAMAPiMF_02132 AMP_phosphorylase, 1 hit
InterProiView protein in InterPro
IPR017713 AMP_phosphorylase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR017872 Pyrmidine_PPase_CS
IPR013466 Thymidine/AMP_Pase
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR03327 AMP_phos, 1 hit
TIGR02645 ARCH_P_rylase, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TL01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLNLEHFDI KIGQHKVMFN VADAKELGVN PGDRVRIRGH QSISAIVDTT
60 70 80 90 100
EDMVPPGTLG VFSEVYEHFE DWDKPVEVVP ALRSKSSGVI KKMLDKKSVL
110 120 130 140 150
QDEIKLLVND IVEENLSDVE LSAFITASYI HGMTDDEVEW LTRAMIDTGD
160 170 180 190 200
TIEFDTHPVM DKHSIGGVPG NKISLLVVPI VAANGLLIPK TSSRAITGAG
210 220 230 240 250
GTADLMEVLS PVEFSSEEVK EIAEKVGGAL VWGGATNIAP ADDKLIRVEY
260 270 280 290 300
PLSIDPYYQM LASIMAKKGA IGAENVVMDI PIGPSTKVPT VQEGQKLARD
310 320 330 340 350
LINLGHRLGM NVECAITYGS SPIGRRVGPC LEVREAMKVL ESMEGPNSLI
360 370 380 390 400
EKSAALAGIL LEMGGAAPRD RGKELALETL RNGKALEKMK QIIEAQGGDP
410 420 430 440 450
NIKSDDIQVG QYTADIYAST DGYVIEFDNK WIIEIARLAG APNDKGAGVA
460 470 480 490 500
IHKKMGEQVK KGDAILTIYA EKEFKLDLAL TTAQRTNPII VEGMLLKRIP

GIYGFQ
Length:506
Mass (Da):54,862
Last modified:June 1, 2002 - v1
Checksum:i17B692D40B346CC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM06613.1
RefSeqiWP_011023176.1, NC_003552.1

Genome annotation databases

EnsemblBacteriaiAAM06613; AAM06613; MA_3242
GeneIDi1475135
KEGGimac:MA_3242

Similar proteinsi

Entry informationi

Entry nameiAMPPA_METAC
AccessioniPrimary (citable) accession number: Q8TL01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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