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Q8TKX2

- TRUD_METAC

UniProt

Q8TKX2 - TRUD_METAC

Protein

Probable tRNA pseudouridine synthase D

Gene

truD

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    • Comment

    Functioni

    Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

    Catalytic activityi

    tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891NucleophileUniRule annotation

    GO - Molecular functioni

    1. pseudouridine synthase activity Source: UniProtKB-HAMAP
    2. RNA binding Source: InterPro

    GO - Biological processi

    1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    tRNA processing

    Enzyme and pathway databases

    BioCyciMACE188937:GI2O-3306-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
    Alternative name(s):
    tRNA pseudouridine(13) synthaseUniRule annotation
    tRNA pseudouridylate synthase DUniRule annotation
    tRNA-uridine isomerase DUniRule annotation
    Gene namesi
    Name:truDUniRule annotation
    Ordered Locus Names:MA_3271
    OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
    Taxonomic identifieri188937 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
    ProteomesiUP000002487: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 441441Probable tRNA pseudouridine synthase DPRO_0000152539Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi188937.MA3271.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TKX2.
    SMRiQ8TKX2. Positions 4-440.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini168 – 393226TRUDUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pseudouridine synthase TruD family.UniRule annotation
    Contains 1 TRUD domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0585.
    KOiK06176.
    OMAiLRYERAM.
    PhylomeDBiQ8TKX2.

    Family and domain databases

    HAMAPiMF_01082. TruD.
    InterProiIPR020103. PsdUridine_synth_cat_dom.
    IPR001656. PsdUridine_synth_TruD.
    IPR020119. PsdUridine_synth_TruD_CS.
    IPR011760. PsdUridine_synth_TruD_insert.
    [Graphical view]
    PANTHERiPTHR13326. PTHR13326. 1 hit.
    PfamiPF01142. TruD. 1 hit.
    [Graphical view]
    SUPFAMiSSF55120. SSF55120. 2 hits.
    TIGRFAMsiTIGR00094. tRNA_TruD_broad. 1 hit.
    PROSITEiPS50984. TRUD. 1 hit.
    PS01268. UPF0024. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TKX2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQPMEVPEIE KQIGINLYST NTEGLGGRLR QEVEDFIVKE ITNREEGKDG    50
    RYLVLELTKR DWDTHHFTRT LAKILQISQK RISVAGTKDK RALTTQKISI 100
    FDIDALEIEK IHLKDVELKV LGRSRKSVEL GDLWGNEFII TIRDISSSPE 150
    ETRTILEKTN SKVLTQGGVP NFFGVQRFGS VRSVTHLVGK AIVEGNFEKA 200
    AMLYIAEPFP EEPEETKAAR QFVKETRDFK EGLKTYPLRL GHERAMMNHL 250
    ISNPEDYSGA FSVLPKNLYR MFVHAYQSYI YNMILCRRIE SGISLNRAVE 300
    GDIVCFRNEA GLPDSSKTEK VTSETVNAMN RLIKHGRAFI TAPLPGFNTE 350
    FASGVPGEIE SKILKELRVS LEGFNVEEFP EMSSKGTRRE VLLQVEPKFE 400
    VGEDELNPGK SKTVLEFMLP KGSYATTVLR EYMKVDPLQM S 441
    Length:441
    Mass (Da):50,058
    Last modified:June 1, 2002 - v1
    Checksum:iA3A401EA4D900365
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010299 Genomic DNA. Translation: AAM06642.1.
    RefSeqiNP_618162.1. NC_003552.1.

    Genome annotation databases

    EnsemblBacteriaiAAM06642; AAM06642; MA_3271.
    GeneIDi1475164.
    KEGGimac:MA3271.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010299 Genomic DNA. Translation: AAM06642.1 .
    RefSeqi NP_618162.1. NC_003552.1.

    3D structure databases

    ProteinModelPortali Q8TKX2.
    SMRi Q8TKX2. Positions 4-440.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 188937.MA3271.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM06642 ; AAM06642 ; MA_3271 .
    GeneIDi 1475164.
    KEGGi mac:MA3271.

    Phylogenomic databases

    eggNOGi COG0585.
    KOi K06176.
    OMAi LRYERAM.
    PhylomeDBi Q8TKX2.

    Enzyme and pathway databases

    BioCyci MACE188937:GI2O-3306-MONOMER.

    Family and domain databases

    HAMAPi MF_01082. TruD.
    InterProi IPR020103. PsdUridine_synth_cat_dom.
    IPR001656. PsdUridine_synth_TruD.
    IPR020119. PsdUridine_synth_TruD_CS.
    IPR011760. PsdUridine_synth_TruD_insert.
    [Graphical view ]
    PANTHERi PTHR13326. PTHR13326. 1 hit.
    Pfami PF01142. TruD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55120. SSF55120. 2 hits.
    TIGRFAMsi TIGR00094. tRNA_TruD_broad. 1 hit.
    PROSITEi PS50984. TRUD. 1 hit.
    PS01268. UPF0024. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity."
      Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.
      , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.
      Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

    Entry informationi

    Entry nameiTRUD_METAC
    AccessioniPrimary (citable) accession number: Q8TKX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3