Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8TKX2 (TRUD_METAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable tRNA pseudouridine synthase D

EC=5.4.99.27
Alternative name(s):
tRNA pseudouridine(13) synthase
tRNA pseudouridylate synthase D
tRNA-uridine isomerase D
Gene names
Name:truD
Ordered Locus Names:MA_3271
OrganismMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) [Reference proteome] [HAMAP]
Taxonomic identifier188937 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina

Protein attributes

Sequence length441 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs By similarity. HAMAP-Rule MF_01082

Catalytic activity

tRNA uridine13 = tRNA pseudouridine13. HAMAP-Rule MF_01082

Sequence similarities

Belongs to the pseudouridine synthase TruD family.

Contains 1 TRUD domain.

Ontologies

Keywords
   Biological processtRNA processing
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtRNA pseudouridine synthesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: InterPro

pseudouridine synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 441441Probable tRNA pseudouridine synthase D HAMAP-Rule MF_01082
PRO_0000152539

Regions

Domain168 – 393226TRUD

Sites

Active site891Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8TKX2 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: A3A401EA4D900365

FASTA44150,058
        10         20         30         40         50         60 
MQPMEVPEIE KQIGINLYST NTEGLGGRLR QEVEDFIVKE ITNREEGKDG RYLVLELTKR 

        70         80         90        100        110        120 
DWDTHHFTRT LAKILQISQK RISVAGTKDK RALTTQKISI FDIDALEIEK IHLKDVELKV 

       130        140        150        160        170        180 
LGRSRKSVEL GDLWGNEFII TIRDISSSPE ETRTILEKTN SKVLTQGGVP NFFGVQRFGS 

       190        200        210        220        230        240 
VRSVTHLVGK AIVEGNFEKA AMLYIAEPFP EEPEETKAAR QFVKETRDFK EGLKTYPLRL 

       250        260        270        280        290        300 
GHERAMMNHL ISNPEDYSGA FSVLPKNLYR MFVHAYQSYI YNMILCRRIE SGISLNRAVE 

       310        320        330        340        350        360 
GDIVCFRNEA GLPDSSKTEK VTSETVNAMN RLIKHGRAFI TAPLPGFNTE FASGVPGEIE 

       370        380        390        400        410        420 
SKILKELRVS LEGFNVEEFP EMSSKGTRRE VLLQVEPKFE VGEDELNPGK SKTVLEFMLP 

       430        440 
KGSYATTVLR EYMKVDPLQM S 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE010299 Genomic DNA. Translation: AAM06642.1.
RefSeqNP_618162.1. NC_003552.1.

3D structure databases

ProteinModelPortalQ8TKX2.
SMRQ8TKX2. Positions 4-440.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING188937.MA3271.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM06642; AAM06642; MA_3271.
GeneID1475164.
KEGGmac:MA3271.

Phylogenomic databases

eggNOGCOG0585.
KOK06176.
OMALRYERAM.
PhylomeDBQ8TKX2.
ProtClustDBPRK00984.

Enzyme and pathway databases

BioCycMACE188937:GI2O-3306-MONOMER.

Family and domain databases

HAMAPMF_01082. TruD.
InterProIPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR020119. PsdUridine_synth_TruD_CS.
IPR011760. PsdUridine_synth_TruD_insert.
[Graphical view]
PANTHERPTHR13326. PTHR13326. 1 hit.
PfamPF01142. TruD. 1 hit.
[Graphical view]
SUPFAMSSF55120. SSF55120. 2 hits.
TIGRFAMsTIGR00094. tRNA_TruD_broad. 1 hit.
PROSITEPS50984. TRUD. 1 hit.
PS01268. UPF0024. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRUD_METAC
AccessionPrimary (citable) accession number: Q8TKX2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families