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Q8TKX2

- TRUD_METAC

UniProt

Q8TKX2 - TRUD_METAC

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Protein

Probable tRNA pseudouridine synthase D

Gene

truD

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891NucleophileUniRule annotation

GO - Molecular functioni

  1. pseudouridine synthase activity Source: UniProtKB-HAMAP
  2. RNA binding Source: InterPro

GO - Biological processi

  1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciMACE188937:GI2O-3306-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:MA_3271
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000002487: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Probable tRNA pseudouridine synthase DPRO_0000152539Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi188937.MA3271.

Structurei

3D structure databases

ProteinModelPortaliQ8TKX2.
SMRiQ8TKX2. Positions 4-440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 393226TRUDUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation
Contains 1 TRUD domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0585.
InParanoidiQ8TKX2.
KOiK06176.
OMAiLRYERAM.
PhylomeDBiQ8TKX2.

Family and domain databases

HAMAPiMF_01082. TruD.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR020119. PsdUridine_synth_TruD_CS.
IPR011760. PsdUridine_synth_TruD_insert.
[Graphical view]
PANTHERiPTHR13326. PTHR13326. 1 hit.
PfamiPF01142. TruD. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 2 hits.
TIGRFAMsiTIGR00094. tRNA_TruD_broad. 1 hit.
PROSITEiPS50984. TRUD. 1 hit.
PS01268. UPF0024. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TKX2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQPMEVPEIE KQIGINLYST NTEGLGGRLR QEVEDFIVKE ITNREEGKDG
60 70 80 90 100
RYLVLELTKR DWDTHHFTRT LAKILQISQK RISVAGTKDK RALTTQKISI
110 120 130 140 150
FDIDALEIEK IHLKDVELKV LGRSRKSVEL GDLWGNEFII TIRDISSSPE
160 170 180 190 200
ETRTILEKTN SKVLTQGGVP NFFGVQRFGS VRSVTHLVGK AIVEGNFEKA
210 220 230 240 250
AMLYIAEPFP EEPEETKAAR QFVKETRDFK EGLKTYPLRL GHERAMMNHL
260 270 280 290 300
ISNPEDYSGA FSVLPKNLYR MFVHAYQSYI YNMILCRRIE SGISLNRAVE
310 320 330 340 350
GDIVCFRNEA GLPDSSKTEK VTSETVNAMN RLIKHGRAFI TAPLPGFNTE
360 370 380 390 400
FASGVPGEIE SKILKELRVS LEGFNVEEFP EMSSKGTRRE VLLQVEPKFE
410 420 430 440
VGEDELNPGK SKTVLEFMLP KGSYATTVLR EYMKVDPLQM S
Length:441
Mass (Da):50,058
Last modified:June 1, 2002 - v1
Checksum:iA3A401EA4D900365
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010299 Genomic DNA. Translation: AAM06642.1.
RefSeqiNP_618162.1. NC_003552.1.
WP_011023205.1. NC_003552.1.

Genome annotation databases

EnsemblBacteriaiAAM06642; AAM06642; MA_3271.
GeneIDi1475164.
KEGGimac:MA3271.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE010299 Genomic DNA. Translation: AAM06642.1 .
RefSeqi NP_618162.1. NC_003552.1.
WP_011023205.1. NC_003552.1.

3D structure databases

ProteinModelPortali Q8TKX2.
SMRi Q8TKX2. Positions 4-440.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 188937.MA3271.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM06642 ; AAM06642 ; MA_3271 .
GeneIDi 1475164.
KEGGi mac:MA3271.

Phylogenomic databases

eggNOGi COG0585.
InParanoidi Q8TKX2.
KOi K06176.
OMAi LRYERAM.
PhylomeDBi Q8TKX2.

Enzyme and pathway databases

BioCyci MACE188937:GI2O-3306-MONOMER.

Family and domain databases

HAMAPi MF_01082. TruD.
InterProi IPR020103. PsdUridine_synth_cat_dom.
IPR001656. PsdUridine_synth_TruD.
IPR020119. PsdUridine_synth_TruD_CS.
IPR011760. PsdUridine_synth_TruD_insert.
[Graphical view ]
PANTHERi PTHR13326. PTHR13326. 1 hit.
Pfami PF01142. TruD. 1 hit.
[Graphical view ]
SUPFAMi SSF55120. SSF55120. 2 hits.
TIGRFAMsi TIGR00094. tRNA_TruD_broad. 1 hit.
PROSITEi PS50984. TRUD. 1 hit.
PS01268. UPF0024. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity."
    Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.
    , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.
    Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

Entry informationi

Entry nameiTRUD_METAC
AccessioniPrimary (citable) accession number: Q8TKX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3