Q8TK19 (ACKA_METAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase
EC=2.7.2.1

Alternative name(s):
Acetokinase

Gene names

Name:	ackA
Synonyms:	ack
Ordered Locus Names:	MA_3606

Organism

Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

Taxonomic identifier

188937 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	408 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 408	408	Acetate kinase HAMAP MF_00020		PRO_0000107648

Sequences

	Sequence		Length	Mass (Da)
	Q8TK19 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: D36FE2068809C37B	FASTA	408	44,285
	10 20 30 40 50 60 MKVLVINAGS SSLKYQLIDM TNESPLAIGL CERIGIDNSI ITQKRSDGKK LEKQTDLPNH 70 80 90 100 110 120 KVALEEVVKA LTDSELGVIK SMDEINAVGH RVVHGGEKFT SSALIDEGVE QAIKDCFELA 130 140 150 160 170 180 PLHNPPNMMG ITACQEIMPG VPMVAVFDTA FHQTIPAYAY MYALPYTLYE KYGIRKYGFH 190 200 210 220 230 240 GTSHFYVARR AAAMLGKPEE EVKVITCHLG NGSSITAVNG GKSVETTMGF TPLEGVAMGT 250 260 270 280 290 300 RCGSIDPAVV PFVMEKEGLT TREIDTLMNK KSGVLGVSGL SNDFRDLDEA ASKGNQRAEL 310 320 330 340 350 360 ALEIFAYKIK KVIGEYSAVL NGADAVVFTA GIGENSASIR KRILSGLDGL GIEIDEEKNK 370 380 390 400 IRGQEIDIST PDAKVRVLVI PTNEELTIAR DTKEICETEV KLRRSVSI

References

[1]

"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity." Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P. , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B. Genome Res. 12:532-542(2002) [PubMed: 11932238] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE010299 Genomic DNA. Translation: AAM06961.1.
RefSeq	NP_618481.1. NC_003552.1.
3D structure databases
ProteinModelPortal	Q8TK19.
SMR	Q8TK19. Positions 1-399.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1475499.
GenomeReviews	Gene locus MA_3606 in contig AE010299_GR.
KEGG	mac:MA3606.
NMPDR	fig|188937.1.peg.3507.
Phylogenomic databases
HOGENOM	HBG285863.
OMA	LIDMTNE.
ProtClustDB	PRK00180.
Enzyme and pathway databases
BioCyc	MACE188937:MA3606-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_METAC

Accession

Primary (citable) accession number: Q8TK19

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	June 1, 2002
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program