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Q8TJP7 (MER_METAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5,10-methylenetetrahydromethanopterin reductase

EC=1.5.98.2
Alternative name(s):
Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase
Methylene-H(4)MPT reductase
Gene names
Name:mer
Ordered Locus Names:MA_3733
OrganismMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) [Reference proteome] [HAMAP]
Taxonomic identifier188937 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible reduction of methylene-H4MPT to methyl-H4MPT By similarity. HAMAP-Rule MF_01091

Catalytic activity

5-methyltetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420. HAMAP-Rule MF_01091

Pathway

One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 1/2. HAMAP-Rule MF_01091

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01091.

Sequence similarities

Belongs to the mer family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3283285,10-methylenetetrahydromethanopterin reductase HAMAP-Rule MF_01091
PRO_0000084806

Sequences

Sequence LengthMass (Da)Tools
Q8TJP7 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: C57ABD6B163CBD4E

FASTA32834,720
        10         20         30         40         50         60 
MKFGIEFVPS DPALKIAYYA KLSEQQGFDY VWITDHYNNR DVYSTLTVLA LNTNSIKIGS 

        70         80         90        100        110        120 
GVTNSYTRNP AITASSIASI AEISGGRAVL GLGPGDKATF DAMGIAWEKP LATTKEAIQA 

       130        140        150        160        170        180 
IRDFIAGKKV SMDGEMVKFA GAKLAFKAGN VPIYMGAQGP KMLELAGEVA DGVLINASHP 

       190        200        210        220        230        240 
KDFEVAVEQI RKGAEKVGRD PSEVDVTAYA CFSIDKDPAK AINAAKVVVA FIVAGSPDLV 

       250        260        270        280        290        300 
LERHGIPVDA KKQIGDAIAK GDFGALMGGL VTPQMIEAFA ICGTPEDCMK RIKDLEAIGV 

       310        320 
TQIVAGSPIG PEKEKAIKLI GKEIIAKM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE010299 Genomic DNA. Translation: AAM07085.1.
RefSeqNP_618605.1. NC_003552.1.

3D structure databases

ProteinModelPortalQ8TJP7.
SMRQ8TJP7. Positions 1-327.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING188937.MA3733.

Proteomic databases

PRIDEQ8TJP7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM07085; AAM07085; MA_3733.
GeneID1475626.
KEGGmac:MA3733.

Phylogenomic databases

eggNOGCOG2141.
KOK00320.
OMAHPRDLEW.
PhylomeDBQ8TJP7.

Enzyme and pathway databases

BioCycMACE188937:GI2O-3776-MONOMER.
UniPathwayUPA00640; UER00697.

Family and domain databases

Gene3D3.20.20.30. 1 hit.
HAMAPMF_01091. F420_mer.
InterProIPR011251. Luciferase-like_dom.
IPR019946. MeH4methanopterin_reductase.
[Graphical view]
PfamPF00296. Bac_luciferase. 1 hit.
[Graphical view]
SUPFAMSSF51679. SSF51679. 1 hit.
TIGRFAMsTIGR03555. F420_mer. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMER_METAC
AccessionPrimary (citable) accession number: Q8TJP7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways