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Q8TJP7

- MER_METAC

UniProt

Q8TJP7 - MER_METAC

Protein

5,10-methylenetetrahydromethanopterin reductase

Gene

mer

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible reduction of methylene-H4MPT to methyl-H4MPT.UniRule annotation

    Catalytic activityi

    5-methyltetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity Source: UniProtKB-HAMAP
    2. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    GO - Biological processi

    1. methanogenesis, from carbon dioxide Source: UniProtKB-UniPathway
    2. one-carbon metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Methanogenesis, One-carbon metabolism

    Enzyme and pathway databases

    BioCyciMACE188937:GI2O-3776-MONOMER.
    UniPathwayiUPA00640; UER00697.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5,10-methylenetetrahydromethanopterin reductaseUniRule annotation (EC:1.5.98.2UniRule annotation)
    Alternative name(s):
    Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductaseUniRule annotation
    Methylene-H(4)MPT reductaseUniRule annotation
    Gene namesi
    Name:merUniRule annotation
    Ordered Locus Names:MA_3733
    OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
    Taxonomic identifieri188937 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
    ProteomesiUP000002487: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3283285,10-methylenetetrahydromethanopterin reductasePRO_0000084806Add
    BLAST

    Proteomic databases

    PRIDEiQ8TJP7.

    Interactioni

    Protein-protein interaction databases

    STRINGi188937.MA3733.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TJP7.
    SMRiQ8TJP7. Positions 1-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the mer family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2141.
    KOiK00320.
    OMAiHPRDLEW.
    PhylomeDBiQ8TJP7.

    Family and domain databases

    Gene3Di3.20.20.30. 1 hit.
    HAMAPiMF_01091. F420_mer.
    InterProiIPR011251. Luciferase-like_dom.
    IPR019946. MeH4methanopterin_reductase.
    [Graphical view]
    PfamiPF00296. Bac_luciferase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51679. SSF51679. 1 hit.
    TIGRFAMsiTIGR03555. F420_mer. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8TJP7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFGIEFVPS DPALKIAYYA KLSEQQGFDY VWITDHYNNR DVYSTLTVLA    50
    LNTNSIKIGS GVTNSYTRNP AITASSIASI AEISGGRAVL GLGPGDKATF 100
    DAMGIAWEKP LATTKEAIQA IRDFIAGKKV SMDGEMVKFA GAKLAFKAGN 150
    VPIYMGAQGP KMLELAGEVA DGVLINASHP KDFEVAVEQI RKGAEKVGRD 200
    PSEVDVTAYA CFSIDKDPAK AINAAKVVVA FIVAGSPDLV LERHGIPVDA 250
    KKQIGDAIAK GDFGALMGGL VTPQMIEAFA ICGTPEDCMK RIKDLEAIGV 300
    TQIVAGSPIG PEKEKAIKLI GKEIIAKM 328
    Length:328
    Mass (Da):34,720
    Last modified:June 1, 2002 - v1
    Checksum:iC57ABD6B163CBD4E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010299 Genomic DNA. Translation: AAM07085.1.
    RefSeqiNP_618605.1. NC_003552.1.

    Genome annotation databases

    EnsemblBacteriaiAAM07085; AAM07085; MA_3733.
    GeneIDi1475626.
    KEGGimac:MA3733.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010299 Genomic DNA. Translation: AAM07085.1 .
    RefSeqi NP_618605.1. NC_003552.1.

    3D structure databases

    ProteinModelPortali Q8TJP7.
    SMRi Q8TJP7. Positions 1-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 188937.MA3733.

    Proteomic databases

    PRIDEi Q8TJP7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM07085 ; AAM07085 ; MA_3733 .
    GeneIDi 1475626.
    KEGGi mac:MA3733.

    Phylogenomic databases

    eggNOGi COG2141.
    KOi K00320.
    OMAi HPRDLEW.
    PhylomeDBi Q8TJP7.

    Enzyme and pathway databases

    UniPathwayi UPA00640 ; UER00697 .
    BioCyci MACE188937:GI2O-3776-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.30. 1 hit.
    HAMAPi MF_01091. F420_mer.
    InterProi IPR011251. Luciferase-like_dom.
    IPR019946. MeH4methanopterin_reductase.
    [Graphical view ]
    Pfami PF00296. Bac_luciferase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51679. SSF51679. 1 hit.
    TIGRFAMsi TIGR03555. F420_mer. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity."
      Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.
      , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.
      Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

    Entry informationi

    Entry nameiMER_METAC
    AccessioniPrimary (citable) accession number: Q8TJP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3