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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei161GTPUniRule annotation1
Binding sitei164GTPUniRule annotation1
Binding sitei207GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 47GTPUniRule annotation5
Nucleotide bindingi130 – 132GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMACE188937:G1FZT-4125-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:MA_3876Imported
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)Imported
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000002487 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi188937.MA3876

Structurei

3D structure databases

ProteinModelPortaliQ8TJB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 225TubulinInterPro annotationAdd BLAST191
Domaini227 – 344Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201 Archaea
COG0206 LUCA
InParanoidiQ8TJB2
KOiK03531
OMAiIMNQGGV
OrthoDBiPOG093Z0942
PhylomeDBiQ8TJB2

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TJB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSIVQEAMK FSEKEKEYRK NSSSEEDIEE FGQPRIMIVG CGGAGNNTVN
60 70 80 90 100
RLYNIGIEGA ETVCINTDKQ HLDNVRADKK ILVGKTLTRG LGAGGYPETG
110 120 130 140 150
KKAAELARGT LEEVLKNVDL VFITAGLGGG TGTGVAPVVA EVAKEQGAIV
160 170 180 190 200
VGMVSSPFRV ERARIFKAEE GLEDLRRAAD TVIVLDNNRL LNYVPNLPID
210 220 230 240 250
QAFSVMDQLI AETVKGITET ITVPSLINLD YADIRTIMSC GGVAVMLVGE
260 270 280 290 300
SKSQDKSTEV VRTALNHPLL DVDYKGATGS LVHVTGGPDL SLKEAEEIAS
310 320 330 340 350
MLTYELSSSA NVIWGARIRE DYEGRVRVMA IMTGVQSAQI LGPQAGAGIF
360 370 380 390
ESRAEAEPIQ EKRFGRLSPG RRGETAGPLR KKHEESIIDF IN
Length:392
Mass (Da):42,262
Last modified:June 1, 2002 - v1
Checksum:i814A805D3097D832
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA Translation: AAM07227.1
RefSeqiWP_011023772.1, NC_003552.1

Genome annotation databases

EnsemblBacteriaiAAM07227; AAM07227; MA_3876
GeneIDi1475769
KEGGimac:MA_3876

Similar proteinsi

Entry informationi

Entry nameiQ8TJB2_METAC
AccessioniPrimary (citable) accession number: Q8TJB2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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