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Protein

Translation initiation factor 6

Gene

eif6

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 6UniRule annotation
Short name:
aIF-6UniRule annotation
Gene namesi
Name:eif6UniRule annotation
Ordered Locus Names:MA_4112
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000002487 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001537451 – 218Translation initiation factor 6Add BLAST218

Interactioni

Protein-protein interaction databases

STRINGi188937.MA4112.

Structurei

3D structure databases

ProteinModelPortaliQ8TIN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04176. Archaea.
COG1976. LUCA.
InParanoidiQ8TIN4.
KOiK03264.
OMAiPNIGVYI.
PhylomeDBiQ8TIN4.

Family and domain databases

CDDicd00527. IF6. 1 hit.
HAMAPiMF_00032. eIF_6. 1 hit.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TIN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRTVDIYDT SIIGVFATCT EDVVLVPPLT KPEVCALLEE VLDVRVIETL
60 70 80 90 100
VNGSIVVGAL SRGNSNGFML PYGARAEMQR FTDIPVGILP DRLNAVGNIV
110 120 130 140 150
FANDSAALVH PDLSDKALEA IARTLKVDVY RGTIAGIKNV GMAGVVTNKG
160 170 180 190 200
LLVHPKVTAS EREVLEKIFG FPVNIGTTNF GTQMLGSGLL ANSKNFVAGS
210
ETTGPELGRI EEALGFLE
Length:218
Mass (Da):23,141
Last modified:June 1, 2002 - v1
Checksum:iA13726B8D9A4597C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA. Translation: AAM07460.1.
RefSeqiWP_011024003.1. NC_003552.1.

Genome annotation databases

EnsemblBacteriaiAAM07460; AAM07460; MA_4112.
GeneIDi1476006.
KEGGimac:MA_4112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA. Translation: AAM07460.1.
RefSeqiWP_011024003.1. NC_003552.1.

3D structure databases

ProteinModelPortaliQ8TIN4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi188937.MA4112.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM07460; AAM07460; MA_4112.
GeneIDi1476006.
KEGGimac:MA_4112.

Phylogenomic databases

eggNOGiarCOG04176. Archaea.
COG1976. LUCA.
InParanoidiQ8TIN4.
KOiK03264.
OMAiPNIGVYI.
PhylomeDBiQ8TIN4.

Family and domain databases

CDDicd00527. IF6. 1 hit.
HAMAPiMF_00032. eIF_6. 1 hit.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIF6_METAC
AccessioniPrimary (citable) accession number: Q8TIN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.