Q8TIN4 (IF6_METAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation initiation factor 6
Short name=aIF-6

Gene names

Name:	eif6
Ordered Locus Names:	MA_4112

Organism

Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) [Reference proteome] [HAMAP]

Taxonomic identifier

188937 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina › Methanosarcina acetivorans

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex By similarity. HAMAP-Rule MF_00032
Sequence similarities	Belongs to the eIF-6 family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Molecular function	Initiation factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mature ribosome assembly Inferred from electronic annotation. Source: InterPro
Molecular_function	ribosome binding Inferred from electronic annotation. Source: InterPro translation initiation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 218	218	Translation initiation factor 6 HAMAP-Rule MF_00032		PRO_0000153745

Sequences

	Sequence		Length	Mass (Da)
	Q8TIN4 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: A13726B8D9A4597C	FASTA	218	23,141
	10 20 30 40 50 60 MIRTVDIYDT SIIGVFATCT EDVVLVPPLT KPEVCALLEE VLDVRVIETL VNGSIVVGAL 70 80 90 100 110 120 SRGNSNGFML PYGARAEMQR FTDIPVGILP DRLNAVGNIV FANDSAALVH PDLSDKALEA 130 140 150 160 170 180 IARTLKVDVY RGTIAGIKNV GMAGVVTNKG LLVHPKVTAS EREVLEKIFG FPVNIGTTNF 190 200 210 GTQMLGSGLL ANSKNFVAGS ETTGPELGRI EEALGFLE

References

[1]

"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity." Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P. , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B. Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE010299 Genomic DNA. Translation: AAM07460.1.
RefSeq	NP_618980.1. NC_003552.1.
3D structure databases
ProteinModelPortal	Q8TIN4.
ModBase	Search...
Protein-protein interaction databases
STRING	188937.MA4112.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM07460; AAM07460; MA_4112.
GeneID	1476006.
KEGG	mac:MA4112.
Phylogenomic databases
eggNOG	COG1976.
KO	K03264.
OMA	QFENSNE.
ProtClustDB	PRK04046.
Enzyme and pathway databases
BioCyc	MACE188937:GI2O-4177-MONOMER.
Family and domain databases
HAMAP	MF_00032. eIF-6.
InterPro	IPR002769. eIF6. [Graphical view]
PANTHER	PTHR10784. PTHR10784. 1 hit.
Pfam	PF01912. eIF-6. 1 hit. [Graphical view]
PIRSF	PIRSF006413. IF-6. 1 hit.
SMART	SM00654. eIF6. 1 hit. [Graphical view]
TIGRFAMs	TIGR00323. eIF-6. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IF6_METAC

Accession

Primary (citable) accession number: Q8TIN4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program