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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei175GTPUniRule annotation1
Binding sitei179GTPUniRule annotation1
Binding sitei222GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi57 – 61GTPUniRule annotation5
Nucleotide bindingi144 – 146GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotationImported
Ordered Locus Names:MA_4271Imported
OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)Imported
Taxonomic identifieri188937 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000002487 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiQ8TI85.

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi188937.MA4271.

Structurei

3D structure databases

ProteinModelPortaliQ8TI85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 240TubulinInterPro annotationAdd BLAST192
Domaini242 – 359Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201. Archaea.
COG0206. LUCA.
KOiK03531.
OMAiMRAVKGI.
OrthoDBiPOG093Z0942.
PhylomeDBiQ8TI85.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiView protein in InterPro
IPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR037103. Tubulin/FtsZ_C_sf.
IPR036525. Tubulin/FtsZ_GTPase_sf.
IPR003008. Tubulin_FtsZ_GTPase.
PfamiView protein in Pfam
PF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiView protein in SMART
SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiView protein in PROSITE
PS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TI85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSIVEEALA RSALEGRAVQ GEYSDSDYSN ENLEVDAELE EILRSLKTTI
60 70 80 90 100
KVIGCGGGGS NSIQRMMGEG IQGADLVALN TDAQHLLHIR SGKKILIGKK
110 120 130 140 150
KTRGLGAGSL PQIGEDAAIE SIDEINKIVQ GSDMVFITAG LGGGTGTGSA
160 170 180 190 200
PIVAEAARDA GALTIAVVTL PFSVEGHVRR TNAEAGLERL RDVADTVIVV
210 220 230 240 250
PNDKLIEVVP RLPLQAAFKV SDEVLMRAVK GITELITKPG LVNLDFADIR
260 270 280 290 300
TVMQNGGVAM IGLGESDGEN KAVESVQKAL RSPLLDVDIS GATSALVNVV
310 320 330 340 350
GGPDMTISEA ECVVQEVYNR IDSNARLIWG AQVDPDLEQT VRTMIVVTGV
360 370
TSAQIYGHGS DKNITYKYGI DFVE
Length:374
Mass (Da):39,520
Last modified:June 1, 2002 - v1
Checksum:i24A38C6996DF8462
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE010299 Genomic DNA. Translation: AAM07615.1.
RefSeqiWP_011024152.1. NC_003552.1.

Genome annotation databases

EnsemblBacteriaiAAM07615; AAM07615; MA_4271.
GeneIDi1476165.
KEGGimac:MA_4271.

Similar proteinsi

Entry informationi

Entry nameiQ8TI85_METAC
AccessioniPrimary (citable) accession number: Q8TI85
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: October 25, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported