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Q8THP1 (DAPA_METAC) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydrodipicolinate synthase
Short name=DHDPS
EC=4.2.1.52
Gene names
Name:dapA
Ordered Locus Names:MA_4473
OrganismMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Taxonomic identifier188937 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418

Subcellular location

Cytoplasm By similarity HAMAP MF_00418.

Sequence similarities

Belongs to the DHDPS family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrodipicolinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 291291Dihydrodipicolinate synthase HAMAP MF_00418
PRO_0000103196

Regions

Region48 – 492Pyruvate binding By similarity

Sites

Active site1591Schiff-base intermediate with substrate By similarity
Binding site1041Pyruvate By similarity
Site1311Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8THP1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: DCBCF5E8FDBEAA75

FASTA29130,632
        10         20         30         40         50         60 
MFEGAMPALI TPFTKDDRID REGLRRNIAF VEEGGVSGIV PCGTTGESAT LSALEHEEVI 

        70         80         90        100        110        120 
DIAVECAKVP VVAGTGSNNT GEALQFTKHA ADAGVDGVLL ISPYYNKPNP AGLLAHFKKI 

       130        140        150        160        170        180 
AEAVDIPMIL YNVPSRTGQD MPVDVITKLA KVENIVGIKE ASGSVGKVSQ ILEQTIDDDF 

       190        200        210        220        230        240 
VVLSGEDGLT LPIISVGGSG VISVAANIVP DKMSGMVSAA LKGDYETARK IHFEIAPLIR 

       250        260        270        280        290 
ALFLETNPIP AKKAAELIGL ASGHLRLPLA PMSDANQLKL VTELKKLGVM K

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE010299 Genomic DNA. Translation: AAM07813.1.
RefSeqNP_619333.1. NC_003552.1.

3D structure databases

ProteinModelPortalQ8THP1.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1476367.
GenomeReviewsGene locus MA_4473 in contig AE010299_GR.
KEGGmac:MA4473.
NMPDRfig|188937.1.peg.4359.

Phylogenomic databases

HOGENOMHBG358848.
OMACEMEDSN.
ProtClustDBPRK03170.

Enzyme and pathway databases

BioCycMACE188937:MA4473-MONOMER.

Family and domain databases

HAMAPMF_00418. DapA.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
IPR020624. Dihydrodipicolinate_synth_CS.
IPR005263. Dihydrodipicolinate_synth_DapA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01714.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
TIGRFAMsTIGR00674. DapA. 1 hit.
PROSITEPS00665. DHDPS_1. 1 hit.
PS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPA_METAC
AccessionPrimary (citable) accession number: Q8THP1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2002
Last modified: November 16, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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