Q8THK3 (GUAAB_METAC) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 58.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: GMP synthase [glutamine-hydrolyzing] subunit B EC=6.3.5.2 Alternative name(s): GMP synthetase | ||||||
| Gene names |
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| Organism | Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) | ||||||
| Taxonomic identifier | 188937 [NCBI] | ||||||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina |
Protein attributes
| Sequence length | 305 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the synthesis of GMP from XMP By similarity. HAMAP MF_00345 |
| Catalytic activity | ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP MF_00345 |
| Pathway | Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP MF_00345 |
| Subunit structure | Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B) Potential. |
| Sequence similarities | Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | GMP biosynthesis Purine biosynthesis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | GMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW GMP synthase (glutamine-hydrolyzing) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 305 | 305 | GMP synthase [glutamine-hydrolyzing] subunit B HAMAP MF_00345 | PRO_0000140240 | |||||
Regions | |||||||||
| Domain | 2 – 184 | 183 | GMPS ATP-PPase | ||||||
| Nucleotide binding | 29 – 35 | 7 | ATP By similarity | ||||||
Sequences
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References
| [1] | "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity." Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P. Birren B.Genome Res. 12:532-542(2002) [PubMed: 11932238] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE010299 Genomic DNA. Translation: AAM07851.1. |
| RefSeq | NP_619371.1. NC_003552.1. |
3D structure databases | |
| ProteinModelPortal | Q8THK3. |
| SMR | Q8THK3. Positions 4-305. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1476405. |
| GenomeReviews | Gene locus MA_4511 in contig AE010299_GR. |
| KEGG | mac:MA4511. |
| NMPDR | fig|188937.1.peg.4397. |
Phylogenomic databases | |
| HOGENOM | HBG391775. |
| OMA | QGTIAPD. |
| ProtClustDB | PRK00919. |
Enzyme and pathway databases | |
| BioCyc | MACE188937:MA4511-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00345. GMP_synthase_B. [Tree] |
| InterPro | IPR001674. GMP_synth_C. IPR022310. NAD/GMP_synthase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit. |
| KO | K01951. |
| Pfam | PF00958. GMP_synt_C. 1 hit. PF02540. NAD_synthase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00884. GuaA_Cterm. 1 hit. |
| PROSITE | PS51553. GMPS_ATP_PPASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GUAAB_METAC | ||||||||
| Accession | Primary (citable) accession number: Q8THK3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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