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Q8THJ7 (MPTA_METAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTP cyclohydrolase MptA
EC=3.5.4.n2
Gene names
Name:mptA
Ordered Locus Names:MA_4517
OrganismMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) [Reference proteome] [HAMAP]
Taxonomic identifier188937 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina ›

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate. HAMAP-Rule MF_01527

Cofactor

Binds 1 Fe2+ ion per subunit By similarity.

Pathway

Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis. HAMAP-Rule MF_01527

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Sequence caution

The sequence AAM07857.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   LigandIron
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionGTP cyclohydrolase activity

Inferred from electronic annotation. Source: HAMAP

iron ion binding

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318GTP cyclohydrolase MptA HAMAP-Rule MF_01527
PRO_0000147742

Sites

Site1671May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8THJ7 [UniParc].

Last modified February 1, 2005. Version 2.
Checksum: BD54C411226E0EFF

FASTA31835,767
        10         20         30         40         50         60 
MEHCTFNLPD VQASKPSIAI NLTRVGVTNM KKLVEIKRKD KRPIVLISTF DVFVDLPSDR 

        70         80         90        100        110        120 
KGANLSRNFE AVDEVLEKVL STPVYEIEQL CSDIAHNLLG RHEYANQAEV RMKSEYMIRR 

       130        140        150        160        170        180 
ASPSTGIKCQ EVVNIFAEAS AVRGVGDKDY FDVKKLIGAE VVGMTACPCA QEIMRDKAAN 

       190        200        210        220        230        240 
ELAELGVDRD TIIRFLEKVP MATHNQRGRG IISIKVAHDF DVSLESIIRI IERSMSSSVY 

       250        260        270        280        290        300 
EVLKRSDEKV VVETAHMNPK FVEDCVRAMA DNIVKEFPNL PDNAVITIKQ INEESIHRHN 

       310 
AFAERVALMG ELRSEINQ

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE010299 Genomic DNA. Translation: AAM07857.1. Different initiation.
RefSeqNP_619377.1. NC_003552.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING188937.MA4517.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM07857; AAM07857; MA_4517.
GeneID1476411.
KEGGmac:MA4517.

Phylogenomic databases

eggNOGCOG1469.
KOK09007.
OMAVEDCVRE.
ProtClustDBPRK13675.

Enzyme and pathway databases

BioCycMACE188937:GI2O-4582-MONOMER.
UniPathwayUPA00065.

Family and domain databases

Gene3D3.10.270.10. 1 hit.
HAMAPMF_01527_A. GTP_cyclohydrol_A.
InterProIPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR022840. GTP_cyclohydrolase_MptA.
IPR002042. Uricase.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00294. TIGR00294. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMPTA_METAC
AccessionPrimary (citable) accession number: Q8THJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: May 1, 2013
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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