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Protein

Probable ribosomal RNA small subunit methyltransferase A

Gene

rsmA

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei23 – 231S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei25 – 251S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
Binding sitei50 – 501S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei71 – 711S-adenosyl-L-methionineUniRule annotation
Binding sitei95 – 951S-adenosyl-L-methionineUniRule annotation
Binding sitei110 – 1101S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ribosomal RNA small subunit methyltransferase AUniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
16S rRNA dimethyladenosine transferaseUniRule annotation
16S rRNA dimethylaseUniRule annotation
S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferaseUniRule annotation
Gene namesi
Name:rsmAUniRule annotation
Synonyms:ksgAUniRule annotation
Ordered Locus Names:PF1863
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Probable ribosomal RNA small subunit methyltransferase APRO_0000101663Add
BLAST

Proteomic databases

PRIDEiQ8TH24.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF1863.

Structurei

3D structure databases

ProteinModelPortaliQ8TH24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04131. Archaea.
COG0030. LUCA.
HOGENOMiHOG000227962.
KOiK02528.
OMAiSKLSITC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00607. 16SrRNA_methyltr_A. 1 hit.
InterProiIPR001737. KsgA/Erm.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11727. PTHR11727. 1 hit.
PfamiPF00398. RrnaAD. 1 hit.
[Graphical view]
SMARTiSM00650. rADc. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00755. ksgA. 1 hit.
PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
PS51689. SAM_RNA_A_N6_MT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TH24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDKLFYFLS KYNFSPRDKI GQNFLIMRDV IIKAVETSEI KKSDVVLEVG
60 70 80 90 100
PGFGFLTDEL SKRAGKVYAI ELDKRIIEIL ENEYNWENVE IIQGDAVKIE
110 120 130 140 150
WPEFNKVVSN IPYQISSPFT FKLLKHDFEK AVVMYQLEFA KRMVAKPGDR
160 170 180 190 200
NYSRLSLMVN ALANAKIVMK IGRGAFYPKP KVDSALVLIV PKPKDERIEL
210 220 230 240 250
NENLVKALFQ HRRKLVSKAL KESCHMLGIN KKELKTLKNI LENVPHAKKR
260 270
VFELTPEEVK EIEEFLKIQG IIN
Length:273
Mass (Da):31,627
Last modified:June 1, 2002 - v1
Checksum:i6C1AE108ADE19842
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81987.1.
RefSeqiWP_011013003.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81987; AAL81987; PF1863.
GeneIDi1469742.
KEGGipfu:PF1863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81987.1.
RefSeqiWP_011013003.1. NC_003413.1.

3D structure databases

ProteinModelPortaliQ8TH24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF1863.

Proteomic databases

PRIDEiQ8TH24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81987; AAL81987; PF1863.
GeneIDi1469742.
KEGGipfu:PF1863.

Phylogenomic databases

eggNOGiarCOG04131. Archaea.
COG0030. LUCA.
HOGENOMiHOG000227962.
KOiK02528.
OMAiSKLSITC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00607. 16SrRNA_methyltr_A. 1 hit.
InterProiIPR001737. KsgA/Erm.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11727. PTHR11727. 1 hit.
PfamiPF00398. RrnaAD. 1 hit.
[Graphical view]
SMARTiSM00650. rADc. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00755. ksgA. 1 hit.
PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
PS51689. SAM_RNA_A_N6_MT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRSMA_PYRFU
AccessioniPrimary (citable) accession number: Q8TH24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.