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Protein

Nucleoside-triphosphatase THEP1

Gene

PF0501

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.UniRule annotation

Catalytic activityi

NTP + H2O = NDP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATPUniRule annotation
Nucleotide bindingi101 – 1088ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside-triphosphatase THEP1UniRule annotation (EC:3.6.1.15UniRule annotation)
Short name:
NTPase THEP1UniRule annotation
Alternative name(s):
Nucleoside triphosphate phosphohydrolaseUniRule annotation
Gene namesi
Ordered Locus Names:PF0501
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184Nucleoside-triphosphatase THEP1PRO_0000146702Add
BLAST

Proteomic databases

PRIDEiQ8TH18.

Interactioni

Protein-protein interaction databases

STRINGi186497.PF0501.

Structurei

3D structure databases

ProteinModelPortaliQ8TH18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the THEP1 NTPase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01034. Archaea.
COG1618. LUCA.
HOGENOMiHOG000006446.
KOiK06928.
OMAiYYWLTPE.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00796. NTPase_1.
InterProiIPR003593. AAA+_ATPase.
IPR004948. Nuc-triphosphatase_THEP1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03266. NTPase_1. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TH18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKFRFFVSG MPGVGKTTLA KRIADEIKRE GFKVGGIITQ EIRSGARRSG
60 70 80 90 100
FRVIALDTGE IGRLAYVGQG YPRLGRYVID VESFEKVAIP AISRALREGD
110 120 130 140 150
LIVIDEIGPM EFKSNEFLKA LGLVLRSEKP LLATVHRRFV ERYRPLGEYY
160 170 180
WLTPENREAV FSEILVKIKE LLRENENAGN KAQD
Length:184
Mass (Da):20,861
Last modified:June 1, 2002 - v1
Checksum:iC0FE00F58C4F5C78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80625.1.
RefSeqiWP_011011618.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL80625; AAL80625; PF0501.
GeneIDi1468342.
KEGGipfu:PF0501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL80625.1.
RefSeqiWP_011011618.1. NC_003413.1.

3D structure databases

ProteinModelPortaliQ8TH18.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi186497.PF0501.

Proteomic databases

PRIDEiQ8TH18.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL80625; AAL80625; PF0501.
GeneIDi1468342.
KEGGipfu:PF0501.

Phylogenomic databases

eggNOGiarCOG01034. Archaea.
COG1618. LUCA.
HOGENOMiHOG000006446.
KOiK06928.
OMAiYYWLTPE.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00796. NTPase_1.
InterProiIPR003593. AAA+_ATPase.
IPR004948. Nuc-triphosphatase_THEP1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03266. NTPase_1. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

Entry informationi

Entry nameiNTPTH_PYRFU
AccessioniPrimary (citable) accession number: Q8TH18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2002
Last modified: November 11, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.