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Q8TGX9

- DUT_METAC

UniProt

Q8TGX9 - DUT_METAC

Protein

Probable deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Enzyme and pathway databases

    BioCyciMACE188937:GI2O-444-MONOMER.
    UniPathwayiUPA00610; UER00666.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
    Short name:
    dUTPaseUniRule annotation
    Alternative name(s):
    dUTP pyrophosphataseUniRule annotation
    Gene namesi
    Name:dutUniRule annotation
    Ordered Locus Names:MA_0440
    OrganismiMethanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
    Taxonomic identifieri188937 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
    ProteomesiUP000002487: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 171171Probable deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000153637Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi188937.MA0440.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TGX9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0717.
    KOiK01520.
    OMAiWDAGYEG.
    PhylomeDBiQ8TGX9.

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    HAMAPiMF_00635. dUTPase_arch.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR023537. dUTPase_archaeal.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8TGX9-1 [UniParc]FASTAAdd to Basket

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    MTLLSSNELR KLIQATPHLL ENAVDIETQI QPNGLELTLK EIKTIEGVGA    50
    VDFDNSERKV PDAKPLEFED DDWIHLPKGI YKVIFNEIVN IPMNLAAIAK 100
    PRSSLIRCGA TLETAVWDAG YRGRSESMLV VYNSAGFRLK KNARIMQLLF 150
    YTLNSEVEEG YSGVYQNENT K 171
    Length:171
    Mass (Da):19,259
    Last modified:June 1, 2002 - v1
    Checksum:i645B29D302AE49E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010299 Genomic DNA. Translation: AAM03887.1.
    RefSeqiNP_615407.1. NC_003552.1.

    Genome annotation databases

    EnsemblBacteriaiAAM03887; AAM03887; MA_0440.
    GeneIDi1472332.
    KEGGimac:MA0440.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE010299 Genomic DNA. Translation: AAM03887.1 .
    RefSeqi NP_615407.1. NC_003552.1.

    3D structure databases

    ProteinModelPortali Q8TGX9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 188937.MA0440.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM03887 ; AAM03887 ; MA_0440 .
    GeneIDi 1472332.
    KEGGi mac:MA0440.

    Phylogenomic databases

    eggNOGi COG0717.
    KOi K01520.
    OMAi WDAGYEG.
    PhylomeDBi Q8TGX9.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00666 .
    BioCyci MACE188937:GI2O-444-MONOMER.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    HAMAPi MF_00635. dUTPase_arch.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR023537. dUTPase_archaeal.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity."
      Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.
      , McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.
      Genome Res. 12:532-542(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35395 / DSM 2834 / JCM 12185 / C2A.

    Entry informationi

    Entry nameiDUT_METAC
    AccessioniPrimary (citable) accession number: Q8TGX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3