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Protein

Protein NAG1

Gene

NAG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in yeast cell wall biogenesis.1 Publication

GO - Biological processi

  1. cell wall biogenesis Source: SGD
  2. cell wall organization Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciYEAST:G3O-31015-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NAG1
Alternative name(s):
Nested antisense gene 1 protein
Gene namesi
Name:NAG1
Ordered Locus Names:YGR031C-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

SGDiS000028636. NAG1.

Subcellular locationi

Membrane Curated; Single-pass membrane protein Curated
Note: Localizes to the cell periphery under conditions of vegetative growth.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Hypersensitive to cell wall-perturbing agent calcofluor white (CFW) at 37 degrees Celsius. A similar phenotype is observed at 30 degrees Celsius, although the severity is decreased. Decreased expression of genes contributing to cell wall organization during vegetative growth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Protein NAG1PRO_0000299922Add
BLAST

Expressioni

Inductioni

Expression is dependent upon the presence of the cell wall integrity pathway mitogen-activated protein kinase SLT2 and its downstream transcription factor RLM1.1 Publication

Gene expression databases

GenevestigatoriQ8TGN9.

Interactioni

Protein-protein interaction databases

STRINGi4932.YGR031C-A.

Structurei

3D structure databases

ProteinModelPortaliQ8TGN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG741ZDV.

Sequencei

Sequence statusi: Complete.

Q8TGN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSAGRVHRS RAGSRGHAAI SPLTMASFSV ARGIRSSNVY DDTDDELSIL
60 70 80 90 100
TFFSAVRRNR LTSSLPPILS ARCSSACFSV RIVLPLSLTI SISALMYSTN
110 120 130 140 150
SALGRKLTGA FSIQTNIEQS CGFFRTSIMA TLPPIECPII IGPPLVFNSC
160
FVIKCFTSSD MTS
Length:163
Mass (Da):17,536
Last modified:June 1, 2002 - v1
Checksum:iCEDDE53B47160CF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115390 Genomic DNA. Translation: AAZ22446.1.
Z72816 Genomic DNA. No translation available.
AF479950 Genomic DNA. Translation: AAL79263.1.
BK006941 Genomic DNA. Translation: DAA08128.1.
RefSeqiNP_001027023.1. NM_001184658.1.

Genome annotation databases

EnsemblFungiiYGR031C-A; YGR031C-A; YGR031C-A.
GeneIDi8656591.
KEGGisce:YGR031C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115390 Genomic DNA. Translation: AAZ22446.1.
Z72816 Genomic DNA. No translation available.
AF479950 Genomic DNA. Translation: AAL79263.1.
BK006941 Genomic DNA. Translation: DAA08128.1.
RefSeqiNP_001027023.1. NM_001184658.1.

3D structure databases

ProteinModelPortaliQ8TGN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4932.YGR031C-A.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR031C-A; YGR031C-A; YGR031C-A.
GeneIDi8656591.
KEGGisce:YGR031C-A.

Organism-specific databases

SGDiS000028636. NAG1.

Phylogenomic databases

OrthoDBiEOG741ZDV.

Enzyme and pathway databases

BioCyciYEAST:G3O-31015-MONOMER.

Gene expression databases

GenevestigatoriQ8TGN9.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Quantitative trait loci mapped to single-nucleotide resolution in yeast."
    Deutschbauer A.M., Davis R.W.
    Nat. Genet. 37:1333-1340(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SK1.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Unconventional genomic architecture in the budding yeast Saccharomyces cerevisiae masks the nested antisense gene NAG1."
    Ma J., Dobry C.J., Krysan D.J., Kumar A.
    Eukaryot. Cell 7:1289-1298(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, INDUCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiNAG1_YEAST
AccessioniPrimary (citable) accession number: Q8TGN9
Secondary accession number(s): D6VUG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2002
Last modified: January 7, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Overlaps completely with ORF YGR031W.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.