Q8TGJ3 (KISH_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein kish

Gene names

Name:	KSH1
Ordered Locus Names:	YNL024C-A

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	72 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the early part of the secretory pathway. Ref.4
Subcellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Golgi apparatus membrane; Single-pass type I membrane protein Ref.4.
Disruption phenotype	Inviable. Ref.4
Sequence similarities	Belongs to the KISH family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Golgi apparatus Membrane
Domain	Signal Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 72	46	Protein kish		PRO_0000247775
Regions
	Topological domain	27 – 53	27	Lumenal Potential
	Transmembrane	54 – 72	19	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8TGJ3 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 5645433999B16B27	FASTA	72	8,196
	10 20 30 40 50 60 MSALFNFRSL LQVILLLICS CSYVHGQWPS LLDRYKNHEV LGAFWKMARV GERASPYVSL 70 ACILMAISQF NS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J. Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"An integrated approach for finding overlooked genes in yeast." Kumar A., Harrison P.M., Cheung K.-H., Lan N., Echols N., Bertone P., Miller P., Gerstein M.B., Snyder M. Nat. Biotechnol. 20:58-63(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway." Wendler F., Gillingham A.K., Sinka R., Rosa-Ferreira C., Gordon D.E., Franch-Marro X., Peden A.A., Vincent J.P., Munro S. EMBO J. 29:304-314(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z71300 Genomic DNA. No translation available. Z71301 Genomic DNA. No translation available. AF480014 Genomic DNA. Translation: AAL79327.1. BK006947 Genomic DNA. Translation: DAA10520.1.
RefSeq	NP_878158.3. NM_001184619.3.
3D structure databases
ProteinModelPortal	Q8TGJ3.
ModBase	Search...
Protein-protein interaction databases
STRING	4932.YNL024C-A.
Proteomic databases
PaxDb	Q8TGJ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YNL024C-A; YNL024C-A; YNL024C-A.
GeneID	1466516.
KEGG	sce:YNL018C. sce:YNL024C-A.
Organism-specific databases
CYGD	YNL024c-a.
SGD	S000028698. YNL024C-A.
Phylogenomic databases
eggNOG	NOG146442.
GeneTree	ENSGT00560000077275.
OMA	FSILFMQ.
OrthoDB	EOG4SN4ZJ.
Gene expression databases
Genevestigator	Q8TGJ3.
GermOnline	YNL024C-A. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR009653. DUF1242. [Graphical view]
PANTHER	PTHR13229. PTHR13229. 1 hit.
Pfam	PF06842. DUF1242. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	983766.

Entry information

Entry name

KISH_YEAST

Accession

Primary (citable) accession number: Q8TGJ3
Secondary accession number(s): D6W1F4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	June 1, 2002
Last modified:	April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program