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Q8TGJ3 (KISH_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein kish
Gene names
Name:KSH1
Ordered Locus Names:YNL024C-A
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length72 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the early part of the secretory pathway. Ref.4

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Golgi apparatus membrane; Single-pass type I membrane protein Ref.4.

Disruption phenotype

Inviable. Ref.4

Sequence similarities

Belongs to the KISH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 7246Protein kish
PRO_0000247775

Regions

Topological domain27 – 5327Lumenal Potential
Transmembrane54 – 7219Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q8TGJ3 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 5645433999B16B27

FASTA728,196
        10         20         30         40         50         60 
MSALFNFRSL LQVILLLICS CSYVHGQWPS LLDRYKNHEV LGAFWKMARV GERASPYVSL 

        70 
ACILMAISQF NS 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"An integrated approach for finding overlooked genes in yeast."
Kumar A., Harrison P.M., Cheung K.-H., Lan N., Echols N., Bertone P., Miller P., Gerstein M.B., Snyder M.
Nat. Biotechnol. 20:58-63(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway."
Wendler F., Gillingham A.K., Sinka R., Rosa-Ferreira C., Gordon D.E., Franch-Marro X., Peden A.A., Vincent J.P., Munro S.
EMBO J. 29:304-314(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z71300 Genomic DNA. No translation available.
Z71301 Genomic DNA. No translation available.
AF480014 Genomic DNA. Translation: AAL79327.1.
BK006947 Genomic DNA. Translation: DAA10520.1.
RefSeqNP_878158.3. NM_001184619.3.

3D structure databases

ProteinModelPortalQ8TGJ3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid37058. 5 interactions.
STRING4932.YNL024C-A.

Proteomic databases

PaxDbQ8TGJ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL024C-A; YNL024C-A; YNL024C-A.
GeneID1466516.
KEGGsce:YNL024C-A.

Organism-specific databases

CYGDYNL024c-a.
SGDS000028698. YNL024C-A.

Phylogenomic databases

eggNOGNOG146442.
GeneTreeENSGT00730000111214.
OMAFSILFMQ.
OrthoDBEOG75MW8M.

Enzyme and pathway databases

BioCycYEAST:G3O-33410-MONOMER.

Gene expression databases

GenevestigatorQ8TGJ3.

Family and domain databases

InterProIPR009653. DUF1242.
[Graphical view]
PANTHERPTHR13229. PTHR13229. 1 hit.
PfamPF06842. DUF1242. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio983766.
PROQ8TGJ3.

Entry information

Entry nameKISH_YEAST
AccessionPrimary (citable) accession number: Q8TGJ3
Secondary accession number(s): D6W1F4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2002
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families