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Protein

Protein kish

Gene

KSH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the early part of the secretory pathway.1 Publication

Enzyme and pathway databases

BioCyciYEAST:G3O-33410-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kish
Gene namesi
Name:KSH1
Ordered Locus Names:YNL024C-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL024c-a.
SGDiS000028698. KSH1.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity. Golgi apparatus membrane 1 Publication; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 5327LumenalSequence AnalysisAdd
BLAST
Transmembranei54 – 7219HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. Golgi membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Inviable.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 7246Protein kishPRO_0000247775Add
BLAST

Proteomic databases

MaxQBiQ8TGJ3.
PaxDbiQ8TGJ3.

Expressioni

Gene expression databases

GenevestigatoriQ8TGJ3.

Interactioni

Protein-protein interaction databases

BioGridi37058. 4 interactions.
STRINGi4932.YNL024C-A.

Structurei

3D structure databases

ProteinModelPortaliQ8TGJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KISH family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146442.
GeneTreeiENSGT00730000111214.
InParanoidiQ8TGJ3.
OMAiFSILFMQ.
OrthoDBiEOG75MW8M.

Family and domain databases

InterProiIPR009653. DUF1242.
[Graphical view]
PANTHERiPTHR13229. PTHR13229. 1 hit.
PfamiPF06842. DUF1242. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TGJ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSALFNFRSL LQVILLLICS CSYVHGQWPS LLDRYKNHEV LGAFWKMARV
60 70
GERASPYVSL ACILMAISQF NS
Length:72
Mass (Da):8,196
Last modified:June 1, 2002 - v1
Checksum:i5645433999B16B27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71300 Genomic DNA. No translation available.
Z71301 Genomic DNA. No translation available.
AF480014 Genomic DNA. Translation: AAL79327.1.
BK006947 Genomic DNA. Translation: DAA10520.1.
RefSeqiNP_878158.3. NM_001184619.3.

Genome annotation databases

EnsemblFungiiYNL024C-A; YNL024C-A; YNL024C-A.
GeneIDi1466516.
KEGGisce:YNL024C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71300 Genomic DNA. No translation available.
Z71301 Genomic DNA. No translation available.
AF480014 Genomic DNA. Translation: AAL79327.1.
BK006947 Genomic DNA. Translation: DAA10520.1.
RefSeqiNP_878158.3. NM_001184619.3.

3D structure databases

ProteinModelPortaliQ8TGJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi37058. 4 interactions.
STRINGi4932.YNL024C-A.

Proteomic databases

MaxQBiQ8TGJ3.
PaxDbiQ8TGJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL024C-A; YNL024C-A; YNL024C-A.
GeneIDi1466516.
KEGGisce:YNL024C-A.

Organism-specific databases

CYGDiYNL024c-a.
SGDiS000028698. KSH1.

Phylogenomic databases

eggNOGiNOG146442.
GeneTreeiENSGT00730000111214.
InParanoidiQ8TGJ3.
OMAiFSILFMQ.
OrthoDBiEOG75MW8M.

Enzyme and pathway databases

BioCyciYEAST:G3O-33410-MONOMER.

Miscellaneous databases

NextBioi983766.
PROiQ8TGJ3.

Gene expression databases

GenevestigatoriQ8TGJ3.

Family and domain databases

InterProiIPR009653. DUF1242.
[Graphical view]
PANTHERiPTHR13229. PTHR13229. 1 hit.
PfamiPF06842. DUF1242. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway."
    Wendler F., Gillingham A.K., Sinka R., Rosa-Ferreira C., Gordon D.E., Franch-Marro X., Peden A.A., Vincent J.P., Munro S.
    EMBO J. 29:304-314(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiKISH_YEAST
AccessioniPrimary (citable) accession number: Q8TGJ3
Secondary accession number(s): D6W1F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2002
Last modified: January 7, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.