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Protein

Guanosine-diphosphatase

Gene

GDA1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.1 Publication
Has a role in cell wall morphogenesis during the transition of budding growth into hyphal growth, a process known as dimorphism.1 Publication

Catalytic activityi

GDP + H2O = GMP + phosphate.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei286Proton acceptorBy similarity1

GO - Molecular functioni

  • guanosine-diphosphatase activity Source: CGD

GO - Biological processi

  • cell growth mode switching, budding to filamentous Source: CGD
  • cellular response to neutral pH Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms in response to neutral pH Source: CGD
  • fungal-type cell wall biogenesis Source: CGD
  • protein glycosylation Source: CGD
  • protein O-linked glycosylation Source: CGD

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDAi3.6.1.42 1096
UniPathwayiUPA00378

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-diphosphatase (EC:3.6.1.42)
Short name:
GDPase
Gene namesi
Name:GDA1
Ordered Locus Names:CAALFM_C306120CA
ORF Names:CaO19.7394
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 3

Organism-specific databases

CGDiCAL0000196532 GDA1
EuPathDBiFungiDB:C3_06120C_A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 24Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST18
Topological domaini25 – 599LumenalSequence analysisAdd BLAST575

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002099161 – 599Guanosine-diphosphataseAdd BLAST599

Proteomic databases

PRIDEiQ8TGH6

Structurei

3D structure databases

ProteinModelPortaliQ8TGH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi52 – 56Poly-Ala5
Compositional biasi125 – 129Poly-Gln5

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ8TGH6
KOiK01526
OMAiTPRGYLT
OrthoDBiEOG092C1F34

Family and domain databases

InterProiView protein in InterPro
IPR000407 GDA1_CD39_NTPase
PANTHERiPTHR11782 PTHR11782, 1 hit
PfamiView protein in Pfam
PF01150 GDA1_CD39, 1 hit
PROSITEiView protein in PROSITE
PS01238 GDA1_CD39_NTPASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TGH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINPRNLRLI IAVIGLVGIF AFFASSQHSL VDRTALQVNK PAADSPHVPP
60 70 80 90 100
PAAAAAPVSP PPPSQQQKQQ EGSQKQLNDE NSDEKNTLQG TSYSGTKPPY
110 120 130 140 150
EKVDGKSNKI LADKLDTTKN SKPNQQQQQN TQKGASEEKS AQNKITTPEE
160 170 180 190 200
VSMDNGKCND IDYVVMIDAG STGSRVHVYE FNTCVKPPQL LSEEFEMLKP
210 220 230 240 250
GLSSFDTDTV GAAKSLDPLL EVALKKVPKN KQSCTPVAVK ATAGLRLLGE
260 270 280 290 300
TKSKAILDEV RSHLEKDYPF AVVSEDGISI MDGKDEGVYA WVTANYLLGN
310 320 330 340 350
IGGKEKLPTA AVFDLGGGST QIVFEPDYKV DEVPVDGETK YHFTFGDNQY
360 370 380 390 400
TLYQFSHLGY GLMQGRNKVN QLVLKNKLSE LNLQKYTKKE VKGAKATVDV
410 420 430 440 450
SNPCIPPGVV AKDVQVELGE DEFYVVNMKG PSSKDSTVAG GSQCRYLAEK
460 470 480 490 500
VLNKDAECTS KPCSFNGVHQ PSLTRTFNKN SDMYVFSYFY DRTNPIGMPS
510 520 530 540 550
SFSVEELKDL SKLVCQGETF WKDILLDDHV KNLNEEPQWC LDLSFITAML
560 570 580 590
HTGYDIPLHR ELKTAKTIDN NELGWCLGAS LPLLDKNNAK WTCRIDKTD
Length:599
Mass (Da):65,953
Last modified:June 1, 2002 - v1
Checksum:iD5BC3A4F6E1B646A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ421721 Genomic DNA Translation: CAD18870.1
CP017625 Genomic DNA Translation: AOW28620.1
RefSeqiXP_716635.1, XM_711542.1

Genome annotation databases

EnsemblFungiiAOW28620; AOW28620; CAALFM_C306120CA
GeneIDi3641762
KEGGical:CAALFM_C306120CA

Similar proteinsi

Entry informationi

Entry nameiGDA1_CANAL
AccessioniPrimary (citable) accession number: Q8TGH6
Secondary accession number(s): A0A1D8PKG9, Q5A4E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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