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Q8TGH6

- GDA1_CANAL

UniProt

Q8TGH6 - GDA1_CANAL

Protein

Guanosine-diphosphatase

Gene

GDA1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.1 Publication
    Has a role in cell wall morphogenesis during the transition of budding growth into hyphal growth, a process known as dimorphism.1 Publication

    Catalytic activityi

    GDP + H2O = GMP + phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei286 – 2861Proton acceptorBy similarity

    GO - Molecular functioni

    1. guanosine-diphosphatase activity Source: CGD

    GO - Biological processi

    1. cell growth mode switching, budding to filamentous Source: CGD
    2. cellular response to neutral pH Source: CGD
    3. filamentous growth Source: CGD
    4. filamentous growth of a population of unicellular organisms in response to neutral pH Source: CGD
    5. fungal-type cell wall biogenesis Source: CGD
    6. protein glycosylation Source: CGD
    7. protein O-linked glycosylation Source: CGD

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BRENDAi3.6.1.42. 1096.
    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-diphosphatase (EC:3.6.1.42)
    Short name:
    GDPase
    Gene namesi
    Name:GDA1
    ORF Names:CaO19.7394
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0004837. GDA1.

    Subcellular locationi

    Golgi apparatus membrane 1 Publication; Single-pass type II membrane protein 1 Publication

    GO - Cellular componenti

    1. Golgi apparatus Source: CGD
    2. Golgi membrane Source: CGD
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane Source: CGD

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 599599Guanosine-diphosphatasePRO_0000209916Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0004837.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TGH6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66CytoplasmicSequence Analysis
    Topological domaini25 – 599575LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2418Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi52 – 565Poly-Ala
    Compositional biasi125 – 1295Poly-Gln

    Sequence similaritiesi

    Belongs to the GDA1/CD39 NTPase family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5371.
    KOiK01526.
    OrthoDBiEOG7QK0PD.

    Family and domain databases

    InterProiIPR000407. GDA1_CD39_NTPase.
    [Graphical view]
    PANTHERiPTHR11782. PTHR11782. 1 hit.
    PfamiPF01150. GDA1_CD39. 1 hit.
    [Graphical view]
    PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TGH6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MINPRNLRLI IAVIGLVGIF AFFASSQHSL VDRTALQVNK PAADSPHVPP    50
    PAAAAAPVSP PPPSQQQKQQ EGSQKQLNDE NSDEKNTLQG TSYSGTKPPY 100
    EKVDGKSNKI LADKLDTTKN SKPNQQQQQN TQKGASEEKS AQNKITTPEE 150
    VSMDNGKCND IDYVVMIDAG STGSRVHVYE FNTCVKPPQL LSEEFEMLKP 200
    GLSSFDTDTV GAAKSLDPLL EVALKKVPKN KQSCTPVAVK ATAGLRLLGE 250
    TKSKAILDEV RSHLEKDYPF AVVSEDGISI MDGKDEGVYA WVTANYLLGN 300
    IGGKEKLPTA AVFDLGGGST QIVFEPDYKV DEVPVDGETK YHFTFGDNQY 350
    TLYQFSHLGY GLMQGRNKVN QLVLKNKLSE LNLQKYTKKE VKGAKATVDV 400
    SNPCIPPGVV AKDVQVELGE DEFYVVNMKG PSSKDSTVAG GSQCRYLAEK 450
    VLNKDAECTS KPCSFNGVHQ PSLTRTFNKN SDMYVFSYFY DRTNPIGMPS 500
    SFSVEELKDL SKLVCQGETF WKDILLDDHV KNLNEEPQWC LDLSFITAML 550
    HTGYDIPLHR ELKTAKTIDN NELGWCLGAS LPLLDKNNAK WTCRIDKTD 599
    Length:599
    Mass (Da):65,953
    Last modified:June 1, 2002 - v1
    Checksum:iD5BC3A4F6E1B646A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ421721 Genomic DNA. Translation: CAD18870.1.
    AACQ01000066 Genomic DNA. Translation: EAK97640.1.
    RefSeqiXP_716635.1. XM_711542.1.

    Genome annotation databases

    GeneIDi3641762.
    KEGGical:CaO19.7394.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ421721 Genomic DNA. Translation: CAD18870.1 .
    AACQ01000066 Genomic DNA. Translation: EAK97640.1 .
    RefSeqi XP_716635.1. XM_711542.1.

    3D structure databases

    ProteinModelPortali Q8TGH6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0004837.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3641762.
    KEGGi cal:CaO19.7394.

    Organism-specific databases

    CGDi CAL0004837. GDA1.

    Phylogenomic databases

    eggNOGi COG5371.
    KOi K01526.
    OrthoDBi EOG7QK0PD.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    BRENDAi 3.6.1.42. 1096.

    Family and domain databases

    InterProi IPR000407. GDA1_CD39_NTPase.
    [Graphical view ]
    PANTHERi PTHR11782. PTHR11782. 1 hit.
    Pfami PF01150. GDA1_CD39. 1 hit.
    [Graphical view ]
    PROSITEi PS01238. GDA1_CD39_NTPASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Golgi GDPase of the fungal pathogen Candida albicans affects morphogenesis, glycosylation, and cell wall properties."
      Herrero A.B., Uccelletti D., Hirschberg C.B., Dominguez A., Abeijon C.
      Eukaryot. Cell 1:420-431(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiGDA1_CANAL
    AccessioniPrimary (citable) accession number: Q8TGH6
    Secondary accession number(s): Q5A4E0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3