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Q8TGH6 (GDA1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-diphosphatase

Short name=GDPase
EC=3.6.1.42
Gene names
Name:GDA1
ORF Names:CaO19.7394
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length599 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol. Ref.1

Has a role in cell wall morphogenesis during the transition of budding growth into hyphal growth, a process known as dimorphism. Ref.1

Catalytic activity

GDP + H2O = GMP + phosphate.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein Ref.1.

Sequence similarities

Belongs to the GDA1/CD39 NTPase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 599599Guanosine-diphosphatase
PRO_0000209916

Regions

Topological domain1 – 66Cytoplasmic Potential
Transmembrane7 – 2418Helical; Signal-anchor for type II membrane protein; Potential
Topological domain25 – 599575Lumenal Potential
Compositional bias52 – 565Poly-Ala
Compositional bias125 – 1295Poly-Gln

Sites

Active site2861Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8TGH6 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: D5BC3A4F6E1B646A

FASTA59965,953
        10         20         30         40         50         60 
MINPRNLRLI IAVIGLVGIF AFFASSQHSL VDRTALQVNK PAADSPHVPP PAAAAAPVSP 

        70         80         90        100        110        120 
PPPSQQQKQQ EGSQKQLNDE NSDEKNTLQG TSYSGTKPPY EKVDGKSNKI LADKLDTTKN 

       130        140        150        160        170        180 
SKPNQQQQQN TQKGASEEKS AQNKITTPEE VSMDNGKCND IDYVVMIDAG STGSRVHVYE 

       190        200        210        220        230        240 
FNTCVKPPQL LSEEFEMLKP GLSSFDTDTV GAAKSLDPLL EVALKKVPKN KQSCTPVAVK 

       250        260        270        280        290        300 
ATAGLRLLGE TKSKAILDEV RSHLEKDYPF AVVSEDGISI MDGKDEGVYA WVTANYLLGN 

       310        320        330        340        350        360 
IGGKEKLPTA AVFDLGGGST QIVFEPDYKV DEVPVDGETK YHFTFGDNQY TLYQFSHLGY 

       370        380        390        400        410        420 
GLMQGRNKVN QLVLKNKLSE LNLQKYTKKE VKGAKATVDV SNPCIPPGVV AKDVQVELGE 

       430        440        450        460        470        480 
DEFYVVNMKG PSSKDSTVAG GSQCRYLAEK VLNKDAECTS KPCSFNGVHQ PSLTRTFNKN 

       490        500        510        520        530        540 
SDMYVFSYFY DRTNPIGMPS SFSVEELKDL SKLVCQGETF WKDILLDDHV KNLNEEPQWC 

       550        560        570        580        590 
LDLSFITAML HTGYDIPLHR ELKTAKTIDN NELGWCLGAS LPLLDKNNAK WTCRIDKTD 

« Hide

References

« Hide 'large scale' references
[1]"The Golgi GDPase of the fungal pathogen Candida albicans affects morphogenesis, glycosylation, and cell wall properties."
Herrero A.B., Uccelletti D., Hirschberg C.B., Dominguez A., Abeijon C.
Eukaryot. Cell 1:420-431(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ421721 Genomic DNA. Translation: CAD18870.1.
AACQ01000066 Genomic DNA. Translation: EAK97640.1.
RefSeqXP_716635.1. XM_711542.1.

3D structure databases

ProteinModelPortalQ8TGH6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0004837.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3641762.
KEGGcal:CaO19.7394.

Organism-specific databases

CGDCAL0004837. GDA1.

Phylogenomic databases

eggNOGCOG5371.
KOK01526.
OrthoDBEOG7QK0PD.

Enzyme and pathway databases

BRENDA3.6.1.42. 1096.
UniPathwayUPA00378.

Family and domain databases

InterProIPR000407. GDA1_CD39_NTPase.
IPR015605. Guanosine_diphosphatase.
[Graphical view]
PANTHERPTHR11782. PTHR11782. 1 hit.
PTHR11782:SF9. PTHR11782:SF9. 1 hit.
PfamPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGDA1_CANAL
AccessionPrimary (citable) accession number: Q8TGH6
Secondary accession number(s): Q5A4E0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Candida albicans

Candida albicans: entries and gene names