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Q8TGH6

- GDA1_CANAL

UniProt

Q8TGH6 - GDA1_CANAL

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Protein

Guanosine-diphosphatase

Gene

GDA1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.1 Publication
Has a role in cell wall morphogenesis during the transition of budding growth into hyphal growth, a process known as dimorphism.1 Publication

Catalytic activityi

GDP + H2O = GMP + phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei286 – 2861Proton acceptorBy similarity

GO - Molecular functioni

  1. guanosine-diphosphatase activity Source: CGD

GO - Biological processi

  1. cell growth mode switching, budding to filamentous Source: CGD
  2. cellular response to neutral pH Source: CGD
  3. filamentous growth Source: CGD
  4. filamentous growth of a population of unicellular organisms in response to neutral pH Source: CGD
  5. fungal-type cell wall biogenesis Source: CGD
  6. protein glycosylation Source: CGD
  7. protein O-linked glycosylation Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.6.1.42. 1096.
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-diphosphatase (EC:3.6.1.42)
Short name:
GDPase
Gene namesi
Name:GDA1
ORF Names:CaO19.7394
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0004837. GDA1.

Subcellular locationi

Golgi apparatus membrane 1 Publication; Single-pass type II membrane protein 1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: CGD
  2. Golgi membrane Source: CGD
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599Guanosine-diphosphatasePRO_0000209916Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0004837.

Structurei

3D structure databases

ProteinModelPortaliQ8TGH6.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence Analysis
Topological domaini25 – 599575LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2418Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi52 – 565Poly-Ala
Compositional biasi125 – 1295Poly-Gln

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5371.
InParanoidiQ8TGH6.
KOiK01526.
OrthoDBiEOG7QK0PD.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 1 hit.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TGH6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MINPRNLRLI IAVIGLVGIF AFFASSQHSL VDRTALQVNK PAADSPHVPP
60 70 80 90 100
PAAAAAPVSP PPPSQQQKQQ EGSQKQLNDE NSDEKNTLQG TSYSGTKPPY
110 120 130 140 150
EKVDGKSNKI LADKLDTTKN SKPNQQQQQN TQKGASEEKS AQNKITTPEE
160 170 180 190 200
VSMDNGKCND IDYVVMIDAG STGSRVHVYE FNTCVKPPQL LSEEFEMLKP
210 220 230 240 250
GLSSFDTDTV GAAKSLDPLL EVALKKVPKN KQSCTPVAVK ATAGLRLLGE
260 270 280 290 300
TKSKAILDEV RSHLEKDYPF AVVSEDGISI MDGKDEGVYA WVTANYLLGN
310 320 330 340 350
IGGKEKLPTA AVFDLGGGST QIVFEPDYKV DEVPVDGETK YHFTFGDNQY
360 370 380 390 400
TLYQFSHLGY GLMQGRNKVN QLVLKNKLSE LNLQKYTKKE VKGAKATVDV
410 420 430 440 450
SNPCIPPGVV AKDVQVELGE DEFYVVNMKG PSSKDSTVAG GSQCRYLAEK
460 470 480 490 500
VLNKDAECTS KPCSFNGVHQ PSLTRTFNKN SDMYVFSYFY DRTNPIGMPS
510 520 530 540 550
SFSVEELKDL SKLVCQGETF WKDILLDDHV KNLNEEPQWC LDLSFITAML
560 570 580 590
HTGYDIPLHR ELKTAKTIDN NELGWCLGAS LPLLDKNNAK WTCRIDKTD
Length:599
Mass (Da):65,953
Last modified:June 1, 2002 - v1
Checksum:iD5BC3A4F6E1B646A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ421721 Genomic DNA. Translation: CAD18870.1.
AACQ01000066 Genomic DNA. Translation: EAK97640.1.
RefSeqiXP_716635.1. XM_711542.1.

Genome annotation databases

GeneIDi3641762.
KEGGical:CaO19.7394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ421721 Genomic DNA. Translation: CAD18870.1 .
AACQ01000066 Genomic DNA. Translation: EAK97640.1 .
RefSeqi XP_716635.1. XM_711542.1.

3D structure databases

ProteinModelPortali Q8TGH6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0004837.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3641762.
KEGGi cal:CaO19.7394.

Organism-specific databases

CGDi CAL0004837. GDA1.

Phylogenomic databases

eggNOGi COG5371.
InParanoidi Q8TGH6.
KOi K01526.
OrthoDBi EOG7QK0PD.

Enzyme and pathway databases

UniPathwayi UPA00378 .
BRENDAi 3.6.1.42. 1096.

Family and domain databases

InterProi IPR000407. GDA1_CD39_NTPase.
[Graphical view ]
PANTHERi PTHR11782. PTHR11782. 1 hit.
Pfami PF01150. GDA1_CD39. 1 hit.
[Graphical view ]
PROSITEi PS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Golgi GDPase of the fungal pathogen Candida albicans affects morphogenesis, glycosylation, and cell wall properties."
    Herrero A.B., Uccelletti D., Hirschberg C.B., Dominguez A., Abeijon C.
    Eukaryot. Cell 1:420-431(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiGDA1_CANAL
AccessioniPrimary (citable) accession number: Q8TGH6
Secondary accession number(s): Q5A4E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3