Reviewed,
UniProtKB/Swiss-Prot Q8TGH6 (GDA1_CANAL)
Last modified
November 3, 2009.
Version 44.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Guanosine-diphosphatase Short name=GDPase EC=3.6.1.42 | ||||
| Gene names |
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| Organism | Candida albicans (Yeast) | ||||
| Taxonomic identifier | 5476 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida |
Protein attributes
| Sequence length | 599 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol. Ref.1 Has a role in cell wall morphogenesis during the transition of budding growth into hyphal growth, a process known as dimorphism. Ref.1 |
| Catalytic activity | GDP + H2O = GMP + phosphate. |
| Pathway | |
| Subcellular location | Golgi apparatus membrane; Single-pass type II membrane protein. Ref.1 |
| Sequence similarities | Belongs to the GDA1/CD39 NTPase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Golgi apparatus Membrane |
| Domain | Signal-anchor Transmembrane |
| Molecular function | Hydrolase |
| Gene Ontology (GO) | |
| Biological process | protein modification process Inferred from electronic annotation. Source: InterPro |
| Cellular component | Golgi membrane Inferred from electronic annotation. Source: InterPro integral to membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | guanosine-diphosphatase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 599 | 599 | Guanosine-diphosphatase | PRO_0000209916 | |||||
Regions | |||||||||
| Topological domain | 1 – 6 | 6 | Cytoplasmic Potential | ||||||
| Transmembrane | 7 – 24 | 18 | Signal-anchor for type II membrane protein Potential | ||||||
| Topological domain | 25 – 599 | 575 | Lumenal Potential | ||||||
| Compositional bias | 52 – 56 | 5 | Poly-Ala | ||||||
| Compositional bias | 125 – 129 | 5 | Poly-Gln | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The Golgi GDPase of the fungal pathogen Candida albicans affects morphogenesis, glycosylation, and cell wall properties." Herrero A.B., Uccelletti D., Hirschberg C.B., Dominguez A., Abeijon C. Eukaryot. Cell 1:420-431(2002) [PubMed: 12455990] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION. |
| [2] | "The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314. |
Cross-references
Sequence databases | |
|---|---|
| AJ421721 Genomic DNA. Translation: CAD18870.1. AACQ01000066 Genomic DNA. Translation: EAK97640.1. | |
| RefSeq | XP_716635.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3641762. |
| KEGG | cal:CaO19.7394. |
Organism-specific databases | |
| CGD | CAL0004837. GDA1. |
Phylogenomic databases | |
| OMA | YLLGNIG. |
Enzyme and pathway databases | |
| BRENDA | 3.6.1.42. 1124. |
Family and domain databases | |
| InterPro | IPR000407. GDA1_CD39_NTPase. IPR015605. Guanosine_diphosphatase. [Graphical view] |
| PANTHER | PTHR11782. GDA1_CD39_NTPase. 1 hit. PTHR11782:SF9. Gda1p. 1 hit. |
| Pfam | PF01150. GDA1_CD39. 1 hit. [Graphical view] |
| PROSITE | PS01238. GDA1_CD39_NTPASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GDA1_CANAL | ||||||||
| Accession | Primary (citable) accession number: Q8TGH6 Secondary accession number(s): Q5A4E0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Candida albicans Candida albicans: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


