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Protein

GPI ethanolamine phosphate transferase 2

Gene

GPI7

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose (By similarity).By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • cellular response to starvation Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  • GPI anchor biosynthetic process Source: UniProtKB-UniPathway
  • GPI anchor metabolic process Source: CGD
  • pathogenesis Source: CGD

Keywordsi

Molecular functionTransferase
Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI ethanolamine phosphate transferase 2 (EC:2.-.-.-)
Alternative name(s):
Glycosylphosphatidylinositol-anchor biosynthesis protein 7
Gene namesi
Name:GPI7
Synonyms:LAS21
Ordered Locus Names:CAALFM_C105070CA
ORF Names:CaO19.11547, CaO19.4064
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000200443. GPI7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Transmembranei495 – 514HelicalSequence analysisAdd BLAST20
Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Transmembranei581 – 601HelicalSequence analysisAdd BLAST21
Transmembranei648 – 668HelicalSequence analysisAdd BLAST21
Transmembranei697 – 717HelicalSequence analysisAdd BLAST21
Transmembranei726 – 746HelicalSequence analysisAdd BLAST21
Transmembranei768 – 788HelicalSequence analysisAdd BLAST21
Transmembranei820 – 840HelicalSequence analysisAdd BLAST21
Transmembranei865 – 885HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Cell-wall protein anchorage defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002461931 – 885GPI ethanolamine phosphate transferase 2Add BLAST885

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi82N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi155N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi194N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi443N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi516N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8TGB2.

Structurei

3D structure databases

ProteinModelPortaliQ8TGB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ8TGB2.
KOiK05310.
OrthoDBiEOG092C16XQ.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiView protein in InterPro
IPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR002591. Phosphodiest/P_Trfase.
PfamiView protein in Pfam
PF01663. Phosphodiest. 1 hit.
SUPFAMiSSF53649. SSF53649. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TGB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSLNSRWV VQVSLTIINI IGFLVFLRGF FPSKVVLPGF NSFQDSTKSP
60 70 80 90 100
FSDQYGNPQF NKFILMVVDA MRSDFCFSDR SNFSFLHQLI NQGRALPFTA
110 120 130 140 150
FSNPPTVTLP RLKGITTGGT PNFLDAILNV ADDQDDSQGL HNQDSWVHQF
160 170 180 190 200
RHSNNKTINF FGDDTWLKLF QDQFTEFEGT NSFFVSDFTE VDNNVTRHLD
210 220 230 240 250
DQLSSNKWDG LILHYLGLDH IGHKGGPESP YMKPKQIEMD KILQRLYTYV
260 270 280 290 300
TKNDDTLIVL MGDHGMNEIG NHGGSSPGET SAALSFISPK FNHKGESPLP
310 320 330 340 350
YNSDYSYHHK ISQIDLVPTL AALLNFPIPK NSLGVIAKEI LEIWPENQRI
360 370 380 390 400
KILLENCAQI MNLYEAKYGP SGKVWSQWEN LQAKQHPIAD YYEFLQDIQS
410 420 430 440 450
EMASSATNYG YKDIYAGALI LVITALAVIV VFNRYFLTAS NMNISSVMFY
460 470 480 490 500
ELFVVLYSLH FHGSSLIEEE HQIWYFFTTA TLLFLAITFF DTFKSLQNFI
510 520 530 540 550
SFGVLFACIR FMRSWNNSGQ KYSSQYNIAY YLSHSNPNLM WGLIILTYFV
560 570 580 590 600
LTLCIYIQGS LVPTFAFSFG KRLPDVKDPG GLISFIVVFV ATSVSFSFKL
610 620 630 640 650
LQYYIDGNTI PKWLNRFLLW IIESHHIDLS SATLEDNELK FQLQSVSIQL
660 670 680 690 700
SKFTTIILLL LVISRVIIGK IRKIRYGTIT DITNIMTIYL IHQTRHENIP
710 720 730 740 750
IFLALMFAKF ALSKLIYRKT NRIDQYILTV TMTVLCLQNL TFFCMGNTNS
760 770 780 790 800
LATVDLSNAY NGVKAYNVFL VGLLTFVSNF AGPIFWSLSG LQLLYEPSLL
810 820 830 840 850
NFNGPATTDL LHYTGLKKSI LLVKSLISLF FYTVSAVNLV GSCINLRFHL
860 870 880
FIWTVFSPKL LFFGSWILFV NVLIDLILAV IVLLF
Length:885
Mass (Da):100,727
Last modified:May 10, 2017 - v3
Checksum:i1ED8089BF74EA234
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54Q → H in AAL83897 (PubMed:11994163).Curated1
Sequence conflicti57N → T in AAL83897 (PubMed:11994163).Curated1
Sequence conflicti94R → H in AAL83897 (PubMed:11994163).Curated1
Sequence conflicti373K → E in AAL83897 (PubMed:11994163).Curated1
Sequence conflicti376S → T in AAL83897 (PubMed:11994163).Curated1
Sequence conflicti425A → V in AAL83897 (PubMed:11994163).Curated1
Sequence conflicti877 – 885ILAVIVLLF → YFGNNSIVVLKTNILL in AAL83897 (PubMed:11994163).Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348498 Genomic DNA. Translation: AAL83897.1.
CP017623 Genomic DNA. Translation: AOW26178.1.
RefSeqiXP_710733.2. XM_705641.2.

Genome annotation databases

GeneIDi3647672.
KEGGical:CAALFM_C105070CA.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGPI7_CANAL
AccessioniPrimary (citable) accession number: Q8TGB2
Secondary accession number(s): A0A1D8PDH8, Q59LX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 10, 2017
Last modified: June 7, 2017
This is version 73 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families