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Q8TGB2

- GPI7_CANAL

UniProt

Q8TGB2 - GPI7_CANAL

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Protein

GPI ethanolamine phosphate transferase 2

Gene

LAS21

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose (By similarity).By similarity

Pathwayi

GO - Molecular functioni

  1. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to starvation Source: CGD
  2. filamentous growth Source: CGD
  3. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  4. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  5. GPI anchor biosynthetic process Source: UniProtKB-UniPathway
  6. GPI anchor metabolic process Source: CGD
  7. pathogenesis Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI ethanolamine phosphate transferase 2 (EC:2.-.-.-)
Alternative name(s):
Glycosylphosphatidylinositol-anchor biosynthesis protein 7
Gene namesi
Name:LAS21
Synonyms:GPI7
ORF Names:CaO19.11547, CaO19.4064
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Cell-wall protein anchorage defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 892892GPI ethanolamine phosphate transferase 2PRO_0000246193Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi880 – 8801N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ8TGB2.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei413 – 43321HelicalSequence AnalysisAdd
BLAST
Transmembranei447 – 46721HelicalSequence AnalysisAdd
BLAST
Transmembranei473 – 49321HelicalSequence AnalysisAdd
BLAST
Transmembranei495 – 51420HelicalSequence AnalysisAdd
BLAST
Transmembranei539 – 55921HelicalSequence AnalysisAdd
BLAST
Transmembranei581 – 60121HelicalSequence AnalysisAdd
BLAST
Transmembranei648 – 66821HelicalSequence AnalysisAdd
BLAST
Transmembranei697 – 71721HelicalSequence AnalysisAdd
BLAST
Transmembranei726 – 74621HelicalSequence AnalysisAdd
BLAST
Transmembranei768 – 78821HelicalSequence AnalysisAdd
BLAST
Transmembranei820 – 84021HelicalSequence AnalysisAdd
BLAST
Transmembranei850 – 87021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1524.
InParanoidiQ8TGB2.
KOiK05310.
OrthoDBiEOG78D7TF.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR002591. Phosphodiest/P_Trfase.
[Graphical view]
PfamiPF01663. Phosphodiest. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TGB2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGSLNSRWV VQVSLTIINI IGFLVFLRGF FPSKVVLPGF NSFQDSTKSP
60 70 80 90 100
FSDQYGNPQF NKFILMVVDA MRSDFCFSDR SNFSFLHQLI NQGRALPFTA
110 120 130 140 150
FSNPPTVTLP RLKGITTGGT PNFLDAILNV ADDQDDSQGL HNQDSWVHQF
160 170 180 190 200
RHSNNKTINF FGDDTWLKLF QDQFTEFEGT NSFFVSDFTE VDNNVTRHLD
210 220 230 240 250
DQLSSNKWDG LILHYLGLDH IGHKGGPESP YMKPKQIEMD KILQRLYTYV
260 270 280 290 300
TKNDDTLIVL MGDHGMNEIG NHGGSSPGET SAALSFISPK FNHKGESPLP
310 320 330 340 350
YNSDYSYHHK ISQIDLVPTL AALLNFPIPK NSLGVIAKEI LEIWPENQRI
360 370 380 390 400
KILLENCAQI MNLYEAKYGP SGEVWTQWEN LQAKQHPIAD YYEFLQDIQS
410 420 430 440 450
EMASSATNYG YKDIYAGALI LVITVLAVIV VFNRYFFTVS NMNISSVMFY
460 470 480 490 500
ELFVVLYSLH FHGSSLIEEE HQIWYFFTTA TLLFLAITFF DTFKSLQNFI
510 520 530 540 550
SFGVLFACIR FMRSWNNSGQ KYSSQYNIAY YLSHSNPNLM WGLIILTYFV
560 570 580 590 600
LTLCIYIQGS LVPTFAFSFG KRLPDVKDPG GLISFIVVFV ATSVSFSFKL
610 620 630 640 650
LQYYIDGNTI PKWLNRFLLW IIESHHIDLS SATLEDNELK FQLQSVSIQL
660 670 680 690 700
SKFTTIILLL LVISRVIIGK IRKIRYGTIT DITNIMTIYL IHQTRHENIP
710 720 730 740 750
IFLALMFAKF ALSKLIYRKT NRIDQYILTV TMTVLCLQNL TFFCMGNTNS
760 770 780 790 800
LATVDLSNAY NGVKAYNVFL VGLLTFVSNF AGPIFWSLSG LQLLYEPSLL
810 820 830 840 850
NFNGPATTDL LHYTGLKKSI LLVKSLISLF FYTVSAVNLV GSCINLRFHL
860 870 880 890
FIWTVFSPKL LFFGSWILFV NVLIDLYFGN NSIVVLKTNI LL
Length:892
Mass (Da):101,640
Last modified:July 25, 2006 - v2
Checksum:i3A5C37241363A19A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541Q → H in AAL83897. (PubMed:11994163)Curated
Sequence conflicti57 – 571N → T in AAL83897. (PubMed:11994163)Curated
Sequence conflicti94 – 941R → H in AAL83897. (PubMed:11994163)Curated
Sequence conflicti437 – 4371F → L in AAL83897. (PubMed:11994163)Curated
Sequence conflicti439 – 4391V → A in AAL83897. (PubMed:11994163)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF348498 Genomic DNA. Translation: AAL83897.1.
AACQ01000242 Genomic DNA. Translation: EAK91495.1.
AACQ01000243 Genomic DNA. Translation: EAK91485.1.
AACQ01000231 Genomic DNA. No translation available.
AACQ01000232 Genomic DNA. No translation available.
RefSeqiXP_710733.1. XM_705641.1.
XP_710743.1. XM_705651.1.

Genome annotation databases

GeneIDi3647663.
3647672.
KEGGical:CaO19.11547.
cal:CaO19.4064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF348498 Genomic DNA. Translation: AAL83897.1 .
AACQ01000242 Genomic DNA. Translation: EAK91495.1 .
AACQ01000243 Genomic DNA. Translation: EAK91485.1 .
AACQ01000231 Genomic DNA. No translation available.
AACQ01000232 Genomic DNA. No translation available.
RefSeqi XP_710733.1. XM_705641.1.
XP_710743.1. XM_705651.1.

3D structure databases

ProteinModelPortali Q8TGB2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3647663.
3647672.
KEGGi cal:CaO19.11547.
cal:CaO19.4064.

Phylogenomic databases

eggNOGi COG1524.
InParanoidi Q8TGB2.
KOi K05310.
OrthoDBi EOG78D7TF.

Enzyme and pathway databases

UniPathwayi UPA00196 .

Family and domain databases

Gene3Di 3.40.720.10. 1 hit.
InterProi IPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR002591. Phosphodiest/P_Trfase.
[Graphical view ]
Pfami PF01663. Phosphodiest. 1 hit.
[Graphical view ]
SUPFAMi SSF53649. SSF53649. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete glycosylphosphatidylinositol anchors are required in Candida albicans for full morphogenesis, virulence and resistance to macrophages."
    Richard M., Ibata-Ombetta S., Dromer F., Bordon-Pallier F., Jouault T., Gaillardin C.
    Mol. Microbiol. 44:841-853(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  3. "GPI7 affects cell-wall protein anchorage in Saccharomyces cerevisiae and Candida albicans."
    Richard M., De Groot P., Courtin O., Poulain D., Klis F., Gaillardin C.
    Microbiology 148:2125-2133(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiGPI7_CANAL
AccessioniPrimary (citable) accession number: Q8TGB2
Secondary accession number(s): Q59LX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: October 29, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3