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Q8TGB2

- GPI7_CANAL

UniProt

Q8TGB2 - GPI7_CANAL

Protein

GPI ethanolamine phosphate transferase 2

Gene

LAS21

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose By similarity.By similarity

    Pathwayi

    GO - Molecular functioni

    1. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cellular response to starvation Source: CGD
    2. filamentous growth Source: CGD
    3. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
    4. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
    5. GPI anchor biosynthetic process Source: UniProtKB-UniPathway
    6. GPI anchor metabolic process Source: CGD
    7. pathogenesis Source: CGD

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    GPI-anchor biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00196.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GPI ethanolamine phosphate transferase 2 (EC:2.-.-.-)
    Alternative name(s):
    Glycosylphosphatidylinositol-anchor biosynthesis protein 7
    Gene namesi
    Name:LAS21
    Synonyms:GPI7
    ORF Names:CaO19.11547, CaO19.4064
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: CGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Cell-wall protein anchorage defects.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 892892GPI ethanolamine phosphate transferase 2PRO_0000246193Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi880 – 8801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TGB2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei413 – 43321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei447 – 46721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei473 – 49321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei495 – 51420HelicalSequence AnalysisAdd
    BLAST
    Transmembranei539 – 55921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei581 – 60121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei648 – 66821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei697 – 71721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei726 – 74621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei768 – 78821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei820 – 84021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei850 – 87021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1524.
    KOiK05310.
    OrthoDBiEOG78D7TF.

    Family and domain databases

    Gene3Di3.40.720.10. 1 hit.
    InterProiIPR017849. Alkaline_Pase-like_a/b/a.
    IPR017850. Alkaline_phosphatase_core.
    IPR002591. Phosphodiest/P_Trfase.
    [Graphical view]
    PfamiPF01663. Phosphodiest. 1 hit.
    [Graphical view]
    SUPFAMiSSF53649. SSF53649. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8TGB2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGSLNSRWV VQVSLTIINI IGFLVFLRGF FPSKVVLPGF NSFQDSTKSP    50
    FSDQYGNPQF NKFILMVVDA MRSDFCFSDR SNFSFLHQLI NQGRALPFTA 100
    FSNPPTVTLP RLKGITTGGT PNFLDAILNV ADDQDDSQGL HNQDSWVHQF 150
    RHSNNKTINF FGDDTWLKLF QDQFTEFEGT NSFFVSDFTE VDNNVTRHLD 200
    DQLSSNKWDG LILHYLGLDH IGHKGGPESP YMKPKQIEMD KILQRLYTYV 250
    TKNDDTLIVL MGDHGMNEIG NHGGSSPGET SAALSFISPK FNHKGESPLP 300
    YNSDYSYHHK ISQIDLVPTL AALLNFPIPK NSLGVIAKEI LEIWPENQRI 350
    KILLENCAQI MNLYEAKYGP SGEVWTQWEN LQAKQHPIAD YYEFLQDIQS 400
    EMASSATNYG YKDIYAGALI LVITVLAVIV VFNRYFFTVS NMNISSVMFY 450
    ELFVVLYSLH FHGSSLIEEE HQIWYFFTTA TLLFLAITFF DTFKSLQNFI 500
    SFGVLFACIR FMRSWNNSGQ KYSSQYNIAY YLSHSNPNLM WGLIILTYFV 550
    LTLCIYIQGS LVPTFAFSFG KRLPDVKDPG GLISFIVVFV ATSVSFSFKL 600
    LQYYIDGNTI PKWLNRFLLW IIESHHIDLS SATLEDNELK FQLQSVSIQL 650
    SKFTTIILLL LVISRVIIGK IRKIRYGTIT DITNIMTIYL IHQTRHENIP 700
    IFLALMFAKF ALSKLIYRKT NRIDQYILTV TMTVLCLQNL TFFCMGNTNS 750
    LATVDLSNAY NGVKAYNVFL VGLLTFVSNF AGPIFWSLSG LQLLYEPSLL 800
    NFNGPATTDL LHYTGLKKSI LLVKSLISLF FYTVSAVNLV GSCINLRFHL 850
    FIWTVFSPKL LFFGSWILFV NVLIDLYFGN NSIVVLKTNI LL 892
    Length:892
    Mass (Da):101,640
    Last modified:July 25, 2006 - v2
    Checksum:i3A5C37241363A19A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 541Q → H in AAL83897. (PubMed:11994163)Curated
    Sequence conflicti57 – 571N → T in AAL83897. (PubMed:11994163)Curated
    Sequence conflicti94 – 941R → H in AAL83897. (PubMed:11994163)Curated
    Sequence conflicti437 – 4371F → L in AAL83897. (PubMed:11994163)Curated
    Sequence conflicti439 – 4391V → A in AAL83897. (PubMed:11994163)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF348498 Genomic DNA. Translation: AAL83897.1.
    AACQ01000242 Genomic DNA. Translation: EAK91495.1.
    AACQ01000243 Genomic DNA. Translation: EAK91485.1.
    AACQ01000231 Genomic DNA. No translation available.
    AACQ01000232 Genomic DNA. No translation available.
    RefSeqiXP_710733.1. XM_705641.1.
    XP_710743.1. XM_705651.1.

    Genome annotation databases

    GeneIDi3647663.
    3647672.
    KEGGical:CaO19.11547.
    cal:CaO19.4064.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF348498 Genomic DNA. Translation: AAL83897.1 .
    AACQ01000242 Genomic DNA. Translation: EAK91495.1 .
    AACQ01000243 Genomic DNA. Translation: EAK91485.1 .
    AACQ01000231 Genomic DNA. No translation available.
    AACQ01000232 Genomic DNA. No translation available.
    RefSeqi XP_710733.1. XM_705641.1.
    XP_710743.1. XM_705651.1.

    3D structure databases

    ProteinModelPortali Q8TGB2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3647663.
    3647672.
    KEGGi cal:CaO19.11547.
    cal:CaO19.4064.

    Phylogenomic databases

    eggNOGi COG1524.
    KOi K05310.
    OrthoDBi EOG78D7TF.

    Enzyme and pathway databases

    UniPathwayi UPA00196 .

    Family and domain databases

    Gene3Di 3.40.720.10. 1 hit.
    InterProi IPR017849. Alkaline_Pase-like_a/b/a.
    IPR017850. Alkaline_phosphatase_core.
    IPR002591. Phosphodiest/P_Trfase.
    [Graphical view ]
    Pfami PF01663. Phosphodiest. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53649. SSF53649. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete glycosylphosphatidylinositol anchors are required in Candida albicans for full morphogenesis, virulence and resistance to macrophages."
      Richard M., Ibata-Ombetta S., Dromer F., Bordon-Pallier F., Jouault T., Gaillardin C.
      Mol. Microbiol. 44:841-853(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    3. "GPI7 affects cell-wall protein anchorage in Saccharomyces cerevisiae and Candida albicans."
      Richard M., De Groot P., Courtin O., Poulain D., Klis F., Gaillardin C.
      Microbiology 148:2125-2133(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiGPI7_CANAL
    AccessioniPrimary (citable) accession number: Q8TGB2
    Secondary accession number(s): Q59LX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3