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Q8TGB2

- GPI7_CANAL

UniProt

Q8TGB2 - GPI7_CANAL

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Protein
GPI ethanolamine phosphate transferase 2
Gene
LAS21, GPI7, CaO19.11547, CaO19.4064
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose By similarity.

Pathwayi

GO - Molecular functioni

  1. transferase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. GPI anchor biosynthetic process Source: UniProtKB-UniPathway
  2. GPI anchor metabolic process Source: CGD
  3. cellular response to starvation Source: CGD
  4. filamentous growth Source: CGD
  5. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  6. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  7. pathogenesis Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI ethanolamine phosphate transferase 2 (EC:2.-.-.-)
Alternative name(s):
Glycosylphosphatidylinositol-anchor biosynthesis protein 7
Gene namesi
Name:LAS21
Synonyms:GPI7
ORF Names:CaO19.11547, CaO19.4064
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei413 – 43321Helical; Reviewed prediction
Add
BLAST
Transmembranei447 – 46721Helical; Reviewed prediction
Add
BLAST
Transmembranei473 – 49321Helical; Reviewed prediction
Add
BLAST
Transmembranei495 – 51420Helical; Reviewed prediction
Add
BLAST
Transmembranei539 – 55921Helical; Reviewed prediction
Add
BLAST
Transmembranei581 – 60121Helical; Reviewed prediction
Add
BLAST
Transmembranei648 – 66821Helical; Reviewed prediction
Add
BLAST
Transmembranei697 – 71721Helical; Reviewed prediction
Add
BLAST
Transmembranei726 – 74621Helical; Reviewed prediction
Add
BLAST
Transmembranei768 – 78821Helical; Reviewed prediction
Add
BLAST
Transmembranei820 – 84021Helical; Reviewed prediction
Add
BLAST
Transmembranei850 – 87021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Cell-wall protein anchorage defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 892892GPI ethanolamine phosphate transferase 2
PRO_0000246193Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi155 – 1551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi194 – 1941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi516 – 5161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi880 – 8801N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ8TGB2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1524.
KOiK05310.
OrthoDBiEOG78D7TF.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR002591. Phosphodiest/P_Trfase.
[Graphical view]
PfamiPF01663. Phosphodiest. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TGB2-1 [UniParc]FASTAAdd to Basket

« Hide

MSGSLNSRWV VQVSLTIINI IGFLVFLRGF FPSKVVLPGF NSFQDSTKSP    50
FSDQYGNPQF NKFILMVVDA MRSDFCFSDR SNFSFLHQLI NQGRALPFTA 100
FSNPPTVTLP RLKGITTGGT PNFLDAILNV ADDQDDSQGL HNQDSWVHQF 150
RHSNNKTINF FGDDTWLKLF QDQFTEFEGT NSFFVSDFTE VDNNVTRHLD 200
DQLSSNKWDG LILHYLGLDH IGHKGGPESP YMKPKQIEMD KILQRLYTYV 250
TKNDDTLIVL MGDHGMNEIG NHGGSSPGET SAALSFISPK FNHKGESPLP 300
YNSDYSYHHK ISQIDLVPTL AALLNFPIPK NSLGVIAKEI LEIWPENQRI 350
KILLENCAQI MNLYEAKYGP SGEVWTQWEN LQAKQHPIAD YYEFLQDIQS 400
EMASSATNYG YKDIYAGALI LVITVLAVIV VFNRYFFTVS NMNISSVMFY 450
ELFVVLYSLH FHGSSLIEEE HQIWYFFTTA TLLFLAITFF DTFKSLQNFI 500
SFGVLFACIR FMRSWNNSGQ KYSSQYNIAY YLSHSNPNLM WGLIILTYFV 550
LTLCIYIQGS LVPTFAFSFG KRLPDVKDPG GLISFIVVFV ATSVSFSFKL 600
LQYYIDGNTI PKWLNRFLLW IIESHHIDLS SATLEDNELK FQLQSVSIQL 650
SKFTTIILLL LVISRVIIGK IRKIRYGTIT DITNIMTIYL IHQTRHENIP 700
IFLALMFAKF ALSKLIYRKT NRIDQYILTV TMTVLCLQNL TFFCMGNTNS 750
LATVDLSNAY NGVKAYNVFL VGLLTFVSNF AGPIFWSLSG LQLLYEPSLL 800
NFNGPATTDL LHYTGLKKSI LLVKSLISLF FYTVSAVNLV GSCINLRFHL 850
FIWTVFSPKL LFFGSWILFV NVLIDLYFGN NSIVVLKTNI LL 892
Length:892
Mass (Da):101,640
Last modified:July 25, 2006 - v2
Checksum:i3A5C37241363A19A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541Q → H in AAL83897. 1 Publication
Sequence conflicti57 – 571N → T in AAL83897. 1 Publication
Sequence conflicti94 – 941R → H in AAL83897. 1 Publication
Sequence conflicti437 – 4371F → L in AAL83897. 1 Publication
Sequence conflicti439 – 4391V → A in AAL83897. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF348498 Genomic DNA. Translation: AAL83897.1.
AACQ01000242 Genomic DNA. Translation: EAK91495.1.
AACQ01000243 Genomic DNA. Translation: EAK91485.1.
AACQ01000231 Genomic DNA. No translation available.
AACQ01000232 Genomic DNA. No translation available.
RefSeqiXP_710733.1. XM_705641.1.
XP_710743.1. XM_705651.1.

Genome annotation databases

GeneIDi3647663.
3647672.
KEGGical:CaO19.11547.
cal:CaO19.4064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF348498 Genomic DNA. Translation: AAL83897.1 .
AACQ01000242 Genomic DNA. Translation: EAK91495.1 .
AACQ01000243 Genomic DNA. Translation: EAK91485.1 .
AACQ01000231 Genomic DNA. No translation available.
AACQ01000232 Genomic DNA. No translation available.
RefSeqi XP_710733.1. XM_705641.1.
XP_710743.1. XM_705651.1.

3D structure databases

ProteinModelPortali Q8TGB2.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3647663.
3647672.
KEGGi cal:CaO19.11547.
cal:CaO19.4064.

Phylogenomic databases

eggNOGi COG1524.
KOi K05310.
OrthoDBi EOG78D7TF.

Enzyme and pathway databases

UniPathwayi UPA00196 .

Family and domain databases

Gene3Di 3.40.720.10. 1 hit.
InterProi IPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR002591. Phosphodiest/P_Trfase.
[Graphical view ]
Pfami PF01663. Phosphodiest. 1 hit.
[Graphical view ]
SUPFAMi SSF53649. SSF53649. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete glycosylphosphatidylinositol anchors are required in Candida albicans for full morphogenesis, virulence and resistance to macrophages."
    Richard M., Ibata-Ombetta S., Dromer F., Bordon-Pallier F., Jouault T., Gaillardin C.
    Mol. Microbiol. 44:841-853(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  3. "GPI7 affects cell-wall protein anchorage in Saccharomyces cerevisiae and Candida albicans."
    Richard M., De Groot P., Courtin O., Poulain D., Klis F., Gaillardin C.
    Microbiology 148:2125-2133(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiGPI7_CANAL
AccessioniPrimary (citable) accession number: Q8TGB2
Secondary accession number(s): Q59LX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: April 16, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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