SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8TG07

- PLB1_CANGA

UniProt

Q8TG07 - PLB1_CANGA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Lysophospholipase 1
Gene
PLB1, CAGL0J11770g
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. phospholipid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 1 (EC:3.1.1.5)
Alternative name(s):
Phospholipase B 1
Gene namesi
Name:PLB1
Ordered Locus Names:CAGL0J11770g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
ProteomesiUP000002428: Chromosome J

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 659637Lysophospholipase 1
PRO_0000024633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi45 – 451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi78 – 781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi82 – 821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi96 – 961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi127 – 1271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi164 – 1641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi219 – 2191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi281 – 2811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi349 – 3491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi392 – 3921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi493 – 4931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi517 – 5171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi545 – 5451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi569 – 5691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi605 – 6051N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ8TG07.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 590556PLA2c
Add
BLAST

Sequence similaritiesi

Belongs to the lysophospholipase family.
Contains 1 PLA2c domain.

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000189547.
KOiK13333.
OMAiYQFINAS.
OrthoDBiEOG7N37NC.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TG07-1 [UniParc]FASTAAdd to Basket

« Hide

MQLQDLVVTV SLLAAFNGGV EAWSPTNSYV PANVTCPNDI NLLRNATGLS    50
QSEIDWLKKR DVNTREALES FLKRVTSNFT SNSSASNLID QLFSTNSSNI 100
PKIGIAASGG GYRAMLSGAG MVSAMDNRTD GANEHGLGGL LQAATYLAGL 150
SGGNWLTTTL SWNNWTSVQD IVDSQDNDSA IWDISHSIVS PGGINIFKTG 200
SRWDHISDAV EDKQKAGFNV SLADVWGRAL SYQFFPTLYR GGVAYLWSDL 250
RESDVFKNAE MPMPISVADG RYPGTAVIDL NSTVFEYSPF ELGSWDPSLS 300
AFTDVQYLGT KVSDGKPAEE GKCIAGFDNV GFLMGTSSTL FNQFLLRIND 350
TSIPKFIRNL ATHFLKDLSE DYDDIAVYAP NPFRDADYVN NNRSKSLSES 400
EYLFLVDGGE DGQNVPLVPL IQQERDLDIV FALDNSADTE ENWPDGASLM 450
HTYRRQFGFQ GQGVTFPSVP GTDTFVNLGL NKKPTFFGCD ARNMTDLEYI 500
PPLIVYIPNS RHSYNGNTST FKLSYSEKER LGVIRNGFEA ATMNNLTADS 550
NFAGCIGCAI MRRKQQALNL TLPKECETCF TNYCWNGTID NTPAKGVTAS 600
NDFDNASGSA AADMAEQDAS GAASASSSSR KKNAAVSVDV NAKTLFAIIT 650
AMTAVFQLI 659
Length:659
Mass (Da):71,644
Last modified:August 31, 2004 - v2
Checksum:iDEE85E44AC2C951C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti374 – 3741D → H in AAM16160. 1 Publication
Sequence conflicti439 – 4391T → R in AAM16160. 1 Publication
Sequence conflicti586 – 5905NGTID → KPTMQ in AAM16160. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF498581 Genomic DNA. Translation: AAM16160.1.
CR380956 Genomic DNA. Translation: CAG61176.1.
RefSeqiXP_448225.1. XM_448225.1.

Genome annotation databases

GeneIDi2889465.
KEGGicgr:CAGL0J11770g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF498581 Genomic DNA. Translation: AAM16160.1 .
CR380956 Genomic DNA. Translation: CAG61176.1 .
RefSeqi XP_448225.1. XM_448225.1.

3D structure databases

ProteinModelPortali Q8TG07.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2889465.
KEGGi cgr:CAGL0J11770g.

Phylogenomic databases

HOGENOMi HOG000189547.
KOi K13333.
OMAi YQFINAS.
OrthoDBi EOG7N37NC.

Family and domain databases

InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view ]
Pfami PF01735. PLA2_B. 1 hit.
[Graphical view ]
SMARTi SM00022. PLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 1 hit.
PROSITEi PS51210. PLA2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of phospholipase gene (PLB1) of Candida glabrata."
    Clancy C., Cheng S., Checkley M.A., Lewin A., Nguyen M.-H.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Entry informationi

Entry nameiPLB1_CANGA
AccessioniPrimary (citable) accession number: Q8TG07
Secondary accession number(s): Q6FNG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: August 31, 2004
Last modified: November 13, 2013
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi