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Q8TG07 (PLB1_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase 1

EC=3.1.1.5
Alternative name(s):
Phospholipase B 1
Gene names
Name:PLB1
Ordered Locus Names:CAGL0J11770g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length659 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the lysophospholipase family.

Contains 1 PLA2c domain.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processphospholipid catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlysophospholipase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 659637Lysophospholipase 1
PRO_0000024633

Regions

Domain35 – 590556PLA2c

Amino acid modifications

Glycosylation331N-linked (GlcNAc...) Potential
Glycosylation451N-linked (GlcNAc...) Potential
Glycosylation781N-linked (GlcNAc...) Potential
Glycosylation821N-linked (GlcNAc...) Potential
Glycosylation961N-linked (GlcNAc...) Potential
Glycosylation1271N-linked (GlcNAc...) Potential
Glycosylation1641N-linked (GlcNAc...) Potential
Glycosylation1771N-linked (GlcNAc...) Potential
Glycosylation2191N-linked (GlcNAc...) Potential
Glycosylation2811N-linked (GlcNAc...) Potential
Glycosylation3491N-linked (GlcNAc...) Potential
Glycosylation3921N-linked (GlcNAc...) Potential
Glycosylation4931N-linked (GlcNAc...) Potential
Glycosylation5171N-linked (GlcNAc...) Potential
Glycosylation5451N-linked (GlcNAc...) Potential
Glycosylation5691N-linked (GlcNAc...) Potential
Glycosylation6051N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict3741D → H in AAM16160. Ref.1
Sequence conflict4391T → R in AAM16160. Ref.1
Sequence conflict586 – 5905NGTID → KPTMQ in AAM16160. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8TG07 [UniParc].

Last modified August 31, 2004. Version 2.
Checksum: DEE85E44AC2C951C

FASTA65971,644
        10         20         30         40         50         60 
MQLQDLVVTV SLLAAFNGGV EAWSPTNSYV PANVTCPNDI NLLRNATGLS QSEIDWLKKR 

        70         80         90        100        110        120 
DVNTREALES FLKRVTSNFT SNSSASNLID QLFSTNSSNI PKIGIAASGG GYRAMLSGAG 

       130        140        150        160        170        180 
MVSAMDNRTD GANEHGLGGL LQAATYLAGL SGGNWLTTTL SWNNWTSVQD IVDSQDNDSA 

       190        200        210        220        230        240 
IWDISHSIVS PGGINIFKTG SRWDHISDAV EDKQKAGFNV SLADVWGRAL SYQFFPTLYR 

       250        260        270        280        290        300 
GGVAYLWSDL RESDVFKNAE MPMPISVADG RYPGTAVIDL NSTVFEYSPF ELGSWDPSLS 

       310        320        330        340        350        360 
AFTDVQYLGT KVSDGKPAEE GKCIAGFDNV GFLMGTSSTL FNQFLLRIND TSIPKFIRNL 

       370        380        390        400        410        420 
ATHFLKDLSE DYDDIAVYAP NPFRDADYVN NNRSKSLSES EYLFLVDGGE DGQNVPLVPL 

       430        440        450        460        470        480 
IQQERDLDIV FALDNSADTE ENWPDGASLM HTYRRQFGFQ GQGVTFPSVP GTDTFVNLGL 

       490        500        510        520        530        540 
NKKPTFFGCD ARNMTDLEYI PPLIVYIPNS RHSYNGNTST FKLSYSEKER LGVIRNGFEA 

       550        560        570        580        590        600 
ATMNNLTADS NFAGCIGCAI MRRKQQALNL TLPKECETCF TNYCWNGTID NTPAKGVTAS 

       610        620        630        640        650 
NDFDNASGSA AADMAEQDAS GAASASSSSR KKNAAVSVDV NAKTLFAIIT AMTAVFQLI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF498581 Genomic DNA. Translation: AAM16160.1.
CR380956 Genomic DNA. Translation: CAG61176.1.
RefSeqXP_448225.1. XM_448225.1.

3D structure databases

ProteinModelPortalQ8TG07.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2889465.
KEGGcgr:CAGL0J11770g.

Phylogenomic databases

HOGENOMHOG000189547.
KOK13333.
OMAYQFINAS.
OrthoDBEOG7N37NC.

Family and domain databases

InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMSSF52151. SSF52151. 1 hit.
PROSITEPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLB1_CANGA
AccessionPrimary (citable) accession number: Q8TG07
Secondary accession number(s): Q6FNG9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: August 31, 2004
Last modified: November 13, 2013
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families