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Q8TG07

- PLB1_CANGA

UniProt

Q8TG07 - PLB1_CANGA

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Protein

Lysophospholipase 1

Gene

PLB1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. phospholipid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 1 (EC:3.1.1.5)
Alternative name(s):
Phospholipase B 1
Gene namesi
Name:PLB1
Ordered Locus Names:CAGL0J11770g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome J

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 659637Lysophospholipase 1PRO_0000024633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi493 – 4931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi569 – 5691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi605 – 6051N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ8TG07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 590556PLA2cPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated
Contains 1 PLA2c domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000189547.
InParanoidiQ8TG07.
KOiK13333.
OMAiYQFINAS.
OrthoDBiEOG7N37NC.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TG07-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQLQDLVVTV SLLAAFNGGV EAWSPTNSYV PANVTCPNDI NLLRNATGLS
60 70 80 90 100
QSEIDWLKKR DVNTREALES FLKRVTSNFT SNSSASNLID QLFSTNSSNI
110 120 130 140 150
PKIGIAASGG GYRAMLSGAG MVSAMDNRTD GANEHGLGGL LQAATYLAGL
160 170 180 190 200
SGGNWLTTTL SWNNWTSVQD IVDSQDNDSA IWDISHSIVS PGGINIFKTG
210 220 230 240 250
SRWDHISDAV EDKQKAGFNV SLADVWGRAL SYQFFPTLYR GGVAYLWSDL
260 270 280 290 300
RESDVFKNAE MPMPISVADG RYPGTAVIDL NSTVFEYSPF ELGSWDPSLS
310 320 330 340 350
AFTDVQYLGT KVSDGKPAEE GKCIAGFDNV GFLMGTSSTL FNQFLLRIND
360 370 380 390 400
TSIPKFIRNL ATHFLKDLSE DYDDIAVYAP NPFRDADYVN NNRSKSLSES
410 420 430 440 450
EYLFLVDGGE DGQNVPLVPL IQQERDLDIV FALDNSADTE ENWPDGASLM
460 470 480 490 500
HTYRRQFGFQ GQGVTFPSVP GTDTFVNLGL NKKPTFFGCD ARNMTDLEYI
510 520 530 540 550
PPLIVYIPNS RHSYNGNTST FKLSYSEKER LGVIRNGFEA ATMNNLTADS
560 570 580 590 600
NFAGCIGCAI MRRKQQALNL TLPKECETCF TNYCWNGTID NTPAKGVTAS
610 620 630 640 650
NDFDNASGSA AADMAEQDAS GAASASSSSR KKNAAVSVDV NAKTLFAIIT

AMTAVFQLI
Length:659
Mass (Da):71,644
Last modified:August 31, 2004 - v2
Checksum:iDEE85E44AC2C951C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti374 – 3741D → H in AAM16160. 1 PublicationCurated
Sequence conflicti439 – 4391T → R in AAM16160. 1 PublicationCurated
Sequence conflicti586 – 5905NGTID → KPTMQ in AAM16160. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498581 Genomic DNA. Translation: AAM16160.1.
CR380956 Genomic DNA. Translation: CAG61176.1.
RefSeqiXP_448225.1. XM_448225.1.

Genome annotation databases

GeneIDi2889465.
KEGGicgr:CAGL0J11770g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498581 Genomic DNA. Translation: AAM16160.1 .
CR380956 Genomic DNA. Translation: CAG61176.1 .
RefSeqi XP_448225.1. XM_448225.1.

3D structure databases

ProteinModelPortali Q8TG07.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2889465.
KEGGi cgr:CAGL0J11770g.

Phylogenomic databases

HOGENOMi HOG000189547.
InParanoidi Q8TG07.
KOi K13333.
OMAi YQFINAS.
OrthoDBi EOG7N37NC.

Family and domain databases

InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view ]
Pfami PF01735. PLA2_B. 1 hit.
[Graphical view ]
SMARTi SM00022. PLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 1 hit.
PROSITEi PS51210. PLA2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of phospholipase gene (PLB1) of Candida glabrata."
    Clancy C., Cheng S., Checkley M.A., Lewin A., Nguyen M.-H.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Entry informationi

Entry nameiPLB1_CANGA
AccessioniPrimary (citable) accession number: Q8TG07
Secondary accession number(s): Q6FNG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: August 31, 2004
Last modified: October 29, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3