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Protein

Lysophospholipase 2

Gene

PLB2

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 2 (EC:3.1.1.5)
Alternative name(s):
Phospholipase B 2
Gene namesi
Name:PLB2
Ordered Locus Names:CAGL0J11748g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome J

Organism-specific databases

CGDiCAL0133296. PLB2.
EuPathDBiFungiDB:CAGL0J11748g.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • fungal-type cell wall Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002463420 – 695Lysophospholipase 2Add BLAST676

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi83N-linked (GlcNAc...)Sequence analysis1
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Glycosylationi171N-linked (GlcNAc...)Sequence analysis1
Glycosylationi207N-linked (GlcNAc...)Sequence analysis1
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1
Glycosylationi335N-linked (GlcNAc...)Sequence analysis1
Glycosylationi379N-linked (GlcNAc...)Sequence analysis1
Glycosylationi480N-linked (GlcNAc...)Sequence analysis1
Glycosylationi504N-linked (GlcNAc...)Sequence analysis1
Glycosylationi513N-linked (GlcNAc...)Sequence analysis1
Glycosylationi532N-linked (GlcNAc...)Sequence analysis1
Glycosylationi556N-linked (GlcNAc...)Sequence analysis1
Glycosylationi573N-linked (GlcNAc...)Sequence analysis1
Glycosylationi620N-linked (GlcNAc...)Sequence analysis1
Glycosylationi626N-linked (GlcNAc...)Sequence analysis1
Glycosylationi644N-linked (GlcNAc...)Sequence analysis1
Glycosylationi648N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_448224.1.

Structurei

3D structure databases

ProteinModelPortaliQ8TG06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 577PLA2cPROSITE-ProRule annotationAdd BLAST550

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated
Contains 1 PLA2c domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1325. Eukaryota.
ENOG410XR72. LUCA.
HOGENOMiHOG000189547.
InParanoidiQ8TG06.
KOiK13333.
OMAiGMAFPYV.
OrthoDBiEOG092C2IZ9.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TG06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLSVLIASV LAAGAAVDAA SYTPQNVSCP DNANFIRNAA DGLSPAEKEW
60 70 80 90 100
LKKRDPITRD ALQTFLRRAF ANVSTEITSA LFNDTENVPK LGIAVAGGGY
110 120 130 140 150
RAMFVGAGAF AAMDNRTDGA NEHGLGGLLQ AATYMAGLSG GNWLTGTLAY
160 170 180 190 200
NNFTSVQQIL EEGDKADAIW NITNSFLNPY DKDFSKTLAR WTAIGSQVQG
210 220 230 240 250
KRDAGFNVTI TDLWSRALAY GWFPTLPNAG AGLTWSSLRD NEIFMNGEMP
260 270 280 290 300
MPISVADGRY PGTTVINLNA TVFEMTPFEI GSWDPSLNAF SDIKYLGTQV
310 320 330 340 350
TDGKPETERC INGFDDASFI MGTSSSLFNE FTMSNDSAVA YTYLNTLSST
360 370 380 390 400
LVKGIDKENN DIAMYAPNPF KGSKYVDSNY TTSIVDSDSL FLVDGGEDLQ
410 420 430 440 450
GIPFVPLLKQ ERDLDIIFAI DVDTETSDNY PAGGPMMKTY ERQFSKQGKG
460 470 480 490 500
MAFPYVPDMT TFVNLGLGGK PSFYGCDANN LTDLEYIPPL IVYIPNSYHS
510 520 530 540 550
FESNVSTFKL NYNYSERVGM IRNAFEATTR NNLTEDADYV TCVGCAIIRR
560 570 580 590 600
KQQSLNLTLP DICDKCFTNY CWNGTIDNTP TKLLTPNNQD PAAISSAIAA
610 620 630 640 650
VTDDSPIGAL LNTGSGTKSN SSSKTNSTLV TSSRATSTGT LISNSSSNST
660 670 680 690
VSSTAARSST SSTAKKNAGS VLKLEFSKSA SVMVAIAAAA VASLI
Length:695
Mass (Da):74,629
Last modified:August 31, 2004 - v2
Checksum:i929CE2E53036276C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti254S → P in AAM19335 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498582 Genomic DNA. Translation: AAM19335.1.
CR380956 Genomic DNA. Translation: CAG61175.1.
RefSeqiXP_448224.1. XM_448224.1.

Genome annotation databases

EnsemblFungiiCAG61175; CAG61175; CAGL0J11748g.
GeneIDi2889464.
KEGGicgr:CAGL0J11748g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498582 Genomic DNA. Translation: AAM19335.1.
CR380956 Genomic DNA. Translation: CAG61175.1.
RefSeqiXP_448224.1. XM_448224.1.

3D structure databases

ProteinModelPortaliQ8TG06.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284593.XP_448224.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG61175; CAG61175; CAGL0J11748g.
GeneIDi2889464.
KEGGicgr:CAGL0J11748g.

Organism-specific databases

CGDiCAL0133296. PLB2.
EuPathDBiFungiDB:CAGL0J11748g.

Phylogenomic databases

eggNOGiKOG1325. Eukaryota.
ENOG410XR72. LUCA.
HOGENOMiHOG000189547.
InParanoidiQ8TG06.
KOiK13333.
OMAiGMAFPYV.
OrthoDBiEOG092C2IZ9.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLB2_CANGA
AccessioniPrimary (citable) accession number: Q8TG06
Secondary accession number(s): Q6FNH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: August 31, 2004
Last modified: September 7, 2016
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.