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Q8TG06

- PLB2_CANGA

UniProt

Q8TG06 - PLB2_CANGA

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Protein

Lysophospholipase 2

Gene

PLB2

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. phospholipid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 2 (EC:3.1.1.5)
Alternative name(s):
Phospholipase B 2
Gene namesi
Name:PLB2
Ordered Locus Names:CAGL0J11748g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome J

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 695676Lysophospholipase 2PRO_0000024634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi504 – 5041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi513 – 5131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi532 – 5321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi556 – 5561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi573 – 5731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi620 – 6201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi626 – 6261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi644 – 6441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi648 – 6481N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ8TG06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 577550PLA2cPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated
Contains 1 PLA2c domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000189547.
InParanoidiQ8TG06.
KOiK13333.
OMAiPGPSGEY.
OrthoDBiEOG7N37NC.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TG06-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQLSVLIASV LAAGAAVDAA SYTPQNVSCP DNANFIRNAA DGLSPAEKEW
60 70 80 90 100
LKKRDPITRD ALQTFLRRAF ANVSTEITSA LFNDTENVPK LGIAVAGGGY
110 120 130 140 150
RAMFVGAGAF AAMDNRTDGA NEHGLGGLLQ AATYMAGLSG GNWLTGTLAY
160 170 180 190 200
NNFTSVQQIL EEGDKADAIW NITNSFLNPY DKDFSKTLAR WTAIGSQVQG
210 220 230 240 250
KRDAGFNVTI TDLWSRALAY GWFPTLPNAG AGLTWSSLRD NEIFMNGEMP
260 270 280 290 300
MPISVADGRY PGTTVINLNA TVFEMTPFEI GSWDPSLNAF SDIKYLGTQV
310 320 330 340 350
TDGKPETERC INGFDDASFI MGTSSSLFNE FTMSNDSAVA YTYLNTLSST
360 370 380 390 400
LVKGIDKENN DIAMYAPNPF KGSKYVDSNY TTSIVDSDSL FLVDGGEDLQ
410 420 430 440 450
GIPFVPLLKQ ERDLDIIFAI DVDTETSDNY PAGGPMMKTY ERQFSKQGKG
460 470 480 490 500
MAFPYVPDMT TFVNLGLGGK PSFYGCDANN LTDLEYIPPL IVYIPNSYHS
510 520 530 540 550
FESNVSTFKL NYNYSERVGM IRNAFEATTR NNLTEDADYV TCVGCAIIRR
560 570 580 590 600
KQQSLNLTLP DICDKCFTNY CWNGTIDNTP TKLLTPNNQD PAAISSAIAA
610 620 630 640 650
VTDDSPIGAL LNTGSGTKSN SSSKTNSTLV TSSRATSTGT LISNSSSNST
660 670 680 690
VSSTAARSST SSTAKKNAGS VLKLEFSKSA SVMVAIAAAA VASLI
Length:695
Mass (Da):74,629
Last modified:August 31, 2004 - v2
Checksum:i929CE2E53036276C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti254 – 2541S → P in AAM19335. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF498582 Genomic DNA. Translation: AAM19335.1.
CR380956 Genomic DNA. Translation: CAG61175.1.
RefSeqiXP_448224.1. XM_448224.1.

Genome annotation databases

GeneIDi2889464.
KEGGicgr:CAGL0J11748g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF498582 Genomic DNA. Translation: AAM19335.1 .
CR380956 Genomic DNA. Translation: CAG61175.1 .
RefSeqi XP_448224.1. XM_448224.1.

3D structure databases

ProteinModelPortali Q8TG06.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2889464.
KEGGi cgr:CAGL0J11748g.

Phylogenomic databases

HOGENOMi HOG000189547.
InParanoidi Q8TG06.
KOi K13333.
OMAi PGPSGEY.
OrthoDBi EOG7N37NC.

Family and domain databases

InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view ]
Pfami PF01735. PLA2_B. 1 hit.
[Graphical view ]
SMARTi SM00022. PLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 1 hit.
PROSITEi PS51210. PLA2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and charaterization of phospholipase B gene (PLB2) of Candida glabrata."
    Clancy C., Cheng S., Chekley M.A., Lewin A., Nguyen M.-H.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Entry informationi

Entry nameiPLB2_CANGA
AccessioniPrimary (citable) accession number: Q8TG06
Secondary accession number(s): Q6FNH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: August 31, 2004
Last modified: October 29, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3