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Q8TG06 (PLB2_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase 2

EC=3.1.1.5
Alternative name(s):
Phospholipase B 2
Gene names
Name:PLB2
Ordered Locus Names:CAGL0J11748g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length695 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the lysophospholipase family.

Contains 1 PLA2c domain.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processphospholipid catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlysophospholipase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 695676Lysophospholipase 2
PRO_0000024634

Regions

Domain28 – 577550PLA2c

Amino acid modifications

Glycosylation261N-linked (GlcNAc...) Potential
Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation831N-linked (GlcNAc...) Potential
Glycosylation1151N-linked (GlcNAc...) Potential
Glycosylation1521N-linked (GlcNAc...) Potential
Glycosylation1711N-linked (GlcNAc...) Potential
Glycosylation2071N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential
Glycosylation3351N-linked (GlcNAc...) Potential
Glycosylation3791N-linked (GlcNAc...) Potential
Glycosylation4801N-linked (GlcNAc...) Potential
Glycosylation5041N-linked (GlcNAc...) Potential
Glycosylation5131N-linked (GlcNAc...) Potential
Glycosylation5321N-linked (GlcNAc...) Potential
Glycosylation5561N-linked (GlcNAc...) Potential
Glycosylation5731N-linked (GlcNAc...) Potential
Glycosylation6201N-linked (GlcNAc...) Potential
Glycosylation6261N-linked (GlcNAc...) Potential
Glycosylation6441N-linked (GlcNAc...) Potential
Glycosylation6481N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2541S → P in AAM19335. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8TG06 [UniParc].

Last modified August 31, 2004. Version 2.
Checksum: 929CE2E53036276C

FASTA69574,629
        10         20         30         40         50         60 
MQLSVLIASV LAAGAAVDAA SYTPQNVSCP DNANFIRNAA DGLSPAEKEW LKKRDPITRD 

        70         80         90        100        110        120 
ALQTFLRRAF ANVSTEITSA LFNDTENVPK LGIAVAGGGY RAMFVGAGAF AAMDNRTDGA 

       130        140        150        160        170        180 
NEHGLGGLLQ AATYMAGLSG GNWLTGTLAY NNFTSVQQIL EEGDKADAIW NITNSFLNPY 

       190        200        210        220        230        240 
DKDFSKTLAR WTAIGSQVQG KRDAGFNVTI TDLWSRALAY GWFPTLPNAG AGLTWSSLRD 

       250        260        270        280        290        300 
NEIFMNGEMP MPISVADGRY PGTTVINLNA TVFEMTPFEI GSWDPSLNAF SDIKYLGTQV 

       310        320        330        340        350        360 
TDGKPETERC INGFDDASFI MGTSSSLFNE FTMSNDSAVA YTYLNTLSST LVKGIDKENN 

       370        380        390        400        410        420 
DIAMYAPNPF KGSKYVDSNY TTSIVDSDSL FLVDGGEDLQ GIPFVPLLKQ ERDLDIIFAI 

       430        440        450        460        470        480 
DVDTETSDNY PAGGPMMKTY ERQFSKQGKG MAFPYVPDMT TFVNLGLGGK PSFYGCDANN 

       490        500        510        520        530        540 
LTDLEYIPPL IVYIPNSYHS FESNVSTFKL NYNYSERVGM IRNAFEATTR NNLTEDADYV 

       550        560        570        580        590        600 
TCVGCAIIRR KQQSLNLTLP DICDKCFTNY CWNGTIDNTP TKLLTPNNQD PAAISSAIAA 

       610        620        630        640        650        660 
VTDDSPIGAL LNTGSGTKSN SSSKTNSTLV TSSRATSTGT LISNSSSNST VSSTAARSST 

       670        680        690 
SSTAKKNAGS VLKLEFSKSA SVMVAIAAAA VASLI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF498582 Genomic DNA. Translation: AAM19335.1.
CR380956 Genomic DNA. Translation: CAG61175.1.
RefSeqXP_448224.1. XM_448224.1.

3D structure databases

ProteinModelPortalQ8TG06.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2889464.
KEGGcgr:CAGL0J11748g.

Phylogenomic databases

HOGENOMHOG000189547.
KOK13333.
OMAPGPSGEY.
OrthoDBEOG7N37NC.

Family and domain databases

InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMSSF52151. SSF52151. 1 hit.
PROSITEPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLB2_CANGA
AccessionPrimary (citable) accession number: Q8TG06
Secondary accession number(s): Q6FNH0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: August 31, 2004
Last modified: November 13, 2013
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families