Q8TFM9 (RLA2_FUSCU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: 60S acidic ribosomal protein P2 Alternative name(s): Allergen=Fus c 1
Organism	Fusarium culmorum
Taxonomic identifier	5516 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Hypocreomycetidae › Hypocreales › Nectriaceae › mitosporic Nectriaceae › Fusarium

Protein attributes

Sequence length	109 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an important role in the elongation step of protein synthesis By similarity. HAMAP-Rule MF_01478
Subunit structure	P1 and P2 exist as dimers at the large ribosomal subunit.
Allergenic properties	Causes an allergic reaction in human. Binds to IgE. Ref.1
Sequence similarities	Belongs to the ribosomal protein L12P family.

Ontologies

Keywords
Disease	Allergen
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Phosphoprotein
Gene Ontology (GO)
Biological_process	translational elongation Inferred from electronic annotation. Source: InterPro
Cellular_component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 109	109	60S acidic ribosomal protein P2 HAMAP-Rule MF_01478		PRO_0000157678
Amino acid modifications
	Modified residue	99	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8TFM9 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: D20E40DB073BDF77	FASTA	109	11,036
	10 20 30 40 50 60 MKHLAAYLLL GLGGNTSPSA ADVKAVLTSV GIDADEDRLN KLISELEGKD IQQLIAEGSE 70 80 90 100 KLASVPSGGA GGASGGAAAA GGAAEEAKEE EKEEEKEESD EDMGFGLFD

References

[1]

"Molecular cloning and immunological characterisation of potential allergens from the mould Fusarium culmorum." Hoff M., Ballmer-Weber B.K., Niggemann B., Cistero-Bahima A., San Miguel-Moncin M., Conti A., Haustein D., Vieths S. Mol. Immunol. 39:965-975(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY077706 mRNA. Translation: AAL79930.1.
3D structure databases
ModBase	Search...
Protein family/group databases
Allergome	3288. Fus c 1.0101. 700. Fus c 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_01478. Ribosomal_L12_arch.
InterPro	IPR001813. Ribosomal_60S. [Graphical view]
Pfam	PF00428. Ribosomal_60s. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RLA2_FUSCU

Accession

Primary (citable) accession number: Q8TFM9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
Last sequence update:	June 1, 2002
Last modified:	April 3, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program