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Protein

Glucanase

Gene

cbh1

Organism
Talaromyces emersonii (Thermophilic fungus) (Rasamsonia emersonii)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationImported, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradationUniRule annotation, Polysaccharide degradation

Protein family/group databases

CAZyiGH7. Glycoside Hydrolase Family 7.

Names & Taxonomyi

Protein namesi
Recommended name:
GlucanaseUniRule annotation (EC:3.2.1.-UniRule annotation)
Gene namesi
Name:cbh1Imported
Synonyms:cbh1AImported
OrganismiTalaromyces emersonii (Thermophilic fungus) (Rasamsonia emersonii)Imported
Taxonomic identifieri68825 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeRasamsonia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 455437GlucanaseSequence analysisPRO_5007214889Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 43Combined sources
Disulfide bondi68 ↔ 89Combined sources
Disulfide bondi79 ↔ 85Combined sources
Disulfide bondi153 ↔ 419Combined sources
Disulfide bondi187 ↔ 225Combined sources
Disulfide bondi191 ↔ 224Combined sources
Disulfide bondi245 ↔ 271Combined sources
Disulfide bondi253 ↔ 258Combined sources
Disulfide bondi276 ↔ 352Combined sources
Glycosylationi285 – 2851N-linked (GlcNAc...)Combined sourcesCAR_5006993853
Glycosylationi449 – 4491N-linked (GlcNAc...)Combined sourcesCAR_5006993854

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q9HX-ray2.35A20-455[»]
3PFJX-ray1.36A20-455[»]
3PFXX-ray1.26A20-455[»]
3PFZX-ray1.10A20-455[»]
3PL3X-ray1.18A20-455[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 7 (cellulase C) family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di2.70.100.10. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001722. Glyco_hydro_7.
[Graphical view]
PfamiPF00840. Glyco_hydro_7. 1 hit.
[Graphical view]
PRINTSiPR00734. GLHYDRLASE7.
SUPFAMiSSF49899. SSF49899. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TFL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRALLLSS SAILAVKAQQ AGTATAENHP PLTWQECTAP GSCTTQNGAV
60 70 80 90 100
VLDANWRWVH DVNGYTNCYT GNTWDPTYCP DDETCAQNCA LDGADYEGTY
110 120 130 140 150
GVTSSGSSLK LNFVTGSNVG SRLYLLQDDS TYQIFKLLNR EFSFDVDVSN
160 170 180 190 200
LPCGLNGALY FVAMDADGGV SKYPNNKAGA KYGTGYCDSQ CPRDLKFIDG
210 220 230 240 250
EANVEGWQPS SNNANTGIGD HGSCCAEMDV WEANSISNAV TPHPCDTPGQ
260 270 280 290 300
TMCSGDDCGG TYSNDRYAGT CDPDGCDFNP YRMGNTSFYG PGKIIDTTKP
310 320 330 340 350
FTVVTQFLTD DGTDTGTLSE IKRFYIQNSN VIPQPNSDIS GVTGNSITTE
360 370 380 390 400
FCTAQKQAFG DTDDFSQHGG LAKMGAAMQQ GMVLVMSLWD DYAAQMLWLD
410 420 430 440 450
SDYPTDADPT TPGIARGTCP TDSGVPSDVE SQSPNSYVTY SNIKFGPINS

TFTAS
Length:455
Mass (Da):48,737
Last modified:June 1, 2002 - v1
Checksum:i6DFABF6B8A545840
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF439935 Genomic DNA. Translation: AAL33603.2.
AY081766 mRNA. Translation: AAL89553.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF439935 Genomic DNA. Translation: AAL33603.2.
AY081766 mRNA. Translation: AAL89553.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q9HX-ray2.35A20-455[»]
3PFJX-ray1.36A20-455[»]
3PFXX-ray1.26A20-455[»]
3PFZX-ray1.10A20-455[»]
3PL3X-ray1.18A20-455[»]
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH7. Glycoside Hydrolase Family 7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.70.100.10. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001722. Glyco_hydro_7.
[Graphical view]
PfamiPF00840. Glyco_hydro_7. 1 hit.
[Graphical view]
PRINTSiPR00734. GLHYDRLASE7.
SUPFAMiSSF49899. SSF49899. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The molecular cloning of the cellobiohydrolases of Talaromyces emersonii."
    Collins C.M., Murray P.G., Denman S., Grassick A., Teeri T.T., Byrnes L., Tuohy M.G.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Molecular cloning of the cellobiohydrolase genes of Talaromyces emersonii."
    Collins C.M., Murray P.G., Tuohy M.G.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Three-dimensional structure of a thermostable native cellobiohydrolase, CBH IB, and molecular characterization of the cel7 gene from the filamentous fungus, Talaromyces emersonii."
    Grassick A., Murray P.G., Thompson R., Collins C.M., Byrnes L., Birrane G., Higgins T.M., Tuohy M.G.
    Eur. J. Biochem. 271:4495-4506(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 20-455, GLYCOSYLATION AT ASN-285 AND ASN-449, DISULFIDE BONDS.
  4. "Crystal structure of Cel7A from Talaromyces emersonii in complex with cellobiose."
    Qin L., Pereira J.H., McAndrew R.P., Simmons B.A., Sapra R., Adams P.D., Sale K.L.
    Submitted (OCT-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.26 ANGSTROMS) OF 20-455, GLYCOSYLATION AT ASN-285 AND ASN-449, DISULFIDE BONDS.
  5. "Crystal structure of Cel7A from Talaromyces emersonii in complex with cellotetraose."
    Qin L., Pereira J.H., McAndrew R.P., Simmons B.A., Sapra R., Adams P.D., Sale K.L.
    Submitted (OCT-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.10 ANGSTROMS) OF 20-455, GLYCOSYLATION AT ASN-285 AND ASN-449, DISULFIDE BONDS.
  6. "Crystal structure of Cel7A from Talaromyces emersonii."
    Qin L., Pereira J.H., McAndrew R.P., Simmons B.A., Sapra R., Adams P.D., Sale K.L.
    Submitted (OCT-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.36 ANGSTROMS) OF 20-455, GLYCOSYLATION AT ASN-285 AND ASN-449, DISULFIDE BONDS.
  7. "Crystal structure of Cel7A from Talaromyces emersonii in complex with cellopentaose."
    Qin L., Pereira J.H., McAndrew R.P., Simmons B.A., Sapra R., Adams P.D., Sale K.L.
    Submitted (NOV-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.18 ANGSTROMS) OF 20-455, GLYCOSYLATION AT ASN-285 AND ASN-449, DISULFIDE BONDS.

Entry informationi

Entry nameiQ8TFL9_TALEM
AccessioniPrimary (citable) accession number: Q8TFL9
Secondary accession number(s): Q8X210
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: May 11, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.