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Protein

Probable 6-phosphofructo-2-kinase PB17E12.14c

Gene

SPAPB17E12.14c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Synthesis of fructose 2,6-bisphosphate.By similarity

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei281 – 2811Sequence analysis
Active sitei312 – 3121Sequence analysis
Binding sitei346 – 3461Fructose-6-phosphateBy similarity
Active sitei540 – 5401Sequence analysis
Active sitei608 – 6081Proton donorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi197 – 2048ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 6-phosphofructo-2-kinase PB17E12.14c (EC:2.7.1.105)
Gene namesi
ORF Names:SPAPB17E12.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAPB17E12.14c.
PomBaseiSPAPB17E12.14c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 668668Probable 6-phosphofructo-2-kinase PB17E12.14cPRO_0000318494Add
BLAST

Proteomic databases

MaxQBiQ8TFH0.

Interactioni

Protein-protein interaction databases

BioGridi280454. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8TFH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000181112.
InParanoidiQ8TFH0.
KOiK00900.
OMAiNWEMLNE.
OrthoDBiEOG092C2SJU.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR003094. 6Pfruct_kin.
IPR013079. 6Phosfructo_kin.
IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR027417. P-loop_NTPase.
IPR001345. PG/BPGM_mutase_AS.
[Graphical view]
PANTHERiPTHR10606. PTHR10606. 2 hits.
PfamiPF01591. 6PF2K. 1 hit.
PF00300. His_Phos_1. 1 hit.
[Graphical view]
PRINTSiPR00991. 6PFRUCTKNASE.
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53254. SSF53254. 2 hits.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TFH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNNNKDDS ELQSRTHYYN PDRTAIPVKD DVDQLDKFGS PKLSANDHSF
60 70 80 90 100
TNTDSVTSED RPFSSPVSTL TSNSANFSDS SLQNSPVHPI PSPALSPTLN
110 120 130 140 150
LGSRPDVKRV SSGGYFALPK QLTSIRQTHR PMSQQHRVPS FHPASDTAPP
160 170 180 190 200
SPIPFHHHLR KKGSSMSIPG QTSIVSSNNG SEATNPPEEK LAIIMVGLPA
210 220 230 240 250
RGKSYIVNKL VRYYNWLQYN CKAFNVGNFR RKHASHSHDD ASFFDPSNEE
260 270 280 290 300
ASKLRESFAM DTLDALLQWF EEEDGVVGIF DATNSTSKRR KAIVDHLSKV
310 320 330 340 350
PYVTTLFIES ICNDEQLIAA NMRMKLVGPD YKDLNPEQSL RDFQERVRMY
360 370 380 390 400
ERKYEPLGKS EEDLNLRYIK VINVGKKVVA FNIRGFLAGQ AVFFLLNFNL
410 420 430 440 450
SPRQIWVTRH GESVDNVRGR IGGNAELTPL GRQFSEDLAL FIDEKRDEFQ
460 470 480 490 500
ERLYNDYSKE SHLLQHGSHS FNGKQFETSF NCLTPSENTV NDPQVLDPED
510 520 530 540 550
EERLEKPYSV WTSMMQRSIQ TAAYFDEEQY DIKAMRMLNE ICSGICDGLT
560 570 580 590 600
YEEIKSIYPK EYEARKLDKL NYRYPGSGGE SYLDVIYRLQ SVIVEIERMK
610 620 630 640 650
HHVLVIGHRV ITRIIIAYFL GCRREDIAYL NVPLHTVYCI EPQPYGTDFY
660
QYNYDPNTRK FSRVPFSL
Length:668
Mass (Da):76,393
Last modified:April 18, 2012 - v2
Checksum:iBA1228BA08951A78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAD27507.2.
RefSeqiNP_001018229.2. NM_001018709.2.

Genome annotation databases

EnsemblFungiiSPAPB17E12.14c.1; SPAPB17E12.14c.1:pep; SPAPB17E12.14c.
GeneIDi3361378.
KEGGispo:SPAPB17E12.14c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAD27507.2.
RefSeqiNP_001018229.2. NM_001018709.2.

3D structure databases

ProteinModelPortaliQ8TFH0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi280454. 1 interaction.

Proteomic databases

MaxQBiQ8TFH0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAPB17E12.14c.1; SPAPB17E12.14c.1:pep; SPAPB17E12.14c.
GeneIDi3361378.
KEGGispo:SPAPB17E12.14c.

Organism-specific databases

EuPathDBiFungiDB:SPAPB17E12.14c.
PomBaseiSPAPB17E12.14c.

Phylogenomic databases

HOGENOMiHOG000181112.
InParanoidiQ8TFH0.
KOiK00900.
OMAiNWEMLNE.
OrthoDBiEOG092C2SJU.

Miscellaneous databases

PROiQ8TFH0.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR003094. 6Pfruct_kin.
IPR013079. 6Phosfructo_kin.
IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR027417. P-loop_NTPase.
IPR001345. PG/BPGM_mutase_AS.
[Graphical view]
PANTHERiPTHR10606. PTHR10606. 2 hits.
PfamiPF01591. 6PF2K. 1 hit.
PF00300. His_Phos_1. 1 hit.
[Graphical view]
PRINTSiPR00991. 6PFRUCTKNASE.
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53254. SSF53254. 2 hits.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYIKE_SCHPO
AccessioniPrimary (citable) accession number: Q8TFH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 18, 2012
Last modified: September 7, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.