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Q8TFF6

- DHE4_SACU7

UniProt

Q8TFF6 - DHE4_SACU7

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Protein

NADP-specific glutamate dehydrogenase 1

Gene
GDH1
Organism
Saccharomyces uvarum (strain ATCC 76518 / CBS 7001 / CLIB 283 / NBRC 10550 / MCYC 623 / NCYC 2669 / NRRL Y-11845) (Yeast) (Saccharomyces bayanus var. uvarum)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei110 – 1101 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi174 – 20330NAD By similarityAdd
BLAST

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase 1 (EC:1.4.1.4)
Short name:
NADP-GDH 1
Alternative name(s):
NADP-dependent glutamate dehydrogenase 1
Gene namesi
Name:GDH1
OrganismiSaccharomyces uvarum (strain ATCC 76518 / CBS 7001 / CLIB 283 / NBRC 10550 / MCYC 623 / NCYC 2669 / NRRL Y-11845) (Yeast) (Saccharomyces bayanus var. uvarum)
Taxonomic identifieri226127 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454NADP-specific glutamate dehydrogenase 1PRO_0000182797Add
BLAST

Proteomic databases

PRIDEiQ8TFF6.

Interactioni

Subunit structurei

Homohexamer By similarity.

Protein-protein interaction databases

IntActiQ8TFF6. 1 interaction.
MINTiMINT-1324351.

Structurei

3D structure databases

ProteinModelPortaliQ8TFF6.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TFF6-1 [UniParc]FASTAAdd to Basket

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MSEPEFQQAY DEVVSSLEDS TLFEQHPKYR KVLPIVSVPE RIIQFRVTWE    50
NDKGEQEVAQ GYRVQYNSAK GPYKGGLRFH PSVNLSILKF LGFEQIFKNS 100
LTGLDMGGGK GGLCVDLKGR SNNEIRRICY AFMRELSRHI GQDTDVPAGD 150
IGVGGREIGY LFGAYRTYKN SWEGVLTGKG LNWGGSLIRP EATGYGLVYY 200
TQAMIDYATN GKESFEGKRV TISGSGNVAQ FAALKVIELG GTVVSLSDSK 250
GCIISETGIT SEQVADISSA KVNFKSLEQI VGEYSTFTEN KVQYISGARP 300
WTHVQKVDIA LPCATQNEVS GDEAKALVAQ GVKFVAEGSN MGSTPEAIAV 350
FETARATAST LKESVWYGPP KAANLGGVAV SGLEMAQNSQ RITWSSERVD 400
QELKKIMVNC FNECIDSAKK YTKEGNALPS LVKGANIASF IKVSDAMFDQ 450
GDVF 454
Length:454
Mass (Da):49,425
Last modified:June 1, 2002 - v1
Checksum:i98DF52A68BDE0D12
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ418037 Genomic DNA. Translation: CAD10750.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ418037 Genomic DNA. Translation: CAD10750.1 .

3D structure databases

ProteinModelPortali Q8TFF6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8TFF6. 1 interaction.
MINTi MINT-1324351.

Proteomic databases

PRIDEi Q8TFF6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "New S. pastorianus strains and Saccharomyces natural hybrids revealed by polyphasis identification of CBS strains formerly uncompletely identified by conventional method."
    Nguyen H.V.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 623-6C / CBS 9787 / CLIB 533.

Entry informationi

Entry nameiDHE4_SACU7
AccessioniPrimary (citable) accession number: Q8TFF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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