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Q8TFF6 (DHE4_SACU7) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADP-specific glutamate dehydrogenase 1

Short name=NADP-GDH 1
EC=1.4.1.4
Alternative name(s):
NADP-dependent glutamate dehydrogenase 1
Gene names
Name:GDH1
OrganismSaccharomyces uvarum (strain ATCC 76518 / CBS 7001 / CLIB 283 / NBRC 10550 / MCYC 623 / NCYC 2669 / NRRL Y-11845) (Yeast) (Saccharomyces bayanus var. uvarum)
Taxonomic identifier226127 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length454 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Subunit structure

Homohexamer By similarity.

Sequence similarities

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processcellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutamate dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 454454NADP-specific glutamate dehydrogenase 1
PRO_0000182797

Regions

Nucleotide binding174 – 20330NAD By similarity

Sites

Active site1101 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8TFF6 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 98DF52A68BDE0D12

FASTA45449,425
        10         20         30         40         50         60 
MSEPEFQQAY DEVVSSLEDS TLFEQHPKYR KVLPIVSVPE RIIQFRVTWE NDKGEQEVAQ 

        70         80         90        100        110        120 
GYRVQYNSAK GPYKGGLRFH PSVNLSILKF LGFEQIFKNS LTGLDMGGGK GGLCVDLKGR 

       130        140        150        160        170        180 
SNNEIRRICY AFMRELSRHI GQDTDVPAGD IGVGGREIGY LFGAYRTYKN SWEGVLTGKG 

       190        200        210        220        230        240 
LNWGGSLIRP EATGYGLVYY TQAMIDYATN GKESFEGKRV TISGSGNVAQ FAALKVIELG 

       250        260        270        280        290        300 
GTVVSLSDSK GCIISETGIT SEQVADISSA KVNFKSLEQI VGEYSTFTEN KVQYISGARP 

       310        320        330        340        350        360 
WTHVQKVDIA LPCATQNEVS GDEAKALVAQ GVKFVAEGSN MGSTPEAIAV FETARATAST 

       370        380        390        400        410        420 
LKESVWYGPP KAANLGGVAV SGLEMAQNSQ RITWSSERVD QELKKIMVNC FNECIDSAKK 

       430        440        450 
YTKEGNALPS LVKGANIASF IKVSDAMFDQ GDVF 

« Hide

References

[1]"New S. pastorianus strains and Saccharomyces natural hybrids revealed by polyphasis identification of CBS strains formerly uncompletely identified by conventional method."
Nguyen H.V.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 623-6C / CBS 9787 / CLIB 533.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ418037 Genomic DNA. Translation: CAD10750.1.

3D structure databases

ProteinModelPortalQ8TFF6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8TFF6. 1 interaction.
MINTMINT-1324351.

Proteomic databases

PRIDEQ8TFF6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFPIRSF000185. Glu_DH. 1 hit.
PRINTSPR00082. GLFDHDRGNASE.
SMARTSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHE4_SACU7
AccessionPrimary (citable) accession number: Q8TFF6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families