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Protein

NADP-specific glutamate dehydrogenase 1

Gene

GDH1

Organism
Saccharomyces uvarum (strain ATCC 76518 / CBS 7001 / CLIB 283 / NBRC 10550 / MCYC 623 / NCYC 2669 / NRRL Y-11845) (Yeast) (Saccharomyces bayanus var. uvarum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei110 – 1101PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi174 – 20330NADBy similarityAdd
BLAST

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase 1 (EC:1.4.1.4)
Short name:
NADP-GDH 1
Alternative name(s):
NADP-dependent glutamate dehydrogenase 1
Gene namesi
Name:GDH1
OrganismiSaccharomyces uvarum (strain ATCC 76518 / CBS 7001 / CLIB 283 / NBRC 10550 / MCYC 623 / NCYC 2669 / NRRL Y-11845) (Yeast) (Saccharomyces bayanus var. uvarum)
Taxonomic identifieri226127 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454NADP-specific glutamate dehydrogenase 1PRO_0000182797Add
BLAST

Proteomic databases

PRIDEiQ8TFF6.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

IntActiQ8TFF6. 1 interaction.
MINTiMINT-1324351.

Structurei

3D structure databases

ProteinModelPortaliQ8TFF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TFF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPEFQQAY DEVVSSLEDS TLFEQHPKYR KVLPIVSVPE RIIQFRVTWE
60 70 80 90 100
NDKGEQEVAQ GYRVQYNSAK GPYKGGLRFH PSVNLSILKF LGFEQIFKNS
110 120 130 140 150
LTGLDMGGGK GGLCVDLKGR SNNEIRRICY AFMRELSRHI GQDTDVPAGD
160 170 180 190 200
IGVGGREIGY LFGAYRTYKN SWEGVLTGKG LNWGGSLIRP EATGYGLVYY
210 220 230 240 250
TQAMIDYATN GKESFEGKRV TISGSGNVAQ FAALKVIELG GTVVSLSDSK
260 270 280 290 300
GCIISETGIT SEQVADISSA KVNFKSLEQI VGEYSTFTEN KVQYISGARP
310 320 330 340 350
WTHVQKVDIA LPCATQNEVS GDEAKALVAQ GVKFVAEGSN MGSTPEAIAV
360 370 380 390 400
FETARATAST LKESVWYGPP KAANLGGVAV SGLEMAQNSQ RITWSSERVD
410 420 430 440 450
QELKKIMVNC FNECIDSAKK YTKEGNALPS LVKGANIASF IKVSDAMFDQ

GDVF
Length:454
Mass (Da):49,425
Last modified:June 1, 2002 - v1
Checksum:i98DF52A68BDE0D12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ418037 Genomic DNA. Translation: CAD10750.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ418037 Genomic DNA. Translation: CAD10750.1.

3D structure databases

ProteinModelPortaliQ8TFF6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8TFF6. 1 interaction.
MINTiMINT-1324351.

Proteomic databases

PRIDEiQ8TFF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "New S. pastorianus strains and Saccharomyces natural hybrids revealed by polyphasis identification of CBS strains formerly uncompletely identified by conventional method."
    Nguyen H.V.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 623-6C / CBS 9787 / CLIB 533.

Entry informationi

Entry nameiDHE4_SACU7
AccessioniPrimary (citable) accession number: Q8TFF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: June 1, 2002
Last modified: October 1, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.