Q8TF72 (SHRM3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Shroom3

Alternative name(s):
Shroom-related protein
Short name=hShrmL

Gene names

Name:	SHROOM3
Synonyms:	KIAA1481, SHRML
ORF Names:	MSTP013

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1996 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays By similarity.
Subunit structure	Interacts with F-actin By similarity.
Subcellular location	Cell junction › adherens junction By similarity. Cytoplasm › cytoskeleton By similarity. Note: Colocalizes with F-actin in stress fibers and adherens junctions By similarity.
Domain	The ASD1 domain mediates F-actin binding By similarity. The ASD2 domain is required for apical constriction induction By similarity.
Sequence similarities	Belongs to the shroom family. Contains 1 ASD1 domain. Contains 1 ASD2 domain. Contains 1 PDZ (DHR) domain.
Caution	It is uncertain whether Met-1 or Met-2 is the initiator. Met-2 is more conserved than Met-1 among the orthologs.
Sequence caution	The sequence AAQ13515.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB84689.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Cell shape
Cellular component	Cell junction Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Actin-binding
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Inferred from electronic annotation. Source: Compara apical protein localization Inferred from sequence or structural similarity. Source: HGNC cell morphogenesis Inferred from sequence or structural similarity. Source: HGNC cellular pigment accumulation Inferred from sequence or structural similarity. Source: HGNC columnar/cuboidal epithelial cell development Inferred from electronic annotation. Source: Compara neural tube closure Inferred from electronic annotation. Source: Compara pattern specification process Inferred from sequence or structural similarity. Source: HGNC regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	adherens junction Inferred from sequence or structural similarity. Source: HGNC apical junction complex Inferred from sequence or structural similarity. Source: UniProtKB apical plasma membrane Inferred from sequence or structural similarity. Source: HGNC cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from sequence or structural similarity. Source: HGNC microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TF72-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TF72-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.
     126-153: SPEHLTSGPQHRKAAWSGGVKLRLKHRR → MAFYSTPEYDIQLARGLLSGMFLFATRR
     277-311: ISGRERSGSMDNTSARGGLLEGMRQADIRYVKTVY → KRVKTRDLPGSQSPGRAISRKTTMPTSGGGWREKA
     312-1996: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1996	1996	Protein Shroom3		PRO_0000286066
Regions
	Domain	25 – 110	86	PDZ
	Domain	928 – 1030	103	ASD1
	Domain	1669 – 1957	289	ASD2
Amino acid modifications
	Modified residue	439	1	Phosphoserine Ref.9
	Modified residue	443	1	Phosphoserine Ref.9
	Modified residue	890	1	Phosphoserine By similarity
	Modified residue	910	1	Phosphoserine Ref.8 Ref.9 Ref.10 Ref.11
	Modified residue	913	1	Phosphoserine Ref.8 Ref.9
	Modified residue	970	1	Phosphoserine Ref.11
	Modified residue	1221	1	Phosphoserine Ref.9
Natural variations
	Alternative sequence	1 – 125	125	Missing in isoform 2.		VSP_024965
	Alternative sequence	126 – 153	28	SPEHL…LKHRR → MAFYSTPEYDIQLARGLLSG MFLFATRR in isoform 2.		VSP_024966
	Alternative sequence	277 – 311	35	ISGRE…VKTVY → KRVKTRDLPGSQSPGRAISR KTTMPTSGGGWREKA in isoform 2.		VSP_024967
	Alternative sequence	312 – 1996	1685	Missing in isoform 2.		VSP_024968
	Natural variant	147	1	L → H. Corresponds to variant rs3821979 [ dbSNP | Ensembl ].		VAR_032062
	Natural variant	279	1	G → A. Ref.1 Corresponds to variant rs344140 [ dbSNP | Ensembl ].		VAR_032063
	Natural variant	469	1	P → A. Ref.1 Corresponds to variant rs344141 [ dbSNP | Ensembl ].		VAR_032064
	Natural variant	1290	1	P → L. Ref.1 Ref.4 Corresponds to variant rs3733242 [ dbSNP | Ensembl ].		VAR_032065
Experimental info
	Sequence conflict	153	1	R → S in BAB84689. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 13, 2010. Version 2. Checksum: 735F6CD20FF64BC6	FASTA	1,996	216,857
	10 20 30 40 50 60 MMRTTEDFHK PSATLNSNTA TKGRYIYLEA FLEGGAPWGF TLKGGLEHGE PLIISKVEEG 70 80 90 100 110 120 GKADTLSSKL QAGDEVVHIN EVTLSSSRKE AVSLVKGSYK TLRLVVRRDV CTDPGHADTG 130 140 150 160 170 180 ASNFVSPEHL TSGPQHRKAA WSGGVKLRLK HRRSEPAGRP HSWHTTKSGE KQPDASMMQI 190 200 210 220 230 240 SQGMIGPPWH QSYHSSSSTS DLSNYDHAYL RRSPDQCSSQ GSMESLEPSG AYPPCHLSPA 250 260 270 280 290 300 KSTGSIDQLS HFHNKRDSAY SSFSTSSSIL EYPHPGISGR ERSGSMDNTS ARGGLLEGMR 310 320 330 340 350 360 QADIRYVKTV YDTRRGVSAE YEVNSSALLL QGREARASAN GQGYDKWSNI PRGKGVPPPS 370 380 390 400 410 420 WSQQCPSSLE TATDNLPPKV GAPLPPARSD SYAAFRHRER PSSWSSLDQK RLCRPQANSL 430 440 450 460 470 480 GSLKSPFIEE QLHTVLEKSP ENSPPVKPKH NYTQKAQPGQ PLLPTSIYPV PSLEPHFAQV 490 500 510 520 530 540 PQPSVSSNGM LYPALAKESG YIAPQGACNK MATIDENGNQ NGSGRPGFAF CQPLEHDLLS 550 560 570 580 590 600 PVEKKPEATA KYVPSKVHFC SVPENEEDAS LKRHLTPPQG NSPHSNERKS THSNKPSSHP 610 620 630 640 650 660 HSLKCPQAQA WQAGEDKRSS RLSEPWEGDF QEDHNANLWR RLEREGLGQS LSGNFGKTKS 670 680 690 700 710 720 AFSSLQNIPE SLRRHSSLEL GRGTQEGYPG GRPTCAVNTK AEDPGRKAAP DLGSHLDRQV 730 740 750 760 770 780 SYPRPEGRTG ASASFNSTDP SPEEPPAPSH PHTSSLGRRG PGPGSASALQ GFQYGKPHCS 790 800 810 820 830 840 VLEKVSKFEQ REQGSQRPSV GGSGFGHNYR PHRTVSTSST SGNDFEETKA HIRFSESAEP 850 860 870 880 890 900 LGNGEQHFKN GELKLEEASR QPCGQQLSGG ASDSGRGPQR PDARLLRSQS TFQLSSEPER 910 920 930 940 950 960 EPEWRDRPGS PESPLLDAPF SRAYRNSIKD AQSRVLGATS FRRRDLELGA PVASRSWRPR 970 980 990 1000 1010 1020 PSSAHVGLRS PEASASASPH TPRERHSVTP AEGDLARPVP PAARRGARRR LTPEQKKRSY 1030 1040 1050 1060 1070 1080 SEPEKMNEVG IVEEAEPAPL GPQRNGMRFP ESSVADRRRL FERDGKACST LSLSGPELKQ 1090 1100 1110 1120 1130 1140 FQQSALADYI QRKTGKRPTS AAGCSLQEPG PLRERAQSAY LQPGPAALEG SGLASASSLS 1150 1160 1170 1180 1190 1200 SLREPSLQPR REATLLPATV AETQQAPRDR SSSFAGGRRL GERRRGDLLS GANGGTRGTQ 1210 1220 1230 1240 1250 1260 RGDETPREPS SWGARAGKSM SAEDLLERSD VLAGPVHVRS RSSPATADKR QDVLLGQDSG 1270 1280 1290 1300 1310 1320 FGLVKDPCYL AGPGSRSLSC SERGQEEMLP LFHHLTPRWG GSGCKAIGDS SVPSECPGTL 1330 1340 1350 1360 1370 1380 DHQRQASRTP CPRPPLAGTQ GLVTDTRAAP LTPIGTPLPS AIPSGYCSQD GQTGRQPLPP 1390 1400 1410 1420 1430 1440 YTPAMMHRSN GHTLTQPPGP RGCEGDGPEH GVEEGTRKRV SLPQWPPPSR AKWAHAARED 1450 1460 1470 1480 1490 1500 SLPEESSAPD FANLKHYQKQ QSLPSLCSTS DPDTPLGAPS TPGRISLRIS ESVLRDSPPP 1510 1520 1530 1540 1550 1560 HEDYEDEVFV RDPHPKATSS PTFEPLPPPP PPPPSQETPV YSMDDFPPPP PHTVCEAQLD 1570 1580 1590 1600 1610 1620 SEDPEGPRPS FNKLSKVTIA RERHMPGAAH VVGSQTLASR LQTSIKGSEA ESTPPSFMSV 1630 1640 1650 1660 1670 1680 HAQLAGSLGG QPAPIQTQSL SHDPVSGTQG LEKKVSPDPQ KSSEDIRTEA LAKEIVHQDK 1690 1700 1710 1720 1730 1740 SLADILDPDS RLKTTMDLME GLFPRDVNLL KENSVKRKAI QRTVSSSGCE GKRNEDKEAV 1750 1760 1770 1780 1790 1800 SMLVNCPAYY SVSAPKAELL NKIKEMPAEV NEEEEQADVN EKKAELIGSL THKLETLQEA 1810 1820 1830 1840 1850 1860 KGSLLTDIKL NNALGEEVEA LISELCKPNE FDKYRMFIGD LDKVVNLLLS LSGRLARVEN 1870 1880 1890 1900 1910 1920 VLSGLGEDAS NEERSSLYEK RKILAGQHED ARELKENLDR RERVVLGILA NYLSEEQLQD 1930 1940 1950 1960 1970 1980 YQHFVKMKST LLIEQRKLDD KIKLGQEQVK CLLESLPSDF IPKAGALALP PNLTSEPIPA 1990 GGCTFSGIFP TLTSPL
	Isoform 2 [UniParc]. Checksum: 5A9561BA6C6EF074	FASTA	186	20,457
	10 20 30 40 50 60 MAFYSTPEYD IQLARGLLSG MFLFATRRSE PAGRPHSWHT TKSGEKQPDA SMMQISQGMI 70 80 90 100 110 120 GPPWHQSYHS SSSTSDLSNY DHAYLRRSPD QCSSQGSMES LEPSGAYPPC HLSPAKSTGS 130 140 150 160 170 180 IDQLSHFHNK RDSAYSSFST SSSILEYPHP GKRVKTRDLP GSQSPGRAIS RKTTMPTSGG GWREKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of FKBP12-associated protein." Koide M., Iio A., Obata K., Inagaki M., Yokota M., Ono T., Tuan R.S. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ALA-279; ALA-469 AND LEU-1290.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Spleen.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 617-1996 (ISOFORM 1), VARIANT LEU-1290.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1230-1996 (ISOFORM 1). Tissue: Colon.
[6]	Hui R.T., Liu Y.Q., Liu B., Zhao B., Meng X.M., Sheng H., Xu Y.Y., Wang X.Y., Ye J., Song L., Gao Y., Wei Y.J., Zhang C.L., Zhang J., Chai M.Q., Chen J.Z., Sun Y.H., Zhou X.L. , Jiang Y.X., Zhao X.W., Liu S., Cao H.Q., Zhao Y., Liu D.Q., Ding J.F., Liu L.S., Gao R.L., Wu Q.Y., Qiang B.Q., Yuan J.G., Liew C.C., Zhao M.S. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1799-1996 (ISOFORM 1). Tissue: Aorta.
[7]	"A new standard nomenclature for proteins related to Apx and Shroom." Hagens O., Ballabio A., Kalscheuer V., Kraehenbuhl J.-P., Schiaffino M.V., Smith P., Staub O., Hildebrand J.D., Wallingford J.B. BMC Cell Biol. 7:18-18(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.
[8]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-910 AND SER-913, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439; SER-443; SER-910; SER-913 AND SER-1221, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-910, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-910 AND SER-970, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB055660 mRNA. Translation: BAB84689.1. Different initiation. AK127929 mRNA. Translation: BAC87195.1. AC096743 Genomic DNA. No translation available. AC107051 Genomic DNA. No translation available. AC107072 Genomic DNA. No translation available. AC112249 Genomic DNA. No translation available. AC121158 Genomic DNA. No translation available. AB040914 mRNA. Translation: BAA96005.1. BC007291 mRNA. Translation: AAH07291.1. AF109367 mRNA. Translation: AAQ13515.1. Different initiation.
IPI	IPI00152881. IPI01018742.
RefSeq	NP_065910.3. NM_020859.3.
UniGene	Hs.702168.
3D structure databases
HSSP	HSSP built from PDB template 1VB7 based on UniProtKB Q8R1G6.
ProteinModelPortal	Q8TF72.
SMR	Q8TF72. Positions 25-108, 1779-1955.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TF72. 2 interactions.
MINT	MINT-2812419.
STRING	9606.ENSP00000296043.
PTM databases
PhosphoSite	Q8TF72.
Polymorphism databases
DMDM	300669666.
Proteomic databases
PaxDb	Q8TF72.
PRIDE	Q8TF72.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000296043; ENSP00000296043; ENSG00000138771.
GeneID	57619.
KEGG	hsa:57619.
UCSC	uc003hkf.1. human.
Organism-specific databases
CTD	57619.
GeneCards	GC04P077356.
H-InvDB	HIX0004309. HIX0163999.
HGNC	HGNC:30422. SHROOM3.
HPA	HPA047784.
MIM	604570. gene.
neXtProt	NX_Q8TF72.
PharmGKB	PA147357295.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG72784.
HOGENOM	HOG000169233.
HOVERGEN	HBG108489.
InParanoid	Q8TF72.
OMA	RNSIKDA.
OrthoDB	EOG44QT03.
Gene expression databases
Bgee	Q8TF72.
CleanEx	HS_SHROOM3.
Genevestigator	Q8TF72.
Family and domain databases
InterPro	IPR014800. ASD1. IPR014799. ASD2. IPR001478. PDZ. [Graphical view]
Pfam	PF08688. ASD1. 1 hit. PF08687. ASD2. 1 hit. PF00595. PDZ. 1 hit. [Graphical view]
SMART	SM00228. PDZ. 1 hit. [Graphical view]
SUPFAM	SSF50156. PDZ. 1 hit.
PROSITE	PS51306. ASD1. 1 hit. PS51307. ASD2. 1 hit. PS50106. PDZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SHROOM3. human.
GenomeRNAi	57619.
NextBio	64290.
SOURCE	Search...

Entry information

Entry name

SHRM3_HUMAN

Accession

Primary (citable) accession number: Q8TF72
Secondary accession number(s): Q5QTQ3 , Q6ZRW3, Q96IR9, Q9P247

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	July 13, 2010
Last modified:	May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.