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Q8TF71

- MOT10_HUMAN

UniProt

Q8TF71 - MOT10_HUMAN

Protein

Monocarboxylate transporter 10

Gene

SLC16A10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells By similarity.By similarity

    GO - Biological processi

    1. amino acid transport Source: Reactome
    2. aromatic amino acid transport Source: HGNC
    3. ion transport Source: Reactome
    4. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

    Protein family/group databases

    TCDBi2.A.1.13.8. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Monocarboxylate transporter 10
    Short name:
    MCT 10
    Alternative name(s):
    Aromatic amino acid transporter 1
    Solute carrier family 16 member 10
    T-type amino acid transporter 1
    Gene namesi
    Name:SLC16A10
    Synonyms:MCT10, TAT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:17027. SLC16A10.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Basolateral cell membrane By similarity

    GO - Cellular componenti

    1. basolateral plasma membrane Source: HGNC
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38197.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 515515Monocarboxylate transporter 10PRO_0000314253Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei498 – 4981Phosphoserine1 Publication
    Modified residuei501 – 5011PhosphoserineBy similarity
    Modified residuei504 – 5041PhosphoserineBy similarity

    Post-translational modificationi

    Not N-glycosylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8TF71.
    PaxDbiQ8TF71.
    PRIDEiQ8TF71.

    PTM databases

    PhosphoSiteiQ8TF71.

    Expressioni

    Tissue specificityi

    Strongly expressed in kidney and skeletal muscle and at lower level in placenta and heart.1 Publication

    Gene expression databases

    ArrayExpressiQ8TF71.
    BgeeiQ8TF71.
    CleanExiHS_SLC16A10.
    GenevestigatoriQ8TF71.

    Organism-specific databases

    HPAiHPA016860.

    Interactioni

    Protein-protein interaction databases

    BioGridi125582. 1 interaction.
    STRINGi9606.ENSP00000357844.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TF71.
    SMRiQ8TF71. Positions 196-269.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6666ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini88 – 11427CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini136 – 1449ExtracellularSequence Analysis
    Topological domaini166 – 1716CytoplasmicSequence Analysis
    Topological domaini193 – 2008ExtracellularSequence Analysis
    Topological domaini222 – 2287CytoplasmicSequence Analysis
    Topological domaini250 – 29142ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini313 – 32917CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini351 – 3511ExtracellularSequence Analysis
    Topological domaini373 – 39624CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini418 – 4192ExtracellularSequence Analysis
    Topological domaini441 – 45111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini473 – 51543ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei67 – 8721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei115 – 13521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei292 – 31221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei330 – 35021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei352 – 37221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei397 – 41721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei420 – 44021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei452 – 47221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000046644.
    HOVERGENiHBG006387.
    InParanoidiQ8TF71.
    KOiK08187.
    OMAiHLMKHVN.
    OrthoDBiEOG7KWSH8.
    PhylomeDBiQ8TF71.
    TreeFamiTF313792.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TF71-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLSQEEPDS ARGTSEAQPL GPAPTGAAPP PGPGPSDSPE AAVEKVEVEL    50
    AGPATAEPHE PPEPPEGGWG WLVMLAAMWC NGSVFGIQNA CGVLFVSMLE 100
    TFGSKDDDKM VFKTAWVGSL SMGMIFFCCP IVSVFTDLFG CRKTAVVGAA 150
    VGFVGLMSSS FVSSIEPLYL TYGIIFACGC SFAYQPSLVI LGHYFKKRLG 200
    LVNGIVTAGS SVFTILLPLL LRVLIDSVGL FYTLRVLCIF MFVLFLAGFT 250
    YRPLATSTKD KESGGSGSSL FSRKKFSPPK KIFNFAIFKV TAYAVWAVGI 300
    PLALFGYFVP YVHLMKHVNE RFQDEKNKEV VLMCIGVTSG VGRLLFGRIA 350
    DYVPGVKKVY LQVLSFFFIG LMSMMIPLCS IFGALIAVCL IMGLFDGCFI 400
    SIMAPIAFEL VGAQDVSQAI GFLLGFMSIP MTVGPPIAGL LRDKLGSYDV 450
    AFYLAGVPPL IGGAVLCFIP WIHSKKQREI SKTTGKEKME KMLENQNSLL 500
    SSSSGMFKKE SDSII 515
    Length:515
    Mass (Da):55,493
    Last modified:June 1, 2002 - v1
    Checksum:iA870E4DDC26B918E
    GO

    Sequence cautioni

    The sequence AAH17968.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti422 – 4221F → L in AAH17968. (PubMed:15489334)Curated
    Sequence conflicti431 – 4311M → T in BAD18768. (PubMed:14702039)Curated
    Sequence conflicti443 – 4431D → G in BAD18768. (PubMed:14702039)Curated
    Sequence conflicti508 – 5081K → E in AAH17968. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti508 – 5081K → Q.
    Corresponds to variant rs17072442 [ dbSNP | Ensembl ].
    VAR_037874

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB057445 mRNA. Translation: BAB84670.1.
    AK126183 mRNA. Translation: BAG54292.1.
    AK172789 mRNA. Translation: BAD18768.1.
    AL360227 Genomic DNA. Translation: CAH73732.1.
    CH471051 Genomic DNA. Translation: EAW48298.1.
    BC017968 mRNA. Translation: AAH17968.1. Different initiation.
    BC066985 mRNA. Translation: AAH66985.1.
    CCDSiCCDS5089.1.
    RefSeqiNP_061063.2. NM_018593.4.
    UniGeneiHs.591327.

    Genome annotation databases

    EnsembliENST00000368851; ENSP00000357844; ENSG00000112394.
    GeneIDi117247.
    KEGGihsa:117247.
    UCSCiuc003pur.4. human.

    Polymorphism databases

    DMDMi74751472.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB057445 mRNA. Translation: BAB84670.1 .
    AK126183 mRNA. Translation: BAG54292.1 .
    AK172789 mRNA. Translation: BAD18768.1 .
    AL360227 Genomic DNA. Translation: CAH73732.1 .
    CH471051 Genomic DNA. Translation: EAW48298.1 .
    BC017968 mRNA. Translation: AAH17968.1 . Different initiation.
    BC066985 mRNA. Translation: AAH66985.1 .
    CCDSi CCDS5089.1.
    RefSeqi NP_061063.2. NM_018593.4.
    UniGenei Hs.591327.

    3D structure databases

    ProteinModelPortali Q8TF71.
    SMRi Q8TF71. Positions 196-269.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125582. 1 interaction.
    STRINGi 9606.ENSP00000357844.

    Protein family/group databases

    TCDBi 2.A.1.13.8. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q8TF71.

    Polymorphism databases

    DMDMi 74751472.

    Proteomic databases

    MaxQBi Q8TF71.
    PaxDbi Q8TF71.
    PRIDEi Q8TF71.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368851 ; ENSP00000357844 ; ENSG00000112394 .
    GeneIDi 117247.
    KEGGi hsa:117247.
    UCSCi uc003pur.4. human.

    Organism-specific databases

    CTDi 117247.
    GeneCardsi GC06P111454.
    HGNCi HGNC:17027. SLC16A10.
    HPAi HPA016860.
    MIMi 607550. gene.
    neXtProti NX_Q8TF71.
    PharmGKBi PA38197.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000046644.
    HOVERGENi HBG006387.
    InParanoidi Q8TF71.
    KOi K08187.
    OMAi HLMKHVN.
    OrthoDBi EOG7KWSH8.
    PhylomeDBi Q8TF71.
    TreeFami TF313792.

    Enzyme and pathway databases

    Reactomei REACT_13796. Amino acid transport across the plasma membrane.

    Miscellaneous databases

    GeneWikii SLC16A10.
    GenomeRNAii 117247.
    NextBioi 80178.
    PROi Q8TF71.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TF71.
    Bgeei Q8TF71.
    CleanExi HS_SLC16A10.
    Genevestigatori Q8TF71.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location."
      Kim D.K., Kanai Y., Matsuo H., Kim J.Y., Chairoungdua A., Kobayashi Y., Enomoto A., Cha S.H., Goya T., Endou H.
      Genomics 79:95-103(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION.
      Tissue: Thymus.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta, Prostate and Testis.
    6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-498, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMOT10_HUMAN
    AccessioniPrimary (citable) accession number: Q8TF71
    Secondary accession number(s): B3KWY0, Q6ZMG0, Q8WVI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3