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Protein

Monocarboxylate transporter 10

Gene

SLC16A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).By similarity

GO - Molecular functioni

  1. transporter activity Source: GO_Central

GO - Biological processi

  1. amino acid transport Source: Reactome
  2. aromatic amino acid transport Source: HGNC
  3. ion transmembrane transport Source: GO_Central
  4. ion transport Source: Reactome
  5. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.1.13.8. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 10
Short name:
MCT 10
Alternative name(s):
Aromatic amino acid transporter 1
Solute carrier family 16 member 10
T-type amino acid transporter 1
Gene namesi
Name:SLC16A10
Synonyms:MCT10, TAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:17027. SLC16A10.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity. Basolateral cell membrane By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6666ExtracellularSequence AnalysisAdd
BLAST
Transmembranei67 – 8721HelicalSequence AnalysisAdd
BLAST
Topological domaini88 – 11427CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence AnalysisAdd
BLAST
Topological domaini136 – 1449ExtracellularSequence Analysis
Transmembranei145 – 16521HelicalSequence AnalysisAdd
BLAST
Topological domaini166 – 1716CytoplasmicSequence Analysis
Transmembranei172 – 19221HelicalSequence AnalysisAdd
BLAST
Topological domaini193 – 2008ExtracellularSequence Analysis
Transmembranei201 – 22121HelicalSequence AnalysisAdd
BLAST
Topological domaini222 – 2287CytoplasmicSequence Analysis
Transmembranei229 – 24921HelicalSequence AnalysisAdd
BLAST
Topological domaini250 – 29142ExtracellularSequence AnalysisAdd
BLAST
Transmembranei292 – 31221HelicalSequence AnalysisAdd
BLAST
Topological domaini313 – 32917CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence AnalysisAdd
BLAST
Topological domaini351 – 3511ExtracellularSequence Analysis
Transmembranei352 – 37221HelicalSequence AnalysisAdd
BLAST
Topological domaini373 – 39624CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei397 – 41721HelicalSequence AnalysisAdd
BLAST
Topological domaini418 – 4192ExtracellularSequence Analysis
Transmembranei420 – 44021HelicalSequence AnalysisAdd
BLAST
Topological domaini441 – 45111CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei452 – 47221HelicalSequence AnalysisAdd
BLAST
Topological domaini473 – 51543ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: HGNC
  2. integral component of membrane Source: GO_Central
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38197.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Monocarboxylate transporter 10PRO_0000314253Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei498 – 4981Phosphoserine2 Publications
Modified residuei501 – 5011Phosphoserine1 Publication
Modified residuei504 – 5041PhosphoserineBy similarity

Post-translational modificationi

Not N-glycosylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8TF71.
PaxDbiQ8TF71.
PRIDEiQ8TF71.

PTM databases

PhosphoSiteiQ8TF71.

Expressioni

Tissue specificityi

Strongly expressed in kidney and skeletal muscle and at lower level in placenta and heart.1 Publication

Gene expression databases

BgeeiQ8TF71.
CleanExiHS_SLC16A10.
ExpressionAtlasiQ8TF71. baseline and differential.
GenevestigatoriQ8TF71.

Organism-specific databases

HPAiHPA016860.

Interactioni

Protein-protein interaction databases

BioGridi125582. 1 interaction.
STRINGi9606.ENSP00000357844.

Structurei

3D structure databases

ProteinModelPortaliQ8TF71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00740000115479.
HOGENOMiHOG000046644.
HOVERGENiHBG006387.
InParanoidiQ8TF71.
KOiK08187.
OMAiHLMKHVN.
OrthoDBiEOG7KWSH8.
PhylomeDBiQ8TF71.
TreeFamiTF313792.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TF71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSQEEPDS ARGTSEAQPL GPAPTGAAPP PGPGPSDSPE AAVEKVEVEL
60 70 80 90 100
AGPATAEPHE PPEPPEGGWG WLVMLAAMWC NGSVFGIQNA CGVLFVSMLE
110 120 130 140 150
TFGSKDDDKM VFKTAWVGSL SMGMIFFCCP IVSVFTDLFG CRKTAVVGAA
160 170 180 190 200
VGFVGLMSSS FVSSIEPLYL TYGIIFACGC SFAYQPSLVI LGHYFKKRLG
210 220 230 240 250
LVNGIVTAGS SVFTILLPLL LRVLIDSVGL FYTLRVLCIF MFVLFLAGFT
260 270 280 290 300
YRPLATSTKD KESGGSGSSL FSRKKFSPPK KIFNFAIFKV TAYAVWAVGI
310 320 330 340 350
PLALFGYFVP YVHLMKHVNE RFQDEKNKEV VLMCIGVTSG VGRLLFGRIA
360 370 380 390 400
DYVPGVKKVY LQVLSFFFIG LMSMMIPLCS IFGALIAVCL IMGLFDGCFI
410 420 430 440 450
SIMAPIAFEL VGAQDVSQAI GFLLGFMSIP MTVGPPIAGL LRDKLGSYDV
460 470 480 490 500
AFYLAGVPPL IGGAVLCFIP WIHSKKQREI SKTTGKEKME KMLENQNSLL
510
SSSSGMFKKE SDSII
Length:515
Mass (Da):55,493
Last modified:June 1, 2002 - v1
Checksum:iA870E4DDC26B918E
GO

Sequence cautioni

The sequence AAH17968.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti422 – 4221F → L in AAH17968 (PubMed:15489334).Curated
Sequence conflicti431 – 4311M → T in BAD18768 (PubMed:14702039).Curated
Sequence conflicti443 – 4431D → G in BAD18768 (PubMed:14702039).Curated
Sequence conflicti508 – 5081K → E in AAH17968 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti508 – 5081K → Q.
Corresponds to variant rs17072442 [ dbSNP | Ensembl ].
VAR_037874

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB057445 mRNA. Translation: BAB84670.1.
AK126183 mRNA. Translation: BAG54292.1.
AK172789 mRNA. Translation: BAD18768.1.
AL360227 Genomic DNA. Translation: CAH73732.1.
CH471051 Genomic DNA. Translation: EAW48298.1.
BC017968 mRNA. Translation: AAH17968.1. Different initiation.
BC066985 mRNA. Translation: AAH66985.1.
CCDSiCCDS5089.1.
RefSeqiNP_061063.2. NM_018593.4.
UniGeneiHs.591327.

Genome annotation databases

EnsembliENST00000368851; ENSP00000357844; ENSG00000112394.
GeneIDi117247.
KEGGihsa:117247.
UCSCiuc003pur.4. human.

Polymorphism databases

DMDMi74751472.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB057445 mRNA. Translation: BAB84670.1.
AK126183 mRNA. Translation: BAG54292.1.
AK172789 mRNA. Translation: BAD18768.1.
AL360227 Genomic DNA. Translation: CAH73732.1.
CH471051 Genomic DNA. Translation: EAW48298.1.
BC017968 mRNA. Translation: AAH17968.1. Different initiation.
BC066985 mRNA. Translation: AAH66985.1.
CCDSiCCDS5089.1.
RefSeqiNP_061063.2. NM_018593.4.
UniGeneiHs.591327.

3D structure databases

ProteinModelPortaliQ8TF71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125582. 1 interaction.
STRINGi9606.ENSP00000357844.

Chemistry

DrugBankiDB06262. Droxidopa.
DB00145. Glycine.
DB00160. L-Alanine.
DB00125. L-Arginine.
DB00174. L-Asparagine.
DB00128. L-Aspartic Acid.
DB00151. L-Cysteine.
DB00138. L-Cystine.
DB01235. L-DOPA.
DB00130. L-Glutamine.
DB00117. L-Histidine.
DB00167. L-Isoleucine.
DB00149. L-Leucine.
DB00123. L-Lysine.
DB00134. L-Methionine.
DB00120. L-Phenylalanine.
DB00172. L-Proline.
DB00133. L-Serine.
DB00156. L-Threonine.
DB00150. L-Tryptophan.
DB00135. L-Tyrosine.
DB00161. L-Valine.
DB00279. Liothyronine.
DB01583. Liotrix.
DB00119. Pyruvic acid.

Protein family/group databases

TCDBi2.A.1.13.8. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteiQ8TF71.

Polymorphism databases

DMDMi74751472.

Proteomic databases

MaxQBiQ8TF71.
PaxDbiQ8TF71.
PRIDEiQ8TF71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368851; ENSP00000357844; ENSG00000112394.
GeneIDi117247.
KEGGihsa:117247.
UCSCiuc003pur.4. human.

Organism-specific databases

CTDi117247.
GeneCardsiGC06P111454.
HGNCiHGNC:17027. SLC16A10.
HPAiHPA016860.
MIMi607550. gene.
neXtProtiNX_Q8TF71.
PharmGKBiPA38197.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00740000115479.
HOGENOMiHOG000046644.
HOVERGENiHBG006387.
InParanoidiQ8TF71.
KOiK08187.
OMAiHLMKHVN.
OrthoDBiEOG7KWSH8.
PhylomeDBiQ8TF71.
TreeFamiTF313792.

Enzyme and pathway databases

ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

Miscellaneous databases

GeneWikiiSLC16A10.
GenomeRNAii117247.
NextBioi80178.
PROiQ8TF71.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TF71.
CleanExiHS_SLC16A10.
ExpressionAtlasiQ8TF71. baseline and differential.
GenevestigatoriQ8TF71.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location."
    Kim D.K., Kanai Y., Matsuo H., Kim J.Y., Chairoungdua A., Kobayashi Y., Enomoto A., Cha S.H., Goya T., Endou H.
    Genomics 79:95-103(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION.
    Tissue: Thymus.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta, Prostate and Testis.
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-498, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-498 AND SER-501, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMOT10_HUMAN
AccessioniPrimary (citable) accession number: Q8TF71
Secondary accession number(s): B3KWY0, Q6ZMG0, Q8WVI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2002
Last modified: March 4, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.