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Q8TF71

- MOT10_HUMAN

UniProt

Q8TF71 - MOT10_HUMAN

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Protein
Monocarboxylate transporter 10
Gene
SLC16A10, MCT10, TAT1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells By similarity.1 Publication

GO - Biological processi

  1. amino acid transport Source: Reactome
  2. aromatic amino acid transport Source: HGNC
  3. ion transport Source: Reactome
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_13796. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.1.13.8. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 10
Short name:
MCT 10
Alternative name(s):
Aromatic amino acid transporter 1
Solute carrier family 16 member 10
T-type amino acid transporter 1
Gene namesi
Synonyms:MCT10, TAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:17027. SLC16A10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6666Extracellular Reviewed prediction
Add
BLAST
Transmembranei67 – 8721Helical; Reviewed prediction
Add
BLAST
Topological domaini88 – 11427Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei115 – 13521Helical; Reviewed prediction
Add
BLAST
Topological domaini136 – 1449Extracellular Reviewed prediction
Transmembranei145 – 16521Helical; Reviewed prediction
Add
BLAST
Topological domaini166 – 1716Cytoplasmic Reviewed prediction
Transmembranei172 – 19221Helical; Reviewed prediction
Add
BLAST
Topological domaini193 – 2008Extracellular Reviewed prediction
Transmembranei201 – 22121Helical; Reviewed prediction
Add
BLAST
Topological domaini222 – 2287Cytoplasmic Reviewed prediction
Transmembranei229 – 24921Helical; Reviewed prediction
Add
BLAST
Topological domaini250 – 29142Extracellular Reviewed prediction
Add
BLAST
Transmembranei292 – 31221Helical; Reviewed prediction
Add
BLAST
Topological domaini313 – 32917Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei330 – 35021Helical; Reviewed prediction
Add
BLAST
Topological domaini351 – 3511Extracellular Reviewed prediction
Transmembranei352 – 37221Helical; Reviewed prediction
Add
BLAST
Topological domaini373 – 39624Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei397 – 41721Helical; Reviewed prediction
Add
BLAST
Topological domaini418 – 4192Extracellular Reviewed prediction
Transmembranei420 – 44021Helical; Reviewed prediction
Add
BLAST
Topological domaini441 – 45111Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei452 – 47221Helical; Reviewed prediction
Add
BLAST
Topological domaini473 – 51543Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: HGNC
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38197.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Monocarboxylate transporter 10
PRO_0000314253Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei498 – 4981Phosphoserine1 Publication
Modified residuei501 – 5011Phosphoserine By similarity
Modified residuei504 – 5041Phosphoserine By similarity

Post-translational modificationi

Not N-glycosylated By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8TF71.
PaxDbiQ8TF71.
PRIDEiQ8TF71.

PTM databases

PhosphoSiteiQ8TF71.

Expressioni

Tissue specificityi

Strongly expressed in kidney and skeletal muscle and at lower level in placenta and heart.1 Publication

Gene expression databases

ArrayExpressiQ8TF71.
BgeeiQ8TF71.
CleanExiHS_SLC16A10.
GenevestigatoriQ8TF71.

Organism-specific databases

HPAiHPA016860.

Interactioni

Protein-protein interaction databases

BioGridi125582. 1 interaction.
STRINGi9606.ENSP00000357844.

Structurei

3D structure databases

ProteinModelPortaliQ8TF71.
SMRiQ8TF71. Positions 196-269.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000046644.
HOVERGENiHBG006387.
InParanoidiQ8TF71.
KOiK08187.
OMAiHLMKHVN.
OrthoDBiEOG7KWSH8.
PhylomeDBiQ8TF71.
TreeFamiTF313792.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TF71-1 [UniParc]FASTAAdd to Basket

« Hide

MVLSQEEPDS ARGTSEAQPL GPAPTGAAPP PGPGPSDSPE AAVEKVEVEL    50
AGPATAEPHE PPEPPEGGWG WLVMLAAMWC NGSVFGIQNA CGVLFVSMLE 100
TFGSKDDDKM VFKTAWVGSL SMGMIFFCCP IVSVFTDLFG CRKTAVVGAA 150
VGFVGLMSSS FVSSIEPLYL TYGIIFACGC SFAYQPSLVI LGHYFKKRLG 200
LVNGIVTAGS SVFTILLPLL LRVLIDSVGL FYTLRVLCIF MFVLFLAGFT 250
YRPLATSTKD KESGGSGSSL FSRKKFSPPK KIFNFAIFKV TAYAVWAVGI 300
PLALFGYFVP YVHLMKHVNE RFQDEKNKEV VLMCIGVTSG VGRLLFGRIA 350
DYVPGVKKVY LQVLSFFFIG LMSMMIPLCS IFGALIAVCL IMGLFDGCFI 400
SIMAPIAFEL VGAQDVSQAI GFLLGFMSIP MTVGPPIAGL LRDKLGSYDV 450
AFYLAGVPPL IGGAVLCFIP WIHSKKQREI SKTTGKEKME KMLENQNSLL 500
SSSSGMFKKE SDSII 515
Length:515
Mass (Da):55,493
Last modified:June 1, 2002 - v1
Checksum:iA870E4DDC26B918E
GO

Sequence cautioni

The sequence AAH17968.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti508 – 5081K → Q.
Corresponds to variant rs17072442 [ dbSNP | Ensembl ].
VAR_037874

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti422 – 4221F → L in AAH17968. 1 Publication
Sequence conflicti431 – 4311M → T in BAD18768. 1 Publication
Sequence conflicti443 – 4431D → G in BAD18768. 1 Publication
Sequence conflicti508 – 5081K → E in AAH17968. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB057445 mRNA. Translation: BAB84670.1.
AK126183 mRNA. Translation: BAG54292.1.
AK172789 mRNA. Translation: BAD18768.1.
AL360227 Genomic DNA. Translation: CAH73732.1.
CH471051 Genomic DNA. Translation: EAW48298.1.
BC017968 mRNA. Translation: AAH17968.1. Different initiation.
BC066985 mRNA. Translation: AAH66985.1.
CCDSiCCDS5089.1.
RefSeqiNP_061063.2. NM_018593.4.
UniGeneiHs.591327.

Genome annotation databases

EnsembliENST00000368851; ENSP00000357844; ENSG00000112394.
GeneIDi117247.
KEGGihsa:117247.
UCSCiuc003pur.4. human.

Polymorphism databases

DMDMi74751472.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB057445 mRNA. Translation: BAB84670.1 .
AK126183 mRNA. Translation: BAG54292.1 .
AK172789 mRNA. Translation: BAD18768.1 .
AL360227 Genomic DNA. Translation: CAH73732.1 .
CH471051 Genomic DNA. Translation: EAW48298.1 .
BC017968 mRNA. Translation: AAH17968.1 . Different initiation.
BC066985 mRNA. Translation: AAH66985.1 .
CCDSi CCDS5089.1.
RefSeqi NP_061063.2. NM_018593.4.
UniGenei Hs.591327.

3D structure databases

ProteinModelPortali Q8TF71.
SMRi Q8TF71. Positions 196-269.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125582. 1 interaction.
STRINGi 9606.ENSP00000357844.

Protein family/group databases

TCDBi 2.A.1.13.8. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei Q8TF71.

Polymorphism databases

DMDMi 74751472.

Proteomic databases

MaxQBi Q8TF71.
PaxDbi Q8TF71.
PRIDEi Q8TF71.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368851 ; ENSP00000357844 ; ENSG00000112394 .
GeneIDi 117247.
KEGGi hsa:117247.
UCSCi uc003pur.4. human.

Organism-specific databases

CTDi 117247.
GeneCardsi GC06P111454.
HGNCi HGNC:17027. SLC16A10.
HPAi HPA016860.
MIMi 607550. gene.
neXtProti NX_Q8TF71.
PharmGKBi PA38197.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000046644.
HOVERGENi HBG006387.
InParanoidi Q8TF71.
KOi K08187.
OMAi HLMKHVN.
OrthoDBi EOG7KWSH8.
PhylomeDBi Q8TF71.
TreeFami TF313792.

Enzyme and pathway databases

Reactomei REACT_13796. Amino acid transport across the plasma membrane.

Miscellaneous databases

GeneWikii SLC16A10.
GenomeRNAii 117247.
NextBioi 80178.
PROi Q8TF71.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8TF71.
Bgeei Q8TF71.
CleanExi HS_SLC16A10.
Genevestigatori Q8TF71.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location."
    Kim D.K., Kanai Y., Matsuo H., Kim J.Y., Chairoungdua A., Kobayashi Y., Enomoto A., Cha S.H., Goya T., Endou H.
    Genomics 79:95-103(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION.
    Tissue: Thymus.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta, Prostate and Testis.
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-498, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMOT10_HUMAN
AccessioniPrimary (citable) accession number: Q8TF71
Secondary accession number(s): B3KWY0, Q6ZMG0, Q8WVI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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