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Protein

Monocarboxylate transporter 10

Gene

SLC16A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • amino acid transport Source: Reactome
  • aromatic amino acid transport Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112394-MONOMER.
ReactomeiR-HSA-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.1.13.8. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 10
Short name:
MCT 10
Alternative name(s):
Aromatic amino acid transporter 1
Solute carrier family 16 member 10
T-type amino acid transporter 1
Gene namesi
Name:SLC16A10
Synonyms:MCT10, TAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:17027. SLC16A10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 66CytoplasmicSequence analysisAdd BLAST66
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Transmembranei397 – 417HelicalSequence analysisAdd BLAST21
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Topological domaini473 – 515CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi117247.
OpenTargetsiENSG00000112394.
PharmGKBiPA38197.

Chemistry databases

DrugBankiDB06262. Droxidopa.
DB00145. Glycine.
DB00160. L-Alanine.
DB00125. L-Arginine.
DB00174. L-Asparagine.
DB00128. L-Aspartic Acid.
DB00151. L-Cysteine.
DB00138. L-Cystine.
DB00130. L-Glutamine.
DB00117. L-Histidine.
DB00167. L-Isoleucine.
DB00149. L-Leucine.
DB00123. L-Lysine.
DB00134. L-Methionine.
DB00120. L-Phenylalanine.
DB00172. L-Proline.
DB00133. L-Serine.
DB00156. L-Threonine.
DB00150. L-Tryptophan.
DB00135. L-Tyrosine.
DB00161. L-Valine.
DB04398. Lactic Acid.
DB01235. Levodopa.
DB00279. Liothyronine.
DB01583. Liotrix.
DB00119. Pyruvic acid.

Polymorphism and mutation databases

BioMutaiSLC16A10.
DMDMi74751472.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003142531 – 515Monocarboxylate transporter 10Add BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei263PhosphoserineBy similarity1
Modified residuei498PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1
Modified residuei503PhosphoserineBy similarity1
Modified residuei504PhosphoserineBy similarity1

Post-translational modificationi

Not N-glycosylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TF71.
MaxQBiQ8TF71.
PaxDbiQ8TF71.
PeptideAtlasiQ8TF71.
PRIDEiQ8TF71.

PTM databases

iPTMnetiQ8TF71.
PhosphoSitePlusiQ8TF71.

Expressioni

Tissue specificityi

Strongly expressed in kidney and skeletal muscle and at lower level in placenta and heart.1 Publication

Gene expression databases

BgeeiENSG00000112394.
CleanExiHS_SLC16A10.
ExpressionAtlasiQ8TF71. baseline and differential.
GenevisibleiQ8TF71. HS.

Organism-specific databases

HPAiHPA016860.

Interactioni

Protein-protein interaction databases

BioGridi125582. 13 interactors.
STRINGi9606.ENSP00000357844.

Structurei

3D structure databases

ProteinModelPortaliQ8TF71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00740000115479.
HOGENOMiHOG000046644.
HOVERGENiHBG006387.
InParanoidiQ8TF71.
KOiK08187.
OMAiHLMKHVN.
OrthoDBiEOG091G0449.
PhylomeDBiQ8TF71.
TreeFamiTF313792.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR030762. MCT10.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF119. PTHR11360:SF119. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TF71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSQEEPDS ARGTSEAQPL GPAPTGAAPP PGPGPSDSPE AAVEKVEVEL
60 70 80 90 100
AGPATAEPHE PPEPPEGGWG WLVMLAAMWC NGSVFGIQNA CGVLFVSMLE
110 120 130 140 150
TFGSKDDDKM VFKTAWVGSL SMGMIFFCCP IVSVFTDLFG CRKTAVVGAA
160 170 180 190 200
VGFVGLMSSS FVSSIEPLYL TYGIIFACGC SFAYQPSLVI LGHYFKKRLG
210 220 230 240 250
LVNGIVTAGS SVFTILLPLL LRVLIDSVGL FYTLRVLCIF MFVLFLAGFT
260 270 280 290 300
YRPLATSTKD KESGGSGSSL FSRKKFSPPK KIFNFAIFKV TAYAVWAVGI
310 320 330 340 350
PLALFGYFVP YVHLMKHVNE RFQDEKNKEV VLMCIGVTSG VGRLLFGRIA
360 370 380 390 400
DYVPGVKKVY LQVLSFFFIG LMSMMIPLCS IFGALIAVCL IMGLFDGCFI
410 420 430 440 450
SIMAPIAFEL VGAQDVSQAI GFLLGFMSIP MTVGPPIAGL LRDKLGSYDV
460 470 480 490 500
AFYLAGVPPL IGGAVLCFIP WIHSKKQREI SKTTGKEKME KMLENQNSLL
510
SSSSGMFKKE SDSII
Length:515
Mass (Da):55,493
Last modified:June 1, 2002 - v1
Checksum:iA870E4DDC26B918E
GO

Sequence cautioni

The sequence AAH17968 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti422F → L in AAH17968 (PubMed:15489334).Curated1
Sequence conflicti431M → T in BAD18768 (PubMed:14702039).Curated1
Sequence conflicti443D → G in BAD18768 (PubMed:14702039).Curated1
Sequence conflicti508K → E in AAH17968 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037874508K → Q.Corresponds to variant rs17072442dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB057445 mRNA. Translation: BAB84670.1.
AK126183 mRNA. Translation: BAG54292.1.
AK172789 mRNA. Translation: BAD18768.1.
AL360227 Genomic DNA. Translation: CAH73732.1.
CH471051 Genomic DNA. Translation: EAW48298.1.
BC017968 mRNA. Translation: AAH17968.1. Different initiation.
BC066985 mRNA. Translation: AAH66985.1.
CCDSiCCDS5089.1.
RefSeqiNP_061063.2. NM_018593.4.
UniGeneiHs.591327.

Genome annotation databases

EnsembliENST00000368851; ENSP00000357844; ENSG00000112394.
GeneIDi117247.
KEGGihsa:117247.
UCSCiuc003pus.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB057445 mRNA. Translation: BAB84670.1.
AK126183 mRNA. Translation: BAG54292.1.
AK172789 mRNA. Translation: BAD18768.1.
AL360227 Genomic DNA. Translation: CAH73732.1.
CH471051 Genomic DNA. Translation: EAW48298.1.
BC017968 mRNA. Translation: AAH17968.1. Different initiation.
BC066985 mRNA. Translation: AAH66985.1.
CCDSiCCDS5089.1.
RefSeqiNP_061063.2. NM_018593.4.
UniGeneiHs.591327.

3D structure databases

ProteinModelPortaliQ8TF71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125582. 13 interactors.
STRINGi9606.ENSP00000357844.

Chemistry databases

DrugBankiDB06262. Droxidopa.
DB00145. Glycine.
DB00160. L-Alanine.
DB00125. L-Arginine.
DB00174. L-Asparagine.
DB00128. L-Aspartic Acid.
DB00151. L-Cysteine.
DB00138. L-Cystine.
DB00130. L-Glutamine.
DB00117. L-Histidine.
DB00167. L-Isoleucine.
DB00149. L-Leucine.
DB00123. L-Lysine.
DB00134. L-Methionine.
DB00120. L-Phenylalanine.
DB00172. L-Proline.
DB00133. L-Serine.
DB00156. L-Threonine.
DB00150. L-Tryptophan.
DB00135. L-Tyrosine.
DB00161. L-Valine.
DB04398. Lactic Acid.
DB01235. Levodopa.
DB00279. Liothyronine.
DB01583. Liotrix.
DB00119. Pyruvic acid.

Protein family/group databases

TCDBi2.A.1.13.8. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ8TF71.
PhosphoSitePlusiQ8TF71.

Polymorphism and mutation databases

BioMutaiSLC16A10.
DMDMi74751472.

Proteomic databases

EPDiQ8TF71.
MaxQBiQ8TF71.
PaxDbiQ8TF71.
PeptideAtlasiQ8TF71.
PRIDEiQ8TF71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368851; ENSP00000357844; ENSG00000112394.
GeneIDi117247.
KEGGihsa:117247.
UCSCiuc003pus.4. human.

Organism-specific databases

CTDi117247.
DisGeNETi117247.
GeneCardsiSLC16A10.
HGNCiHGNC:17027. SLC16A10.
HPAiHPA016860.
MIMi607550. gene.
neXtProtiNX_Q8TF71.
OpenTargetsiENSG00000112394.
PharmGKBiPA38197.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00740000115479.
HOGENOMiHOG000046644.
HOVERGENiHBG006387.
InParanoidiQ8TF71.
KOiK08187.
OMAiHLMKHVN.
OrthoDBiEOG091G0449.
PhylomeDBiQ8TF71.
TreeFamiTF313792.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112394-MONOMER.
ReactomeiR-HSA-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

GeneWikiiSLC16A10.
GenomeRNAii117247.
PROiQ8TF71.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112394.
CleanExiHS_SLC16A10.
ExpressionAtlasiQ8TF71. baseline and differential.
GenevisibleiQ8TF71. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR030762. MCT10.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF119. PTHR11360:SF119. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOT10_HUMAN
AccessioniPrimary (citable) accession number: Q8TF71
Secondary accession number(s): B3KWY0, Q6ZMG0, Q8WVI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.