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Protein

Leucine-rich repeat-containing protein 15

Gene

LRRC15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • fibronectin binding Source: UniProtKB
  • laminin binding Source: UniProtKB
  • protein kinase inhibitor activity Source: GO_Central

GO - Biological processi

  • cytokine-mediated signaling pathway Source: GO_Central
  • negative regulation of establishment of protein localization to plasma membrane Source: UniProtKB
  • negative regulation of JAK-STAT cascade Source: GO_Central
  • negative regulation of protein kinase activity Source: GO_Central
  • positive regulation of cell migration Source: UniProtKB
  • receptor-mediated virion attachment to host cell Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172061-MONOMER.
ZFISH:ENSG00000179796-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 15
Alternative name(s):
Leucine-rich repeat protein induced by beta-amyloid homolog
Short name:
hLib
Gene namesi
Name:LRRC15
Synonyms:LIB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:20818. LRRC15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 538ExtracellularSequence analysisAdd BLAST517
Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Topological domaini560 – 581CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi131578.
OpenTargetsiENSG00000172061.
PharmGKBiPA134956867.

Polymorphism and mutation databases

BioMutaiLRRC15.
DMDMi334302830.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002160522 – 581Leucine-rich repeat-containing protein 15Add BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi369N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8TF66.
MaxQBiQ8TF66.
PaxDbiQ8TF66.
PeptideAtlasiQ8TF66.
PRIDEiQ8TF66.

PTM databases

iPTMnetiQ8TF66.
PhosphoSitePlusiQ8TF66.

Expressioni

Tissue specificityi

Brain and placenta.

Gene expression databases

BgeeiENSG00000172061.
CleanExiHS_LRRC15.
GenevisibleiQ8TF66. HS.

Organism-specific databases

HPAiHPA035503.

Interactioni

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • fibronectin binding Source: UniProtKB
  • laminin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi126287. 52 interactors.
IntActiQ8TF66. 3 interactors.
STRINGi9606.ENSP00000389128.

Structurei

3D structure databases

ProteinModelPortaliQ8TF66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 53LRRNTAdd BLAST32
Repeati54 – 75LRR 1Add BLAST22
Repeati78 – 99LRR 2Add BLAST22
Repeati102 – 123LRR 3Add BLAST22
Repeati126 – 147LRR 4Add BLAST22
Repeati150 – 171LRR 5Add BLAST22
Repeati174 – 195LRR 6Add BLAST22
Repeati198 – 219LRR 7Add BLAST22
Repeati222 – 243LRR 8Add BLAST22
Repeati246 – 267LRR 9Add BLAST22
Repeati270 – 291LRR 10Add BLAST22
Repeati294 – 315LRR 11Add BLAST22
Repeati318 – 339LRR 12Add BLAST22
Repeati342 – 363LRR 13Add BLAST22
Repeati366 – 387LRR 14Add BLAST22
Repeati390 – 411LRR 15Add BLAST22
Domaini423 – 475LRRCTAdd BLAST53

Sequence similaritiesi

Contains 15 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000040004.
HOVERGENiHBG052343.
InParanoidiQ8TF66.
OMAiHGNHLEY.
OrthoDBiEOG091G057B.
TreeFamiTF351124.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 2 hits.
PF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 14 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 14 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TF66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLKHYLLLL VGCQAWGAGL AYHGCPSECT CSRASQVECT GARIVAVPTP
60 70 80 90 100
LPWNAMSLQI LNTHITELNE SPFLNISALI ALRIEKNELS RITPGAFRNL
110 120 130 140 150
GSLRYLSLAN NKLQVLPIGL FQGLDSLESL LLSSNQLLQI QPAHFSQCSN
160 170 180 190 200
LKELQLHGNH LEYIPDGAFD HLVGLTKLNL GKNSLTHISP RVFQHLGNLQ
210 220 230 240 250
VLRLYENRLT DIPMGTFDGL VNLQELALQQ NQIGLLSPGL FHNNHNLQRL
260 270 280 290 300
YLSNNHISQL PPSVFMQLPQ LNRLTLFGNS LKELSPGIFG PMPNLRELWL
310 320 330 340 350
YDNHISSLPD NVFSNLRQLQ VLILSRNQIS FISPGAFNGL TELRELSLHT
360 370 380 390 400
NALQDLDGNV FRMLANLQNI SLQNNRLRQL PGNIFANVNG LMAIQLQNNQ
410 420 430 440 450
LENLPLGIFD HLGKLCELRL YDNPWRCDSD ILPLRNWLLL NQPRLGTDTV
460 470 480 490 500
PVCFSPANVR GQSLIIINVN VAVPSVHVPE VPSYPETPWY PDTPSYPDTT
510 520 530 540 550
SVSSTTELTS PVEDYTDLTT IQVTDDRSVW GMTQAQSGLA IAAIVIGIVA
560 570 580
LACSLAACVG CCCCKKRSQA VLMQMKAPNE C
Length:581
Mass (Da):64,366
Last modified:May 31, 2011 - v2
Checksum:i1CA7B1752C7FE5B3
GO
Isoform 2 (identifier: Q8TF66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPLDKAM

Show »
Length:587
Mass (Da):65,022
Checksum:i3B047531FCF9EF9F
GO

Sequence cautioni

The sequence AAI01065 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence DAA01740 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051101264V → I.2 PublicationsCorresponds to variant rs13060627dbSNPEnsembl.1
Natural variantiVAR_051102286P → L.2 PublicationsCorresponds to variant rs13070515dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0411301M → MPLDKAM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071037 mRNA. Translation: BAB84587.1.
AC125362 Genomic DNA. No translation available.
AC174158 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78054.1.
BC101064 mRNA. Translation: AAI01065.1. Different initiation.
BC101065 mRNA. Translation: AAI01066.1.
BK001325 mRNA. Translation: DAA01740.1. Different initiation.
CCDSiCCDS3306.1. [Q8TF66-1]
CCDS46984.1. [Q8TF66-2]
RefSeqiNP_001128529.2. NM_001135057.2. [Q8TF66-2]
NP_570843.2. NM_130830.4. [Q8TF66-1]
UniGeneiHs.288467.

Genome annotation databases

EnsembliENST00000347624; ENSP00000306276; ENSG00000172061. [Q8TF66-1]
ENST00000428839; ENSP00000413707; ENSG00000172061. [Q8TF66-2]
GeneIDi131578.
KEGGihsa:131578.
UCSCiuc003ftt.4. human. [Q8TF66-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071037 mRNA. Translation: BAB84587.1.
AC125362 Genomic DNA. No translation available.
AC174158 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78054.1.
BC101064 mRNA. Translation: AAI01065.1. Different initiation.
BC101065 mRNA. Translation: AAI01066.1.
BK001325 mRNA. Translation: DAA01740.1. Different initiation.
CCDSiCCDS3306.1. [Q8TF66-1]
CCDS46984.1. [Q8TF66-2]
RefSeqiNP_001128529.2. NM_001135057.2. [Q8TF66-2]
NP_570843.2. NM_130830.4. [Q8TF66-1]
UniGeneiHs.288467.

3D structure databases

ProteinModelPortaliQ8TF66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126287. 52 interactors.
IntActiQ8TF66. 3 interactors.
STRINGi9606.ENSP00000389128.

PTM databases

iPTMnetiQ8TF66.
PhosphoSitePlusiQ8TF66.

Polymorphism and mutation databases

BioMutaiLRRC15.
DMDMi334302830.

Proteomic databases

EPDiQ8TF66.
MaxQBiQ8TF66.
PaxDbiQ8TF66.
PeptideAtlasiQ8TF66.
PRIDEiQ8TF66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347624; ENSP00000306276; ENSG00000172061. [Q8TF66-1]
ENST00000428839; ENSP00000413707; ENSG00000172061. [Q8TF66-2]
GeneIDi131578.
KEGGihsa:131578.
UCSCiuc003ftt.4. human. [Q8TF66-1]

Organism-specific databases

CTDi131578.
DisGeNETi131578.
GeneCardsiLRRC15.
H-InvDBHIX0003982.
HGNCiHGNC:20818. LRRC15.
HPAiHPA035503.
neXtProtiNX_Q8TF66.
OpenTargetsiENSG00000172061.
PharmGKBiPA134956867.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000040004.
HOVERGENiHBG052343.
InParanoidiQ8TF66.
OMAiHGNHLEY.
OrthoDBiEOG091G057B.
TreeFamiTF351124.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172061-MONOMER.
ZFISH:ENSG00000179796-MONOMER.

Miscellaneous databases

ChiTaRSiLRRC15. human.
GenomeRNAii131578.
PROiQ8TF66.

Gene expression databases

BgeeiENSG00000172061.
CleanExiHS_LRRC15.
GenevisibleiQ8TF66. HS.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 2 hits.
PF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 14 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC15_HUMAN
AccessioniPrimary (citable) accession number: Q8TF66
Secondary accession number(s): Q495Q6, Q7RTN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 31, 2011
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.