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Protein

Leucine-rich repeat-containing protein 15

Gene

LRRC15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • fibronectin binding Source: UniProtKB
  • laminin binding Source: UniProtKB
  • protein kinase inhibitor activity Source: GO_Central

GO - Biological processi

  • cytokine-mediated signaling pathway Source: GO_Central
  • negative regulation of establishment of protein localization to plasma membrane Source: UniProtKB
  • negative regulation of JAK-STAT cascade Source: GO_Central
  • negative regulation of protein kinase activity Source: GO_Central
  • positive regulation of cell migration Source: UniProtKB
  • receptor-mediated virion attachment to host cell Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 15
Alternative name(s):
Leucine-rich repeat protein induced by beta-amyloid homolog
Short name:
hLib
Gene namesi
Name:LRRC15
Synonyms:LIB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:20818. LRRC15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 538517ExtracellularSequence analysisAdd
BLAST
Transmembranei539 – 55921HelicalSequence analysisAdd
BLAST
Topological domaini560 – 58122CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134956867.

Polymorphism and mutation databases

BioMutaiLRRC15.
DMDMi334302830.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 581560Leucine-rich repeat-containing protein 15PRO_0000021605Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence analysis
Glycosylationi369 – 3691N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8TF66.
MaxQBiQ8TF66.
PaxDbiQ8TF66.
PeptideAtlasiQ8TF66.
PRIDEiQ8TF66.

PTM databases

iPTMnetiQ8TF66.
PhosphoSiteiQ8TF66.

Expressioni

Tissue specificityi

Brain and placenta.

Gene expression databases

BgeeiQ8TF66.
CleanExiHS_LRRC15.
GenevisibleiQ8TF66. HS.

Organism-specific databases

HPAiHPA035503.

Interactioni

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • fibronectin binding Source: UniProtKB
  • laminin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi126287. 52 interactions.
IntActiQ8TF66. 3 interactions.
STRINGi9606.ENSP00000389128.

Structurei

3D structure databases

ProteinModelPortaliQ8TF66.
SMRiQ8TF66. Positions 24-464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 5332LRRNTAdd
BLAST
Repeati54 – 7522LRR 1Add
BLAST
Repeati78 – 9922LRR 2Add
BLAST
Repeati102 – 12322LRR 3Add
BLAST
Repeati126 – 14722LRR 4Add
BLAST
Repeati150 – 17122LRR 5Add
BLAST
Repeati174 – 19522LRR 6Add
BLAST
Repeati198 – 21922LRR 7Add
BLAST
Repeati222 – 24322LRR 8Add
BLAST
Repeati246 – 26722LRR 9Add
BLAST
Repeati270 – 29122LRR 10Add
BLAST
Repeati294 – 31522LRR 11Add
BLAST
Repeati318 – 33922LRR 12Add
BLAST
Repeati342 – 36322LRR 13Add
BLAST
Repeati366 – 38722LRR 14Add
BLAST
Repeati390 – 41122LRR 15Add
BLAST
Domaini423 – 47553LRRCTAdd
BLAST

Sequence similaritiesi

Contains 15 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000040004.
HOVERGENiHBG052343.
InParanoidiQ8TF66.
OMAiNHLEYIP.
OrthoDBiEOG712TVW.
TreeFamiTF351124.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 2 hits.
PF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 14 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 14 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TF66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLKHYLLLL VGCQAWGAGL AYHGCPSECT CSRASQVECT GARIVAVPTP
60 70 80 90 100
LPWNAMSLQI LNTHITELNE SPFLNISALI ALRIEKNELS RITPGAFRNL
110 120 130 140 150
GSLRYLSLAN NKLQVLPIGL FQGLDSLESL LLSSNQLLQI QPAHFSQCSN
160 170 180 190 200
LKELQLHGNH LEYIPDGAFD HLVGLTKLNL GKNSLTHISP RVFQHLGNLQ
210 220 230 240 250
VLRLYENRLT DIPMGTFDGL VNLQELALQQ NQIGLLSPGL FHNNHNLQRL
260 270 280 290 300
YLSNNHISQL PPSVFMQLPQ LNRLTLFGNS LKELSPGIFG PMPNLRELWL
310 320 330 340 350
YDNHISSLPD NVFSNLRQLQ VLILSRNQIS FISPGAFNGL TELRELSLHT
360 370 380 390 400
NALQDLDGNV FRMLANLQNI SLQNNRLRQL PGNIFANVNG LMAIQLQNNQ
410 420 430 440 450
LENLPLGIFD HLGKLCELRL YDNPWRCDSD ILPLRNWLLL NQPRLGTDTV
460 470 480 490 500
PVCFSPANVR GQSLIIINVN VAVPSVHVPE VPSYPETPWY PDTPSYPDTT
510 520 530 540 550
SVSSTTELTS PVEDYTDLTT IQVTDDRSVW GMTQAQSGLA IAAIVIGIVA
560 570 580
LACSLAACVG CCCCKKRSQA VLMQMKAPNE C
Length:581
Mass (Da):64,366
Last modified:May 31, 2011 - v2
Checksum:i1CA7B1752C7FE5B3
GO
Isoform 2 (identifier: Q8TF66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPLDKAM

Show »
Length:587
Mass (Da):65,022
Checksum:i3B047531FCF9EF9F
GO

Sequence cautioni

The sequence AAI01065.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence DAA01740.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti264 – 2641V → I.2 Publications
Corresponds to variant rs13060627 [ dbSNP | Ensembl ].
VAR_051101
Natural varianti286 – 2861P → L.2 Publications
Corresponds to variant rs13070515 [ dbSNP | Ensembl ].
VAR_051102

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MPLDKAM in isoform 2. 1 PublicationVSP_041130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071037 mRNA. Translation: BAB84587.1.
AC125362 Genomic DNA. No translation available.
AC174158 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78054.1.
BC101064 mRNA. Translation: AAI01065.1. Different initiation.
BC101065 mRNA. Translation: AAI01066.1.
BK001325 mRNA. Translation: DAA01740.1. Different initiation.
CCDSiCCDS3306.1. [Q8TF66-1]
CCDS46984.1. [Q8TF66-2]
RefSeqiNP_001128529.2. NM_001135057.2. [Q8TF66-2]
NP_570843.2. NM_130830.4. [Q8TF66-1]
UniGeneiHs.288467.

Genome annotation databases

EnsembliENST00000347624; ENSP00000306276; ENSG00000172061. [Q8TF66-1]
ENST00000428839; ENSP00000413707; ENSG00000172061. [Q8TF66-2]
GeneIDi131578.
KEGGihsa:131578.
UCSCiuc003ftt.4. human. [Q8TF66-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071037 mRNA. Translation: BAB84587.1.
AC125362 Genomic DNA. No translation available.
AC174158 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78054.1.
BC101064 mRNA. Translation: AAI01065.1. Different initiation.
BC101065 mRNA. Translation: AAI01066.1.
BK001325 mRNA. Translation: DAA01740.1. Different initiation.
CCDSiCCDS3306.1. [Q8TF66-1]
CCDS46984.1. [Q8TF66-2]
RefSeqiNP_001128529.2. NM_001135057.2. [Q8TF66-2]
NP_570843.2. NM_130830.4. [Q8TF66-1]
UniGeneiHs.288467.

3D structure databases

ProteinModelPortaliQ8TF66.
SMRiQ8TF66. Positions 24-464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126287. 52 interactions.
IntActiQ8TF66. 3 interactions.
STRINGi9606.ENSP00000389128.

PTM databases

iPTMnetiQ8TF66.
PhosphoSiteiQ8TF66.

Polymorphism and mutation databases

BioMutaiLRRC15.
DMDMi334302830.

Proteomic databases

EPDiQ8TF66.
MaxQBiQ8TF66.
PaxDbiQ8TF66.
PeptideAtlasiQ8TF66.
PRIDEiQ8TF66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347624; ENSP00000306276; ENSG00000172061. [Q8TF66-1]
ENST00000428839; ENSP00000413707; ENSG00000172061. [Q8TF66-2]
GeneIDi131578.
KEGGihsa:131578.
UCSCiuc003ftt.4. human. [Q8TF66-1]

Organism-specific databases

CTDi131578.
GeneCardsiLRRC15.
H-InvDBHIX0003982.
HGNCiHGNC:20818. LRRC15.
HPAiHPA035503.
neXtProtiNX_Q8TF66.
PharmGKBiPA134956867.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000040004.
HOVERGENiHBG052343.
InParanoidiQ8TF66.
OMAiNHLEYIP.
OrthoDBiEOG712TVW.
TreeFamiTF351124.

Miscellaneous databases

ChiTaRSiLRRC15. human.
GenomeRNAii131578.
PROiQ8TF66.

Gene expression databases

BgeeiQ8TF66.
CleanExiHS_LRRC15.
GenevisibleiQ8TF66. HS.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 2 hits.
PF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 14 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel member of the leucine-rich repeat superfamily induced in rat astrocytes by beta-amyloid."
    Satoh K., Hata M., Yokota H.
    Biochem. Biophys. Res. Commun. 290:756-762(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-264 AND LEU-286.
    Tissue: Brain.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  5. "Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein."
    Reynolds P.A., Smolen G.A., Palmer R.E., Sgroi D., Yajnik V., Gerald W.L., Haber D.A.
    Genes Dev. 17:2094-2107(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, ALTERNATIVE SPLICING (ISOFORM 2), VARIANTS ILE-264 AND LEU-286.

Entry informationi

Entry nameiLRC15_HUMAN
AccessioniPrimary (citable) accession number: Q8TF66
Secondary accession number(s): Q495Q6, Q7RTN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 31, 2011
Last modified: July 6, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.