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Protein

PDZ domain-containing protein GIPC2

Gene

GIPC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: IntAct

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ domain-containing protein GIPC2
Gene namesi
Name:GIPC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000137960.5
HGNCiHGNC:18177 GIPC2
neXtProtiNX_Q8TF65

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi54810
OpenTargetsiENSG00000137960
PharmGKBiPA142671735

Polymorphism and mutation databases

BioMutaiGIPC2
DMDMi74716120

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471881 – 315PDZ domain-containing protein GIPC2Add BLAST315

Proteomic databases

EPDiQ8TF65
MaxQBiQ8TF65
PaxDbiQ8TF65
PeptideAtlasiQ8TF65
PRIDEiQ8TF65

PTM databases

iPTMnetiQ8TF65
PhosphoSitePlusiQ8TF65

Expressioni

Tissue specificityi

Expressed at highest levels in ascending colon and at moderate levels in adult kidney. Expressed at low levels in adult pancreas and at very low levels in adult liver. Expression is down-regulated in several primary tumors, such as kidney, colon and rectal tumors.1 Publication

Gene expression databases

BgeeiENSG00000137960
CleanExiHS_GIPC2
GenevisibleiQ8TF65 HS

Organism-specific databases

HPAiHPA051212
HPA062684

Interactioni

Subunit structurei

Probably interacts with SEMA5A.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi120167, 12 interactors
IntActiQ8TF65, 19 interactors
STRINGi9606.ENSP00000359795

Structurei

Secondary structure

1315
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi113 – 121Combined sources9
Beta strandi129 – 132Combined sources4
Beta strandi134 – 137Combined sources4
Beta strandi140 – 144Combined sources5
Helixi149 – 152Combined sources4
Beta strandi161 – 165Combined sources5
Helixi175 – 184Combined sources10
Beta strandi190 – 198Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GGEX-ray2.60A/B/C112-200[»]
ProteinModelPortaliQ8TF65
SMRiQ8TF65
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TF65

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 197PDZPROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the GIPC family.Curated

Phylogenomic databases

eggNOGiKOG3938 Eukaryota
ENOG410XQ87 LUCA
GeneTreeiENSGT00390000003420
HOGENOMiHOG000293347
HOVERGENiHBG000898
InParanoidiQ8TF65
KOiK20056
OMAiWRHYDVA
OrthoDBiEOG091G0D3X
PhylomeDBiQ8TF65
TreeFamiTF313878

Family and domain databases

InterProiView protein in InterPro
IPR017379 GIPC1/2/3
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR12259 PTHR12259, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PIRSFiPIRSF038083 UCP038083_GIPC, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TF65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLKLRGKKK AKSKETAGLV EGEPTGAGGG SLSASRAPAR RLVFHAQLAH
60 70 80 90 100
GSATGRVEGF SSIQELYAQI AGAFEISPSE ILYCTLNTPK IDMERLLGGQ
110 120 130 140 150
LGLEDFIFAH VKGIEKEVNV YKSEDSLGLT ITDNGVGYAF IKRIKDGGVI
160 170 180 190 200
DSVKTICVGD HIESINGENI VGWRHYDVAK KLKELKKEEL FTMKLIEPKK
210 220 230 240 250
AFEIELRSKA GKSSGEKIGC GRATLRLRSK GPATVEEMPS ETKAKAIEKI
260 270 280 290 300
DDVLELYMGI RDIDLATTMF EAGKDKVNPD EFAVALDETL GDFAFPDEFV
310
FDVWGVIGDA KRRGL
Length:315
Mass (Da):34,354
Last modified:June 1, 2002 - v1
Checksum:i244894C6100C679F
GO

Sequence cautioni

The sequence BAA90933 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02708461S → F. Corresponds to variant dbSNP:rs17101180Ensembl.1
Natural variantiVAR_027085206L → P1 PublicationCorresponds to variant dbSNP:rs540742Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073737 mRNA Translation: BAB84711.1
BC036075 mRNA Translation: AAH36075.1
AK000082 mRNA Translation: BAA90933.1 Different initiation.
CCDSiCCDS685.1
RefSeqiNP_001291654.1, NM_001304725.1
NP_060125.4, NM_017655.5
UniGeneiHs.603818
Hs.659356

Genome annotation databases

EnsembliENST00000370759; ENSP00000359795; ENSG00000137960
GeneIDi54810
KEGGihsa:54810
UCSCiuc001dik.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGIPC2_HUMAN
AccessioniPrimary (citable) accession number: Q8TF65
Secondary accession number(s): Q8IYD3, Q9NXS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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