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Protein

PDZ domain-containing protein GIPC2

Gene

GIPC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ domain-containing protein GIPC2
Gene namesi
Name:GIPC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18177. GIPC2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671735.

Polymorphism and mutation databases

BioMutaiGIPC2.
DMDMi74716120.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315PDZ domain-containing protein GIPC2PRO_0000247188Add
BLAST

Proteomic databases

EPDiQ8TF65.
MaxQBiQ8TF65.
PaxDbiQ8TF65.
PRIDEiQ8TF65.

PTM databases

PhosphoSiteiQ8TF65.

Expressioni

Tissue specificityi

Expressed at highest levels in ascending colon and at moderate levels in adult kidney. Expressed at low levels in adult pancreas and at very low levels in adult liver. Expression is down-regulated in several primary tumors, such as kidney, colon and rectal tumors.1 Publication

Gene expression databases

BgeeiQ8TF65.
CleanExiHS_GIPC2.
GenevisibleiQ8TF65. HS.

Organism-specific databases

HPAiHPA051212.

Interactioni

Subunit structurei

Probably interacts with SEMA5A.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SP100P234973EBI-712067,EBI-751145
ZBTB26Q9HCK03EBI-712067,EBI-3918996

Protein-protein interaction databases

BioGridi120167. 10 interactions.
IntActiQ8TF65. 14 interactions.
MINTiMINT-1368358.
STRINGi9606.ENSP00000359795.

Structurei

Secondary structure

1
315
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi113 – 1219Combined sources
Beta strandi129 – 1324Combined sources
Beta strandi134 – 1374Combined sources
Beta strandi140 – 1445Combined sources
Helixi149 – 1524Combined sources
Beta strandi161 – 1655Combined sources
Helixi175 – 18410Combined sources
Beta strandi190 – 1989Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GGEX-ray2.60A/B/C112-200[»]
ProteinModelPortaliQ8TF65.
SMRiQ8TF65. Positions 113-203.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TF65.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini117 – 19781PDZPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GIPC family.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3938. Eukaryota.
ENOG410XQ87. LUCA.
GeneTreeiENSGT00390000003420.
HOGENOMiHOG000293347.
HOVERGENiHBG000898.
InParanoidiQ8TF65.
OMAiWRHYDVA.
OrthoDBiEOG793B86.
PhylomeDBiQ8TF65.
TreeFamiTF313878.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR017379. UCP038083_PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
PIRSFiPIRSF038083. UCP038083_GIPC. 1 hit.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TF65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLKLRGKKK AKSKETAGLV EGEPTGAGGG SLSASRAPAR RLVFHAQLAH
60 70 80 90 100
GSATGRVEGF SSIQELYAQI AGAFEISPSE ILYCTLNTPK IDMERLLGGQ
110 120 130 140 150
LGLEDFIFAH VKGIEKEVNV YKSEDSLGLT ITDNGVGYAF IKRIKDGGVI
160 170 180 190 200
DSVKTICVGD HIESINGENI VGWRHYDVAK KLKELKKEEL FTMKLIEPKK
210 220 230 240 250
AFEIELRSKA GKSSGEKIGC GRATLRLRSK GPATVEEMPS ETKAKAIEKI
260 270 280 290 300
DDVLELYMGI RDIDLATTMF EAGKDKVNPD EFAVALDETL GDFAFPDEFV
310
FDVWGVIGDA KRRGL
Length:315
Mass (Da):34,354
Last modified:June 1, 2002 - v1
Checksum:i244894C6100C679F
GO

Sequence cautioni

The sequence BAA90933.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611S → F.
Corresponds to variant rs17101180 [ dbSNP | Ensembl ].
VAR_027084
Natural varianti206 – 2061L → P.1 Publication
Corresponds to variant rs540742 [ dbSNP | Ensembl ].
VAR_027085

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073737 mRNA. Translation: BAB84711.1.
BC036075 mRNA. Translation: AAH36075.1.
AK000082 mRNA. Translation: BAA90933.1. Different initiation.
CCDSiCCDS685.1.
RefSeqiNP_001291654.1. NM_001304725.1.
NP_060125.4. NM_017655.5.
UniGeneiHs.603818.
Hs.659356.

Genome annotation databases

EnsembliENST00000370759; ENSP00000359795; ENSG00000137960.
GeneIDi54810.
KEGGihsa:54810.
UCSCiuc001dik.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073737 mRNA. Translation: BAB84711.1.
BC036075 mRNA. Translation: AAH36075.1.
AK000082 mRNA. Translation: BAA90933.1. Different initiation.
CCDSiCCDS685.1.
RefSeqiNP_001291654.1. NM_001304725.1.
NP_060125.4. NM_017655.5.
UniGeneiHs.603818.
Hs.659356.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GGEX-ray2.60A/B/C112-200[»]
ProteinModelPortaliQ8TF65.
SMRiQ8TF65. Positions 113-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120167. 10 interactions.
IntActiQ8TF65. 14 interactions.
MINTiMINT-1368358.
STRINGi9606.ENSP00000359795.

PTM databases

PhosphoSiteiQ8TF65.

Polymorphism and mutation databases

BioMutaiGIPC2.
DMDMi74716120.

Proteomic databases

EPDiQ8TF65.
MaxQBiQ8TF65.
PaxDbiQ8TF65.
PRIDEiQ8TF65.

Protocols and materials databases

DNASUi54810.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370759; ENSP00000359795; ENSG00000137960.
GeneIDi54810.
KEGGihsa:54810.
UCSCiuc001dik.4. human.

Organism-specific databases

CTDi54810.
GeneCardsiGIPC2.
HGNCiHGNC:18177. GIPC2.
HPAiHPA051212.
neXtProtiNX_Q8TF65.
PharmGKBiPA142671735.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3938. Eukaryota.
ENOG410XQ87. LUCA.
GeneTreeiENSGT00390000003420.
HOGENOMiHOG000293347.
HOVERGENiHBG000898.
InParanoidiQ8TF65.
OMAiWRHYDVA.
OrthoDBiEOG793B86.
PhylomeDBiQ8TF65.
TreeFamiTF313878.

Miscellaneous databases

EvolutionaryTraceiQ8TF65.
GeneWikiiGIPC2.
GenomeRNAii54810.
NextBioi57529.
PROiQ8TF65.

Gene expression databases

BgeeiQ8TF65.
CleanExiHS_GIPC2.
GenevisibleiQ8TF65. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR017379. UCP038083_PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
PIRSFiPIRSF038083. UCP038083_GIPC. 1 hit.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of human GIPC2, a novel gene homologous to human GIPC1 and Xenopus Kermit."
    Kirikoshi H., Katoh M.
    Int. J. Oncol. 20:571-576(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-206.
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 85-315.
    Tissue: Colon.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Crystal structure of the PDZ domain of PDZ domain-containing protein GIPC2."
    Structural genomics consortium (SGC)
    Submitted (MAR-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 112-200.

Entry informationi

Entry nameiGIPC2_HUMAN
AccessioniPrimary (citable) accession number: Q8TF65
Secondary accession number(s): Q8IYD3, Q9NXS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2002
Last modified: March 16, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.