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Protein

F-box only protein 41

Gene

FBXO41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 41
Gene namesi
Name:FBXO41
Synonyms:FBX41, KIAA1940
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163013.11
HGNCiHGNC:29409 FBXO41
MIMi609108 gene
neXtProtiNX_Q8TF61

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi150726
OpenTargetsiENSG00000163013
PharmGKBiPA134946052

Polymorphism and mutation databases

BioMutaiFBXO41
DMDMi387912926

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199401 – 875F-box only protein 41Add BLAST875

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei360Omega-N-methylarginineBy similarity1
Modified residuei478PhosphoserineBy similarity1
Modified residuei479PhosphothreonineBy similarity1
Modified residuei762PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ8TF61
PeptideAtlasiQ8TF61
PRIDEiQ8TF61

PTM databases

iPTMnetiQ8TF61
PhosphoSitePlusiQ8TF61

Expressioni

Gene expression databases

BgeeiENSG00000163013
CleanExiHS_FBXO41
GenevisibleiQ8TF61 HS

Organism-specific databases

HPAiHPA055246
HPA058386

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi127320, 1 interactor
IntActiQ8TF61, 2 interactors
STRINGi9606.ENSP00000428646

Structurei

3D structure databases

ProteinModelPortaliQ8TF61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini496 – 540F-boxAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili209 – 351Sequence analysisAdd BLAST143

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 61Poly-AlaAdd BLAST11
Compositional biasi107 – 112Poly-His6
Compositional biasi140 – 143Poly-Ala4
Compositional biasi359 – 368Poly-Gly10

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IPN2 Eukaryota
ENOG410YK32 LUCA
GeneTreeiENSGT00530000063713
HOGENOMiHOG000112547
HOVERGENiHBG051581
InParanoidiQ8TF61
KOiK10316
OMAiSCGTTPN
OrthoDBiEOG091G01PD
TreeFamiTF329439

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TF61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLDLPYRC PRCGEHKRFR SLSSLRAHLE YSHTYETLYI LSKTNSICDG
60 70 80 90 100
AAAAAAAAAA ASGFPLAPEP AALLAVPGAR REVFESTSFQ GKEQAAGPSP
110 120 130 140 150
AAPHLLHHHH HHAPLAHFPG DLVPASLPCE ELAEPGLVPA AAARYALREI
160 170 180 190 200
EIPLGELFAR KSVASSACST PPPGPGPGPC PGPASASPAS PSPADVAYEE
210 220 230 240 250
GLARLKIRAL EKLEVDRRLE RLSEEVEQKI AGQVGRLQAE LERKAAELET
260 270 280 290 300
ARQESARLGR EKEELEERAS ELSRQVDVSV ELLASLKQDL VHKEQELSRK
310 320 330 340 350
QQEVVQIDQF LKETAAREAS AKLRLQQFIE ELLERADRAE RQLQVISSSC
360 370 380 390 400
GSTPSASLGR GGGGGGAGPN ARGPGRMREH HVGPAVPNTY AVSRHGSSPS
410 420 430 440 450
TGASSRVPAA SQSSGCYDSD SLELPRPEEG APEDSGPGGL GTRAQAANGG
460 470 480 490 500
SERSQPPRSS GLRRQAIQNW QRRPRRHSTE GEEGDVSDVG SRTTESEAEG
510 520 530 540 550
PLDAPRPGPA MAGPLSSCRL SARPEGGSGR GRRAERVSPS RSNEVISPEI
560 570 580 590 600
LKMRAALFCI FTYLDTRTLL HAAEVCRDWR FVARHPAVWT RVLLENARVC
610 620 630 640 650
SKFLAMLAQW CTQAHSLTLQ NLKPRQRGKK ESKEEYARST RGCLEAGLES
660 670 680 690 700
LLKAAGGNLL ILRISHCPNI LTDRSLWLAS CYCRALQAVT YRSATDPVGH
710 720 730 740 750
EVIWALGAGC REIVSLQVAP LHPCQQPTRF SNRCLQMIGR CWPHLRALGV
760 770 780 790 800
GGAGCGVQGL ASLARNCMRL QVLELDHVSE ITQEVAAEVC REGLKGLEML
810 820 830 840 850
VLTATPVTPK ALLHFNSICR NLKSIVVQIG IADYFKEPSS PEAQKLFEDM
860 870
VTKLQALRRR PGFSKILHIK VEGGC
Length:875
Mass (Da):94,496
Last modified:May 16, 2012 - v5
Checksum:iB1491A923068389C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti454S → T in BAB85526 (PubMed:11853319).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010913 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99736.1
AB075820 mRNA Translation: BAB85526.1
BC112202 mRNA Translation: AAI12203.1
CCDSiCCDS46337.2
RefSeqiNP_001073879.2, NM_001080410.2
XP_006712013.1, XM_006711950.2
XP_011530864.1, XM_011532562.1
XP_016858910.1, XM_017003421.1
XP_016858911.1, XM_017003422.1
XP_016858912.1, XM_017003423.1
UniGeneiHs.23158

Genome annotation databases

EnsembliENST00000295133; ENSP00000295133; ENSG00000163013
ENST00000520530; ENSP00000430968; ENSG00000163013
ENST00000521871; ENSP00000428646; ENSG00000163013
GeneIDi150726
KEGGihsa:150726
UCSCiuc021vjh.2 human

Similar proteinsi

Entry informationi

Entry nameiFBX41_HUMAN
AccessioniPrimary (citable) accession number: Q8TF61
Secondary accession number(s): G3V0Z7, Q2M1V8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 16, 2012
Last modified: March 28, 2018
This is version 126 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health