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Protein

F-box only protein 41

Gene

FBXO41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163013-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 41
Gene namesi
Name:FBXO41
Synonyms:FBX41, KIAA1940
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29409. FBXO41.

Pathology & Biotechi

Organism-specific databases

DisGeNETi150726.
OpenTargetsiENSG00000163013.
PharmGKBiPA134946052.

Polymorphism and mutation databases

BioMutaiFBXO41.
DMDMi387912926.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199401 – 875F-box only protein 41Add BLAST875

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei360Omega-N-methylarginineBy similarity1
Modified residuei478PhosphoserineBy similarity1
Modified residuei479PhosphothreonineBy similarity1
Modified residuei762PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ8TF61.
PeptideAtlasiQ8TF61.
PRIDEiQ8TF61.

PTM databases

iPTMnetiQ8TF61.
PhosphoSitePlusiQ8TF61.

Expressioni

Gene expression databases

BgeeiENSG00000163013.
CleanExiHS_FBXO41.
GenevisibleiQ8TF61. HS.

Organism-specific databases

HPAiHPA055246.
HPA058386.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi127320. 1 interactor.
IntActiQ8TF61. 2 interactors.
STRINGi9606.ENSP00000428646.

Structurei

3D structure databases

ProteinModelPortaliQ8TF61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini496 – 540F-boxAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili209 – 351Sequence analysisAdd BLAST143

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 61Poly-AlaAdd BLAST11
Compositional biasi107 – 112Poly-His6
Compositional biasi140 – 143Poly-Ala4
Compositional biasi359 – 368Poly-Gly10

Sequence similaritiesi

Contains 1 F-box domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IPN2. Eukaryota.
ENOG410YK32. LUCA.
GeneTreeiENSGT00530000063713.
HOGENOMiHOG000112547.
HOVERGENiHBG051581.
InParanoidiQ8TF61.
KOiK10316.
OMAiWGLRKQA.
OrthoDBiEOG091G01PD.
TreeFamiTF329439.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8TF61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLDLPYRC PRCGEHKRFR SLSSLRAHLE YSHTYETLYI LSKTNSICDG
60 70 80 90 100
AAAAAAAAAA ASGFPLAPEP AALLAVPGAR REVFESTSFQ GKEQAAGPSP
110 120 130 140 150
AAPHLLHHHH HHAPLAHFPG DLVPASLPCE ELAEPGLVPA AAARYALREI
160 170 180 190 200
EIPLGELFAR KSVASSACST PPPGPGPGPC PGPASASPAS PSPADVAYEE
210 220 230 240 250
GLARLKIRAL EKLEVDRRLE RLSEEVEQKI AGQVGRLQAE LERKAAELET
260 270 280 290 300
ARQESARLGR EKEELEERAS ELSRQVDVSV ELLASLKQDL VHKEQELSRK
310 320 330 340 350
QQEVVQIDQF LKETAAREAS AKLRLQQFIE ELLERADRAE RQLQVISSSC
360 370 380 390 400
GSTPSASLGR GGGGGGAGPN ARGPGRMREH HVGPAVPNTY AVSRHGSSPS
410 420 430 440 450
TGASSRVPAA SQSSGCYDSD SLELPRPEEG APEDSGPGGL GTRAQAANGG
460 470 480 490 500
SERSQPPRSS GLRRQAIQNW QRRPRRHSTE GEEGDVSDVG SRTTESEAEG
510 520 530 540 550
PLDAPRPGPA MAGPLSSCRL SARPEGGSGR GRRAERVSPS RSNEVISPEI
560 570 580 590 600
LKMRAALFCI FTYLDTRTLL HAAEVCRDWR FVARHPAVWT RVLLENARVC
610 620 630 640 650
SKFLAMLAQW CTQAHSLTLQ NLKPRQRGKK ESKEEYARST RGCLEAGLES
660 670 680 690 700
LLKAAGGNLL ILRISHCPNI LTDRSLWLAS CYCRALQAVT YRSATDPVGH
710 720 730 740 750
EVIWALGAGC REIVSLQVAP LHPCQQPTRF SNRCLQMIGR CWPHLRALGV
760 770 780 790 800
GGAGCGVQGL ASLARNCMRL QVLELDHVSE ITQEVAAEVC REGLKGLEML
810 820 830 840 850
VLTATPVTPK ALLHFNSICR NLKSIVVQIG IADYFKEPSS PEAQKLFEDM
860 870
VTKLQALRRR PGFSKILHIK VEGGC
Length:875
Mass (Da):94,496
Last modified:May 16, 2012 - v5
Checksum:iB1491A923068389C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti454S → T in BAB85526 (PubMed:11853319).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010913 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAW99736.1.
AB075820 mRNA. Translation: BAB85526.1.
BC112202 mRNA. Translation: AAI12203.1.
CCDSiCCDS46337.2.
RefSeqiNP_001073879.2. NM_001080410.2.
XP_006712013.1. XM_006711950.2.
XP_011530864.1. XM_011532562.1.
XP_016858910.1. XM_017003421.1.
XP_016858911.1. XM_017003422.1.
XP_016858912.1. XM_017003423.1.
UniGeneiHs.23158.

Genome annotation databases

EnsembliENST00000295133; ENSP00000295133; ENSG00000163013.
ENST00000520530; ENSP00000430968; ENSG00000163013.
ENST00000521871; ENSP00000428646; ENSG00000163013.
GeneIDi150726.
KEGGihsa:150726.
UCSCiuc021vjh.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010913 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAW99736.1.
AB075820 mRNA. Translation: BAB85526.1.
BC112202 mRNA. Translation: AAI12203.1.
CCDSiCCDS46337.2.
RefSeqiNP_001073879.2. NM_001080410.2.
XP_006712013.1. XM_006711950.2.
XP_011530864.1. XM_011532562.1.
XP_016858910.1. XM_017003421.1.
XP_016858911.1. XM_017003422.1.
XP_016858912.1. XM_017003423.1.
UniGeneiHs.23158.

3D structure databases

ProteinModelPortaliQ8TF61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127320. 1 interactor.
IntActiQ8TF61. 2 interactors.
STRINGi9606.ENSP00000428646.

PTM databases

iPTMnetiQ8TF61.
PhosphoSitePlusiQ8TF61.

Polymorphism and mutation databases

BioMutaiFBXO41.
DMDMi387912926.

Proteomic databases

PaxDbiQ8TF61.
PeptideAtlasiQ8TF61.
PRIDEiQ8TF61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295133; ENSP00000295133; ENSG00000163013.
ENST00000520530; ENSP00000430968; ENSG00000163013.
ENST00000521871; ENSP00000428646; ENSG00000163013.
GeneIDi150726.
KEGGihsa:150726.
UCSCiuc021vjh.2. human.

Organism-specific databases

CTDi150726.
DisGeNETi150726.
GeneCardsiFBXO41.
H-InvDBHIX0002162.
HGNCiHGNC:29409. FBXO41.
HPAiHPA055246.
HPA058386.
MIMi609108. gene.
neXtProtiNX_Q8TF61.
OpenTargetsiENSG00000163013.
PharmGKBiPA134946052.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPN2. Eukaryota.
ENOG410YK32. LUCA.
GeneTreeiENSGT00530000063713.
HOGENOMiHOG000112547.
HOVERGENiHBG051581.
InParanoidiQ8TF61.
KOiK10316.
OMAiWGLRKQA.
OrthoDBiEOG091G01PD.
TreeFamiTF329439.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163013-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiFBXO41. human.
GenomeRNAii150726.
PROiQ8TF61.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163013.
CleanExiHS_FBXO41.
GenevisibleiQ8TF61. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFBX41_HUMAN
AccessioniPrimary (citable) accession number: Q8TF61
Secondary accession number(s): G3V0Z7, Q2M1V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 16, 2012
Last modified: November 2, 2016
This is version 115 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.