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Protein

Zinc finger protein 526

Gene

ZNF526

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri57 – 7923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri108 – 13023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri140 – 16324C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 40922C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46524C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri472 – 49423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri500 – 52223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri528 – 55023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri573 – 59523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 526
Gene namesi
Name:ZNF526
Synonyms:KIAA1951
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29415. ZNF526.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134967668.

Polymorphism and mutation databases

BioMutaiZNF526.
DMDMi158706495.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Zinc finger protein 526PRO_0000306875Add
BLAST

Proteomic databases

MaxQBiQ8TF50.
PaxDbiQ8TF50.
PRIDEiQ8TF50.

Expressioni

Gene expression databases

BgeeiQ8TF50.
CleanExiHS_ZNF526.
ExpressionAtlasiQ8TF50. baseline and differential.
GenevisibleiQ8TF50. HS.

Organism-specific databases

HPAiHPA023070.
HPA056609.

Interactioni

Protein-protein interaction databases

BioGridi125475. 18 interactions.
IntActiQ8TF50. 17 interactions.
STRINGi9606.ENSP00000301215.

Structurei

3D structure databases

ProteinModelPortaliQ8TF50.
SMRiQ8TF50. Positions 48-87, 98-135, 275-595.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi191 – 25666Glu-richAdd
BLAST
Compositional biasi416 – 44530Pro-richAdd
BLAST
Compositional biasi605 – 61915Pro-richAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri57 – 7923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri108 – 13023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri140 – 16324C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 40922C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46524C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri472 – 49423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri500 – 52223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri528 – 55023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri573 – 59523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00670000098063.
HOGENOMiHOG000065747.
HOVERGENiHBG103121.
InParanoidiQ8TF50.
OMAiTIMCTEL.
OrthoDBiEOG77M8N6.
PhylomeDBiQ8TF50.
TreeFamiTF350791.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TF50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVVAEVAE MPTQMSPGAV EMSTPMSAEM MEMSTEVTEM TPGEALASSL
60 70 80 90 100
FFQHHQFMCS ECGSLYNTLE EVLSHQEQHM LAVSEEEALT TQNVGLEPEL
110 120 130 140 150
VPGAEGPFQC GECSQLILSP GELLAHQDAH LRESANQIQY QCWDCQELFP
160 170 180 190 200
SPELWVAHRK AQHLSATVAE PPVPPPLPPP TPLPPPSPPS EVKMEPYECP
210 220 230 240 250
ECSTLCATPE EFLEHQGTHF DSLEKEERNG LEEEEEDDEE DEEDDEEMED
260 270 280 290 300
EEAMAEVGDD AVGGDESTAG WAQGCGDCPQ HQPSAGARRQ HRRTAHSPAS
310 320 330 340 350
ATHPFHCSQC QRSFSSANRL QAHGRAHVGG THECTTCSKV FKKAASLEQH
360 370 380 390 400
LRLHRGEARY LCVDCGRGFG TELTLVAHRR AHTANPLHRC RCGKTFSNMT
410 420 430 440 450
KFLYHRRTHA GKSGAPPTGA TAPPAPAEPT PPPPPPAPPA QLPCPQCSKS
460 470 480 490 500
FASASRLSRH RRAVHGPPER RHRCGVCGKG FKKLIHVRNH LRTHTGERPF
510 520 530 540 550
QCHSCGKTFA SLANLSRHQL THTGARPYQC LDCGKRFTQS SNLQQHRRLH
560 570 580 590 600
LRPVAFARAP RLPITGLYNK SPYYCGTCGR WFRAMAGLRL HQRVHARART
610 620 630 640 650
LTLQPPRSPS PAPPPPPEPQ QTIMCTELGE TIAIIETSQP LALEDTLQLC
660 670
QAALGASEAG GLLQLDTAFV
Length:670
Mass (Da):73,622
Last modified:October 2, 2007 - v2
Checksum:i83C09EB3961765E8
GO

Sequence cautioni

The sequence BAB85537.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti94 – 941V → A.
Corresponds to variant rs3810151 [ dbSNP | Ensembl ].
VAR_035331
Natural varianti511 – 5111S → F.1 Publication
Corresponds to variant rs17850994 [ dbSNP | Ensembl ].
VAR_035332

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075831 mRNA. Translation: BAB85537.1. Different initiation.
AK122649 mRNA. Translation: BAG53641.1.
CH471126 Genomic DNA. Translation: EAW57113.1.
BC013013 mRNA. Translation: AAH13013.1.
AL833399 mRNA. Translation: CAH10586.1.
CCDSiCCDS12598.1.
RefSeqiNP_001300962.1. NM_001314033.1.
NP_597701.1. NM_133444.2.
UniGeneiHs.137282.

Genome annotation databases

EnsembliENST00000301215; ENSP00000301215; ENSG00000167625.
GeneIDi116115.
KEGGihsa:116115.
UCSCiuc002osz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075831 mRNA. Translation: BAB85537.1. Different initiation.
AK122649 mRNA. Translation: BAG53641.1.
CH471126 Genomic DNA. Translation: EAW57113.1.
BC013013 mRNA. Translation: AAH13013.1.
AL833399 mRNA. Translation: CAH10586.1.
CCDSiCCDS12598.1.
RefSeqiNP_001300962.1. NM_001314033.1.
NP_597701.1. NM_133444.2.
UniGeneiHs.137282.

3D structure databases

ProteinModelPortaliQ8TF50.
SMRiQ8TF50. Positions 48-87, 98-135, 275-595.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125475. 18 interactions.
IntActiQ8TF50. 17 interactions.
STRINGi9606.ENSP00000301215.

Polymorphism and mutation databases

BioMutaiZNF526.
DMDMi158706495.

Proteomic databases

MaxQBiQ8TF50.
PaxDbiQ8TF50.
PRIDEiQ8TF50.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301215; ENSP00000301215; ENSG00000167625.
GeneIDi116115.
KEGGihsa:116115.
UCSCiuc002osz.2. human.

Organism-specific databases

CTDi116115.
GeneCardsiZNF526.
HGNCiHGNC:29415. ZNF526.
HPAiHPA023070.
HPA056609.
MIMi614387. gene.
neXtProtiNX_Q8TF50.
PharmGKBiPA134967668.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00670000098063.
HOGENOMiHOG000065747.
HOVERGENiHBG103121.
InParanoidiQ8TF50.
OMAiTIMCTEL.
OrthoDBiEOG77M8N6.
PhylomeDBiQ8TF50.
TreeFamiTF350791.

Miscellaneous databases

GenomeRNAii116115.
NextBioi79773.
PROiQ8TF50.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TF50.
CleanExiHS_ZNF526.
ExpressionAtlasiQ8TF50. baseline and differential.
GenevisibleiQ8TF50. HS.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-511.
    Tissue: Muscle.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 210-670.
    Tissue: Melanoma.

Entry informationi

Entry nameiZN526_HUMAN
AccessioniPrimary (citable) accession number: Q8TF50
Secondary accession number(s): B3KV29, Q69YI2, Q96E24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: May 11, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.