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Q8TF47 (ZFP90_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 90 homolog

Short name=Zfp-90
Alternative name(s):
Zinc finger protein 756
Gene names
Name:ZFP90
Synonyms:KIAA1954, ZNF756
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length636 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as a repressor or silencer protein, and most likely exerts its repressing activity upon zinc-dependent binding to DNA. May be involved in proper spermatogenesis by repressing the expression of genes unnecessary or incompatible with the maintenance of a haploid cell state By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 13 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence AX721106 differs from that shown. Reason: Frameshift at positions 341, 358 and 370.

The sequence BAB71228.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAG53759.1 differs from that shown. Reason: Intron retention.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 636636Zinc finger protein 90 homolog
PRO_0000047310

Regions

Domain14 – 8572KRAB
Zinc finger211 – 23323C2H2-type 1
Zinc finger254 – 27623C2H2-type 2
Zinc finger282 – 30423C2H2-type 3
Zinc finger310 – 33223C2H2-type 4
Zinc finger338 – 36023C2H2-type 5
Zinc finger366 – 38823C2H2-type 6
Zinc finger394 – 41623C2H2-type 7
Zinc finger450 – 47223C2H2-type 8
Zinc finger497 – 51923C2H2-type 9
Zinc finger525 – 54723C2H2-type 10
Zinc finger553 – 57523C2H2-type 11
Zinc finger581 – 60323C2H2-type 12
Zinc finger609 – 63123C2H2-type 13

Experimental info

Sequence conflict5501E → V in BAB71228. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8TF47 [UniParc].

Last modified May 2, 2006. Version 2.
Checksum: 2D645DD5F5EFD8A6

FASTA63673,031
        10         20         30         40         50         60 
MAPRPPTAAP QESVTFKDVS VDFTQEEWYH VDPAQRSLYR DVMLENYSHL VSLGYQVSKP 

        70         80         90        100        110        120 
EVIFKLEQGE EPWISEGEIQ RPFYPDWKTR PEVKSSHLQQ DVSEVSHCTH DLLHATLEDS 

       130        140        150        160        170        180 
WDVSSQLDRQ QENWKRHLGS EASTQKKIIT PQENFEQNKF GENSRLNTNL VTQLNIPARI 

       190        200        210        220        230        240 
RPSECETLGS NLGHNADLLN ENNILAKKKP YKCDKCRKAF IHRSSLTKHE KTHKGEGAFP 

       250        260        270        280        290        300 
NGTDQGIYPG KKHHECTDCG KTFLWKTQLT EHQRIHTGEK PFECNVCGKA FRHSSSLGQH 

       310        320        330        340        350        360 
ENAHTGEKPY QCSLCGKAFQ RSSSLVQHQR IHTGEKPYRC NLCGRSFRHG TSLTQHEVTH 

       370        380        390        400        410        420 
SGEKPFQCKE CGKAFSRCSS LVQHERTHTG EKPFECSICG RAFGQSPSLY KHMRIHKRGK 

       430        440        450        460        470        480 
PYQSSNYSID FKHSTSLTQD ESTLTEVKSY HCNDCGEDFS HITDFTDHQR IHTAENPYDC 

       490        500        510        520        530        540 
EQAFSQQAIS HPGEKPYQCN VCGKAFKRST SFIEHHRIHT GEKPYECNEC GEAFSRRSSL 

       550        560        570        580        590        600 
TQHERTHTGE KPYECIDCGK AFSQSSSLIQ HERTHTGEKP YECNECGRAF RKKTNLHDHQ 

       610        620        630 
RIHTGEKPYS CKECGKNFSR SSALTKHQRI HTRNKL 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hippocampus and Tongue.
[2]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 338-636.
Tissue: Melanoma and Testis.
[5]"Molecules for diagnostics and therapeutics."
Lincoln S.E., Altus C.M., Dufour G.E., Chalup M.S., Hillman J.L., Jones A., Yu J.Y., Wright R.J., Gietzen D., Liu T.F., Yap P., Dahl C.R., Momiyama M., Bradley D., Rohatgi S., Harris B., Roseberry A.M., Gerstin E.H. expand/collapse author list , Peralta C.H., David M., Panzer S., Flores V., Daffo A., Marwaha R., Chen A., Chang S.C., Inman R.R.
Patent number WO0220754, 14-MAR-2002
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-372.
[6]"Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
Nagase T., Kikuno R., Ohara O.
DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 169-636.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK056596 mRNA. Translation: BAB71228.1. Different initiation.
AK122847 mRNA. Translation: BAG53759.1. Sequence problems.
AK304152 mRNA. Translation: BAG65042.1.
AK316251 mRNA. Translation: BAH14622.1.
AC009162 Genomic DNA. No translation available.
AC126773 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83234.1.
BC033165 mRNA. Translation: AAH33165.2.
BC140886 mRNA. Translation: AAI40887.1.
BC140887 mRNA. Translation: AAI40888.1.
AX721106 mRNA. No translation available.
AB075834 mRNA. Translation: BAB85540.1.
CCDSCCDS42183.1.
RefSeqNP_597715.2. NM_133458.2.
XP_005255859.1. XM_005255802.2.
XP_005255860.1. XM_005255803.2.
XP_005255861.1. XM_005255804.2.
XP_006721199.1. XM_006721136.1.
UniGeneHs.461074.
Hs.709017.

3D structure databases

ProteinModelPortalQ8TF47.
SMRQ8TF47. Positions 14-55, 154-633.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8TF47.

Polymorphism databases

DMDM94730444.

Proteomic databases

MaxQBQ8TF47.
PaxDbQ8TF47.
PRIDEQ8TF47.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000398253; ENSP00000381304; ENSG00000184939.
ENST00000563169; ENSP00000454418; ENSG00000184939.
ENST00000570495; ENSP00000460547; ENSG00000184939.
GeneID146198.
KEGGhsa:146198.
UCSCuc002ewd.3. human.

Organism-specific databases

CTD146198.
GeneCardsGC16P068563.
HGNCHGNC:23329. ZFP90.
HPAHPA029017.
MIM609451. gene.
neXtProtNX_Q8TF47.
Orphanet67047. 3-methylglutaconic aciduria type 3.
PharmGKBPA134967487.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ8TF47.
KOK09228.
OMAHENAHTG.
OrthoDBEOG7KSX7Q.
PhylomeDBQ8TF47.
TreeFamTF350822.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ8TF47.
BgeeQ8TF47.
CleanExHS_ZFP90.
GenevestigatorQ8TF47.

Family and domain databases

Gene3D3.30.160.60. 13 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZFP90. human.
GenomeRNAi146198.
NextBio85291.
PROQ8TF47.
SOURCESearch...

Entry information

Entry nameZFP90_HUMAN
AccessionPrimary (citable) accession number: Q8TF47
Secondary accession number(s): B2RU00 expand/collapse secondary AC list , B3KVE7, Q49AD1, Q96MQ6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: May 2, 2006
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM