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Protein

Zinc finger protein 90 homolog

Gene

ZFP90

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a repressor or silencer protein, and most likely exerts its repressing activity upon zinc-dependent binding to DNA. May be involved in proper spermatogenesis by repressing the expression of genes unnecessary or incompatible with the maintenance of a haploid cell state (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri211 – 23323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri254 – 27623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 54723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri553 – 57523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri581 – 60323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri609 – 63123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl

GO - Biological processi

  1. negative regulation of DNA binding Source: Ensembl
  2. positive regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 90 homolog
Short name:
Zfp-90
Alternative name(s):
Zinc finger protein 756
Gene namesi
Name:ZFP90
Synonyms:KIAA1954, ZNF756
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:23329. ZFP90.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

Orphaneti67047. 3-methylglutaconic aciduria type 3.
PharmGKBiPA134967487.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 636636Zinc finger protein 90 homologPRO_0000047310Add
BLAST

Proteomic databases

MaxQBiQ8TF47.
PaxDbiQ8TF47.
PRIDEiQ8TF47.

PTM databases

PhosphoSiteiQ8TF47.

Expressioni

Gene expression databases

BgeeiQ8TF47.
CleanExiHS_ZFP90.
ExpressionAtlasiQ8TF47. baseline and differential.
GenevestigatoriQ8TF47.

Organism-specific databases

HPAiHPA029017.

Structurei

3D structure databases

ProteinModelPortaliQ8TF47.
SMRiQ8TF47. Positions 14-55, 181-633.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri211 – 23323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri254 – 27623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 54723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri553 – 57523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri581 – 60323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri609 – 63123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121890.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TF47.
KOiK09228.
OMAiHENAHTG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8TF47.
TreeFamiTF350822.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TF47-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPRPPTAAP QESVTFKDVS VDFTQEEWYH VDPAQRSLYR DVMLENYSHL
60 70 80 90 100
VSLGYQVSKP EVIFKLEQGE EPWISEGEIQ RPFYPDWKTR PEVKSSHLQQ
110 120 130 140 150
DVSEVSHCTH DLLHATLEDS WDVSSQLDRQ QENWKRHLGS EASTQKKIIT
160 170 180 190 200
PQENFEQNKF GENSRLNTNL VTQLNIPARI RPSECETLGS NLGHNADLLN
210 220 230 240 250
ENNILAKKKP YKCDKCRKAF IHRSSLTKHE KTHKGEGAFP NGTDQGIYPG
260 270 280 290 300
KKHHECTDCG KTFLWKTQLT EHQRIHTGEK PFECNVCGKA FRHSSSLGQH
310 320 330 340 350
ENAHTGEKPY QCSLCGKAFQ RSSSLVQHQR IHTGEKPYRC NLCGRSFRHG
360 370 380 390 400
TSLTQHEVTH SGEKPFQCKE CGKAFSRCSS LVQHERTHTG EKPFECSICG
410 420 430 440 450
RAFGQSPSLY KHMRIHKRGK PYQSSNYSID FKHSTSLTQD ESTLTEVKSY
460 470 480 490 500
HCNDCGEDFS HITDFTDHQR IHTAENPYDC EQAFSQQAIS HPGEKPYQCN
510 520 530 540 550
VCGKAFKRST SFIEHHRIHT GEKPYECNEC GEAFSRRSSL TQHERTHTGE
560 570 580 590 600
KPYECIDCGK AFSQSSSLIQ HERTHTGEKP YECNECGRAF RKKTNLHDHQ
610 620 630
RIHTGEKPYS CKECGKNFSR SSALTKHQRI HTRNKL
Length:636
Mass (Da):73,031
Last modified:May 2, 2006 - v2
Checksum:i2D645DD5F5EFD8A6
GO

Sequence cautioni

The sequence AX721106 differs from that shown. Reason: Frameshift at positions 341, 358 and 370. Curated
The sequence BAB71228.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG53759.1 differs from that shown.Intron retention.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti550 – 5501E → V in BAB71228. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056596 mRNA. Translation: BAB71228.1. Different initiation.
AK122847 mRNA. Translation: BAG53759.1. Sequence problems.
AK304152 mRNA. Translation: BAG65042.1.
AK316251 mRNA. Translation: BAH14622.1.
AC009162 Genomic DNA. No translation available.
AC126773 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83234.1.
BC033165 mRNA. Translation: AAH33165.2.
BC140886 mRNA. Translation: AAI40887.1.
BC140887 mRNA. Translation: AAI40888.1.
AX721106 mRNA. No translation available.
AB075834 mRNA. Translation: BAB85540.1.
CCDSiCCDS42183.1.
RefSeqiNP_597715.2. NM_133458.2.
XP_005255859.1. XM_005255802.2.
XP_005255860.1. XM_005255803.2.
XP_005255861.1. XM_005255804.2.
XP_006721199.1. XM_006721136.1.
UniGeneiHs.461074.
Hs.709017.

Genome annotation databases

EnsembliENST00000398253; ENSP00000381304; ENSG00000184939.
ENST00000563169; ENSP00000454418; ENSG00000184939.
ENST00000570495; ENSP00000460547; ENSG00000184939.
GeneIDi146198.
KEGGihsa:146198.
UCSCiuc002ewd.3. human.

Polymorphism databases

DMDMi94730444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056596 mRNA. Translation: BAB71228.1. Different initiation.
AK122847 mRNA. Translation: BAG53759.1. Sequence problems.
AK304152 mRNA. Translation: BAG65042.1.
AK316251 mRNA. Translation: BAH14622.1.
AC009162 Genomic DNA. No translation available.
AC126773 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83234.1.
BC033165 mRNA. Translation: AAH33165.2.
BC140886 mRNA. Translation: AAI40887.1.
BC140887 mRNA. Translation: AAI40888.1.
AX721106 mRNA. No translation available.
AB075834 mRNA. Translation: BAB85540.1.
CCDSiCCDS42183.1.
RefSeqiNP_597715.2. NM_133458.2.
XP_005255859.1. XM_005255802.2.
XP_005255860.1. XM_005255803.2.
XP_005255861.1. XM_005255804.2.
XP_006721199.1. XM_006721136.1.
UniGeneiHs.461074.
Hs.709017.

3D structure databases

ProteinModelPortaliQ8TF47.
SMRiQ8TF47. Positions 14-55, 181-633.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8TF47.

Polymorphism databases

DMDMi94730444.

Proteomic databases

MaxQBiQ8TF47.
PaxDbiQ8TF47.
PRIDEiQ8TF47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398253; ENSP00000381304; ENSG00000184939.
ENST00000563169; ENSP00000454418; ENSG00000184939.
ENST00000570495; ENSP00000460547; ENSG00000184939.
GeneIDi146198.
KEGGihsa:146198.
UCSCiuc002ewd.3. human.

Organism-specific databases

CTDi146198.
GeneCardsiGC16P068563.
HGNCiHGNC:23329. ZFP90.
HPAiHPA029017.
MIMi609451. gene.
neXtProtiNX_Q8TF47.
Orphaneti67047. 3-methylglutaconic aciduria type 3.
PharmGKBiPA134967487.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121890.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8TF47.
KOiK09228.
OMAiHENAHTG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8TF47.
TreeFamiTF350822.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZFP90. human.
GenomeRNAii146198.
NextBioi85291.
PROiQ8TF47.
SOURCEiSearch...

Gene expression databases

BgeeiQ8TF47.
CleanExiHS_ZFP90.
ExpressionAtlasiQ8TF47. baseline and differential.
GenevestigatoriQ8TF47.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus and Tongue.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 338-636.
    Tissue: Melanoma and Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-372.
  6. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 169-636.
    Tissue: Brain.

Entry informationi

Entry nameiZFP90_HUMAN
AccessioniPrimary (citable) accession number: Q8TF47
Secondary accession number(s): B2RU00
, B3KVE7, Q49AD1, Q96MQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: May 2, 2006
Last modified: February 4, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.