Q8TF47 (ZFP90_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 90 homolog
Short name=Zfp-90

Alternative name(s):
Zinc finger protein 756

Gene names

Name:	ZFP90
Synonyms:	KIAA1954, ZNF756

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	636 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May function as a repressor or silencer protein, and most likely exerts its repressing activity upon zinc-dependent binding to DNA. May be involved in proper spermatogenesis by repressing the expression of genes unnecessary or incompatible with the maintenance of a haploid cell state By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 13 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence AX721106 differs from that shown. Reason: Frameshift at positions 341, 358 and 370. The sequence BAB71228.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAG53759.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of DNA binding Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from mutant phenotype PubMed 21284946. Source: UniProtKB
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 636	636	Zinc finger protein 90 homolog		PRO_0000047310
Regions
	Domain	14 – 85	72	KRAB
	Zinc finger	211 – 233	23	C2H2-type 1
	Zinc finger	254 – 276	23	C2H2-type 2
	Zinc finger	282 – 304	23	C2H2-type 3
	Zinc finger	310 – 332	23	C2H2-type 4
	Zinc finger	338 – 360	23	C2H2-type 5
	Zinc finger	366 – 388	23	C2H2-type 6
	Zinc finger	394 – 416	23	C2H2-type 7
	Zinc finger	450 – 472	23	C2H2-type 8
	Zinc finger	497 – 519	23	C2H2-type 9
	Zinc finger	525 – 547	23	C2H2-type 10
	Zinc finger	553 – 575	23	C2H2-type 11
	Zinc finger	581 – 603	23	C2H2-type 12
	Zinc finger	609 – 631	23	C2H2-type 13
Experimental info
	Sequence conflict	550	1	E → V in BAB71228. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8TF47 [UniParc]. Last modified May 2, 2006. Version 2. Checksum: 2D645DD5F5EFD8A6	FASTA	636	73,031
	10 20 30 40 50 60 MAPRPPTAAP QESVTFKDVS VDFTQEEWYH VDPAQRSLYR DVMLENYSHL VSLGYQVSKP 70 80 90 100 110 120 EVIFKLEQGE EPWISEGEIQ RPFYPDWKTR PEVKSSHLQQ DVSEVSHCTH DLLHATLEDS 130 140 150 160 170 180 WDVSSQLDRQ QENWKRHLGS EASTQKKIIT PQENFEQNKF GENSRLNTNL VTQLNIPARI 190 200 210 220 230 240 RPSECETLGS NLGHNADLLN ENNILAKKKP YKCDKCRKAF IHRSSLTKHE KTHKGEGAFP 250 260 270 280 290 300 NGTDQGIYPG KKHHECTDCG KTFLWKTQLT EHQRIHTGEK PFECNVCGKA FRHSSSLGQH 310 320 330 340 350 360 ENAHTGEKPY QCSLCGKAFQ RSSSLVQHQR IHTGEKPYRC NLCGRSFRHG TSLTQHEVTH 370 380 390 400 410 420 SGEKPFQCKE CGKAFSRCSS LVQHERTHTG EKPFECSICG RAFGQSPSLY KHMRIHKRGK 430 440 450 460 470 480 PYQSSNYSID FKHSTSLTQD ESTLTEVKSY HCNDCGEDFS HITDFTDHQR IHTAENPYDC 490 500 510 520 530 540 EQAFSQQAIS HPGEKPYQCN VCGKAFKRST SFIEHHRIHT GEKPYECNEC GEAFSRRSSL 550 560 570 580 590 600 TQHERTHTGE KPYECIDCGK AFSQSSSLIQ HERTHTGEKP YECNECGRAF RKKTNLHDHQ 610 620 630 RIHTGEKPYS CKECGKNFSR SSALTKHQRI HTRNKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hippocampus and Tongue.
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 338-636. Tissue: Melanoma and Testis.
[5]	"Molecules for diagnostics and therapeutics." Lincoln S.E., Altus C.M., Dufour G.E., Chalup M.S., Hillman J.L., Jones A., Yu J.Y., Wright R.J., Gietzen D., Liu T.F., Yap P., Dahl C.R., Momiyama M., Bradley D., Rohatgi S., Harris B., Roseberry A.M., Gerstin E.H. , Peralta C.H., David M., Panzer S., Flores V., Daffo A., Marwaha R., Chen A., Chang S.C., Inman R.R. Patent number WO0220754, 14-MAR-2002 Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-372.
[6]	"Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins." Nagase T., Kikuno R., Ohara O. DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 169-636. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK056596 mRNA. Translation: BAB71228.1. Different initiation. AK122847 mRNA. Translation: BAG53759.1. Sequence problems. AK304152 mRNA. Translation: BAG65042.1. AK316251 mRNA. Translation: BAH14622.1. AC009162 Genomic DNA. No translation available. AC126773 Genomic DNA. No translation available. CH471092 Genomic DNA. Translation: EAW83234.1. BC033165 mRNA. Translation: AAH33165.2. BC140886 mRNA. Translation: AAI40887.1. BC140887 mRNA. Translation: AAI40888.1. AX721106 mRNA. No translation available. AB075834 mRNA. Translation: BAB85540.1.
IPI	IPI00291840.
RefSeq	NP_597715.2. NM_133458.2.
UniGene	Hs.461074. Hs.709017.
3D structure databases
ProteinModelPortal	Q8TF47.
ModBase	Search...
PTM databases
PhosphoSite	Q8TF47.
Polymorphism databases
DMDM	94730444.
Proteomic databases
PaxDb	Q8TF47.
PRIDE	Q8TF47.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000398253; ENSP00000381304; ENSG00000184939. ENST00000563169; ENSP00000454418; ENSG00000184939. ENST00000570495; ENSP00000460547; ENSG00000184939.
GeneID	146198.
KEGG	hsa:146198.
UCSC	uc002ewd.3. human.
Organism-specific databases
CTD	146198.
GeneCards	GC16P068563.
HGNC	HGNC:23329. ZFP90.
HPA	HPA029017.
MIM	609451. gene.
neXtProt	NX_Q8TF47.
Orphanet	67047. 3-methylglutaconic aciduria type 3.
PharmGKB	PA134967487.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q8TF47.
KO	K09228.
OMA	HENAHTG.
OrthoDB	EOG4868BX.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q8TF47.
Bgee	Q8TF47.
CleanEx	HS_ZFP90.
Genevestigator	Q8TF47.
Family and domain databases
Gene3D	3.30.160.60. 13 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 2 hits. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 13 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 13 hits. PS50157. ZINC_FINGER_C2H2_2. 13 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZFP90. human.
GenomeRNAi	146198.
NextBio	85291.
SOURCE	Search...

Entry information

Entry name

ZFP90_HUMAN

Accession

Primary (citable) accession number: Q8TF47
Secondary accession number(s): B2RU00 , B3KVE7, Q49AD1, Q96MQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	May 2, 2006
Last modified:	May 1, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.