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Protein

Zinc finger protein 90 homolog

Gene

ZFP90

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes.1 Publication
Isoform 2: Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri211 – 233C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • negative regulation of DNA binding Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 90 homolog
Short name:
Zfp-90
Alternative name(s):
Zinc finger protein 756
Gene namesi
Name:ZFP90
Synonyms:KIAA1954, ZNF756
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000184939.15
HGNCiHGNC:23329 ZFP90
MIMi609451 gene
neXtProtiNX_Q8TF47

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi146198
OpenTargetsiENSG00000184939
Orphaneti67047 3-methylglutaconic aciduria type 3
PharmGKBiPA134967487

Polymorphism and mutation databases

BioMutaiZFP90
DMDMi94730444

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473101 – 636Zinc finger protein 90 homologAdd BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki448Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8TF47
MaxQBiQ8TF47
PaxDbiQ8TF47
PeptideAtlasiQ8TF47
PRIDEiQ8TF47

PTM databases

iPTMnetiQ8TF47
PhosphoSitePlusiQ8TF47

Expressioni

Tissue specificityi

Expressed in heart (PubMed:21284946). Isoform 2: Highly expressed in regulatory T-cells (Treg) (PubMed:23543754).2 Publications

Gene expression databases

BgeeiENSG00000184939
CleanExiHS_ZFP90
ExpressionAtlasiQ8TF47 baseline and differential
GenevisibleiQ8TF47 HS

Organism-specific databases

HPAiHPA029017

Interactioni

Subunit structurei

Interacts (via N- and C-termini) with REST (via zinc-finger DNA-binding domain); the interaction inhibits REST repressor activity (PubMed:21284946). Isoform 2: Interacts with FOXP3 and TRIM28 (PubMed:23543754).2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ8TF47, 2 interactors
STRINGi9606.ENSP00000381304

Structurei

3D structure databases

ProteinModelPortaliQ8TF47
SMRiQ8TF47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri211 – 233C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144148
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8TF47
KOiK09228
OMAiHENAHTG
OrthoDBiEOG091G02KC
PhylomeDBiQ8TF47
TreeFamiTF350822

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TF47-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPRPPTAAP QESVTFKDVS VDFTQEEWYH VDPAQRSLYR DVMLENYSHL
60 70 80 90 100
VSLGYQVSKP EVIFKLEQGE EPWISEGEIQ RPFYPDWKTR PEVKSSHLQQ
110 120 130 140 150
DVSEVSHCTH DLLHATLEDS WDVSSQLDRQ QENWKRHLGS EASTQKKIIT
160 170 180 190 200
PQENFEQNKF GENSRLNTNL VTQLNIPARI RPSECETLGS NLGHNADLLN
210 220 230 240 250
ENNILAKKKP YKCDKCRKAF IHRSSLTKHE KTHKGEGAFP NGTDQGIYPG
260 270 280 290 300
KKHHECTDCG KTFLWKTQLT EHQRIHTGEK PFECNVCGKA FRHSSSLGQH
310 320 330 340 350
ENAHTGEKPY QCSLCGKAFQ RSSSLVQHQR IHTGEKPYRC NLCGRSFRHG
360 370 380 390 400
TSLTQHEVTH SGEKPFQCKE CGKAFSRCSS LVQHERTHTG EKPFECSICG
410 420 430 440 450
RAFGQSPSLY KHMRIHKRGK PYQSSNYSID FKHSTSLTQD ESTLTEVKSY
460 470 480 490 500
HCNDCGEDFS HITDFTDHQR IHTAENPYDC EQAFSQQAIS HPGEKPYQCN
510 520 530 540 550
VCGKAFKRST SFIEHHRIHT GEKPYECNEC GEAFSRRSSL TQHERTHTGE
560 570 580 590 600
KPYECIDCGK AFSQSSSLIQ HERTHTGEKP YECNECGRAF RKKTNLHDHQ
610 620 630
RIHTGEKPYS CKECGKNFSR SSALTKHQRI HTRNKL
Length:636
Mass (Da):73,031
Last modified:May 2, 2006 - v2
Checksum:i2D645DD5F5EFD8A6
GO
Isoform 2 (identifier: Q8TF47-3) [UniParc]FASTAAdd to basket
Also known as: FOXP3-interacting KRAB-domain containing protein, FIK1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     86-113: DWKTRPEVKSSHLQQDVSEVSHCTHDLL → GFVCLLPLSLPSGSKGERRQKLPRKNPE
     114-636: Missing.

Note: Interacts (via 75-113 AA) with FOXP3. Interacts (via KRAB domain) with TRIM28.1 Publication
Show »
Length:113
Mass (Da):13,006
Checksum:i61D16304A863D683
GO

Sequence cautioni

The sequence AX721106 differs from that shown. Reason: Frameshift at positions 341, 358 and 370.Curated
The sequence BAB71228 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG53759 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti550E → V in BAB71228 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05751686 – 113DWKTR…THDLL → GFVCLLPLSLPSGSKGERRQ KLPRKNPE in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_057517114 – 636Missing in isoform 2. 1 PublicationAdd BLAST523

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC249978 mRNA Translation: AGC13464.1
AK056596 mRNA Translation: BAB71228.1 Different initiation.
AK122847 mRNA Translation: BAG53759.1 Sequence problems.
AK304152 mRNA Translation: BAG65042.1
AK316251 mRNA Translation: BAH14622.1
AC009162 Genomic DNA No translation available.
AC126773 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83234.1
BC033165 mRNA Translation: AAH33165.2
BC140886 mRNA Translation: AAI40887.1
BC140887 mRNA Translation: AAI40888.1
AX721106 mRNA No translation available.
AB075834 mRNA Translation: BAB85540.1
CCDSiCCDS42183.1 [Q8TF47-1]
CCDS76892.1 [Q8TF47-3]
RefSeqiNP_001292132.1, NM_001305203.1 [Q8TF47-1]
NP_001292133.1, NM_001305204.1 [Q8TF47-3]
NP_597715.2, NM_133458.3 [Q8TF47-1]
XP_005255861.1, XM_005255804.2 [Q8TF47-1]
UniGeneiHs.461074
Hs.709017

Genome annotation databases

EnsembliENST00000398253; ENSP00000381304; ENSG00000184939 [Q8TF47-1]
ENST00000563169; ENSP00000454418; ENSG00000184939 [Q8TF47-1]
ENST00000570495; ENSP00000460547; ENSG00000184939 [Q8TF47-1]
ENST00000611381; ENSP00000480309; ENSG00000184939 [Q8TF47-3]
GeneIDi146198
KEGGihsa:146198
UCSCiuc002ewd.4 human [Q8TF47-1]
uc031qws.2 human

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZFP90_HUMAN
AccessioniPrimary (citable) accession number: Q8TF47
Secondary accession number(s): B2RU00
, B3KVE7, L7S2P3, Q49AD1, Q96MQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: May 2, 2006
Last modified: May 23, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health