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Q8TF47

- ZFP90_HUMAN

UniProt

Q8TF47 - ZFP90_HUMAN

Protein

Zinc finger protein 90 homolog

Gene

ZFP90

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (02 May 2006)
      Previous versions | rss
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    Functioni

    May function as a repressor or silencer protein, and most likely exerts its repressing activity upon zinc-dependent binding to DNA. May be involved in proper spermatogenesis by repressing the expression of genes unnecessary or incompatible with the maintenance of a haploid cell state By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri211 – 23323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri254 – 27623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri282 – 30423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri310 – 33223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri338 – 36023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri366 – 38823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri394 – 41623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri450 – 47223C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri497 – 51923C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri525 – 54723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri553 – 57523C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri581 – 60323C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri609 – 63123C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl

    GO - Biological processi

    1. negative regulation of DNA binding Source: Ensembl
    2. positive regulation of transcription, DNA-templated Source: UniProtKB

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 90 homolog
    Short name:
    Zfp-90
    Alternative name(s):
    Zinc finger protein 756
    Gene namesi
    Name:ZFP90
    Synonyms:KIAA1954, ZNF756
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:23329. ZFP90.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti67047. 3-methylglutaconic aciduria type 3.
    PharmGKBiPA134967487.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 636636Zinc finger protein 90 homologPRO_0000047310Add
    BLAST

    Proteomic databases

    MaxQBiQ8TF47.
    PaxDbiQ8TF47.
    PRIDEiQ8TF47.

    PTM databases

    PhosphoSiteiQ8TF47.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8TF47.
    BgeeiQ8TF47.
    CleanExiHS_ZFP90.
    GenevestigatoriQ8TF47.

    Organism-specific databases

    HPAiHPA029017.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TF47.
    SMRiQ8TF47. Positions 14-55, 154-633.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri211 – 23323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri254 – 27623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri282 – 30423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri310 – 33223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri338 – 36023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri366 – 38823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri394 – 41623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri450 – 47223C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri497 – 51923C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri525 – 54723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri553 – 57523C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri581 – 60323C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri609 – 63123C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ8TF47.
    KOiK09228.
    OMAiHENAHTG.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ8TF47.
    TreeFamiTF350822.

    Family and domain databases

    Gene3Di3.30.160.60. 13 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 3 hits.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 13 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 13 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TF47-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPRPPTAAP QESVTFKDVS VDFTQEEWYH VDPAQRSLYR DVMLENYSHL    50
    VSLGYQVSKP EVIFKLEQGE EPWISEGEIQ RPFYPDWKTR PEVKSSHLQQ 100
    DVSEVSHCTH DLLHATLEDS WDVSSQLDRQ QENWKRHLGS EASTQKKIIT 150
    PQENFEQNKF GENSRLNTNL VTQLNIPARI RPSECETLGS NLGHNADLLN 200
    ENNILAKKKP YKCDKCRKAF IHRSSLTKHE KTHKGEGAFP NGTDQGIYPG 250
    KKHHECTDCG KTFLWKTQLT EHQRIHTGEK PFECNVCGKA FRHSSSLGQH 300
    ENAHTGEKPY QCSLCGKAFQ RSSSLVQHQR IHTGEKPYRC NLCGRSFRHG 350
    TSLTQHEVTH SGEKPFQCKE CGKAFSRCSS LVQHERTHTG EKPFECSICG 400
    RAFGQSPSLY KHMRIHKRGK PYQSSNYSID FKHSTSLTQD ESTLTEVKSY 450
    HCNDCGEDFS HITDFTDHQR IHTAENPYDC EQAFSQQAIS HPGEKPYQCN 500
    VCGKAFKRST SFIEHHRIHT GEKPYECNEC GEAFSRRSSL TQHERTHTGE 550
    KPYECIDCGK AFSQSSSLIQ HERTHTGEKP YECNECGRAF RKKTNLHDHQ 600
    RIHTGEKPYS CKECGKNFSR SSALTKHQRI HTRNKL 636
    Length:636
    Mass (Da):73,031
    Last modified:May 2, 2006 - v2
    Checksum:i2D645DD5F5EFD8A6
    GO

    Sequence cautioni

    The sequence BAG53759.1 differs from that shown. Reason: Intron retention.
    The sequence AX721106 differs from that shown. Reason: Frameshift at positions 341, 358 and 370.
    The sequence BAB71228.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti550 – 5501E → V in BAB71228. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056596 mRNA. Translation: BAB71228.1. Different initiation.
    AK122847 mRNA. Translation: BAG53759.1. Sequence problems.
    AK304152 mRNA. Translation: BAG65042.1.
    AK316251 mRNA. Translation: BAH14622.1.
    AC009162 Genomic DNA. No translation available.
    AC126773 Genomic DNA. No translation available.
    CH471092 Genomic DNA. Translation: EAW83234.1.
    BC033165 mRNA. Translation: AAH33165.2.
    BC140886 mRNA. Translation: AAI40887.1.
    BC140887 mRNA. Translation: AAI40888.1.
    AX721106 mRNA. No translation available.
    AB075834 mRNA. Translation: BAB85540.1.
    CCDSiCCDS42183.1.
    RefSeqiNP_597715.2. NM_133458.2.
    XP_005255859.1. XM_005255802.2.
    XP_005255860.1. XM_005255803.2.
    XP_005255861.1. XM_005255804.2.
    XP_006721199.1. XM_006721136.1.
    UniGeneiHs.461074.
    Hs.709017.

    Genome annotation databases

    EnsembliENST00000398253; ENSP00000381304; ENSG00000184939.
    ENST00000563169; ENSP00000454418; ENSG00000184939.
    ENST00000570495; ENSP00000460547; ENSG00000184939.
    GeneIDi146198.
    KEGGihsa:146198.
    UCSCiuc002ewd.3. human.

    Polymorphism databases

    DMDMi94730444.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056596 mRNA. Translation: BAB71228.1 . Different initiation.
    AK122847 mRNA. Translation: BAG53759.1 . Sequence problems.
    AK304152 mRNA. Translation: BAG65042.1 .
    AK316251 mRNA. Translation: BAH14622.1 .
    AC009162 Genomic DNA. No translation available.
    AC126773 Genomic DNA. No translation available.
    CH471092 Genomic DNA. Translation: EAW83234.1 .
    BC033165 mRNA. Translation: AAH33165.2 .
    BC140886 mRNA. Translation: AAI40887.1 .
    BC140887 mRNA. Translation: AAI40888.1 .
    AX721106 mRNA. No translation available.
    AB075834 mRNA. Translation: BAB85540.1 .
    CCDSi CCDS42183.1.
    RefSeqi NP_597715.2. NM_133458.2.
    XP_005255859.1. XM_005255802.2.
    XP_005255860.1. XM_005255803.2.
    XP_005255861.1. XM_005255804.2.
    XP_006721199.1. XM_006721136.1.
    UniGenei Hs.461074.
    Hs.709017.

    3D structure databases

    ProteinModelPortali Q8TF47.
    SMRi Q8TF47. Positions 14-55, 154-633.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8TF47.

    Polymorphism databases

    DMDMi 94730444.

    Proteomic databases

    MaxQBi Q8TF47.
    PaxDbi Q8TF47.
    PRIDEi Q8TF47.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000398253 ; ENSP00000381304 ; ENSG00000184939 .
    ENST00000563169 ; ENSP00000454418 ; ENSG00000184939 .
    ENST00000570495 ; ENSP00000460547 ; ENSG00000184939 .
    GeneIDi 146198.
    KEGGi hsa:146198.
    UCSCi uc002ewd.3. human.

    Organism-specific databases

    CTDi 146198.
    GeneCardsi GC16P068563.
    HGNCi HGNC:23329. ZFP90.
    HPAi HPA029017.
    MIMi 609451. gene.
    neXtProti NX_Q8TF47.
    Orphaneti 67047. 3-methylglutaconic aciduria type 3.
    PharmGKBi PA134967487.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q8TF47.
    KOi K09228.
    OMAi HENAHTG.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q8TF47.
    TreeFami TF350822.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    ChiTaRSi ZFP90. human.
    GenomeRNAii 146198.
    NextBioi 85291.
    PROi Q8TF47.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8TF47.
    Bgeei Q8TF47.
    CleanExi HS_ZFP90.
    Genevestigatori Q8TF47.

    Family and domain databases

    Gene3Di 3.30.160.60. 13 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 3 hits.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 13 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 13 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hippocampus and Tongue.
    2. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 338-636.
      Tissue: Melanoma and Testis.
    5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-372.
    6. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 169-636.
      Tissue: Brain.

    Entry informationi

    Entry nameiZFP90_HUMAN
    AccessioniPrimary (citable) accession number: Q8TF47
    Secondary accession number(s): B2RU00
    , B3KVE7, Q49AD1, Q96MQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3