Q8TF46 (DI3L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DIS3-like exonuclease 1
EC=3.1.13.-

Gene names

Name:	DIS3L
Synonyms:	DIS3L1, KIAA1955

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1054 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. Ref.6 Ref.7
Cofactor	Magnesium. Ref.6 Ref.7
Subunit structure	Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms.
Subcellular location	Cytoplasm Ref.6 Ref.7.
Sequence similarities	Belongs to the RNR ribonuclease family.
Sequence caution	The sequence BAB85541.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cytoplasm Exosome
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Magnesium RNA-binding
Molecular function	Exonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	rRNA catabolic process Inferred from direct assay Ref.7. Source: UniProtKB
Cellular_component	centrosome Inferred from direct assay. Source: HPA cytoplasmic exosome (RNase complex) Inferred from direct assay Ref.6Ref.7. Source: UniProtKB plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	3'-5'-exoribonuclease activity Inferred from direct assay Ref.7. Source: UniProtKB RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EXOSC2	Q13868	2	EBI-3895807,EBI-301735

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8TF46-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8TF46-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8TF46-3)

The sequence of this isoform differs from the canonical sequence as follows:
     735-750: SNKTLADSLDNANDPH → YSSFEGAEEWSGMLYI
     751-1054: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8TF46-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1054	1054	DIS3-like exonuclease 1		PRO_0000314810
Natural variations
	Alternative sequence	1 – 134	134	Missing in isoform 2.		VSP_030366
	Alternative sequence	1 – 83	83	Missing in isoform 4.		VSP_030367
	Alternative sequence	735 – 750	16	SNKTL…ANDPH → YSSFEGAEEWSGMLYI in isoform 3.		VSP_030368
	Alternative sequence	751 – 1054	304	Missing in isoform 3.		VSP_030369
	Natural variant	518	1	I → V. Corresponds to variant rs34668776 [ dbSNP | Ensembl ].		VAR_038056
	Natural variant	614	1	D → G. Ref.2 Ref.5 Corresponds to variant rs3803412 [ dbSNP | Ensembl ].		VAR_038057
	Natural variant	747	1	N → S. Corresponds to variant rs17258507 [ dbSNP | Ensembl ].		VAR_038058
Experimental info
	Mutagenesis	62	1	D → N: No change of exonuclease activity. Ref.7
	Mutagenesis	166	1	D → N: No change of exonuclease activity. Ref.7
	Mutagenesis	486	1	D → N: Complete loss of exonuclease activity. Ref.6 Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: B57B691CC25F65B8	FASTA	1,054	120,787
	10 20 30 40 50 60 MLQKREKVLL LRTFQGRTLR IVREHYLRPC VPCHSPLCPQ PAACSHDGKL LSSDVTHYVI 70 80 90 100 110 120 PDWKVVQDYL EILEFPELKG IIFMQTACQA VQHQRGRRQY NKLRNLLKDA RHDCILFANE 130 140 150 160 170 180 FQQCCYLPRE RGESMEKWQT RSIYNAAVWY YHHCQDRMPI VMVTEDEEAI QQYGSETEGV 190 200 210 220 230 240 FVITFKNYLD NFWPDLKAAH ELCDSILQSR RERENESQES HGKEYPEHLP LEVLEAGIKS 250 260 270 280 290 300 GRYIQGILNV NKHRAQIEAF VRLQGASSKD SDLVSDILIH GMKARNRSIH GDVVVVELLP 310 320 330 340 350 360 KNEWKGRTVA LCENDCDDKA SGESPSEPMP TGRVVGILQK NWRDYVVTFP SKEEVQSQGK 370 380 390 400 410 420 NAQKILVTPW DYRIPKIRIS TQQAETLQDF RVVVRIDSWE STSVYPNGHF VRVLGRIGDL 430 440 450 460 470 480 EGEIATILVE NSISVIPFSE AQMCEMPVNT PESPWKVSPE EEQKRKDLRK SHLVFSIDPK 490 500 510 520 530 540 GCEDVDDTLS VRTLNNGNLE LGVHIADVTH FVAPNSYIDI EARTRATTYY LADRRYDMLP 550 560 570 580 590 600 SVLSADLCSL LGGVDRYAVS IMWELDKASY EIKKVWYGRT IIRSAYKLFY EAAQELLDGN 610 620 630 640 650 660 LSVVDDIPEF KDLDEKSRQA KLEELVWAIG KLTDIARHVR AKRDGCGALE LEGVEVCVQL 670 680 690 700 710 720 DDKKNIHDLI PKQPLEVHET VAECMILANH WVAKKIWESF PHQALLRQHP PPHQEFFSEL 730 740 750 760 770 780 RECAKAKGFF IDTRSNKTLA DSLDNANDPH DPIVNRLLRS MATQAMSNAL YFSTGSCAEE 790 800 810 820 830 840 EFHHYGLALD KYTHFTSPIR RYSDIVVHRL LMAAISKDKK MEIKGNLFSN KDLEELCRHI 850 860 870 880 890 900 NNRNQAAQHS QKQSTELFQC MYFKDKDPAT EERCISDGVI YSIRTNGVLL FIPRFGIKGA 910 920 930 940 950 960 AYLKNKDGLV ISCGPDSCSE WKPGSLQRFQ NKITSTTTDG ESVTFHLFDH VTVRISIQAS 970 980 990 1000 1010 1020 RCHSDTIRLE IISNKPYKIP NTELIHQSSP LLKSELVKEV TKSVEEAQLA QEVKVNIIQE 1030 1040 1050 EYQEYRQTKG RSLYTLLEEI RDLALLDVSN NYGI
	Isoform 2 [UniParc]. Checksum: 2F7FB46F906C79A0	FASTA	920	105,012
	10 20 30 40 50 60 MEKWQTRSIY NAAVWYYHHC QDRMPIVMVT EDEEAIQQYG SETEGVFVIT FKNYLDNFWP 70 80 90 100 110 120 DLKAAHELCD SILQSRRERE NESQESHGKE YPEHLPLEVL EAGIKSGRYI QGILNVNKHR 130 140 150 160 170 180 AQIEAFVRLQ GASSKDSDLV SDILIHGMKA RNRSIHGDVV VVELLPKNEW KGRTVALCEN 190 200 210 220 230 240 DCDDKASGES PSEPMPTGRV VGILQKNWRD YVVTFPSKEE VQSQGKNAQK ILVTPWDYRI 250 260 270 280 290 300 PKIRISTQQA ETLQDFRVVV RIDSWESTSV YPNGHFVRVL GRIGDLEGEI ATILVENSIS 310 320 330 340 350 360 VIPFSEAQMC EMPVNTPESP WKVSPEEEQK RKDLRKSHLV FSIDPKGCED VDDTLSVRTL 370 380 390 400 410 420 NNGNLELGVH IADVTHFVAP NSYIDIEART RATTYYLADR RYDMLPSVLS ADLCSLLGGV 430 440 450 460 470 480 DRYAVSIMWE LDKASYEIKK VWYGRTIIRS AYKLFYEAAQ ELLDGNLSVV DDIPEFKDLD 490 500 510 520 530 540 EKSRQAKLEE LVWAIGKLTD IARHVRAKRD GCGALELEGV EVCVQLDDKK NIHDLIPKQP 550 560 570 580 590 600 LEVHETVAEC MILANHWVAK KIWESFPHQA LLRQHPPPHQ EFFSELRECA KAKGFFIDTR 610 620 630 640 650 660 SNKTLADSLD NANDPHDPIV NRLLRSMATQ AMSNALYFST GSCAEEEFHH YGLALDKYTH 670 680 690 700 710 720 FTSPIRRYSD IVVHRLLMAA ISKDKKMEIK GNLFSNKDLE ELCRHINNRN QAAQHSQKQS 730 740 750 760 770 780 TELFQCMYFK DKDPATEERC ISDGVIYSIR TNGVLLFIPR FGIKGAAYLK NKDGLVISCG 790 800 810 820 830 840 PDSCSEWKPG SLQRFQNKIT STTTDGESVT FHLFDHVTVR ISIQASRCHS DTIRLEIISN 850 860 870 880 890 900 KPYKIPNTEL IHQSSPLLKS ELVKEVTKSV EEAQLAQEVK VNIIQEEYQE YRQTKGRSLY 910 920 TLLEEIRDLA LLDVSNNYGI
	Isoform 3 [UniParc]. Checksum: DBACF862A569703A	FASTA	750	86,260
	10 20 30 40 50 60 MLQKREKVLL LRTFQGRTLR IVREHYLRPC VPCHSPLCPQ PAACSHDGKL LSSDVTHYVI 70 80 90 100 110 120 PDWKVVQDYL EILEFPELKG IIFMQTACQA VQHQRGRRQY NKLRNLLKDA RHDCILFANE 130 140 150 160 170 180 FQQCCYLPRE RGESMEKWQT RSIYNAAVWY YHHCQDRMPI VMVTEDEEAI QQYGSETEGV 190 200 210 220 230 240 FVITFKNYLD NFWPDLKAAH ELCDSILQSR RERENESQES HGKEYPEHLP LEVLEAGIKS 250 260 270 280 290 300 GRYIQGILNV NKHRAQIEAF VRLQGASSKD SDLVSDILIH GMKARNRSIH GDVVVVELLP 310 320 330 340 350 360 KNEWKGRTVA LCENDCDDKA SGESPSEPMP TGRVVGILQK NWRDYVVTFP SKEEVQSQGK 370 380 390 400 410 420 NAQKILVTPW DYRIPKIRIS TQQAETLQDF RVVVRIDSWE STSVYPNGHF VRVLGRIGDL 430 440 450 460 470 480 EGEIATILVE NSISVIPFSE AQMCEMPVNT PESPWKVSPE EEQKRKDLRK SHLVFSIDPK 490 500 510 520 530 540 GCEDVDDTLS VRTLNNGNLE LGVHIADVTH FVAPNSYIDI EARTRATTYY LADRRYDMLP 550 560 570 580 590 600 SVLSADLCSL LGGVDRYAVS IMWELDKASY EIKKVWYGRT IIRSAYKLFY EAAQELLDGN 610 620 630 640 650 660 LSVVDDIPEF KDLDEKSRQA KLEELVWAIG KLTDIARHVR AKRDGCGALE LEGVEVCVQL 670 680 690 700 710 720 DDKKNIHDLI PKQPLEVHET VAECMILANH WVAKKIWESF PHQALLRQHP PPHQEFFSEL 730 740 750 RECAKAKGFF IDTRYSSFEG AEEWSGMLYI
	Isoform 4 [UniParc]. Checksum: A3145DE249DF5279	FASTA	971	111,119
	10 20 30 40 50 60 MQTACQAVQH QRGRRQYNKL RNLLKDARHD CILFANEFQQ CCYLPRERGE SMEKWQTRSI 70 80 90 100 110 120 YNAAVWYYHH CQDRMPIVMV TEDEEAIQQY GSETEGVFVI TFKNYLDNFW PDLKAAHELC 130 140 150 160 170 180 DSILQSRRER ENESQESHGK EYPEHLPLEV LEAGIKSGRY IQGILNVNKH RAQIEAFVRL 190 200 210 220 230 240 QGASSKDSDL VSDILIHGMK ARNRSIHGDV VVVELLPKNE WKGRTVALCE NDCDDKASGE 250 260 270 280 290 300 SPSEPMPTGR VVGILQKNWR DYVVTFPSKE EVQSQGKNAQ KILVTPWDYR IPKIRISTQQ 310 320 330 340 350 360 AETLQDFRVV VRIDSWESTS VYPNGHFVRV LGRIGDLEGE IATILVENSI SVIPFSEAQM 370 380 390 400 410 420 CEMPVNTPES PWKVSPEEEQ KRKDLRKSHL VFSIDPKGCE DVDDTLSVRT LNNGNLELGV 430 440 450 460 470 480 HIADVTHFVA PNSYIDIEAR TRATTYYLAD RRYDMLPSVL SADLCSLLGG VDRYAVSIMW 490 500 510 520 530 540 ELDKASYEIK KVWYGRTIIR SAYKLFYEAA QELLDGNLSV VDDIPEFKDL DEKSRQAKLE 550 560 570 580 590 600 ELVWAIGKLT DIARHVRAKR DGCGALELEG VEVCVQLDDK KNIHDLIPKQ PLEVHETVAE 610 620 630 640 650 660 CMILANHWVA KKIWESFPHQ ALLRQHPPPH QEFFSELREC AKAKGFFIDT RSNKTLADSL 670 680 690 700 710 720 DNANDPHDPI VNRLLRSMAT QAMSNALYFS TGSCAEEEFH HYGLALDKYT HFTSPIRRYS 730 740 750 760 770 780 DIVVHRLLMA AISKDKKMEI KGNLFSNKDL EELCRHINNR NQAAQHSQKQ STELFQCMYF 790 800 810 820 830 840 KDKDPATEER CISDGVIYSI RTNGVLLFIP RFGIKGAAYL KNKDGLVISC GPDSCSEWKP 850 860 870 880 890 900 GSLQRFQNKI TSTTTDGESV TFHLFDHVTV RISIQASRCH SDTIRLEIIS NKPYKIPNTE 910 920 930 940 950 960 LIHQSSPLLK SELVKEVTKS VEEAQLAQEV KVNIIQEEYQ EYRQTKGRSL YTLLEEIRDL 970 ALLDVSNNYG I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins." Nagase T., Kikuno R., Ohara O. DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLY-614. Tissue: Tongue.
[3]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT GLY-614. Tissue: Kidney and Muscle.
[6]	"The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L." Tomecki R., Kristiansen M.S., Lykke-Andersen S., Chlebowski A., Larsen K.M., Szczesny R.J., Drazkowska K., Pastula A., Andersen J.S., Stepien P.P., Dziembowski A., Jensen T.H. EMBO J. 29:2342-2357(2010) [PubMed] [Europe PMC] [Abstract] Cited for: ASSOCIATION WITH THE RNA EXOSOME COMPLEX, MASS SPECTROMETRY, FUNCTION, COFACTOR, SUBCELLULAR LOCATION, MUTAGENESIS OF ASP-486.
[7]	"Dis3-like 1: a novel exoribonuclease associated with the human exosome." Staals R.H., Bronkhorst A.W., Schilders G., Slomovic S., Schuster G., Heck A.J., Raijmakers R., Pruijn G.J. EMBO J. 29:2358-2367(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, COFACTOR, SUBCELLULAR LOCATION, MUTAGENESIS OF ASP-62; ASP-166 AND ASP-486.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB075835 mRNA. Translation: BAB85541.1. Different initiation. AK095407 mRNA. Translation: BAC04542.1. AC055855 Genomic DNA. No translation available. CH471082 Genomic DNA. Translation: EAW77759.1. BC014124 mRNA. Translation: AAH14124.2. BC022089 mRNA. Translation: AAH22089.1.
IPI	IPI00291003. IPI00295876. IPI00879677. IPI00879828.
RefSeq	NP_001137160.1. NM_001143688.1. NP_588616.1. NM_133375.3.
UniGene	Hs.446251.
3D structure databases
ProteinModelPortal	Q8TF46.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8TF46. 2 interactions.
STRING	9606.ENSP00000321711.
PTM databases
PhosphoSite	Q8TF46.
Polymorphism databases
DMDM	166201903.
Proteomic databases
PaxDb	Q8TF46.
PeptideAtlas	Q8TF46.
PRIDE	Q8TF46.
Protocols and materials databases
DNASU	115752.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000319194; ENSP00000321583; ENSG00000166938. ENST00000319212; ENSP00000321711; ENSG00000166938.
GeneID	115752.
KEGG	hsa:115752.
UCSC	uc002app.3. human. uc002apq.2. human.
Organism-specific databases
CTD	115752.
GeneCards	GC15P066585.
HGNC	HGNC:28698. DIS3L.
HPA	HPA041805.
MIM	614183. gene.
neXtProt	NX_Q8TF46.
PharmGKB	PA162383675.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0557.
HOGENOM	HOG000191945.
HOVERGEN	HBG059397.
InParanoid	Q8TF46.
OMA	IPRFGIK.
Gene expression databases
ArrayExpress	Q8TF46.
Bgee	Q8TF46.
CleanEx	HS_DIS3L.
Genevestigator	Q8TF46.
Family and domain databases
InterPro	IPR001900. RNase_II/R. IPR022966. RNase_II/R_CS. [Graphical view]
Pfam	PF00773. RNB. 1 hit. [Graphical view]
SMART	SM00955. RNB. 1 hit. [Graphical view]
PROSITE	PS01175. RIBONUCLEASE_II. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DIS3L. human.
GenomeRNAi	115752.
NextBio	79674.
SOURCE	Search...

Entry information

Entry name

DI3L1_HUMAN

Accession

Primary (citable) accession number: Q8TF46
Secondary accession number(s): Q8N1N8, Q8WTU9, Q96CM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.