Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8TF45

- ZN418_HUMAN

UniProt

Q8TF45 - ZN418_HUMAN

Protein

Zinc finger protein 418

Gene

ZNF418

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (19 Sep 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional repressor.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri82 – 10524C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri230 – 25223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri258 – 28023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri286 – 30823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri314 – 33623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri342 – 36423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri370 – 39223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri398 – 42023C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri426 – 44823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri454 – 47623C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri482 – 50423C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri510 – 53223C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri538 – 56023C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri591 – 61323C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri619 – 64123C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri647 – 66923C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 418
    Gene namesi
    Name:ZNF418
    Synonyms:KIAA1956
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:20647. ZNF418.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134912102.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 676676Zinc finger protein 418PRO_0000047573Add
    BLAST

    Proteomic databases

    PaxDbiQ8TF45.
    PeptideAtlasiQ8TF45.
    PRIDEiQ8TF45.

    PTM databases

    PhosphoSiteiQ8TF45.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8TF45.
    BgeeiQ8TF45.
    CleanExiHS_ZNF418.
    GenevestigatoriQ8TF45.

    Interactioni

    Protein-protein interaction databases

    BioGridi127074. 2 interactions.
    IntActiQ8TF45. 1 interaction.
    STRINGi9606.ENSP00000379451.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8TF45.
    SMRiQ8TF45. Positions 96-676.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 9187KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri82 – 10524C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri230 – 25223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri258 – 28023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri286 – 30823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri314 – 33623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri342 – 36423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri370 – 39223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri398 – 42023C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri426 – 44823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri454 – 47623C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri482 – 50423C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri510 – 53223C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri538 – 56023C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri591 – 61323C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri619 – 64123C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri647 – 66923C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOVERGENiHBG018163.
    InParanoidiQ8TF45.
    KOiK09228.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ8TF45.
    TreeFamiTF339848.

    Family and domain databases

    Gene3Di3.30.160.60. 16 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 17 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 16 hits.
    PS50157. ZINC_FINGER_C2H2_2. 16 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8TF45-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQGTVAFEDV AVNFSQEEWS LLSEVQRCLY HDVMLENWVL ISSLGCWCGS    50
    EDEEAPSKKS ISIQRVSQVS TPGAGVSPKK AHSCEMCGAI LGDILHLADH 100
    QGTHHKQKLH RCEAWGNKLY DSSNRPHQNQ YLGEKPYRSS VEEALFVKRC 150
    KFHVSEESSI FIQSGKDFLP SSGLLLQEAT HTGEKSNSKP ECESPFQWGD 200
    THYSCGECMK HSSTKHVFVQ QQRLPSREEC YCWECGKSFS KYDSVSNHQR 250
    VHTGKRPYEC GECGKSFSHK GSLVQHQRVH TGKRPYECGE CGKSFSHKGS 300
    LVQHQRVHTG ERPYECGECG KSFSQNGTLI KHQRVHTGER PYECEECGKC 350
    FTQKGNLIQH QRGHTSERPY ECEECGKCFS QKGTLTEHHR VHTRERPYEC 400
    GECGKSFSRK GHLRNHQRGH TGERPYECGE CGKSFSRKGN LIQHQRSHTG 450
    ERPYECRECR KLFRGKSHLI EHQRVHTGER PYECNECGKS FQDSSGFRVH 500
    QRVHTGEKPF ECSECGKSFP QSCSLLRHRR VHTGERPYEC GECGKSFHQS 550
    SSLLRHQKTH TAERPYECRE CGKFFSSLLE HRRVHTGERP YECRECGKTF 600
    TRRSAHFKHQ RLHTRGKPYE CSECGKSFAE TFSLTEHRRV HTGERPYECS 650
    ECGKSFHRSS SLLRHQRVHT ERSPYK 676
    Length:676
    Mass (Da):77,858
    Last modified:September 19, 2002 - v2
    Checksum:i1BB0F0064B8F3BD3
    GO

    Sequence cautioni

    The sequence BAB85542.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti290 – 2901E → G in BAB71096. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY695825 mRNA. Translation: AAU05132.1.
    AB075836 mRNA. Translation: BAB85542.1. Different initiation.
    AK056113 mRNA. Translation: BAB71096.1.
    BC112244 mRNA. Translation: AAI12245.1.
    BC113707 mRNA. Translation: AAI13708.1.
    CCDSiCCDS42642.1.
    RefSeqiNP_597717.1. NM_133460.1.
    UniGeneiHs.660728.

    Genome annotation databases

    EnsembliENST00000396147; ENSP00000379451; ENSG00000196724.
    ENST00000595830; ENSP00000471652; ENSG00000196724.
    GeneIDi147686.
    KEGGihsa:147686.
    UCSCiuc002qqs.1. human.

    Polymorphism databases

    DMDMi23396985.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY695825 mRNA. Translation: AAU05132.1 .
    AB075836 mRNA. Translation: BAB85542.1 . Different initiation.
    AK056113 mRNA. Translation: BAB71096.1 .
    BC112244 mRNA. Translation: AAI12245.1 .
    BC113707 mRNA. Translation: AAI13708.1 .
    CCDSi CCDS42642.1.
    RefSeqi NP_597717.1. NM_133460.1.
    UniGenei Hs.660728.

    3D structure databases

    ProteinModelPortali Q8TF45.
    SMRi Q8TF45. Positions 96-676.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127074. 2 interactions.
    IntActi Q8TF45. 1 interaction.
    STRINGi 9606.ENSP00000379451.

    PTM databases

    PhosphoSitei Q8TF45.

    Polymorphism databases

    DMDMi 23396985.

    Proteomic databases

    PaxDbi Q8TF45.
    PeptideAtlasi Q8TF45.
    PRIDEi Q8TF45.

    Protocols and materials databases

    DNASUi 147686.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000396147 ; ENSP00000379451 ; ENSG00000196724 .
    ENST00000595830 ; ENSP00000471652 ; ENSG00000196724 .
    GeneIDi 147686.
    KEGGi hsa:147686.
    UCSCi uc002qqs.1. human.

    Organism-specific databases

    CTDi 147686.
    GeneCardsi GC19M058433.
    HGNCi HGNC:20647. ZNF418.
    neXtProti NX_Q8TF45.
    PharmGKBi PA134912102.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOVERGENi HBG018163.
    InParanoidi Q8TF45.
    KOi K09228.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q8TF45.
    TreeFami TF339848.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 147686.
    NextBioi 85679.
    PROi Q8TF45.

    Gene expression databases

    ArrayExpressi Q8TF45.
    Bgeei Q8TF45.
    CleanExi HS_ZNF418.
    Genevestigatori Q8TF45.

    Family and domain databases

    Gene3Di 3.30.160.60. 16 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 17 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 16 hits.
    PS50157. ZINC_FINGER_C2H2_2. 16 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ZNF418, a novel KRAB-containing zinc finger protein, is a transcription repressor."
      Li Y., Wang Q., Yuan W., Zhu C., Wu X., Liu M.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    2. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiZN418_HUMAN
    AccessioniPrimary (citable) accession number: Q8TF45
    Secondary accession number(s): Q2M1S2, Q670L5, Q96N18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: September 19, 2002
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3