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Q8TF45 (ZN418_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 418
Gene names
Name:ZNF418
Synonyms:KIAA1956
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length676 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional repressor. Ref.1

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 16 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence BAB85542.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionRepressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 676676Zinc finger protein 418
PRO_0000047573

Regions

Domain5 – 9187KRAB
Zinc finger82 – 10524C2H2-type 1
Zinc finger230 – 25223C2H2-type 2
Zinc finger258 – 28023C2H2-type 3
Zinc finger286 – 30823C2H2-type 4
Zinc finger314 – 33623C2H2-type 5
Zinc finger342 – 36423C2H2-type 6
Zinc finger370 – 39223C2H2-type 7
Zinc finger398 – 42023C2H2-type 8
Zinc finger426 – 44823C2H2-type 9
Zinc finger454 – 47623C2H2-type 10
Zinc finger482 – 50423C2H2-type 11
Zinc finger510 – 53223C2H2-type 12
Zinc finger538 – 56023C2H2-type 13
Zinc finger591 – 61323C2H2-type 14
Zinc finger619 – 64123C2H2-type 15
Zinc finger647 – 66923C2H2-type 16

Experimental info

Sequence conflict2901E → G in BAB71096. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8TF45 [UniParc].

Last modified September 19, 2002. Version 2.
Checksum: 1BB0F0064B8F3BD3

FASTA67677,858
        10         20         30         40         50         60 
MQGTVAFEDV AVNFSQEEWS LLSEVQRCLY HDVMLENWVL ISSLGCWCGS EDEEAPSKKS 

        70         80         90        100        110        120 
ISIQRVSQVS TPGAGVSPKK AHSCEMCGAI LGDILHLADH QGTHHKQKLH RCEAWGNKLY 

       130        140        150        160        170        180 
DSSNRPHQNQ YLGEKPYRSS VEEALFVKRC KFHVSEESSI FIQSGKDFLP SSGLLLQEAT 

       190        200        210        220        230        240 
HTGEKSNSKP ECESPFQWGD THYSCGECMK HSSTKHVFVQ QQRLPSREEC YCWECGKSFS 

       250        260        270        280        290        300 
KYDSVSNHQR VHTGKRPYEC GECGKSFSHK GSLVQHQRVH TGKRPYECGE CGKSFSHKGS 

       310        320        330        340        350        360 
LVQHQRVHTG ERPYECGECG KSFSQNGTLI KHQRVHTGER PYECEECGKC FTQKGNLIQH 

       370        380        390        400        410        420 
QRGHTSERPY ECEECGKCFS QKGTLTEHHR VHTRERPYEC GECGKSFSRK GHLRNHQRGH 

       430        440        450        460        470        480 
TGERPYECGE CGKSFSRKGN LIQHQRSHTG ERPYECRECR KLFRGKSHLI EHQRVHTGER 

       490        500        510        520        530        540 
PYECNECGKS FQDSSGFRVH QRVHTGEKPF ECSECGKSFP QSCSLLRHRR VHTGERPYEC 

       550        560        570        580        590        600 
GECGKSFHQS SSLLRHQKTH TAERPYECRE CGKFFSSLLE HRRVHTGERP YECRECGKTF 

       610        620        630        640        650        660 
TRRSAHFKHQ RLHTRGKPYE CSECGKSFAE TFSLTEHRRV HTGERPYECS ECGKSFHRSS 

       670 
SLLRHQRVHT ERSPYK 

« Hide

References

« Hide 'large scale' references
[1]"ZNF418, a novel KRAB-containing zinc finger protein, is a transcription repressor."
Li Y., Wang Q., Yuan W., Zhu C., Wu X., Liu M.
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[2]"Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
Nagase T., Kikuno R., Ohara O.
DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY695825 mRNA. Translation: AAU05132.1.
AB075836 mRNA. Translation: BAB85542.1. Different initiation.
AK056113 mRNA. Translation: BAB71096.1.
BC112244 mRNA. Translation: AAI12245.1.
BC113707 mRNA. Translation: AAI13708.1.
RefSeqNP_597717.1. NM_133460.1.
UniGeneHs.660728.

3D structure databases

ProteinModelPortalQ8TF45.
SMRQ8TF45. Positions 1-55, 96-676.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127074. 2 interactions.
IntActQ8TF45. 1 interaction.
STRING9606.ENSP00000379451.

PTM databases

PhosphoSiteQ8TF45.

Polymorphism databases

DMDM23396985.

Proteomic databases

PaxDbQ8TF45.
PeptideAtlasQ8TF45.
PRIDEQ8TF45.

Protocols and materials databases

DNASU147686.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000396147; ENSP00000379451; ENSG00000196724.
ENST00000595830; ENSP00000471652; ENSG00000196724.
GeneID147686.
KEGGhsa:147686.
UCSCuc002qqs.1. human.

Organism-specific databases

CTD147686.
GeneCardsGC19M058433.
HGNCHGNC:20647. ZNF418.
neXtProtNX_Q8TF45.
PharmGKBPA134912102.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOVERGENHBG018163.
InParanoidQ8TF45.
KOK09228.
OrthoDBEOG7KSX7Q.
PhylomeDBQ8TF45.
TreeFamTF339848.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ8TF45.
BgeeQ8TF45.
CleanExHS_ZNF418.
GenevestigatorQ8TF45.

Family and domain databases

Gene3D3.30.160.60. 16 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi147686.
NextBio85679.
PROQ8TF45.

Entry information

Entry nameZN418_HUMAN
AccessionPrimary (citable) accession number: Q8TF45
Secondary accession number(s): Q2M1S2, Q670L5, Q96N18
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: April 16, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM