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Protein

Zinc finger protein 418

Gene

ZNF418

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri82 – 105C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri230 – 252C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri591 – 613C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri619 – 641C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri647 – 669C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 418
Gene namesi
Name:ZNF418
Synonyms:KIAA1956
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000196724.12
HGNCiHGNC:20647 ZNF418
neXtProtiNX_Q8TF45

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196724
PharmGKBiPA134912102

Polymorphism and mutation databases

BioMutaiZNF418
DMDMi23396985

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475731 – 676Zinc finger protein 418Add BLAST676

Proteomic databases

PaxDbiQ8TF45
PeptideAtlasiQ8TF45
PRIDEiQ8TF45

PTM databases

iPTMnetiQ8TF45
PhosphoSitePlusiQ8TF45

Expressioni

Gene expression databases

BgeeiENSG00000196724
CleanExiHS_ZNF418
ExpressionAtlasiQ8TF45 baseline and differential
GenevisibleiQ8TF45 HS

Organism-specific databases

HPAiHPA043800
HPA053762
HPA072145

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-3446851,EBI-10172290

Protein-protein interaction databases

BioGridi127074, 2 interactors
IntActiQ8TF45, 3 interactors
STRINGi9606.ENSP00000379451

Structurei

3D structure databases

ProteinModelPortaliQ8TF45
SMRiQ8TF45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 91KRABPROSITE-ProRule annotationAdd BLAST87

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri82 – 105C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri230 – 252C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri591 – 613C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri619 – 641C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri647 – 669C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOVERGENiHBG018163
InParanoidiQ8TF45
KOiK09228
PhylomeDBiQ8TF45
TreeFamiTF339848

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 17 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

Sequencei

Sequence statusi: Complete.

Q8TF45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGTVAFEDV AVNFSQEEWS LLSEVQRCLY HDVMLENWVL ISSLGCWCGS
60 70 80 90 100
EDEEAPSKKS ISIQRVSQVS TPGAGVSPKK AHSCEMCGAI LGDILHLADH
110 120 130 140 150
QGTHHKQKLH RCEAWGNKLY DSSNRPHQNQ YLGEKPYRSS VEEALFVKRC
160 170 180 190 200
KFHVSEESSI FIQSGKDFLP SSGLLLQEAT HTGEKSNSKP ECESPFQWGD
210 220 230 240 250
THYSCGECMK HSSTKHVFVQ QQRLPSREEC YCWECGKSFS KYDSVSNHQR
260 270 280 290 300
VHTGKRPYEC GECGKSFSHK GSLVQHQRVH TGKRPYECGE CGKSFSHKGS
310 320 330 340 350
LVQHQRVHTG ERPYECGECG KSFSQNGTLI KHQRVHTGER PYECEECGKC
360 370 380 390 400
FTQKGNLIQH QRGHTSERPY ECEECGKCFS QKGTLTEHHR VHTRERPYEC
410 420 430 440 450
GECGKSFSRK GHLRNHQRGH TGERPYECGE CGKSFSRKGN LIQHQRSHTG
460 470 480 490 500
ERPYECRECR KLFRGKSHLI EHQRVHTGER PYECNECGKS FQDSSGFRVH
510 520 530 540 550
QRVHTGEKPF ECSECGKSFP QSCSLLRHRR VHTGERPYEC GECGKSFHQS
560 570 580 590 600
SSLLRHQKTH TAERPYECRE CGKFFSSLLE HRRVHTGERP YECRECGKTF
610 620 630 640 650
TRRSAHFKHQ RLHTRGKPYE CSECGKSFAE TFSLTEHRRV HTGERPYECS
660 670
ECGKSFHRSS SLLRHQRVHT ERSPYK
Length:676
Mass (Da):77,858
Last modified:September 19, 2002 - v2
Checksum:i1BB0F0064B8F3BD3
GO

Sequence cautioni

The sequence BAB85542 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti290E → G in BAB71096 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY695825 mRNA Translation: AAU05132.1
AB075836 mRNA Translation: BAB85542.1 Different initiation.
AK056113 mRNA Translation: BAB71096.1
BC112244 mRNA Translation: AAI12245.1
BC113707 mRNA Translation: AAI13708.1
CCDSiCCDS42642.1
RefSeqiNP_001303956.1, NM_001317027.1
NP_001303957.1, NM_001317028.1
NP_001303958.1, NM_001317029.1
NP_001303959.1, NM_001317030.1
NP_597717.1, NM_133460.2
XP_016881801.1, XM_017026312.1
XP_016881802.1, XM_017026313.1
UniGeneiHs.660728

Genome annotation databases

EnsembliENST00000396147; ENSP00000379451; ENSG00000196724
ENST00000595830; ENSP00000471652; ENSG00000196724
ENST00000616958; ENSP00000483763; ENSG00000196724
GeneIDi147686
KEGGihsa:147686
UCSCiuc002qqs.1 human

Similar proteinsi

Entry informationi

Entry nameiZN418_HUMAN
AccessioniPrimary (citable) accession number: Q8TF45
Secondary accession number(s): Q2M1S2, Q670L5, Q96N18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: May 23, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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