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Protein

Zinc finger protein 418

Gene

ZNF418

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri82 – 10524C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 25223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri286 – 30823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri342 – 36423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri426 – 44823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri482 – 50423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri510 – 53223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri538 – 56023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri591 – 61323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri619 – 64123C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri647 – 66923C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 418
Gene namesi
Name:ZNF418
Synonyms:KIAA1956
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20647. ZNF418.

Subcellular locationi

  1. Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134912102.

Polymorphism and mutation databases

BioMutaiZNF418.
DMDMi23396985.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 676676Zinc finger protein 418PRO_0000047573Add
BLAST

Proteomic databases

PaxDbiQ8TF45.
PeptideAtlasiQ8TF45.
PRIDEiQ8TF45.

PTM databases

PhosphoSiteiQ8TF45.

Expressioni

Gene expression databases

BgeeiQ8TF45.
CleanExiHS_ZNF418.
ExpressionAtlasiQ8TF45. baseline and differential.
GenevestigatoriQ8TF45.

Organism-specific databases

HPAiHPA043800.
HPA053762.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-3446851,EBI-10172290

Protein-protein interaction databases

BioGridi127074. 3 interactions.
IntActiQ8TF45. 2 interactions.
STRINGi9606.ENSP00000379451.

Structurei

3D structure databases

ProteinModelPortaliQ8TF45.
SMRiQ8TF45. Positions 96-676.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 9187KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri82 – 10524C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 25223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri286 – 30823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri342 – 36423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri426 – 44823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri482 – 50423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri510 – 53223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri538 – 56023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri591 – 61323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri619 – 64123C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri647 – 66923C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119107.
HOVERGENiHBG018163.
InParanoidiQ8TF45.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8TF45.
TreeFamiTF339848.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TF45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGTVAFEDV AVNFSQEEWS LLSEVQRCLY HDVMLENWVL ISSLGCWCGS
60 70 80 90 100
EDEEAPSKKS ISIQRVSQVS TPGAGVSPKK AHSCEMCGAI LGDILHLADH
110 120 130 140 150
QGTHHKQKLH RCEAWGNKLY DSSNRPHQNQ YLGEKPYRSS VEEALFVKRC
160 170 180 190 200
KFHVSEESSI FIQSGKDFLP SSGLLLQEAT HTGEKSNSKP ECESPFQWGD
210 220 230 240 250
THYSCGECMK HSSTKHVFVQ QQRLPSREEC YCWECGKSFS KYDSVSNHQR
260 270 280 290 300
VHTGKRPYEC GECGKSFSHK GSLVQHQRVH TGKRPYECGE CGKSFSHKGS
310 320 330 340 350
LVQHQRVHTG ERPYECGECG KSFSQNGTLI KHQRVHTGER PYECEECGKC
360 370 380 390 400
FTQKGNLIQH QRGHTSERPY ECEECGKCFS QKGTLTEHHR VHTRERPYEC
410 420 430 440 450
GECGKSFSRK GHLRNHQRGH TGERPYECGE CGKSFSRKGN LIQHQRSHTG
460 470 480 490 500
ERPYECRECR KLFRGKSHLI EHQRVHTGER PYECNECGKS FQDSSGFRVH
510 520 530 540 550
QRVHTGEKPF ECSECGKSFP QSCSLLRHRR VHTGERPYEC GECGKSFHQS
560 570 580 590 600
SSLLRHQKTH TAERPYECRE CGKFFSSLLE HRRVHTGERP YECRECGKTF
610 620 630 640 650
TRRSAHFKHQ RLHTRGKPYE CSECGKSFAE TFSLTEHRRV HTGERPYECS
660 670
ECGKSFHRSS SLLRHQRVHT ERSPYK
Length:676
Mass (Da):77,858
Last modified:September 19, 2002 - v2
Checksum:i1BB0F0064B8F3BD3
GO

Sequence cautioni

The sequence BAB85542.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti290 – 2901E → G in BAB71096 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY695825 mRNA. Translation: AAU05132.1.
AB075836 mRNA. Translation: BAB85542.1. Different initiation.
AK056113 mRNA. Translation: BAB71096.1.
BC112244 mRNA. Translation: AAI12245.1.
BC113707 mRNA. Translation: AAI13708.1.
CCDSiCCDS42642.1.
RefSeqiNP_597717.1. NM_133460.1.
UniGeneiHs.660728.

Genome annotation databases

EnsembliENST00000396147; ENSP00000379451; ENSG00000196724.
ENST00000595830; ENSP00000471652; ENSG00000196724.
ENST00000616958; ENSP00000483763; ENSG00000196724.
GeneIDi147686.
KEGGihsa:147686.
UCSCiuc002qqs.1. human.

Polymorphism and mutation databases

BioMutaiZNF418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY695825 mRNA. Translation: AAU05132.1.
AB075836 mRNA. Translation: BAB85542.1. Different initiation.
AK056113 mRNA. Translation: BAB71096.1.
BC112244 mRNA. Translation: AAI12245.1.
BC113707 mRNA. Translation: AAI13708.1.
CCDSiCCDS42642.1.
RefSeqiNP_597717.1. NM_133460.1.
UniGeneiHs.660728.

3D structure databases

ProteinModelPortaliQ8TF45.
SMRiQ8TF45. Positions 96-676.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127074. 3 interactions.
IntActiQ8TF45. 2 interactions.
STRINGi9606.ENSP00000379451.

PTM databases

PhosphoSiteiQ8TF45.

Polymorphism and mutation databases

BioMutaiZNF418.
DMDMi23396985.

Proteomic databases

PaxDbiQ8TF45.
PeptideAtlasiQ8TF45.
PRIDEiQ8TF45.

Protocols and materials databases

DNASUi147686.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396147; ENSP00000379451; ENSG00000196724.
ENST00000595830; ENSP00000471652; ENSG00000196724.
ENST00000616958; ENSP00000483763; ENSG00000196724.
GeneIDi147686.
KEGGihsa:147686.
UCSCiuc002qqs.1. human.

Organism-specific databases

CTDi147686.
GeneCardsiGC19M058433.
HGNCiHGNC:20647. ZNF418.
HPAiHPA043800.
HPA053762.
neXtProtiNX_Q8TF45.
PharmGKBiPA134912102.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119107.
HOVERGENiHBG018163.
InParanoidiQ8TF45.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8TF45.
TreeFamiTF339848.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF418. human.
GenomeRNAii147686.
NextBioi85679.
PROiQ8TF45.

Gene expression databases

BgeeiQ8TF45.
CleanExiHS_ZNF418.
ExpressionAtlasiQ8TF45. baseline and differential.
GenevestigatoriQ8TF45.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ZNF418, a novel KRAB-containing zinc finger protein, is a transcription repressor."
    Li Y., Wang Q., Yuan W., Zhu C., Wu X., Liu M.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiZN418_HUMAN
AccessioniPrimary (citable) accession number: Q8TF45
Secondary accession number(s): Q2M1S2, Q670L5, Q96N18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: April 29, 2015
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.