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Q8TF45

- ZN418_HUMAN

UniProt

Q8TF45 - ZN418_HUMAN

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Protein

Zinc finger protein 418

Gene

ZNF418

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri82 – 10524C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 25223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri286 – 30823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri342 – 36423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri426 – 44823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri482 – 50423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri510 – 53223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri538 – 56023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri591 – 61323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri619 – 64123C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri647 – 66923C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 418
Gene namesi
Name:ZNF418
Synonyms:KIAA1956
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:20647. ZNF418.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134912102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 676676Zinc finger protein 418PRO_0000047573Add
BLAST

Proteomic databases

PaxDbiQ8TF45.
PeptideAtlasiQ8TF45.
PRIDEiQ8TF45.

PTM databases

PhosphoSiteiQ8TF45.

Expressioni

Gene expression databases

BgeeiQ8TF45.
CleanExiHS_ZNF418.
ExpressionAtlasiQ8TF45. baseline and differential.
GenevestigatoriQ8TF45.

Interactioni

Protein-protein interaction databases

BioGridi127074. 2 interactions.
IntActiQ8TF45. 1 interaction.
STRINGi9606.ENSP00000379451.

Structurei

3D structure databases

ProteinModelPortaliQ8TF45.
SMRiQ8TF45. Positions 96-676.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 9187KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri82 – 10524C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 25223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri286 – 30823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri342 – 36423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri426 – 44823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri482 – 50423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri510 – 53223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri538 – 56023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri591 – 61323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri619 – 64123C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri647 – 66923C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119107.
HOVERGENiHBG018163.
InParanoidiQ8TF45.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8TF45.
TreeFamiTF339848.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8TF45-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQGTVAFEDV AVNFSQEEWS LLSEVQRCLY HDVMLENWVL ISSLGCWCGS
60 70 80 90 100
EDEEAPSKKS ISIQRVSQVS TPGAGVSPKK AHSCEMCGAI LGDILHLADH
110 120 130 140 150
QGTHHKQKLH RCEAWGNKLY DSSNRPHQNQ YLGEKPYRSS VEEALFVKRC
160 170 180 190 200
KFHVSEESSI FIQSGKDFLP SSGLLLQEAT HTGEKSNSKP ECESPFQWGD
210 220 230 240 250
THYSCGECMK HSSTKHVFVQ QQRLPSREEC YCWECGKSFS KYDSVSNHQR
260 270 280 290 300
VHTGKRPYEC GECGKSFSHK GSLVQHQRVH TGKRPYECGE CGKSFSHKGS
310 320 330 340 350
LVQHQRVHTG ERPYECGECG KSFSQNGTLI KHQRVHTGER PYECEECGKC
360 370 380 390 400
FTQKGNLIQH QRGHTSERPY ECEECGKCFS QKGTLTEHHR VHTRERPYEC
410 420 430 440 450
GECGKSFSRK GHLRNHQRGH TGERPYECGE CGKSFSRKGN LIQHQRSHTG
460 470 480 490 500
ERPYECRECR KLFRGKSHLI EHQRVHTGER PYECNECGKS FQDSSGFRVH
510 520 530 540 550
QRVHTGEKPF ECSECGKSFP QSCSLLRHRR VHTGERPYEC GECGKSFHQS
560 570 580 590 600
SSLLRHQKTH TAERPYECRE CGKFFSSLLE HRRVHTGERP YECRECGKTF
610 620 630 640 650
TRRSAHFKHQ RLHTRGKPYE CSECGKSFAE TFSLTEHRRV HTGERPYECS
660 670
ECGKSFHRSS SLLRHQRVHT ERSPYK
Length:676
Mass (Da):77,858
Last modified:September 19, 2002 - v2
Checksum:i1BB0F0064B8F3BD3
GO

Sequence cautioni

The sequence BAB85542.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti290 – 2901E → G in BAB71096. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY695825 mRNA. Translation: AAU05132.1.
AB075836 mRNA. Translation: BAB85542.1. Different initiation.
AK056113 mRNA. Translation: BAB71096.1.
BC112244 mRNA. Translation: AAI12245.1.
BC113707 mRNA. Translation: AAI13708.1.
CCDSiCCDS42642.1.
RefSeqiNP_597717.1. NM_133460.1.
UniGeneiHs.660728.

Genome annotation databases

EnsembliENST00000396147; ENSP00000379451; ENSG00000196724.
ENST00000595830; ENSP00000471652; ENSG00000196724.
ENST00000616958; ENSP00000483763; ENSG00000196724.
GeneIDi147686.
KEGGihsa:147686.
UCSCiuc002qqs.1. human.

Polymorphism databases

DMDMi23396985.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY695825 mRNA. Translation: AAU05132.1 .
AB075836 mRNA. Translation: BAB85542.1 . Different initiation.
AK056113 mRNA. Translation: BAB71096.1 .
BC112244 mRNA. Translation: AAI12245.1 .
BC113707 mRNA. Translation: AAI13708.1 .
CCDSi CCDS42642.1.
RefSeqi NP_597717.1. NM_133460.1.
UniGenei Hs.660728.

3D structure databases

ProteinModelPortali Q8TF45.
SMRi Q8TF45. Positions 96-676.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127074. 2 interactions.
IntActi Q8TF45. 1 interaction.
STRINGi 9606.ENSP00000379451.

PTM databases

PhosphoSitei Q8TF45.

Polymorphism databases

DMDMi 23396985.

Proteomic databases

PaxDbi Q8TF45.
PeptideAtlasi Q8TF45.
PRIDEi Q8TF45.

Protocols and materials databases

DNASUi 147686.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000396147 ; ENSP00000379451 ; ENSG00000196724 .
ENST00000595830 ; ENSP00000471652 ; ENSG00000196724 .
ENST00000616958 ; ENSP00000483763 ; ENSG00000196724 .
GeneIDi 147686.
KEGGi hsa:147686.
UCSCi uc002qqs.1. human.

Organism-specific databases

CTDi 147686.
GeneCardsi GC19M058433.
HGNCi HGNC:20647. ZNF418.
neXtProti NX_Q8TF45.
PharmGKBi PA134912102.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000119107.
HOVERGENi HBG018163.
InParanoidi Q8TF45.
KOi K09228.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q8TF45.
TreeFami TF339848.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSi ZNF418. human.
GenomeRNAii 147686.
NextBioi 85679.
PROi Q8TF45.

Gene expression databases

Bgeei Q8TF45.
CleanExi HS_ZNF418.
ExpressionAtlasi Q8TF45. baseline and differential.
Genevestigatori Q8TF45.

Family and domain databases

Gene3Di 3.30.160.60. 16 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ZNF418, a novel KRAB-containing zinc finger protein, is a transcription repressor."
    Li Y., Wang Q., Yuan W., Zhu C., Wu X., Liu M.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiZN418_HUMAN
AccessioniPrimary (citable) accession number: Q8TF45
Secondary accession number(s): Q2M1S2, Q670L5, Q96N18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: November 26, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3